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Sequenom mass-arraytm platform
Mass Arraytm Platform, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mass+arraytm+platform/mass+arraytm+platform/pmc04660625-67-1-5
Average 90 stars, based on 1 article reviews
mass-arraytm platform - by Bioz Stars, 2026-09
90/100 stars

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Real-time Polymerase Chain Reaction:

Article Title: A predictive model for the development of chronic obstructive pulmonary disease
Article Snippet: The Mass-ArrayTM Technology platform of Sequenom, Inc., (San Diego, CA, USA) was used to perform genotyping.

Article Title: The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
Article Snippet: To investigate the effects of genetic and nongenetic factors on bone mineral densities (BMDs) and osteoporotic fractures.. This was a cross-sectional study to investigate the relationships between 18 SNPs and nongenetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women.. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures.

Article Title: Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study
Article Snippet: Genotyping was achieved using the Mass-ArrayTM Technology platform of Sequenom, Inc. (San Diego, CA, USA).

Article Title: The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study
Article Snippet: The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes.. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer’s disease (AD) and dementia.. Thus, our aim was to explore the impact of FTO on AD and dementia risk.

Article Title: Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.
Article Snippet: Interestingly, when stratified by table 1 Characteristics of studies included in the meta-analysis First author referrnce Published year Country Ethnicity Genotyping methods Matching criteria Types of diseases Sample size (male/female) Mean age (±SD) (year) Genotypes of controls Genotypes of cases HWE controls cases controls cases CC CT TT CC CT TT Gu [3] 2010 China Asian Mass-ArrayTM Technology Platform from Sequenom NA GD 316 (98/218) 436 (117/319) 49.2±12.7 39.3±12.3 315 0 0 423 0 0 NA Kahles [7] 2005 Germany Caucasian real-time PCR NA HT 239 (133/106) 94 (17/77) 49.4±16.6 (23-83) 51.6±17.0 (23-95) 187 50 2 67 25 2 Yes Zheng [16] 2008 China Asian PCR-RFLP age, sex GD 218 (77/141) 283 (88/195) 41±12 (15~58) 39 ±13 (11~70) 213 5 0 275 8 0 Yes Velaga [17] 2004 U.K Caucasian PCR-RFLP NA GD 429 549 (119/430) NA NA 365 61 3 404 139 6 Yes Chabchoub [18] 2009 Tunisia Caucasian PCR-RFLP NA AITD 236 (86/150) 204 (54/150) NA 34.2 (22~58) 224 12 200 4 Yes Smyth [19] 2004 U.K Caucasian PCR-RFLP ethnically GD 833 901 NA NA 669 154 10 661 222 18 Yes Skórka [20] 2005 Poland Caucasian PCR-RFLP ethnically GD 310 290 (60/230) NA 42.5 (6~78) 238 68 4 189 90 11 Yes Dultz [21] 2009 Germany Caucasian PCR-based reverse dot-blot technique NA AITD 100 (43/57) 70 (14/56) 38.9±15.6 42.3±13.8 86 12 2 58 12 0 Yes Ichimura [22] 2008 Japan Asian PCR-RFLP NA GD 231 (102/129) 414 (90/324) 29.2±8.3 (21-60) 41.9±15.8 (11-87) 231 0 0 414 0 0 NA Zhebrun [23] 2011 Russia Caucasian PCR-RFLP NA GD 200 171 NA NA 132 66 2 115 49 7 No Zheng [24] Doctoral Dissertation 2008 China Asian PCR-RFLP NA GD, HT 216 (76/140) 279 (86/193) (GD) 73(10/63) (HT) 41.46±12.26 39.43±13.64 (GD) 42.13±14.84 (HT) 211 5 0 271 (GD) 73 (HT) 8 (GD) 0 (HT) 0 (GD) 0 (HT) Yes PCR–RFLP, polymerase chain reaction–restriction fragment length polymorphism; NA, not available; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; AITD, autoimmune thyroid disease; HWE, Hardy-Weinberg equilibrium table 2 Stratified analyses of the Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) 1858 C/T polymorphism on autoimmune thyroid disease (AITD) risk.

Article Title: Study on the relationship between TSHR gene and thyroid diseases.
Article Snippet: Thyroid stimulating hormone receptor (TSHR) is thought to play a critical role in the pathogenesis of certain thyroid diseases, including Graves’ disease (GD), multinodular thyroid goiter (MTG), and Hashimoto’s thyroiditis (HT).. In order to understand whether single nucleotide polymorphisms in the TSHR gene contribute to thyroid diseases, we have conducted a case–control study in which, we examined 8 TSHR gene single-nucleotide polymorphisms in introns 1, 4, 5, 6 and exons 7 and 8, respectively, among patients with thyroid diseases.. These included one family with GD (3 patients and 9 healthy members); 60 patients with familiar thyroid diseases (30 with GD, 20 with MTG, and 10 with HT patients), 48 sporadic patients with GD and 96 healthy control individuals.

Article Title: Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease.
Article Snippet: The risk of developing chronic obstructive pulmonary disease (COPD) is partially determined by genetic and environmental factors.. Many published candidate gene studies show conflicting results due to ethnic differences and sample sizes.. The number of these studies carried out in Chinese populations is small.

Article Title: Lack of association between the TGF-β(1) gene and development of COPD in Asians: a case-control study and meta-analysis.
Article Snippet: Abnormalities in the transforming growth factor-b1 (TGF-b1) gene are thought to be linked to chronic obstructive pulmonary disease (COPD).. We investigated the association between the single nuclear polymorphisms (SNPs) of TGF-b1 and the risk of COPD in a case–control study and meta-analysis.. We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array Technology Platform and then tested the association of four SNPs in TGF-b1 (rs6957, rs1800469, rs2241712, and rs2241718) with COPD.

Polymerase Chain Reaction:

Article Title: A predictive model for the development of chronic obstructive pulmonary disease
Article Snippet: The Mass-ArrayTM Technology platform of Sequenom, Inc., (San Diego, CA, USA) was used to perform genotyping.

Article Title: The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
Article Snippet: To investigate the effects of genetic and nongenetic factors on bone mineral densities (BMDs) and osteoporotic fractures.. This was a cross-sectional study to investigate the relationships between 18 SNPs and nongenetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women.. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures.

Article Title: Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study
Article Snippet: Genotyping was achieved using the Mass-ArrayTM Technology platform of Sequenom, Inc. (San Diego, CA, USA).

Article Title: The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study
Article Snippet: The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes.. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer’s disease (AD) and dementia.. Thus, our aim was to explore the impact of FTO on AD and dementia risk.

Article Title: Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.
Article Snippet: Interestingly, when stratified by table 1 Characteristics of studies included in the meta-analysis First author referrnce Published year Country Ethnicity Genotyping methods Matching criteria Types of diseases Sample size (male/female) Mean age (±SD) (year) Genotypes of controls Genotypes of cases HWE controls cases controls cases CC CT TT CC CT TT Gu [3] 2010 China Asian Mass-ArrayTM Technology Platform from Sequenom NA GD 316 (98/218) 436 (117/319) 49.2±12.7 39.3±12.3 315 0 0 423 0 0 NA Kahles [7] 2005 Germany Caucasian real-time PCR NA HT 239 (133/106) 94 (17/77) 49.4±16.6 (23-83) 51.6±17.0 (23-95) 187 50 2 67 25 2 Yes Zheng [16] 2008 China Asian PCR-RFLP age, sex GD 218 (77/141) 283 (88/195) 41±12 (15~58) 39 ±13 (11~70) 213 5 0 275 8 0 Yes Velaga [17] 2004 U.K Caucasian PCR-RFLP NA GD 429 549 (119/430) NA NA 365 61 3 404 139 6 Yes Chabchoub [18] 2009 Tunisia Caucasian PCR-RFLP NA AITD 236 (86/150) 204 (54/150) NA 34.2 (22~58) 224 12 200 4 Yes Smyth [19] 2004 U.K Caucasian PCR-RFLP ethnically GD 833 901 NA NA 669 154 10 661 222 18 Yes Skórka [20] 2005 Poland Caucasian PCR-RFLP ethnically GD 310 290 (60/230) NA 42.5 (6~78) 238 68 4 189 90 11 Yes Dultz [21] 2009 Germany Caucasian PCR-based reverse dot-blot technique NA AITD 100 (43/57) 70 (14/56) 38.9±15.6 42.3±13.8 86 12 2 58 12 0 Yes Ichimura [22] 2008 Japan Asian PCR-RFLP NA GD 231 (102/129) 414 (90/324) 29.2±8.3 (21-60) 41.9±15.8 (11-87) 231 0 0 414 0 0 NA Zhebrun [23] 2011 Russia Caucasian PCR-RFLP NA GD 200 171 NA NA 132 66 2 115 49 7 No Zheng [24] Doctoral Dissertation 2008 China Asian PCR-RFLP NA GD, HT 216 (76/140) 279 (86/193) (GD) 73(10/63) (HT) 41.46±12.26 39.43±13.64 (GD) 42.13±14.84 (HT) 211 5 0 271 (GD) 73 (HT) 8 (GD) 0 (HT) 0 (GD) 0 (HT) Yes PCR–RFLP, polymerase chain reaction–restriction fragment length polymorphism; NA, not available; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; AITD, autoimmune thyroid disease; HWE, Hardy-Weinberg equilibrium table 2 Stratified analyses of the Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) 1858 C/T polymorphism on autoimmune thyroid disease (AITD) risk.

Article Title: Study on the relationship between TSHR gene and thyroid diseases.
Article Snippet: Thyroid stimulating hormone receptor (TSHR) is thought to play a critical role in the pathogenesis of certain thyroid diseases, including Graves’ disease (GD), multinodular thyroid goiter (MTG), and Hashimoto’s thyroiditis (HT).. In order to understand whether single nucleotide polymorphisms in the TSHR gene contribute to thyroid diseases, we have conducted a case–control study in which, we examined 8 TSHR gene single-nucleotide polymorphisms in introns 1, 4, 5, 6 and exons 7 and 8, respectively, among patients with thyroid diseases.. These included one family with GD (3 patients and 9 healthy members); 60 patients with familiar thyroid diseases (30 with GD, 20 with MTG, and 10 with HT patients), 48 sporadic patients with GD and 96 healthy control individuals.

Article Title: Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease.
Article Snippet: The risk of developing chronic obstructive pulmonary disease (COPD) is partially determined by genetic and environmental factors.. Many published candidate gene studies show conflicting results due to ethnic differences and sample sizes.. The number of these studies carried out in Chinese populations is small.

Article Title: Lack of association between the TGF-β(1) gene and development of COPD in Asians: a case-control study and meta-analysis.
Article Snippet: Abnormalities in the transforming growth factor-b1 (TGF-b1) gene are thought to be linked to chronic obstructive pulmonary disease (COPD).. We investigated the association between the single nuclear polymorphisms (SNPs) of TGF-b1 and the risk of COPD in a case–control study and meta-analysis.. We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array Technology Platform and then tested the association of four SNPs in TGF-b1 (rs6957, rs1800469, rs2241712, and rs2241718) with COPD.

Sequencing:

Article Title: A predictive model for the development of chronic obstructive pulmonary disease
Article Snippet: The Mass-ArrayTM Technology platform of Sequenom, Inc., (San Diego, CA, USA) was used to perform genotyping.

Article Title: The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
Article Snippet: To investigate the effects of genetic and nongenetic factors on bone mineral densities (BMDs) and osteoporotic fractures.. This was a cross-sectional study to investigate the relationships between 18 SNPs and nongenetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women.. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures.

Article Title: Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study
Article Snippet: Genotyping was achieved using the Mass-ArrayTM Technology platform of Sequenom, Inc. (San Diego, CA, USA).

Article Title: The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study
Article Snippet: The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes.. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer’s disease (AD) and dementia.. Thus, our aim was to explore the impact of FTO on AD and dementia risk.

Article Title: Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.
Article Snippet: Interestingly, when stratified by table 1 Characteristics of studies included in the meta-analysis First author referrnce Published year Country Ethnicity Genotyping methods Matching criteria Types of diseases Sample size (male/female) Mean age (±SD) (year) Genotypes of controls Genotypes of cases HWE controls cases controls cases CC CT TT CC CT TT Gu [3] 2010 China Asian Mass-ArrayTM Technology Platform from Sequenom NA GD 316 (98/218) 436 (117/319) 49.2±12.7 39.3±12.3 315 0 0 423 0 0 NA Kahles [7] 2005 Germany Caucasian real-time PCR NA HT 239 (133/106) 94 (17/77) 49.4±16.6 (23-83) 51.6±17.0 (23-95) 187 50 2 67 25 2 Yes Zheng [16] 2008 China Asian PCR-RFLP age, sex GD 218 (77/141) 283 (88/195) 41±12 (15~58) 39 ±13 (11~70) 213 5 0 275 8 0 Yes Velaga [17] 2004 U.K Caucasian PCR-RFLP NA GD 429 549 (119/430) NA NA 365 61 3 404 139 6 Yes Chabchoub [18] 2009 Tunisia Caucasian PCR-RFLP NA AITD 236 (86/150) 204 (54/150) NA 34.2 (22~58) 224 12 200 4 Yes Smyth [19] 2004 U.K Caucasian PCR-RFLP ethnically GD 833 901 NA NA 669 154 10 661 222 18 Yes Skórka [20] 2005 Poland Caucasian PCR-RFLP ethnically GD 310 290 (60/230) NA 42.5 (6~78) 238 68 4 189 90 11 Yes Dultz [21] 2009 Germany Caucasian PCR-based reverse dot-blot technique NA AITD 100 (43/57) 70 (14/56) 38.9±15.6 42.3±13.8 86 12 2 58 12 0 Yes Ichimura [22] 2008 Japan Asian PCR-RFLP NA GD 231 (102/129) 414 (90/324) 29.2±8.3 (21-60) 41.9±15.8 (11-87) 231 0 0 414 0 0 NA Zhebrun [23] 2011 Russia Caucasian PCR-RFLP NA GD 200 171 NA NA 132 66 2 115 49 7 No Zheng [24] Doctoral Dissertation 2008 China Asian PCR-RFLP NA GD, HT 216 (76/140) 279 (86/193) (GD) 73(10/63) (HT) 41.46±12.26 39.43±13.64 (GD) 42.13±14.84 (HT) 211 5 0 271 (GD) 73 (HT) 8 (GD) 0 (HT) 0 (GD) 0 (HT) Yes PCR–RFLP, polymerase chain reaction–restriction fragment length polymorphism; NA, not available; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; AITD, autoimmune thyroid disease; HWE, Hardy-Weinberg equilibrium table 2 Stratified analyses of the Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) 1858 C/T polymorphism on autoimmune thyroid disease (AITD) risk.

Article Title: Study on the relationship between TSHR gene and thyroid diseases.
Article Snippet: Thyroid stimulating hormone receptor (TSHR) is thought to play a critical role in the pathogenesis of certain thyroid diseases, including Graves’ disease (GD), multinodular thyroid goiter (MTG), and Hashimoto’s thyroiditis (HT).. In order to understand whether single nucleotide polymorphisms in the TSHR gene contribute to thyroid diseases, we have conducted a case–control study in which, we examined 8 TSHR gene single-nucleotide polymorphisms in introns 1, 4, 5, 6 and exons 7 and 8, respectively, among patients with thyroid diseases.. These included one family with GD (3 patients and 9 healthy members); 60 patients with familiar thyroid diseases (30 with GD, 20 with MTG, and 10 with HT patients), 48 sporadic patients with GD and 96 healthy control individuals.

Article Title: Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease.
Article Snippet: The risk of developing chronic obstructive pulmonary disease (COPD) is partially determined by genetic and environmental factors.. Many published candidate gene studies show conflicting results due to ethnic differences and sample sizes.. The number of these studies carried out in Chinese populations is small.

Article Title: Lack of association between the TGF-β(1) gene and development of COPD in Asians: a case-control study and meta-analysis.
Article Snippet: Abnormalities in the transforming growth factor-b1 (TGF-b1) gene are thought to be linked to chronic obstructive pulmonary disease (COPD).. We investigated the association between the single nuclear polymorphisms (SNPs) of TGF-b1 and the risk of COPD in a case–control study and meta-analysis.. We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array Technology Platform and then tested the association of four SNPs in TGF-b1 (rs6957, rs1800469, rs2241712, and rs2241718) with COPD.

Isolation:

Article Title: A predictive model for the development of chronic obstructive pulmonary disease
Article Snippet: The Mass-ArrayTM Technology platform of Sequenom, Inc., (San Diego, CA, USA) was used to perform genotyping.

Article Title: The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
Article Snippet: To investigate the effects of genetic and nongenetic factors on bone mineral densities (BMDs) and osteoporotic fractures.. This was a cross-sectional study to investigate the relationships between 18 SNPs and nongenetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women.. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures.

Article Title: Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study
Article Snippet: Genotyping was achieved using the Mass-ArrayTM Technology platform of Sequenom, Inc. (San Diego, CA, USA).

Article Title: The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study
Article Snippet: The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes.. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer’s disease (AD) and dementia.. Thus, our aim was to explore the impact of FTO on AD and dementia risk.

Article Title: Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.
Article Snippet: Interestingly, when stratified by table 1 Characteristics of studies included in the meta-analysis First author referrnce Published year Country Ethnicity Genotyping methods Matching criteria Types of diseases Sample size (male/female) Mean age (±SD) (year) Genotypes of controls Genotypes of cases HWE controls cases controls cases CC CT TT CC CT TT Gu [3] 2010 China Asian Mass-ArrayTM Technology Platform from Sequenom NA GD 316 (98/218) 436 (117/319) 49.2±12.7 39.3±12.3 315 0 0 423 0 0 NA Kahles [7] 2005 Germany Caucasian real-time PCR NA HT 239 (133/106) 94 (17/77) 49.4±16.6 (23-83) 51.6±17.0 (23-95) 187 50 2 67 25 2 Yes Zheng [16] 2008 China Asian PCR-RFLP age, sex GD 218 (77/141) 283 (88/195) 41±12 (15~58) 39 ±13 (11~70) 213 5 0 275 8 0 Yes Velaga [17] 2004 U.K Caucasian PCR-RFLP NA GD 429 549 (119/430) NA NA 365 61 3 404 139 6 Yes Chabchoub [18] 2009 Tunisia Caucasian PCR-RFLP NA AITD 236 (86/150) 204 (54/150) NA 34.2 (22~58) 224 12 200 4 Yes Smyth [19] 2004 U.K Caucasian PCR-RFLP ethnically GD 833 901 NA NA 669 154 10 661 222 18 Yes Skórka [20] 2005 Poland Caucasian PCR-RFLP ethnically GD 310 290 (60/230) NA 42.5 (6~78) 238 68 4 189 90 11 Yes Dultz [21] 2009 Germany Caucasian PCR-based reverse dot-blot technique NA AITD 100 (43/57) 70 (14/56) 38.9±15.6 42.3±13.8 86 12 2 58 12 0 Yes Ichimura [22] 2008 Japan Asian PCR-RFLP NA GD 231 (102/129) 414 (90/324) 29.2±8.3 (21-60) 41.9±15.8 (11-87) 231 0 0 414 0 0 NA Zhebrun [23] 2011 Russia Caucasian PCR-RFLP NA GD 200 171 NA NA 132 66 2 115 49 7 No Zheng [24] Doctoral Dissertation 2008 China Asian PCR-RFLP NA GD, HT 216 (76/140) 279 (86/193) (GD) 73(10/63) (HT) 41.46±12.26 39.43±13.64 (GD) 42.13±14.84 (HT) 211 5 0 271 (GD) 73 (HT) 8 (GD) 0 (HT) 0 (GD) 0 (HT) Yes PCR–RFLP, polymerase chain reaction–restriction fragment length polymorphism; NA, not available; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; AITD, autoimmune thyroid disease; HWE, Hardy-Weinberg equilibrium table 2 Stratified analyses of the Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) 1858 C/T polymorphism on autoimmune thyroid disease (AITD) risk.

Article Title: Study on the relationship between TSHR gene and thyroid diseases.
Article Snippet: Thyroid stimulating hormone receptor (TSHR) is thought to play a critical role in the pathogenesis of certain thyroid diseases, including Graves’ disease (GD), multinodular thyroid goiter (MTG), and Hashimoto’s thyroiditis (HT).. In order to understand whether single nucleotide polymorphisms in the TSHR gene contribute to thyroid diseases, we have conducted a case–control study in which, we examined 8 TSHR gene single-nucleotide polymorphisms in introns 1, 4, 5, 6 and exons 7 and 8, respectively, among patients with thyroid diseases.. These included one family with GD (3 patients and 9 healthy members); 60 patients with familiar thyroid diseases (30 with GD, 20 with MTG, and 10 with HT patients), 48 sporadic patients with GD and 96 healthy control individuals.

Article Title: Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease.
Article Snippet: The risk of developing chronic obstructive pulmonary disease (COPD) is partially determined by genetic and environmental factors.. Many published candidate gene studies show conflicting results due to ethnic differences and sample sizes.. The number of these studies carried out in Chinese populations is small.

Article Title: Lack of association between the TGF-β(1) gene and development of COPD in Asians: a case-control study and meta-analysis.
Article Snippet: Abnormalities in the transforming growth factor-b1 (TGF-b1) gene are thought to be linked to chronic obstructive pulmonary disease (COPD).. We investigated the association between the single nuclear polymorphisms (SNPs) of TGF-b1 and the risk of COPD in a case–control study and meta-analysis.. We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array Technology Platform and then tested the association of four SNPs in TGF-b1 (rs6957, rs1800469, rs2241712, and rs2241718) with COPD.



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