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GenScript corporation codon optimized cptrxr open reading frames
Codon Optimized Cptrxr Open Reading Frames, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/codon-optimized+open+reading+frames/codon+optimized+open+reading+frames/pm40304242-59-1-13
Average 90 stars, based on 1 article reviews
codon optimized cptrxr open reading frames - by Bioz Stars, 2026-11
90/100 stars

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Article Title: Evaluation of a minimal array of Treponema pallidum antigens as biomarkers for syphilis diagnosis, infection staging, and response to treatment
Article Snippet: Coding sequences (synthesized by GenScript as codon-optimized open reading frames for expression in E. coli ) were obtained based on the Nichols strain genome of T. pallidum ( ) (NC_021490.2 /CP004010.2) and were cloned either into the pEXP-5-NT (Life Technologies, Carlsbad, CA) plasmid, which adds an amino-terminal His-tag, or the pET28a+/pET23b+ vectors (Millipore Sigma, St. Louis, MO) between restriction sites that would retain the vector-encoded amino (pET28a+) or carboxyl-terminal (pET23b+) His-tag, respectively.

Article Title: Evaluation of a minimal array of Treponema pallidum antigens as biomarkers for syphilis diagnosis, infection staging, and response to treatment.
Article Snippet: Coding sequences (synthesized by GenScript as codon-optimized open reading frames for expression in E. coli) were obtained based on the Nichols strain genome of T. pallidum (32) (NC_021490.2 /CP004010.2) and were cloned either into the pEXP-5-NT (Life Technologies, Carlsbad, CA) plasmid, which adds an amino-terminal His-tag, or the pET28a+/pET23b+ vectors (Millipore Sigma, St. Louis, MO) between restriction sites that would retain the vector-encoded amino (pET28a+) or carboxyl-terminal (pET23b+) His-tag, respectively.

Article Title: Protein interaction mapping reveals widespread targeting of development-related host transcription factors by phytoplasma effectors.
Article Snippet: Generation of SAP06 transgenic plants A synthetic plant codon-optimized ORF was created for AY-WB SAP06 by GenScript Biotech (Piscataway, NJ, USA) and subcloned by Gateway-based cloning into the entry vector pDONR207 (Invitrogen, Thermo Fisher Scientific, Inc., UK).

Article Title: Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains
Article Snippet: An amino acid sequence starting N-terminal to ZF1 was given a non-native methionine start codon for expression from a codon-optimized synthetic ORF (GenScript).

Article Title: Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains
Article Snippet: The translated amino acid sequence, starting after an in-frame methionine N-terminal to ZF1, was expressed using a codon-optimized synthetic ORF (GenScript).

Synthesized:

Article Title: Pleiotropic anti-cancer activities of novel non-covalent thioredoxin reductase inhibitors against triple negative breast cancer.
Article Snippet: Mounting evidence shows that tumor growth and progression rely on thioredoxin reductase 1 (TXNRD1)-mediated detoxification of oxidative stress that results from deregulated metabolism and mitogenic signaling in tumors.. TXNRD1 levels are significant higher in triple negative breast cancer (TNBC) compared to normal tissue, making TXNRD1 a compelling TNBC therapeutic target.. Despite the many attempts to generate TXNRD1 inhibitors, all known and reported compounds inhibiting TXNRD1 are problematic; they interact with TXNRD1 irreversibly and non-specifically resulting in numerous adverse side effects.

Article Title: Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target.
Article Snippet: Cryptosporidiosis poses a significant health threat to young children and immunocompromised individuals due to the lack of effective therapies.. Here, we demonstrate that the Cryptosporidium parvum redox system is fundamentally different from their human host.. Humans possess independent glutathione (GSH) and thioredoxin (Trx) pathways.

Clone Assay:

Article Title: Pleiotropic anti-cancer activities of novel non-covalent thioredoxin reductase inhibitors against triple negative breast cancer.
Article Snippet: Mounting evidence shows that tumor growth and progression rely on thioredoxin reductase 1 (TXNRD1)-mediated detoxification of oxidative stress that results from deregulated metabolism and mitogenic signaling in tumors.. TXNRD1 levels are significant higher in triple negative breast cancer (TNBC) compared to normal tissue, making TXNRD1 a compelling TNBC therapeutic target.. Despite the many attempts to generate TXNRD1 inhibitors, all known and reported compounds inhibiting TXNRD1 are problematic; they interact with TXNRD1 irreversibly and non-specifically resulting in numerous adverse side effects.

Article Title: Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target.
Article Snippet: Cryptosporidiosis poses a significant health threat to young children and immunocompromised individuals due to the lack of effective therapies.. Here, we demonstrate that the Cryptosporidium parvum redox system is fundamentally different from their human host.. Humans possess independent glutathione (GSH) and thioredoxin (Trx) pathways.



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