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    U73122 PLC scd40l release
    Schematic illustration of DPV-Asn-induced oxidative stress in platelets causing aggregation and <t>sCD40L</t> release. The model depicts that catalase-tolerant peroxide DPV-Asn mediates sequential induction of a signaling cascade in platelets, chiefly regulated by PLC-γ2, which apparently played a central role in upregulating dense granule secretion, calcium influx, p38 and ERK1/2 MAP kinase phosphorylation, and subsequently directed COX activation and enhanced TxA 2 generation to further amplify platelet aggregation and thrombus formation. DPV-Asn further augments GPIIbIIIa-dependent release of proinflammatory cytokine sCD40L, thereby exhibiting a thrombo-inflammatory phenotype. DPV-Asn, diperoxovanadate-asparagine; ROS, reactive oxygen species; NAC, N -acetyl cysteine; AA, arachidonic acid; COX, cycloxygenase; TxA 2 , thromboxane A 2 ; TP, thromboxane-prostanoid receptor.
    Scd40l Release, supplied by U73122 PLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/scd40l release/product/U73122 PLC
    Average 90 stars, based on 1 article reviews
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    scd40l release - by Bioz Stars, 2021-01
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    Schematic illustration of DPV-Asn-induced oxidative stress in platelets causing aggregation and sCD40L release. The model depicts that catalase-tolerant peroxide DPV-Asn mediates sequential induction of a signaling cascade in platelets, chiefly regulated by PLC-γ2, which apparently played a central role in upregulating dense granule secretion, calcium influx, p38 and ERK1/2 MAP kinase phosphorylation, and subsequently directed COX activation and enhanced TxA 2 generation to further amplify platelet aggregation and thrombus formation. DPV-Asn further augments GPIIbIIIa-dependent release of proinflammatory cytokine sCD40L, thereby exhibiting a thrombo-inflammatory phenotype. DPV-Asn, diperoxovanadate-asparagine; ROS, reactive oxygen species; NAC, N -acetyl cysteine; AA, arachidonic acid; COX, cycloxygenase; TxA 2 , thromboxane A 2 ; TP, thromboxane-prostanoid receptor.

    Journal: Redox Report : Communications in Free Radical Research

    Article Title: Phospholipase C-γ2 via p38 and ERK1/2 MAP kinase mediates diperoxovanadate-asparagine induced human platelet aggregation and sCD40L release

    doi: 10.1179/1351000213Y.0000000057

    Figure Lengend Snippet: Schematic illustration of DPV-Asn-induced oxidative stress in platelets causing aggregation and sCD40L release. The model depicts that catalase-tolerant peroxide DPV-Asn mediates sequential induction of a signaling cascade in platelets, chiefly regulated by PLC-γ2, which apparently played a central role in upregulating dense granule secretion, calcium influx, p38 and ERK1/2 MAP kinase phosphorylation, and subsequently directed COX activation and enhanced TxA 2 generation to further amplify platelet aggregation and thrombus formation. DPV-Asn further augments GPIIbIIIa-dependent release of proinflammatory cytokine sCD40L, thereby exhibiting a thrombo-inflammatory phenotype. DPV-Asn, diperoxovanadate-asparagine; ROS, reactive oxygen species; NAC, N -acetyl cysteine; AA, arachidonic acid; COX, cycloxygenase; TxA 2 , thromboxane A 2 ; TP, thromboxane-prostanoid receptor.

    Article Snippet: Results Platelet aggregation induced by DPV-Asn was chiefly regulated by dense granule secretion, thromboxane A2 (TxA2 ) generation, intra-platelet [Ca2+ ] influx, GPIIbIIIa activation and sCD40L release, which were significantly reduced in presence of U73122 (PLC inhibitor), aspirin (COX), SB203580 (p38 inhibitor), and PD98059 (ERK inhibitor).

    Techniques: Planar Chromatography, Activation Assay

    DPV-Asn-induced release of sCD40L is regulated by PLC-γ2 and thromboxane A 2 . (A) DPV-Asn, H 2 O 2 (8 mM) or collagen (6 µg/ml)-induced release of soluble CD40L (sCD40L) from human washed platelets. The soluble CD40L (sCD40L) released from activated platelets in the presence of DPV-Asn, H 2 O 2 or collagen was measured by enzyme-linked immunosorbent assay. (B) Effect of various pharmacologic interventions on DPV-Asn-induced sCD40L release from platelets (NAC (5 mM), aspirin (100 µM), U73122 (1 µM), SB203580 (10 µM), PD98059 (10 µM), eptifibatide (10 µM), SQ29548 (100 nM)). Data have been presented as mean ± SEM of amount of sCD40L released (pg/ml) of four independent experiments (* P

    Journal: Redox Report : Communications in Free Radical Research

    Article Title: Phospholipase C-γ2 via p38 and ERK1/2 MAP kinase mediates diperoxovanadate-asparagine induced human platelet aggregation and sCD40L release

    doi: 10.1179/1351000213Y.0000000057

    Figure Lengend Snippet: DPV-Asn-induced release of sCD40L is regulated by PLC-γ2 and thromboxane A 2 . (A) DPV-Asn, H 2 O 2 (8 mM) or collagen (6 µg/ml)-induced release of soluble CD40L (sCD40L) from human washed platelets. The soluble CD40L (sCD40L) released from activated platelets in the presence of DPV-Asn, H 2 O 2 or collagen was measured by enzyme-linked immunosorbent assay. (B) Effect of various pharmacologic interventions on DPV-Asn-induced sCD40L release from platelets (NAC (5 mM), aspirin (100 µM), U73122 (1 µM), SB203580 (10 µM), PD98059 (10 µM), eptifibatide (10 µM), SQ29548 (100 nM)). Data have been presented as mean ± SEM of amount of sCD40L released (pg/ml) of four independent experiments (* P

    Article Snippet: Results Platelet aggregation induced by DPV-Asn was chiefly regulated by dense granule secretion, thromboxane A2 (TxA2 ) generation, intra-platelet [Ca2+ ] influx, GPIIbIIIa activation and sCD40L release, which were significantly reduced in presence of U73122 (PLC inhibitor), aspirin (COX), SB203580 (p38 inhibitor), and PD98059 (ERK inhibitor).

    Techniques: Planar Chromatography, Enzyme-linked Immunosorbent Assay