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U73122 PLC
scd40l release  Scd40l Release, supplied by U73122 PLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/scd40l release/product/U73122 PLC Average 90 stars, based on 1 article reviews Price from $9.99 to $1999.99
scd40l release - by Bioz Stars,
2021-01
90/100 stars
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Journal: Redox Report : Communications in Free Radical Research
Article Title: Phospholipase C-γ2 via p38 and ERK1/2 MAP kinase mediates diperoxovanadate-asparagine induced human platelet aggregation and sCD40L release
doi: 10.1179/1351000213Y.0000000057
Figure Lengend Snippet: Schematic illustration of DPV-Asn-induced oxidative stress in platelets causing aggregation and sCD40L release. The model depicts that catalase-tolerant peroxide DPV-Asn mediates sequential induction of a signaling cascade in platelets, chiefly regulated by PLC-γ2, which apparently played a central role in upregulating dense granule secretion, calcium influx, p38 and ERK1/2 MAP kinase phosphorylation, and subsequently directed COX activation and enhanced TxA 2 generation to further amplify platelet aggregation and thrombus formation. DPV-Asn further augments GPIIbIIIa-dependent release of proinflammatory cytokine sCD40L, thereby exhibiting a thrombo-inflammatory phenotype. DPV-Asn, diperoxovanadate-asparagine; ROS, reactive oxygen species; NAC, N -acetyl cysteine; AA, arachidonic acid; COX, cycloxygenase; TxA 2 , thromboxane A 2 ; TP, thromboxane-prostanoid receptor.
Article Snippet: Results Platelet aggregation induced by DPV-Asn was chiefly regulated by dense granule secretion, thromboxane A2 (TxA2 ) generation, intra-platelet [Ca2+ ] influx, GPIIbIIIa activation and
Techniques: Planar Chromatography, Activation Assay
Journal: Redox Report : Communications in Free Radical Research
Article Title: Phospholipase C-γ2 via p38 and ERK1/2 MAP kinase mediates diperoxovanadate-asparagine induced human platelet aggregation and sCD40L release
doi: 10.1179/1351000213Y.0000000057
Figure Lengend Snippet: DPV-Asn-induced release of sCD40L is regulated by PLC-γ2 and thromboxane A 2 . (A) DPV-Asn, H 2 O 2 (8 mM) or collagen (6 µg/ml)-induced release of soluble CD40L (sCD40L) from human washed platelets. The soluble CD40L (sCD40L) released from activated platelets in the presence of DPV-Asn, H 2 O 2 or collagen was measured by enzyme-linked immunosorbent assay. (B) Effect of various pharmacologic interventions on DPV-Asn-induced sCD40L release from platelets (NAC (5 mM), aspirin (100 µM), U73122 (1 µM), SB203580 (10 µM), PD98059 (10 µM), eptifibatide (10 µM), SQ29548 (100 nM)). Data have been presented as mean ± SEM of amount of sCD40L released (pg/ml) of four independent experiments (* P
Article Snippet: Results Platelet aggregation induced by DPV-Asn was chiefly regulated by dense granule secretion, thromboxane A2 (TxA2 ) generation, intra-platelet [Ca2+ ] influx, GPIIbIIIa activation and
Techniques: Planar Chromatography, Enzyme-linked Immunosorbent Assay