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  • 96
    Millipore sulfaphenazole
    Effect of various CYP inhibitors on ischemia/reperfusion in the Langendorff model. Adult rat hearts were perfused in Langendorff mode for 20 min, then subjected to 30 min of no-flow ischemia followed by 2 h of reperfusion (I/R). Inhibitors were added for the entire procedure or only at reperfusion <t>(Sulfaphenazole</t> Given After Ischemia), at the specified concentrations. ( A ) After 2 h of reperfusion, hearts were frozen and assessed for infarct size. Coronary effluent was collected for 15 min immediately before and after ischemia and assessed for CK release. Coronary flow was measured during the first 15 min of reperfusion. Error bars denote SEM. * , P
    Sulfaphenazole, supplied by Millipore, used in various techniques. Bioz Stars score: 96/100, based on 267 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Santa Cruz Biotechnology sulfaphenazole
    Effect of various CYP inhibitors on ischemia/reperfusion in the Langendorff model. Adult rat hearts were perfused in Langendorff mode for 20 min, then subjected to 30 min of no-flow ischemia followed by 2 h of reperfusion (I/R). Inhibitors were added for the entire procedure or only at reperfusion <t>(Sulfaphenazole</t> Given After Ischemia), at the specified concentrations. ( A ) After 2 h of reperfusion, hearts were frozen and assessed for infarct size. Coronary effluent was collected for 15 min immediately before and after ischemia and assessed for CK release. Coronary flow was measured during the first 15 min of reperfusion. Error bars denote SEM. * , P
    Sulfaphenazole, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Ciba Geigy sulphaphenazole
    Effects of selective cytochrome P450 inhibitors, furafylline (20 μm), coumarin (200 μm), quinidine (10 μm), diethyldithiocarbamate (20 μm), troleandomycin (50 μm), ketoconazole (1.0 μm), <t>sulphaphenazole</t> (20 μm), omeprazole (100 μm), and sulphaphenazole (20 μm) plus omeprazole (100 μm) on the formation of N -demethylsertraline in human liver microsomes ( n = 4, three EMs: HL-A, HL-B, HL-F; one PM: HL-I) at a substrate concentration of 50 μm sertraline. The values are the mean inhibition percentage (±s.d).
    Sulphaphenazole, supplied by Ciba Geigy, used in various techniques. Bioz Stars score: 88/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Becton Dickinson sulfaphenazole
    Effects of selective cytochrome P450 inhibitors, furafylline (20 μm), coumarin (200 μm), quinidine (10 μm), diethyldithiocarbamate (20 μm), troleandomycin (50 μm), ketoconazole (1.0 μm), <t>sulphaphenazole</t> (20 μm), omeprazole (100 μm), and sulphaphenazole (20 μm) plus omeprazole (100 μm) on the formation of N -demethylsertraline in human liver microsomes ( n = 4, three EMs: HL-A, HL-B, HL-F; one PM: HL-I) at a substrate concentration of 50 μm sertraline. The values are the mean inhibition percentage (±s.d).
    Sulfaphenazole, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 91/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Cayman Chemical sulfaphenazole
    Incubation with L81-HP PR and L81-HP/SBE PR affect the substrate turnover of Cytochrome P450 isoforms. Isoforms studied included ( a ) 3A4, ( b ) 2C9, and ( c ) 2D6. Studies characterized the cleavage of fluorogenic CYP substrates in the presence of PR compounds or known inhibitors ketoconazole (3A4), <t>sulphaphenazole</t> (2C9), and quinidine (2D6). The intensity of fluorescence indicates the extent of CYP activity perturbation. Experiments were done in triplicate and expressed as a percent of uninhibited control. *p = 0.05, **p = 0.01, ***p = 0.005, ****p = 0.001.
    Sulfaphenazole, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 91/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Dr Ehrenstorfer GmbH sulfaphenazole
    Incubation with L81-HP PR and L81-HP/SBE PR affect the substrate turnover of Cytochrome P450 isoforms. Isoforms studied included ( a ) 3A4, ( b ) 2C9, and ( c ) 2D6. Studies characterized the cleavage of fluorogenic CYP substrates in the presence of PR compounds or known inhibitors ketoconazole (3A4), <t>sulphaphenazole</t> (2C9), and quinidine (2D6). The intensity of fluorescence indicates the extent of CYP activity perturbation. Experiments were done in triplicate and expressed as a percent of uninhibited control. *p = 0.05, **p = 0.01, ***p = 0.005, ****p = 0.001.
    Sulfaphenazole, supplied by Dr Ehrenstorfer GmbH, used in various techniques. Bioz Stars score: 92/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Toronto Research Chemicals sulphaphenazole sfz
    Incubation with L81-HP PR and L81-HP/SBE PR affect the substrate turnover of Cytochrome P450 isoforms. Isoforms studied included ( a ) 3A4, ( b ) 2C9, and ( c ) 2D6. Studies characterized the cleavage of fluorogenic CYP substrates in the presence of PR compounds or known inhibitors ketoconazole (3A4), <t>sulphaphenazole</t> (2C9), and quinidine (2D6). The intensity of fluorescence indicates the extent of CYP activity perturbation. Experiments were done in triplicate and expressed as a percent of uninhibited control. *p = 0.05, **p = 0.01, ***p = 0.005, ****p = 0.001.
    Sulphaphenazole Sfz, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Carbosynth sulfaphenazole
    Left: Inhibitory effects of colonic flavonoid metabolites and <t>sulfaphenazole</t> (SULF, positive control; 20 μM each) on the CYP2C9-catalyzed diclofenac (5 μM) hydroxylation. O -desmethylangolensin (DESMA) was the sole compound which considerably inhibited the enzyme. Right: Concentration-dependent inhibition of CYP2C9 by DESMA and SULF (* p
    Sulfaphenazole, supplied by Carbosynth, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Certara L.P sim sulfaphenazole model
    Simulated and reported plasma concentration–time profiles of tolbutamide alone (black) and in the presence of <t>sulfaphenazole</t> (red), after an oral 500 mg dose in healthy subjects a linear and b ]. c ]. d ]
    Sim Sulfaphenazole Model, supplied by Certara L.P, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Effect of various CYP inhibitors on ischemia/reperfusion in the Langendorff model. Adult rat hearts were perfused in Langendorff mode for 20 min, then subjected to 30 min of no-flow ischemia followed by 2 h of reperfusion (I/R). Inhibitors were added for the entire procedure or only at reperfusion (Sulfaphenazole Given After Ischemia), at the specified concentrations. ( A ) After 2 h of reperfusion, hearts were frozen and assessed for infarct size. Coronary effluent was collected for 15 min immediately before and after ischemia and assessed for CK release. Coronary flow was measured during the first 15 min of reperfusion. Error bars denote SEM. * , P

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors

    doi: 10.1073/pnas.0308185100

    Figure Lengend Snippet: Effect of various CYP inhibitors on ischemia/reperfusion in the Langendorff model. Adult rat hearts were perfused in Langendorff mode for 20 min, then subjected to 30 min of no-flow ischemia followed by 2 h of reperfusion (I/R). Inhibitors were added for the entire procedure or only at reperfusion (Sulfaphenazole Given After Ischemia), at the specified concentrations. ( A ) After 2 h of reperfusion, hearts were frozen and assessed for infarct size. Coronary effluent was collected for 15 min immediately before and after ischemia and assessed for CK release. Coronary flow was measured during the first 15 min of reperfusion. Error bars denote SEM. * , P

    Article Snippet: Chloramphenicol (300 μM) (Calbiochem), gentamicin sulfate (50 mg/ml), cimetidine (200–600 μM), or sulfaphenazole (10–300 μM) (Sigma) was added to the perfusion buffer 20 min before ischemia or upon reperfusion.

    Techniques: Flow Cytometry

    Effect of sulfaphenazole on AMMC demethylase activity. ( A ) The rate of AHMC product formation was assessed, and the IC 50 value was calculated as described. ( B ) AHMC product formation was measured over2hin baculovirus-infected CYP2D2-specific supersomes treated in the presence or absence of sulfaphenazole (50 μM) (SUL). ( C ) Rat cardiac microsomes were resolved by SDS/PAGE and immunoblotted with anti-CYP2C9 antibody. ( Right ) Three micrograms of liver and 10 μg of cardiac microsomes.

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors

    doi: 10.1073/pnas.0308185100

    Figure Lengend Snippet: Effect of sulfaphenazole on AMMC demethylase activity. ( A ) The rate of AHMC product formation was assessed, and the IC 50 value was calculated as described. ( B ) AHMC product formation was measured over2hin baculovirus-infected CYP2D2-specific supersomes treated in the presence or absence of sulfaphenazole (50 μM) (SUL). ( C ) Rat cardiac microsomes were resolved by SDS/PAGE and immunoblotted with anti-CYP2C9 antibody. ( Right ) Three micrograms of liver and 10 μg of cardiac microsomes.

    Article Snippet: Chloramphenicol (300 μM) (Calbiochem), gentamicin sulfate (50 mg/ml), cimetidine (200–600 μM), or sulfaphenazole (10–300 μM) (Sigma) was added to the perfusion buffer 20 min before ischemia or upon reperfusion.

    Techniques: Activity Assay, Infection, SDS Page

    Effects of selective cytochrome P450 inhibitors, furafylline (20 μm), coumarin (200 μm), quinidine (10 μm), diethyldithiocarbamate (20 μm), troleandomycin (50 μm), ketoconazole (1.0 μm), sulphaphenazole (20 μm), omeprazole (100 μm), and sulphaphenazole (20 μm) plus omeprazole (100 μm) on the formation of N -demethylsertraline in human liver microsomes ( n = 4, three EMs: HL-A, HL-B, HL-F; one PM: HL-I) at a substrate concentration of 50 μm sertraline. The values are the mean inhibition percentage (±s.d).

    Journal: British Journal of Clinical Pharmacology

    Article Title: Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes

    doi: 10.1046/j.1365-2125.1999.00023.x

    Figure Lengend Snippet: Effects of selective cytochrome P450 inhibitors, furafylline (20 μm), coumarin (200 μm), quinidine (10 μm), diethyldithiocarbamate (20 μm), troleandomycin (50 μm), ketoconazole (1.0 μm), sulphaphenazole (20 μm), omeprazole (100 μm), and sulphaphenazole (20 μm) plus omeprazole (100 μm) on the formation of N -demethylsertraline in human liver microsomes ( n = 4, three EMs: HL-A, HL-B, HL-F; one PM: HL-I) at a substrate concentration of 50 μm sertraline. The values are the mean inhibition percentage (±s.d).

    Article Snippet: Sulphaphenazole and ketoconazole were gifts from CibaGeigy Ltd, (Basel, Switzerland) and Janssen Research Foundation (Beerse, Belgium), respectively.

    Techniques: Concentration Assay, Inhibition

    Incubation with L81-HP PR and L81-HP/SBE PR affect the substrate turnover of Cytochrome P450 isoforms. Isoforms studied included ( a ) 3A4, ( b ) 2C9, and ( c ) 2D6. Studies characterized the cleavage of fluorogenic CYP substrates in the presence of PR compounds or known inhibitors ketoconazole (3A4), sulphaphenazole (2C9), and quinidine (2D6). The intensity of fluorescence indicates the extent of CYP activity perturbation. Experiments were done in triplicate and expressed as a percent of uninhibited control. *p = 0.05, **p = 0.01, ***p = 0.005, ****p = 0.001.

    Journal: Scientific Reports

    Article Title: Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease

    doi: 10.1038/srep46737

    Figure Lengend Snippet: Incubation with L81-HP PR and L81-HP/SBE PR affect the substrate turnover of Cytochrome P450 isoforms. Isoforms studied included ( a ) 3A4, ( b ) 2C9, and ( c ) 2D6. Studies characterized the cleavage of fluorogenic CYP substrates in the presence of PR compounds or known inhibitors ketoconazole (3A4), sulphaphenazole (2C9), and quinidine (2D6). The intensity of fluorescence indicates the extent of CYP activity perturbation. Experiments were done in triplicate and expressed as a percent of uninhibited control. *p = 0.05, **p = 0.01, ***p = 0.005, ****p = 0.001.

    Article Snippet: Sulfaphenazole was obtained from Cayman Chemical (Ann Arbor, MI).

    Techniques: Incubation, Fluorescence, Activity Assay

    Left: Inhibitory effects of colonic flavonoid metabolites and sulfaphenazole (SULF, positive control; 20 μM each) on the CYP2C9-catalyzed diclofenac (5 μM) hydroxylation. O -desmethylangolensin (DESMA) was the sole compound which considerably inhibited the enzyme. Right: Concentration-dependent inhibition of CYP2C9 by DESMA and SULF (* p

    Journal: Biomolecules

    Article Title: Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes

    doi: 10.3390/biom10030409

    Figure Lengend Snippet: Left: Inhibitory effects of colonic flavonoid metabolites and sulfaphenazole (SULF, positive control; 20 μM each) on the CYP2C9-catalyzed diclofenac (5 μM) hydroxylation. O -desmethylangolensin (DESMA) was the sole compound which considerably inhibited the enzyme. Right: Concentration-dependent inhibition of CYP2C9 by DESMA and SULF (* p

    Article Snippet: S-mephenytoin, 4-hydroxymephenytoin, diclofenac, 4′-hydroxydiclofenac, and sulfaphenazole were obtained from Carbosynth (Berkshire, UK).

    Techniques: Positive Control, Concentration Assay, Inhibition

    Simulated and reported plasma concentration–time profiles of tolbutamide alone (black) and in the presence of sulfaphenazole (red), after an oral 500 mg dose in healthy subjects a linear and b ]. c ]. d ]

    Journal: European Journal of Drug Metabolism and Pharmacokinetics

    Article Title: Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam

    doi: 10.1007/s13318-017-0447-5

    Figure Lengend Snippet: Simulated and reported plasma concentration–time profiles of tolbutamide alone (black) and in the presence of sulfaphenazole (red), after an oral 500 mg dose in healthy subjects a linear and b ]. c ]. d ]

    Article Snippet: Performance verification has been conducted for the sim-sulfaphenazole model by Certara using published clinical data [ , ].

    Techniques: Concentration Assay