total dabigatran Search Results


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  • 93
    Boehringer Ingelheim dabigatran etexilate
    Activated partial thromboplastin time (aPTT) values (s) with increasing <t>dabigatran</t> plasma concentrations (ng ml −1 ) in individual patients following administration of dabigatran <t>etexilate</t> on day 4 (steady state) following orthopaedic surgery in BISTRO I
    Dabigatran Etexilate, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 93/100, based on 250 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Nuvisan high performance liquid chromatography tandem mass spectrometry
    Activated partial thromboplastin time (aPTT) values (s) with increasing <t>dabigatran</t> plasma concentrations (ng ml −1 ) in individual patients following administration of dabigatran <t>etexilate</t> on day 4 (steady state) following orthopaedic surgery in BISTRO I
    High Performance Liquid Chromatography Tandem Mass Spectrometry, supplied by Nuvisan, used in various techniques. Bioz Stars score: 91/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Boehringer Ingelheim idarucizumab concentrations
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
    Idarucizumab Concentrations, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 93/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Bristol Myers apixaban
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
    Apixaban, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 93/100, based on 177 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Improve Medical edta k3 improvacuter
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
    Edta K3 Improvacuter, supplied by Improve Medical, used in various techniques. Bioz Stars score: 93/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Enzyme Research Laboratories thrombin
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
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    91
    STATA Corporation time series analysis itsa
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
    Time Series Analysis Itsa, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 91/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Thermo Fisher kinetica version 4 4 1 software
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
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    91
    Boston Scientific laac device
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
    Laac Device, supplied by Boston Scientific, used in various techniques. Bioz Stars score: 91/100, based on 104 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Perosphere aripazine
    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after <t>idarucizumab</t> injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P
    Aripazine, supplied by Perosphere, used in various techniques. Bioz Stars score: 90/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    AstraZeneca azd 3293
    Chemical structures of compound <t>AZD-3293.</t> a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C 26 H 28 N 4 O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C 26 H 28 N 4 O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54
    Azd 3293, supplied by AstraZeneca, used in various techniques. Bioz Stars score: 90/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Cowie pan feng
    Chemical structures of compound <t>AZD-3293.</t> a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C 26 H 28 N 4 O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C 26 H 28 N 4 O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54
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    93
    Bristol Myers bristol myers squibb bms
    Chemical structures of compound <t>AZD-3293.</t> a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C 26 H 28 N 4 O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C 26 H 28 N 4 O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54
    Bristol Myers Squibb Bms, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 93/100, based on 950 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Menal GmbH ecarin clotting time
    Chemical structures of compound <t>AZD-3293.</t> a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C 26 H 28 N 4 O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C 26 H 28 N 4 O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54
    Ecarin Clotting Time, supplied by Menal GmbH, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Pentapharm ecarin clotting time
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Ecarin Clotting Time, supplied by Pentapharm, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG rivaroxaban
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Rivaroxaban, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 135 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Janssen rivaroxaban
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Rivaroxaban, supplied by Janssen, used in various techniques. Bioz Stars score: 92/100, based on 77 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Becton Dickinson dabigatran
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Dabigatran, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 92/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Sarstedt sodium citrate tubes
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Sodium Citrate Tubes, supplied by Sarstedt, used in various techniques. Bioz Stars score: 90/100, based on 39 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Nuvisan chromatography tandem mass spectrometry methods
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Chromatography Tandem Mass Spectrometry Methods, supplied by Nuvisan, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Merck KGaA hydrogen chloride
    Correlation between unbound dabigatran with (A) <t>dTT</t> and (B) ECT. dTT, diluted thrombin time; ECT, <t>ecarin</t> clotting time
    Hydrogen Chloride, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Activated partial thromboplastin time (aPTT) values (s) with increasing dabigatran plasma concentrations (ng ml −1 ) in individual patients following administration of dabigatran etexilate on day 4 (steady state) following orthopaedic surgery in BISTRO I

    Journal: British Journal of Clinical Pharmacology

    Article Title: Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis

    doi: 10.1111/j.1365-2125.2006.02667.x

    Figure Lengend Snippet: Activated partial thromboplastin time (aPTT) values (s) with increasing dabigatran plasma concentrations (ng ml −1 ) in individual patients following administration of dabigatran etexilate on day 4 (steady state) following orthopaedic surgery in BISTRO I

    Article Snippet: Absolute bioavailability of dabigatran administered as the prodrug, dabigatran etexilate, is about 5%.

    Techniques:

    The relationship between patient ecarin clotting time (ECT) values and dabigatran plasma concentrations 0–12 h after first administration of dabigatran etexilate following orthopaedic surgery. Individual patient ECT values are indicated by empty squares. The dashed black line represents the fit of the linear ECT model to the early (0–12 h post surgery) data; the solid grey line represents the fit of the model to the late ( > 100 h post surgery) data. SLOP and BASE at time 0 h (- - -), individual values ≤ 12 h (⋄), SLOP and BASE at time 150 h (——)

    Journal: British Journal of Clinical Pharmacology

    Article Title: Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis

    doi: 10.1111/j.1365-2125.2006.02667.x

    Figure Lengend Snippet: The relationship between patient ecarin clotting time (ECT) values and dabigatran plasma concentrations 0–12 h after first administration of dabigatran etexilate following orthopaedic surgery. Individual patient ECT values are indicated by empty squares. The dashed black line represents the fit of the linear ECT model to the early (0–12 h post surgery) data; the solid grey line represents the fit of the model to the late ( > 100 h post surgery) data. SLOP and BASE at time 0 h (- - -), individual values ≤ 12 h (⋄), SLOP and BASE at time 150 h (——)

    Article Snippet: Absolute bioavailability of dabigatran administered as the prodrug, dabigatran etexilate, is about 5%.

    Techniques: Coagulation

    The relationship between patient ecarin clotting time (ECT) values and dabigatran plasma concentrations > 100 h after first administration of dabigatran etexilate (steady state) following orthopaedic surgery. Individual patient ECT values are indicated by empty squares. The dashed black line represents the fit of the linear ECT model to the early (0–12 h post surgery) data; the solid grey line represents the fit of the model to the late ( > 100 h post surgery) data. SLOP and BASE at time 0 h (- - -), individual values > 100 h (⋄), SLOP and BASE at time 150 h (——)

    Journal: British Journal of Clinical Pharmacology

    Article Title: Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis

    doi: 10.1111/j.1365-2125.2006.02667.x

    Figure Lengend Snippet: The relationship between patient ecarin clotting time (ECT) values and dabigatran plasma concentrations > 100 h after first administration of dabigatran etexilate (steady state) following orthopaedic surgery. Individual patient ECT values are indicated by empty squares. The dashed black line represents the fit of the linear ECT model to the early (0–12 h post surgery) data; the solid grey line represents the fit of the model to the late ( > 100 h post surgery) data. SLOP and BASE at time 0 h (- - -), individual values > 100 h (⋄), SLOP and BASE at time 150 h (——)

    Article Snippet: Absolute bioavailability of dabigatran administered as the prodrug, dabigatran etexilate, is about 5%.

    Techniques: Coagulation

    Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after idarucizumab injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P

    Journal: PLoS ONE

    Article Title: Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

    doi: 10.1371/journal.pone.0209350

    Figure Lengend Snippet: Activated partial thromboplastin time (aPTT; A), activated clotting time (ACT; B), plasma fibrinogen concentration (C), and levels of D-dimers (D) after intravenous dabigatran, after hemodilution, and after idarucizumab injection. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P

    Article Snippet: Idarucizumab concentrations in plasma were assessed at Boehringer Ingelheim (Ridgefield, CT, USA) using an enzyme-linked immunosorbent assay (ELISA) for porcine plasma.

    Techniques: Coagulation, Activated Clotting Time Assay, Concentration Assay, Injection

    Plasma concentration of active dabigatran assessed by means of the diluted thrombin time (dTT) assay (unbound dabigatran, A); plasma concentration of total dabigatran assessed by LC-MS/MS (B); and plasma idarucizumab levels assessed by ELISA (C) after intravenous dabigatran, after hemodilution, and after idarucizumab injection. HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group).

    Journal: PLoS ONE

    Article Title: Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

    doi: 10.1371/journal.pone.0209350

    Figure Lengend Snippet: Plasma concentration of active dabigatran assessed by means of the diluted thrombin time (dTT) assay (unbound dabigatran, A); plasma concentration of total dabigatran assessed by LC-MS/MS (B); and plasma idarucizumab levels assessed by ELISA (C) after intravenous dabigatran, after hemodilution, and after idarucizumab injection. HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group).

    Article Snippet: Idarucizumab concentrations in plasma were assessed at Boehringer Ingelheim (Ridgefield, CT, USA) using an enzyme-linked immunosorbent assay (ELISA) for porcine plasma.

    Techniques: Concentration Assay, Liquid Chromatography with Mass Spectroscopy, Mass Spectrometry, Enzyme-linked Immunosorbent Assay, Injection

    Comparison of AUC 0-24 and half-life of idarucizumab (A, C) and unbound dabigatran (B, D) across the treatment groups. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group).

    Journal: PLoS ONE

    Article Title: Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

    doi: 10.1371/journal.pone.0209350

    Figure Lengend Snippet: Comparison of AUC 0-24 and half-life of idarucizumab (A, C) and unbound dabigatran (B, D) across the treatment groups. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group).

    Article Snippet: Idarucizumab concentrations in plasma were assessed at Boehringer Ingelheim (Ridgefield, CT, USA) using an enzyme-linked immunosorbent assay (ELISA) for porcine plasma.

    Techniques:

    Clotting time (CT; A,B), clot formation time (CFT; C,D), and maximum clot firmness (MCF; E,F) after intravenous dabigatran, after hemodilution, and after idarucizumab injection. Left panel showing the results of the EXTEM test, right panel those of the INTEM test. Dashed red horizontal lines indicate a cut-off at 1000 s. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P

    Journal: PLoS ONE

    Article Title: Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

    doi: 10.1371/journal.pone.0209350

    Figure Lengend Snippet: Clotting time (CT; A,B), clot formation time (CFT; C,D), and maximum clot firmness (MCF; E,F) after intravenous dabigatran, after hemodilution, and after idarucizumab injection. Left panel showing the results of the EXTEM test, right panel those of the INTEM test. Dashed red horizontal lines indicate a cut-off at 1000 s. Dotted black horizontal lines indicate median baseline values (n = 25). HD: hemodilution; IDA: idarucizumab. Data are shown as median values; boxes extend from 25 th to 75 th percentiles and whiskers show minimum and maximum values (n = 5/group). * P

    Article Snippet: Idarucizumab concentrations in plasma were assessed at Boehringer Ingelheim (Ridgefield, CT, USA) using an enzyme-linked immunosorbent assay (ELISA) for porcine plasma.

    Techniques: Coagulation, Injection

    Chemical structures of compound AZD-3293. a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C 26 H 28 N 4 O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C 26 H 28 N 4 O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54

    Journal: Translational Neurodegeneration

    Article Title: Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs

    doi: 10.1186/s40035-016-0061-5

    Figure Lengend Snippet: Chemical structures of compound AZD-3293. a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C 26 H 28 N 4 O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C 26 H 28 N 4 O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54

    Article Snippet: To test potential interactions of AZD-3293 with commonly prescribed drugs such as the blood thinners warfarin and dabigatran, the sedative midalozam, a lipid-lowering medication simvastatin (Zocor) as well as inhibitor of cholinesterases donepezil (Aricept), AstraZeneca added three additional phase I trials in a total of 157 healthy volunteers in 2015.

    Techniques: Molecular Weight

    Correlation between unbound dabigatran with (A) dTT and (B) ECT. dTT, diluted thrombin time; ECT, ecarin clotting time

    Journal: Journal of Thrombosis and Haemostasis

    Article Title: Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran, et al. Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran

    doi: 10.1111/jth.14476

    Figure Lengend Snippet: Correlation between unbound dabigatran with (A) dTT and (B) ECT. dTT, diluted thrombin time; ECT, ecarin clotting time

    Article Snippet: Analyses of coagulation assays (dilute thrombin time [dTT; Hemoclot, Hyphen BioMed, Neuville sur Oise, France] and ecarin clotting time [ECT; in‐house assay, 6 U/mL ecarin; Pentapharm, Basel, Switzerland]) was done using validated assays at Menal GmbH (Emmendingen, Germany) ; concentrations of idarucizumab as well as unbound and total dabigatran were estimated at a central laboratory as described previously., Unbound dabigatran was defined as the fraction of dabigatran that was neither bound to idarucizumab nor plasma proteins, and which is an approximate measure of pharmacologically active dabigatran.

    Techniques: Coagulation