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Provencher Inc lcmodel analysis program
Lcmodel Analysis Program, supplied by Provencher Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/analysis+program+lcmodel/software+tool+lcmodel/pm34419762-68-8-13
Average 90 stars, based on 1 article reviews
lcmodel analysis program - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children
Article Snippet: Fourth, the weighted average spectra for each region for each participant in the time domain were passed into LCModel (http://s-provencher.com/lcmodel.shtml) basis-fitting software to compute metabolite ratios (Fig 1 and Online Supplemental Data).20 TE-specific 3T basis sets provided by LCModel were used to compute the NAA/Cr from the spectra for each region.

Article Title: A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial
Article Snippet: All MR spectra were processed and analyzed using the software package LCModel version 6.2-1P by S. W. Provencher.

Article Title: Glutamate levels in the medial prefrontal cortex of healthy pregnant women compared to non-pregnant controls.
Article Snippet: Very little is known about maternal cerebral changes during pregnancy.. Since there is an increased risk for major depression during pregnancy and postpartum, it is important to understand the structural and neurochemical changes that occur in the brain during pregnancy.. Using proton magnetic resonance spectroscopy (1H-MRS) (3 T field strength), glutamate (Glu) levels were measured in the medial prefrontal cortex (MPFC) of 21 healthy gravid subjects 2–3 weeks before their due date (6.74 ± 1.39), and in 14 non-pregnant healthy controls during their follicular phase (8.53 ± 1.55).

Article Title: Disruption of Homeostasis Based on the Right and Left Hemisphere in Patients with Complex Regional Pain Syndrome.
Article Snippet: Objective: Although the clinical features and pathophysiology of complex regional pain syndrome (CRPS) have been studied in the peripheral and central nervous systems, few plausible pathological interactions are known among the metabolites in these systems.. Thus, the purpose of this study was to investigate abnormal relationships and interactions between peripheral metabolites and central neurometabolites in patients with CRPS.. Methods: Various metabolites and molecules were measured in the peripheral blood, and central neurometabolites in the right and left thalamus using proton magnetic resonance spectroscopy in 12 patients with CRPS and 11 healthy controls.

Derivative Assay:

Article Title: A Novel Loss-of-Function SEMA3E Mutation in a Patient with Severe Intellectual Disability and Cognitive Regression
Article Snippet: .. Concentrations derived from the raw data obtained from the spectral curves in the MR were processed by the quantification program LCModel (S. Provencher), analyzing the spectra as a linear combination, based on a group of complete models of spectroscopies of metabolites in “in vitro” solution. ..

In Vitro:

Article Title: A Novel Loss-of-Function SEMA3E Mutation in a Patient with Severe Intellectual Disability and Cognitive Regression
Article Snippet: .. Concentrations derived from the raw data obtained from the spectral curves in the MR were processed by the quantification program LCModel (S. Provencher), analyzing the spectra as a linear combination, based on a group of complete models of spectroscopies of metabolites in “in vitro” solution. ..

Software:

Article Title: Hippocampus Glutamate and N-Acetyl Aspartate Markers of Excitotoxic Neuronal Compromise in Posttraumatic Stress Disorder
Article Snippet: .. All spectroscopic data processing was performed using in-house reconstruction code and LCModel fitting software ( Provencher, 1993 ). ..



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Provencher Inc lcmodel (version 6.0-1) analysis program
Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during <t>LCModel</t> analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.
Lcmodel (Version 6.0 1) Analysis Program, supplied by Provencher Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during LCModel analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.

Journal: Neuropsychopharmacology

Article Title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

doi: 10.1038/npp.2012.101

Figure Lengend Snippet: Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during LCModel analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.

Article Snippet: The in vivo data were analyzed using the LCModel (version 6.0-1) analysis program ( Provencher, 1993 ).

Techniques: Serial Time-encoded Amplified Microscopy

Sample stimulated echo acquisition mode (STEAM) localized magnetic resonance spectroscopy (MRS) data acquired from the medial prefrontal cortex and with sequence timings optimized for recovering signal from glutamate (STEAM TE, TM=240, 27 ms). The spectra illustrate the unfiltered data superimposed with the LCModel fit in red. Glu, glutamate; NAA+NAAG, N-acetylaspartate plus N-acetylaspartylglutamate; t-Cr, creatine plus phosphocreatine; t-Cho, glycerophosphorylcholine plus phosphorylcholine; p.p.m., parts per million.

Journal: Neuropsychopharmacology

Article Title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

doi: 10.1038/npp.2012.101

Figure Lengend Snippet: Sample stimulated echo acquisition mode (STEAM) localized magnetic resonance spectroscopy (MRS) data acquired from the medial prefrontal cortex and with sequence timings optimized for recovering signal from glutamate (STEAM TE, TM=240, 27 ms). The spectra illustrate the unfiltered data superimposed with the LCModel fit in red. Glu, glutamate; NAA+NAAG, N-acetylaspartate plus N-acetylaspartylglutamate; t-Cr, creatine plus phosphocreatine; t-Cho, glycerophosphorylcholine plus phosphorylcholine; p.p.m., parts per million.

Article Snippet: The in vivo data were analyzed using the LCModel (version 6.0-1) analysis program ( Provencher, 1993 ).

Techniques: Serial Time-encoded Amplified Microscopy, Spectroscopy, Sequencing