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  • 97
    Millipore vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 329 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Millipore deuterated phylloquinone
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Deuterated Phylloquinone, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    80
    Merck & Co aquamephyton
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Aquamephyton, supplied by Merck & Co, used in various techniques. Bioz Stars score: 80/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Genechem vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Genechem, used in various techniques. Bioz Stars score: 92/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Becton Dickinson vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 92/100, based on 131 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vitamin k1/product/Becton Dickinson
    Average 92 stars, based on 131 article reviews
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    93
    HiMedia Laboratories vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by HiMedia Laboratories, used in various techniques. Bioz Stars score: 93/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 18 article reviews
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    90
    Merck KGaA vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 90 stars, based on 1 article reviews
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    93
    Thermo Fisher vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Abbott Laboratories vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 92/100, based on 81 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vitamin k1/product/Abbott Laboratories
    Average 92 stars, based on 81 article reviews
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    92
    Phoenix Pharmaceuticals vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Phoenix Pharmaceuticals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Carl Roth GmbH vitamin k1
    Cellular effects of Sorafenib or <t>vitamin</t> K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.
    Vitamin K1, supplied by Carl Roth GmbH, used in various techniques. Bioz Stars score: 91/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Roche konakion
    Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks <t>post-phytomenadione</t> administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p
    Konakion, supplied by Roche, used in various techniques. Bioz Stars score: 86/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    85
    Roche konakion neonatal
    Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks <t>post-phytomenadione</t> administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p
    Konakion Neonatal, supplied by Roche, used in various techniques. Bioz Stars score: 85/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Millipore vitamin k1 solution
    Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks <t>post-phytomenadione</t> administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p
    Vitamin K1 Solution, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Fisher Scientific vitamin k1 agar plates
    Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks <t>post-phytomenadione</t> administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p
    Vitamin K1 Agar Plates, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 3 article reviews
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    92
    Becton Dickinson hemin vitamin k1
    Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks <t>post-phytomenadione</t> administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p
    Hemin Vitamin K1, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 92/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 7 article reviews
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    Image Search Results


    Cellular effects of Sorafenib or vitamin K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.

    Journal: International Journal of Cancer. Journal International du Cancer

    Article Title: Vitamin K enhancement of Sorafenib-mediated HCC cell growth inhibition in vitro and in vivo

    doi: 10.1002/ijc.25498

    Figure Lengend Snippet: Cellular effects of Sorafenib or vitamin K1 alone A : Concentration-dependent inhibition of phospho-ERK and Mcl-1 levels by Sorafenib. B : Vitamin K1 effects on phospho-ERK, phospho-PKA, phospho-Raf (ser43) and phospho-Raf (ser259) levels. C: PKA inhibitor (H-89) antagonizes vitamin k1 induced phophorylation of PKA and Raf. Cells were lysed after 36 hours treatment and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis.

    Article Snippet: Vitamin K1 was purchased from (Sigma-Aldrich Chemical Co.MO) and dissolved in 99.9% ethanol at a stock concentration of 50 mM and then diluted to appropriate concentrations with medium in using.

    Techniques: Concentration Assay, Inhibition, Electrophoresis, SDS Page, Nucleic Acid Electrophoresis, Western Blot

    Activation of the extrinsic caspase death pathway by combination Sorafenib plus vitamin K1 A : Cleaved PARP and caspase-3 detection 36 hr after treatment with vitamin K1 (50 μM) plus Sorafenib (2.5 μM) in PLC/PRF/5 cells; but no cleavage was observed after vitamin K1 or low concentrations of Sorafenib alone. B : Combination treatment with Sorafenib plus vitamin K1 did not effect on caspase-9 activity, but procaspase-8 was activated in the same lysates. C : Sorafenib plus vitamin K1 decreased the expression of Mcl-1. Cells were lysed and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis. Actin was used as loading control.

    Journal: International Journal of Cancer. Journal International du Cancer

    Article Title: Vitamin K enhancement of Sorafenib-mediated HCC cell growth inhibition in vitro and in vivo

    doi: 10.1002/ijc.25498

    Figure Lengend Snippet: Activation of the extrinsic caspase death pathway by combination Sorafenib plus vitamin K1 A : Cleaved PARP and caspase-3 detection 36 hr after treatment with vitamin K1 (50 μM) plus Sorafenib (2.5 μM) in PLC/PRF/5 cells; but no cleavage was observed after vitamin K1 or low concentrations of Sorafenib alone. B : Combination treatment with Sorafenib plus vitamin K1 did not effect on caspase-9 activity, but procaspase-8 was activated in the same lysates. C : Sorafenib plus vitamin K1 decreased the expression of Mcl-1. Cells were lysed and 20 μg of soluble protein were separated by electrophoresis by SDS-PAGE gel electrophoresis. Protein levels were detected by Western blot analysis. Actin was used as loading control.

    Article Snippet: Vitamin K1 was purchased from (Sigma-Aldrich Chemical Co.MO) and dissolved in 99.9% ethanol at a stock concentration of 50 mM and then diluted to appropriate concentrations with medium in using.

    Techniques: Activation Assay, Planar Chromatography, Activity Assay, Expressing, Electrophoresis, SDS Page, Nucleic Acid Electrophoresis, Western Blot

    Inhibition of phospho-ERK and induction of apoptosis A : Combination treatment with Sorafenib plus vitamin K1 decreased phospho-ERK levels in PLC/PRF/5 hepatoma cell. B : Low concentration Sorafenib (2.5 μM) plus vitamin K1 (50 μM) inhibited phospho-ERK and Mcl-1 levels. Cells were isolated after 36 hours treatment and subjected to SDS-PAGE gel electrophoresis, followed by immunoblotting to determine protein expression.

    Journal: International Journal of Cancer. Journal International du Cancer

    Article Title: Vitamin K enhancement of Sorafenib-mediated HCC cell growth inhibition in vitro and in vivo

    doi: 10.1002/ijc.25498

    Figure Lengend Snippet: Inhibition of phospho-ERK and induction of apoptosis A : Combination treatment with Sorafenib plus vitamin K1 decreased phospho-ERK levels in PLC/PRF/5 hepatoma cell. B : Low concentration Sorafenib (2.5 μM) plus vitamin K1 (50 μM) inhibited phospho-ERK and Mcl-1 levels. Cells were isolated after 36 hours treatment and subjected to SDS-PAGE gel electrophoresis, followed by immunoblotting to determine protein expression.

    Article Snippet: Vitamin K1 was purchased from (Sigma-Aldrich Chemical Co.MO) and dissolved in 99.9% ethanol at a stock concentration of 50 mM and then diluted to appropriate concentrations with medium in using.

    Techniques: Inhibition, Planar Chromatography, Concentration Assay, Isolation, SDS Page, Nucleic Acid Electrophoresis, Expressing

    Inhibition of HCC tumor growth in vivo by Sorafenib plus vitamin K1 A : After injection of JM1 hepatoma cells into the liver via a portal vein tributary, rats were treated with either solvent control, vitamin K1, Sorafenib or combination vitamin K 1 plus Sorafenib. They were then sacrificed and whole livers were isolated as described in materials and methods. A tiny tumor in combination group is labeled with arrow. B : Representative histology and histochemistry slides from the tumors and livers stained by H and E and for phospho-ERK , Mcl-1 and Phospho-PKA. Original magnification × 10. C: ) combined Sorafenib/Vitamin K1 treatment. The compounds were injected intra-peritoneally daily for 8 consecutive days. Three days after the last injection, the animals were sacrificed and the tumors were excised. The ratio of total weight of the tumors and liver from each rat liver was counted. The results are expressed as the mean ± the standard deviation.

    Journal: International Journal of Cancer. Journal International du Cancer

    Article Title: Vitamin K enhancement of Sorafenib-mediated HCC cell growth inhibition in vitro and in vivo

    doi: 10.1002/ijc.25498

    Figure Lengend Snippet: Inhibition of HCC tumor growth in vivo by Sorafenib plus vitamin K1 A : After injection of JM1 hepatoma cells into the liver via a portal vein tributary, rats were treated with either solvent control, vitamin K1, Sorafenib or combination vitamin K 1 plus Sorafenib. They were then sacrificed and whole livers were isolated as described in materials and methods. A tiny tumor in combination group is labeled with arrow. B : Representative histology and histochemistry slides from the tumors and livers stained by H and E and for phospho-ERK , Mcl-1 and Phospho-PKA. Original magnification × 10. C: ) combined Sorafenib/Vitamin K1 treatment. The compounds were injected intra-peritoneally daily for 8 consecutive days. Three days after the last injection, the animals were sacrificed and the tumors were excised. The ratio of total weight of the tumors and liver from each rat liver was counted. The results are expressed as the mean ± the standard deviation.

    Article Snippet: Vitamin K1 was purchased from (Sigma-Aldrich Chemical Co.MO) and dissolved in 99.9% ethanol at a stock concentration of 50 mM and then diluted to appropriate concentrations with medium in using.

    Techniques: Inhibition, In Vivo, Injection, Isolation, Labeling, Staining, Standard Deviation

    Inhibition of HCC cell growth by Sorafenib plus vitamin K A , Growth inhibition of PLC/PRF/5 cells by Sorafenib 2.5 μM, VK1 or the combination (upper graph). The inset shows the growth inhibitory actions of each agent alone. The lower graph shows the growth inhibitory effects of vitamin K1 addition to various Sorafenib concentrations. B . Growth inhibition of Hep 3B, Hep G2, Hep 40 and JM1 cells by Sorafenib, VK1 or the combination. C . Inhibition of PLC/PRF/5 cell growth by Sorafenib, with or without VK1, VK2 or VK5. Each experimental point was done in triplicate, repeated three times and expressed mean SD. P value was determined by student’s t test. D .

    Journal: International Journal of Cancer. Journal International du Cancer

    Article Title: Vitamin K enhancement of Sorafenib-mediated HCC cell growth inhibition in vitro and in vivo

    doi: 10.1002/ijc.25498

    Figure Lengend Snippet: Inhibition of HCC cell growth by Sorafenib plus vitamin K A , Growth inhibition of PLC/PRF/5 cells by Sorafenib 2.5 μM, VK1 or the combination (upper graph). The inset shows the growth inhibitory actions of each agent alone. The lower graph shows the growth inhibitory effects of vitamin K1 addition to various Sorafenib concentrations. B . Growth inhibition of Hep 3B, Hep G2, Hep 40 and JM1 cells by Sorafenib, VK1 or the combination. C . Inhibition of PLC/PRF/5 cell growth by Sorafenib, with or without VK1, VK2 or VK5. Each experimental point was done in triplicate, repeated three times and expressed mean SD. P value was determined by student’s t test. D .

    Article Snippet: Vitamin K1 was purchased from (Sigma-Aldrich Chemical Co.MO) and dissolved in 99.9% ethanol at a stock concentration of 50 mM and then diluted to appropriate concentrations with medium in using.

    Techniques: Inhibition, Planar Chromatography

    Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks post-phytomenadione administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p

    Journal: Frontiers in Medicine

    Article Title: The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

    doi: 10.3389/fmed.2018.00086

    Figure Lengend Snippet: Ratio of circulating Glu-osteocalcin (Glu-OC) and Gla-osteocalcin (Gla-OC) measured by ELISA in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and in non-carriers after 1 and 6 weeks post-phytomenadione administration. Data are expressed as percentage reduction (means value ± SD) compared to baseline ( p

    Article Snippet: EDTA, citrated and heparinized plasma, serum and urine samples were obtained at baseline and at 1 and 6 weeks after a single intramuscular injection in the buttock of 10 mg phytomenadione in 1 ml (Konakion©, Roche Pahrma, Madrid).

    Techniques: Enzyme-linked Immunosorbent Assay, Mutagenesis

    5C- and 7C-aglycone urinary vitamin K metabolites were measured by HPLC (mg/g creatinine) in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and non-carriers at baseline (week 0) and after 1 and 6 weeks after parenteral phytomenadione administration. Data are expressed as mean values ± SD in upper panels and as percentage of 5C- or 7C-aglycone ratio on total aglycones in lower panels.

    Journal: Frontiers in Medicine

    Article Title: The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

    doi: 10.3389/fmed.2018.00086

    Figure Lengend Snippet: 5C- and 7C-aglycone urinary vitamin K metabolites were measured by HPLC (mg/g creatinine) in pseudoxanthoma elasticum (PXE) patients, in heterozygous ABCC6 mutation carriers (ABCC6 carriers) and non-carriers at baseline (week 0) and after 1 and 6 weeks after parenteral phytomenadione administration. Data are expressed as mean values ± SD in upper panels and as percentage of 5C- or 7C-aglycone ratio on total aglycones in lower panels.

    Article Snippet: EDTA, citrated and heparinized plasma, serum and urine samples were obtained at baseline and at 1 and 6 weeks after a single intramuscular injection in the buttock of 10 mg phytomenadione in 1 ml (Konakion©, Roche Pahrma, Madrid).

    Techniques: High Performance Liquid Chromatography, Mutagenesis