tofacitinib treatment tofacitinib Search Results


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  • 93
    Cell Signaling Technology Inc jak inhibitor tofacitinib
    Jak Inhibitor Tofacitinib, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak inhibitor tofacitinib/product/Cell Signaling Technology Inc
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    jak inhibitor tofacitinib - by Bioz Stars, 2021-09
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    95
    Selleck Chemicals tofacitinib tofa
    Tofacitinib Tofa, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tofacitinib tofa/product/Selleck Chemicals
    Average 95 stars, based on 1 article reviews
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    tofacitinib tofa - by Bioz Stars, 2021-09
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    96
    MedChemExpress tofacitinib treatment tofacitinib
    <t>Tofacitinib</t> and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p
    Tofacitinib Treatment Tofacitinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tofacitinib treatment tofacitinib/product/MedChemExpress
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tofacitinib treatment tofacitinib - by Bioz Stars, 2021-09
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    86
    MedKoo tofacitinib treatments
    Jak3 KI/KI T cells are sensitive to the JAK3 inhibitor <t>tofacitinib.</t> (A) Representative western blot showing the efficacy of a 6-hour treatment with tofacitinib on Jak3 KI/KI splenocytes. Representative values of band intensity relative to DMSO are indicated. (B) Dose-response curves of tofacitinib treatment over 3 days for KI/KI cell survival in vitro. Data are mean ± SEM. P values are shown (Student t test). (C) Comparison of the sensitivity of CTCL-like Jak3 KI/KI , Ts1Rhr-Jak3 KI/KI , CD4 + Ts1Rhr-Jak3 KI/KI , and T-ALL Ts1Rhr-Jak3 KI/KI to tofacitinib treatment. Mean ± SEM from 2 to 5 mice per group (each in triplicates) is indicated. P values are indicated.
    Tofacitinib Treatments, supplied by MedKoo, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tofacitinib treatments/product/MedKoo
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
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    86/100 stars
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    Image Search Results


    Tofacitinib and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p

    Journal: Scientific Reports

    Article Title: JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

    doi: 10.1038/s41598-021-86493-8

    Figure Lengend Snippet: Tofacitinib and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p

    Article Snippet: Tofacitinib treatment Tofacitinib was purchased from Med Chem Express (Cat. HY-40354/CS-0050).

    Techniques: Mouse Assay, Dissection

    Tofacitnib mediated partial rescue of Clec16a ΔUBC KO phenotype. Model depicting loss of Clec16a leads to a vicious cycle of autophagic impairment and ER stress. ER stress activates lipolytic cascade. Excessive HSL-driven lipolysis stimulates inflammation in adipose tissue of KO mice. Tofacitinib exerts its multifaceted effect on HSL-mediated lipolysis, AMPK, mTOR, JAK-STATs, and autophagy/lipophagy and ER stress signaling, improves survival, and rescues the inflammatory lipodystrophic phenotype exhibited by Clec16a ΔUBC KO mice.

    Journal: Scientific Reports

    Article Title: JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

    doi: 10.1038/s41598-021-86493-8

    Figure Lengend Snippet: Tofacitnib mediated partial rescue of Clec16a ΔUBC KO phenotype. Model depicting loss of Clec16a leads to a vicious cycle of autophagic impairment and ER stress. ER stress activates lipolytic cascade. Excessive HSL-driven lipolysis stimulates inflammation in adipose tissue of KO mice. Tofacitinib exerts its multifaceted effect on HSL-mediated lipolysis, AMPK, mTOR, JAK-STATs, and autophagy/lipophagy and ER stress signaling, improves survival, and rescues the inflammatory lipodystrophic phenotype exhibited by Clec16a ΔUBC KO mice.

    Article Snippet: Tofacitinib treatment Tofacitinib was purchased from Med Chem Express (Cat. HY-40354/CS-0050).

    Techniques: Mouse Assay

    Jak3 KI/KI T cells are sensitive to the JAK3 inhibitor tofacitinib. (A) Representative western blot showing the efficacy of a 6-hour treatment with tofacitinib on Jak3 KI/KI splenocytes. Representative values of band intensity relative to DMSO are indicated. (B) Dose-response curves of tofacitinib treatment over 3 days for KI/KI cell survival in vitro. Data are mean ± SEM. P values are shown (Student t test). (C) Comparison of the sensitivity of CTCL-like Jak3 KI/KI , Ts1Rhr-Jak3 KI/KI , CD4 + Ts1Rhr-Jak3 KI/KI , and T-ALL Ts1Rhr-Jak3 KI/KI to tofacitinib treatment. Mean ± SEM from 2 to 5 mice per group (each in triplicates) is indicated. P values are indicated.

    Journal: Blood Advances

    Article Title: Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

    doi: 10.1182/bloodadvances.2018016089

    Figure Lengend Snippet: Jak3 KI/KI T cells are sensitive to the JAK3 inhibitor tofacitinib. (A) Representative western blot showing the efficacy of a 6-hour treatment with tofacitinib on Jak3 KI/KI splenocytes. Representative values of band intensity relative to DMSO are indicated. (B) Dose-response curves of tofacitinib treatment over 3 days for KI/KI cell survival in vitro. Data are mean ± SEM. P values are shown (Student t test). (C) Comparison of the sensitivity of CTCL-like Jak3 KI/KI , Ts1Rhr-Jak3 KI/KI , CD4 + Ts1Rhr-Jak3 KI/KI , and T-ALL Ts1Rhr-Jak3 KI/KI to tofacitinib treatment. Mean ± SEM from 2 to 5 mice per group (each in triplicates) is indicated. P values are indicated.

    Article Snippet: For tofacitinib treatments (CP-690550, MedKoo Biosciences), harvested spleen or lymph node cells were cultured for 3 days in complete RPMI 1640 with recombinant mouse IL-2 (rmIL-2; 100 U/mL) and mIL-7 (5 ng/mL), 50 µM of 2-mercaptoethanol and Dynabeads T-Activator CD3/CD28 beads (11452D; Thermo Fisher).

    Techniques: Western Blot, In Vitro, Mouse Assay