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shock generator  (Med Associates Inc)


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    Med Associates Inc shock generator
    Shock Generator, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 96/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/generator+module/Constant+Current+Aversive+Stimulation+Module/pmc12890247-346-10-13
    Average 96 stars, based on 15 article reviews
    shock generator - by Bioz Stars, 2026-11
    96/100 stars

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    Related Articles

    Produced:

    Article Title: Pre- and postsynaptic signatures in the prelimbic cortex associated with “alcohol use disorder” in the rat
    Article Snippet: .. The second active lever press produced a foot-shock of (0.25 mA, 0.5 s) via a metal grid connected to a shock generator (ENV-410C, Med Associates, Inc., St. Albans, VT). ..

    other:

    Article Title: Effects of environmental and pharmacological manipulations on cocaine-vs-negative reinforcer choice in male and female rats.
    Article Snippet: Rationale The adverse consequences of human addictive drug use could be the result of either addictive drug consumption resulting in punishment (e.g., incarceration) or failure to engage in negative-reinforced behaviors that might compete with drug-maintained behaviors (e.g., contingency management strategies that reset payment amounts for drug free urines).. Objective The goal of the present study was to establish a discrete-trial cocaine-vs-negative reinforcer (SNR) choice procedure where rats were presented with a simplified model of this conflict: choose negative reinforcement (i.e., escape or avoid foot shock) or choose an intravenous (IV) cocaine infusion followed by an inescapable shock.. Methods Responding was maintained in male and female rats by IV cocaine infusions (0.32–1.8 mg/kg/inf) and a SNR (0.1–0.7 mA shock) under a discrete-trial concurrent “choice” schedule during daily sessions.

    Article Title: Backward conditioning reveals flexibility in infralimbic cortex inhibitory memories
    Article Snippet: The grid floor of each chamber was connected to a shock generator (ENV-410C; MED Associates, Fairfax, VT, USA) that delivered a 0.5 mA, 0.5 s shock.

    Article Title: Backward Conditioning Reveals Flexibility in Infralimbic Cortex Inhibitory Memories
    Article Snippet: The grid floor of each chamber was connected to a shock generator (ENV-410C; MED Associates, Fairfax, VT, USA) that delivered a 0.5 mA, 0.5s shock.

    Control:

    Article Title: From injury to recovery: functional neuronal regeneration after traumatic brain injury in the telencephalon of the young adult killifish
    Article Snippet: .. In the light-dark preference test, fish were allowed to swim freely for 20 min. For the conditioned place avoidance tests, two copper electrodes were added to the setup, one on the left and one on the right side of the maze (light and dark arm) and connected to an aversive stimulator (ENV410-C, Med Associates Inc.) that was controlled via the trial hardware control of the Ethovision Software. ..

    Software:

    Article Title: From injury to recovery: functional neuronal regeneration after traumatic brain injury in the telencephalon of the young adult killifish
    Article Snippet: .. In the light-dark preference test, fish were allowed to swim freely for 20 min. For the conditioned place avoidance tests, two copper electrodes were added to the setup, one on the left and one on the right side of the maze (light and dark arm) and connected to an aversive stimulator (ENV410-C, Med Associates Inc.) that was controlled via the trial hardware control of the Ethovision Software. ..



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    Receptor‐ligand‐pharmacophore generation based on the complex structure of NEP‐sacubitrilat. (A) The complex structure of NEP‐sacubitrilat (PDB ID: 5JMY). The NEP is presented in ribbon (colored in gray); sacubitrilat is shown in spheres (colored in orange). (B) Generated pharmacophore features and structure of the NEP‐sacubitrilat. The interactive residues of NEP are shown as sticks (white) and labeled. The sacubitrilat is presented in balls‐and‐sticks (orange). (C) Features at a specific distance correspond to the pharmacophore model Phar‐A3D2R1 . Pharmacophore features are color‐coded as follows: Hydrogen‐bond acceptor, green; hydrogen‐bond donor, magenta; ring aromatic feature, orange.

    Journal: Chemical Biology & Drug Design

    Article Title: Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

    doi: 10.1111/cbdd.70247

    Figure Lengend Snippet: Receptor‐ligand‐pharmacophore generation based on the complex structure of NEP‐sacubitrilat. (A) The complex structure of NEP‐sacubitrilat (PDB ID: 5JMY). The NEP is presented in ribbon (colored in gray); sacubitrilat is shown in spheres (colored in orange). (B) Generated pharmacophore features and structure of the NEP‐sacubitrilat. The interactive residues of NEP are shown as sticks (white) and labeled. The sacubitrilat is presented in balls‐and‐sticks (orange). (C) Features at a specific distance correspond to the pharmacophore model Phar‐A3D2R1 . Pharmacophore features are color‐coded as follows: Hydrogen‐bond acceptor, green; hydrogen‐bond donor, magenta; ring aromatic feature, orange.

    Article Snippet: The modeling process was conducted with the receptor‐ligand pharmacophore generation module in Discovery Studio 2021 (Accelrys Software Inc., San Diego, CA, USA).

    Techniques: Generated, Labeling

    Pharmacophore‐based inhibitor screening. The results of ligand pharmacophore ( Phar‐A3D2R1 ) mapping of top 10 hits screened from TCM database.

    Journal: Chemical Biology & Drug Design

    Article Title: Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

    doi: 10.1111/cbdd.70247

    Figure Lengend Snippet: Pharmacophore‐based inhibitor screening. The results of ligand pharmacophore ( Phar‐A3D2R1 ) mapping of top 10 hits screened from TCM database.

    Article Snippet: The modeling process was conducted with the receptor‐ligand pharmacophore generation module in Discovery Studio 2021 (Accelrys Software Inc., San Diego, CA, USA).

    Techniques: