build-in parameter estimation functionality (Simcyp)
90
Structured Review
Simcyp
build-in parameter estimation functionality
Build In Parameter Estimation Functionality, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/build-in+parameter+estimation+functionality/build+in+parameter+estimation+functionality/pm26385839-77-9-13
Average 90 stars, based on 1 article reviews
Build In Parameter Estimation Functionality, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/build-in+parameter+estimation+functionality/build+in+parameter+estimation+functionality/pm26385839-77-9-13
Average 90 stars, based on 1 article reviews
build-in parameter estimation functionality - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions. Article Snippet: Introduction Macitentan is a novel dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH).. It is metabolized by cytochrome P450 (CYP) enzymes, mainly CYP3A4, to its active metabolite ACT-132577.. Methods A physiological-based pharmacokinetic (PBPK) model was developed by combining observations from clinical studies and physicochemical parameters as well as absorption, distribution, metabolism and excretion parameters determined in vitro. |