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  • 86
    Millipore shakt1
    Shakt1, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/shakt1/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    shakt1 - by Bioz Stars, 2024-07
    86/100 stars
      Buy from Supplier

    86
    Revvity Signals shakt1
    miR-199a-5p and let-7a-5p expression changes correlate with PCa Gleason score. ( A ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in the DU145 colony collected from the mouse lungs previously administered (via the tail vein) with ShControl and <t>ShAkt1</t> DU145 cells showing increased miR-199a-5p and decreased let-7a-5p expression ( n = 5; fold-change compared to SNORD61 expression). ( B , C ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in high Gleason score PCa tissues compared to low Gleason score ( n = 9–11), respectively. ( D , E ) Data showing the mean normalized log2 miR-199a-5p and let-7a-5p expression changes, respectively, in the high and low Gleason score cohorts. In total, 104 out of 113 patients were included in the analysis (seven were excluded with unknown Gleason Scores). Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. ( F , G ) Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating the EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. * ( p < 0.05), # ( p < 0.01). Data are presented as the mean ± SD.
    Shakt1, supplied by Revvity Signals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/shakt1/product/Revvity Signals
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    shakt1 - by Bioz Stars, 2024-07
    86/100 stars
      Buy from Supplier

    86
    Shanghai GenePharma shakt1
    miR-199a-5p and let-7a-5p expression changes correlate with PCa Gleason score. ( A ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in the DU145 colony collected from the mouse lungs previously administered (via the tail vein) with ShControl and <t>ShAkt1</t> DU145 cells showing increased miR-199a-5p and decreased let-7a-5p expression ( n = 5; fold-change compared to SNORD61 expression). ( B , C ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in high Gleason score PCa tissues compared to low Gleason score ( n = 9–11), respectively. ( D , E ) Data showing the mean normalized log2 miR-199a-5p and let-7a-5p expression changes, respectively, in the high and low Gleason score cohorts. In total, 104 out of 113 patients were included in the analysis (seven were excluded with unknown Gleason Scores). Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. ( F , G ) Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating the EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. * ( p < 0.05), # ( p < 0.01). Data are presented as the mean ± SD.
    Shakt1, supplied by Shanghai GenePharma, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/shakt1/product/Shanghai GenePharma
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    shakt1 - by Bioz Stars, 2024-07
    86/100 stars
      Buy from Supplier

    Image Search Results


    miR-199a-5p and let-7a-5p expression changes correlate with PCa Gleason score. ( A ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in the DU145 colony collected from the mouse lungs previously administered (via the tail vein) with ShControl and ShAkt1 DU145 cells showing increased miR-199a-5p and decreased let-7a-5p expression ( n = 5; fold-change compared to SNORD61 expression). ( B , C ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in high Gleason score PCa tissues compared to low Gleason score ( n = 9–11), respectively. ( D , E ) Data showing the mean normalized log2 miR-199a-5p and let-7a-5p expression changes, respectively, in the high and low Gleason score cohorts. In total, 104 out of 113 patients were included in the analysis (seven were excluded with unknown Gleason Scores). Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. ( F , G ) Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating the EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. * ( p < 0.05), # ( p < 0.01). Data are presented as the mean ± SD.

    Journal: Cancers

    Article Title: Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway

    doi: 10.3390/cancers14071625

    Figure Lengend Snippet: miR-199a-5p and let-7a-5p expression changes correlate with PCa Gleason score. ( A ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in the DU145 colony collected from the mouse lungs previously administered (via the tail vein) with ShControl and ShAkt1 DU145 cells showing increased miR-199a-5p and decreased let-7a-5p expression ( n = 5; fold-change compared to SNORD61 expression). ( B , C ) Quantitative real-time PCR data for miR-199a-5p and let-7a-5p in high Gleason score PCa tissues compared to low Gleason score ( n = 9–11), respectively. ( D , E ) Data showing the mean normalized log2 miR-199a-5p and let-7a-5p expression changes, respectively, in the high and low Gleason score cohorts. In total, 104 out of 113 patients were included in the analysis (seven were excluded with unknown Gleason Scores). Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. ( F , G ) Comparison between the two cohorts showing that miR-199a-5p expression is significantly upregulated in the higher (8–9) compared to lower Gleason score (6–7) samples (N = 17 and 87, respectively), indicating the EMT and metastasis-promoting the role of miR-199a-5p. In contrast, let-7a-5p expression was significantly downregulated in the higher (8–9) compared to lower (6–7) Gleason score cohort (N = 17 and 87, respectively), indicating its potential anti-metastatic role in PCa. * ( p < 0.05), # ( p < 0.01). Data are presented as the mean ± SD.

    Article Snippet: Gene silencing was performed using SMARTvector 2.0 Lentivirus ShControl (non-targeting) and ShAkt1 (5′-3′: ACGCTTAACCTTTCCGCTG) from Dharmacon (Lafayette, CO), followed by selection with 0.6 ng/mL puromycin (Sigma, St. Louis, MO, USA).

    Techniques: Expressing, Real-time Polymerase Chain Reaction, Comparison