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    Ipsen Group synaptotagmin
    Neuronal expression of BARP. (A) Expression of BARP in brain (a) and pancreatic islets (b). Sections of cortex (1), hippocampus (2), and cerebellum (3) stained for BARP (mAb 12B1) and analyzed by immunofluorescence microscopy. BARP is detected in cell bodies and the dendritic extensions of Purkinje (white arrows) and pyramidal (green arrow) cells. In pancreatic islets, BARP is expressed in insulin-positive β cells but absent from α cells labeled for glucagon. The inset shows a higher magnification of the Purkinje cell layer. (B) Neuronal expression of BARP. Primary cells isolated from hippocampus or cerebellum were costained with mAb 12B1 to BARP and Ab to the neuronal marker MAP2 (a), the glial marker GFAP (b), the Purkinje marker calbindin (d), or the dense core vesicle protein BDNF (f). The insets show a higher magnification of the vesicular staining in the soma. Nuclei were stained with Hoechst (blue). (C) Colocalization of BARP with <t>synaptotagmin</t> in PC12 cells. Control or NGF-differentiated PC12 cells were costained with Ab to the regulated secretory vesicle marker synaptotagmin and BARP (Ab 72) and analyzed by confocal microscopy.
    Synaptotagmin, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Ipsen Group synaptotagmin 1
    Analysis of the solubility of WT and mutant <t>synaptotagmin-1</t> fragments in the presence of SNARE complex. Samples containing 10 µM C 2 AB fragment ( A,C ) or 10 µM C 2 B domain ( B,D ) were incubated with 10 µM ( A,B ) or 20 µM ( C,D
    Synaptotagmin 1, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/synaptotagmin 1/product/Ipsen Group
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    synaptotagmin 1 - by Bioz Stars, 2022-11
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    93
    Synaptic Systems synaptotagmin i
    Analysis of the solubility of WT and mutant <t>synaptotagmin-1</t> fragments in the presence of SNARE complex. Samples containing 10 µM C 2 AB fragment ( A,C ) or 10 µM C 2 B domain ( B,D ) were incubated with 10 µM ( A,B ) or 20 µM ( C,D
    Synaptotagmin I, supplied by Synaptic Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Price from $9.99 to $1999.99
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    88
    Synaptic Systems synaptotagmin
    Analysis of the solubility of WT and mutant <t>synaptotagmin-1</t> fragments in the presence of SNARE complex. Samples containing 10 µM C 2 AB fragment ( A,C ) or 10 µM C 2 B domain ( B,D ) were incubated with 10 µM ( A,B ) or 20 µM ( C,D
    Synaptotagmin, supplied by Synaptic Systems, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/synaptotagmin/product/Synaptic Systems
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    synaptotagmin - by Bioz Stars, 2022-11
    88/100 stars
      Buy from Supplier

    Image Search Results


    Neuronal expression of BARP. (A) Expression of BARP in brain (a) and pancreatic islets (b). Sections of cortex (1), hippocampus (2), and cerebellum (3) stained for BARP (mAb 12B1) and analyzed by immunofluorescence microscopy. BARP is detected in cell bodies and the dendritic extensions of Purkinje (white arrows) and pyramidal (green arrow) cells. In pancreatic islets, BARP is expressed in insulin-positive β cells but absent from α cells labeled for glucagon. The inset shows a higher magnification of the Purkinje cell layer. (B) Neuronal expression of BARP. Primary cells isolated from hippocampus or cerebellum were costained with mAb 12B1 to BARP and Ab to the neuronal marker MAP2 (a), the glial marker GFAP (b), the Purkinje marker calbindin (d), or the dense core vesicle protein BDNF (f). The insets show a higher magnification of the vesicular staining in the soma. Nuclei were stained with Hoechst (blue). (C) Colocalization of BARP with synaptotagmin in PC12 cells. Control or NGF-differentiated PC12 cells were costained with Ab to the regulated secretory vesicle marker synaptotagmin and BARP (Ab 72) and analyzed by confocal microscopy.

    Journal: The Journal of Cell Biology

    Article Title: BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis

    doi: 10.1083/jcb.201304101

    Figure Lengend Snippet: Neuronal expression of BARP. (A) Expression of BARP in brain (a) and pancreatic islets (b). Sections of cortex (1), hippocampus (2), and cerebellum (3) stained for BARP (mAb 12B1) and analyzed by immunofluorescence microscopy. BARP is detected in cell bodies and the dendritic extensions of Purkinje (white arrows) and pyramidal (green arrow) cells. In pancreatic islets, BARP is expressed in insulin-positive β cells but absent from α cells labeled for glucagon. The inset shows a higher magnification of the Purkinje cell layer. (B) Neuronal expression of BARP. Primary cells isolated from hippocampus or cerebellum were costained with mAb 12B1 to BARP and Ab to the neuronal marker MAP2 (a), the glial marker GFAP (b), the Purkinje marker calbindin (d), or the dense core vesicle protein BDNF (f). The insets show a higher magnification of the vesicular staining in the soma. Nuclei were stained with Hoechst (blue). (C) Colocalization of BARP with synaptotagmin in PC12 cells. Control or NGF-differentiated PC12 cells were costained with Ab to the regulated secretory vesicle marker synaptotagmin and BARP (Ab 72) and analyzed by confocal microscopy.

    Article Snippet: VGCCs interact via the Cav α1 subunit with several pre- and postsynaptic proteins, including SNAP-25, synaptotagmin, syntaxin, Mint, and calcium/calmodulin-dependent serine protein kinase ( ; ; ; ; ; ; ).

    Techniques: Expressing, Staining, Immunofluorescence, Microscopy, Labeling, Isolation, Marker, Confocal Microscopy

    Analysis of the solubility of WT and mutant synaptotagmin-1 fragments in the presence of SNARE complex. Samples containing 10 µM C 2 AB fragment ( A,C ) or 10 µM C 2 B domain ( B,D ) were incubated with 10 µM ( A,B ) or 20 µM ( C,D

    Journal: Biochemistry

    Article Title: Analysis of SNARE complex/Synaptotagmin-1 Interactions by One-dimensional NMR Spectroscopy †

    doi: 10.1021/bi400230u

    Figure Lengend Snippet: Analysis of the solubility of WT and mutant synaptotagmin-1 fragments in the presence of SNARE complex. Samples containing 10 µM C 2 AB fragment ( A,C ) or 10 µM C 2 B domain ( B,D ) were incubated with 10 µM ( A,B ) or 20 µM ( C,D

    Article Snippet: It is important to emphasize that the results presented here were obtained in the absence of membranes and that binding of synaptotagmin-1 to membranes most likely influences its interactions with the SNARE complex ( ; ).

    Techniques: Solubility, Mutagenesis, Incubation

    Mutational analysis of SNARE complex/synaptotagmin-1 C2 AB fragment interactions

    Journal: Biochemistry

    Article Title: Analysis of SNARE complex/Synaptotagmin-1 Interactions by One-dimensional NMR Spectroscopy †

    doi: 10.1021/bi400230u

    Figure Lengend Snippet: Mutational analysis of SNARE complex/synaptotagmin-1 C2 AB fragment interactions

    Article Snippet: It is important to emphasize that the results presented here were obtained in the absence of membranes and that binding of synaptotagmin-1 to membranes most likely influences its interactions with the SNARE complex ( ; ).

    Techniques:

    Analysis of the relative contributions of the synaptotagmin-1 C 2 domains to SNARE complex binding. A . Plots of the SMR intensities observed in 1D 13 C-edited 1 H-NMR spectra of 3 µM synaptotagmin-1 C 2 A domain (solid squares), pure C 2 B domain (solid

    Journal: Biochemistry

    Article Title: Analysis of SNARE complex/Synaptotagmin-1 Interactions by One-dimensional NMR Spectroscopy †

    doi: 10.1021/bi400230u

    Figure Lengend Snippet: Analysis of the relative contributions of the synaptotagmin-1 C 2 domains to SNARE complex binding. A . Plots of the SMR intensities observed in 1D 13 C-edited 1 H-NMR spectra of 3 µM synaptotagmin-1 C 2 A domain (solid squares), pure C 2 B domain (solid

    Article Snippet: It is important to emphasize that the results presented here were obtained in the absence of membranes and that binding of synaptotagmin-1 to membranes most likely influences its interactions with the SNARE complex ( ; ).

    Techniques: Binding Assay, Nuclear Magnetic Resonance

    Ribbon diagrams of the synaptotagmin-1 C 2 A and C 2 B domains. Ca 2+ ions are shown as green spheres. The side chains that were mutated are represented by stick models and labeled.

    Journal: Biochemistry

    Article Title: Analysis of SNARE complex/Synaptotagmin-1 Interactions by One-dimensional NMR Spectroscopy †

    doi: 10.1021/bi400230u

    Figure Lengend Snippet: Ribbon diagrams of the synaptotagmin-1 C 2 A and C 2 B domains. Ca 2+ ions are shown as green spheres. The side chains that were mutated are represented by stick models and labeled.

    Article Snippet: It is important to emphasize that the results presented here were obtained in the absence of membranes and that binding of synaptotagmin-1 to membranes most likely influences its interactions with the SNARE complex ( ; ).

    Techniques: Labeling