sb 202190 Search Results


  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 99
    Millipore sb202190
    Sb202190, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sb202190/product/Millipore
    Average 99 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sb202190 - by Bioz Stars, 2021-06
    99/100 stars
      Buy from Supplier

    95
    Tocris sb202190
    Inhibition of GSK3 promotes activation of the MKK3/6-p38 MAPK-ATF2 signaling module. ( a ) Immunoblot analysis for activating phosphorylations of proteins of the MKK3/6-p38 MAPK-ATF2 signaling module in primary brown adipocytes pre-treated with 10 μM SB216763 for 1 h before stimulation with 0.1 μM ISO for 1 h. ( b ) Immunoblot analysis of total and phosphorylated p38 MAPK in immortalized brown adipocytes overexpressing GSK3β mutants or empty vector. Cells were treated with 0.1 μM ISO for 1 h. ( c ) Fgf21 expression in primary brown adipocytes pre-treated with 10 μM <t>SB202190</t> (p38 MAPK inhibitor) for 1 h before treatment with 10 μM SB216763 (GSK3 inhibitor) for 1 h, followed by stimulation with 0.1 μM ISO for additional 6 h. ( d ) Schematic presentation of the proposed mechanism through which GSK3 regulates the thermogenic gene program in brown adipocytes. Data presented as mean of means +SEM (n = 3). Statistical significance was determined by two-way ANOVA with repeated measures and Tukey’s post hoc test for multiple comparisons. *p
    Sb202190, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sb202190/product/Tocris
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sb202190 - by Bioz Stars, 2021-06
    95/100 stars
      Buy from Supplier

    86
    Millipore sb 202190
    Inhibition of GSK3 promotes activation of the MKK3/6-p38 MAPK-ATF2 signaling module. ( a ) Immunoblot analysis for activating phosphorylations of proteins of the MKK3/6-p38 MAPK-ATF2 signaling module in primary brown adipocytes pre-treated with 10 μM SB216763 for 1 h before stimulation with 0.1 μM ISO for 1 h. ( b ) Immunoblot analysis of total and phosphorylated p38 MAPK in immortalized brown adipocytes overexpressing GSK3β mutants or empty vector. Cells were treated with 0.1 μM ISO for 1 h. ( c ) Fgf21 expression in primary brown adipocytes pre-treated with 10 μM <t>SB202190</t> (p38 MAPK inhibitor) for 1 h before treatment with 10 μM SB216763 (GSK3 inhibitor) for 1 h, followed by stimulation with 0.1 μM ISO for additional 6 h. ( d ) Schematic presentation of the proposed mechanism through which GSK3 regulates the thermogenic gene program in brown adipocytes. Data presented as mean of means +SEM (n = 3). Statistical significance was determined by two-way ANOVA with repeated measures and Tukey’s post hoc test for multiple comparisons. *p
    Sb 202190, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sb 202190/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sb 202190 - by Bioz Stars, 2021-06
    86/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc sb202190
    FSTL1 modulates myofibroblast differentiation by facilitating p38/JNK signaling. (a and b) Primary lung fibroblasts from Fstl1+/− and their WT littermates were treated with 5 ng/ml TGF-β1. (a) Immunofluorescence staining of α-SMA in lung fibroblasts. (b) Protein expression levels of α-SMA and type I collagen. (c-e) MLgs were pretreated with U0126, <t>SB202190,</t> and SP600125. Protein expression levels of α-SMA and type I collagen were detected by Western blotting. n = 4; Bars = 100 μm. * P
    Sb202190, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sb202190/product/Cell Signaling Technology Inc
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sb202190 - by Bioz Stars, 2021-06
    96/100 stars
      Buy from Supplier

    N/A
    SB 202190 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2 respectively SB 202190 binds to the ATP pocket of
      Buy from Supplier

    N/A
    SB 202190 is a selective and potent p38 MAP kinases inhibitor binding to its ATP pocket It has negligible inhibiting properties on other MAP kinases such as ERKs and JNKs
      Buy from Supplier

    N/A
    SB 202190 is a selective potent cell permeable inhibitor of p38 MAP kinases inhibiting p38α SAPK2A MAPK14 and p38β SAPK2B MAPK11 with IC values of 50 and 100 nM respectively
      Buy from Supplier


    Image Search Results


    Inhibition of GSK3 promotes activation of the MKK3/6-p38 MAPK-ATF2 signaling module. ( a ) Immunoblot analysis for activating phosphorylations of proteins of the MKK3/6-p38 MAPK-ATF2 signaling module in primary brown adipocytes pre-treated with 10 μM SB216763 for 1 h before stimulation with 0.1 μM ISO for 1 h. ( b ) Immunoblot analysis of total and phosphorylated p38 MAPK in immortalized brown adipocytes overexpressing GSK3β mutants or empty vector. Cells were treated with 0.1 μM ISO for 1 h. ( c ) Fgf21 expression in primary brown adipocytes pre-treated with 10 μM SB202190 (p38 MAPK inhibitor) for 1 h before treatment with 10 μM SB216763 (GSK3 inhibitor) for 1 h, followed by stimulation with 0.1 μM ISO for additional 6 h. ( d ) Schematic presentation of the proposed mechanism through which GSK3 regulates the thermogenic gene program in brown adipocytes. Data presented as mean of means +SEM (n = 3). Statistical significance was determined by two-way ANOVA with repeated measures and Tukey’s post hoc test for multiple comparisons. *p

    Journal: Scientific Reports

    Article Title: GSK3 is a negative regulator of the thermogenic program in brown adipocytes

    doi: 10.1038/s41598-018-21795-y

    Figure Lengend Snippet: Inhibition of GSK3 promotes activation of the MKK3/6-p38 MAPK-ATF2 signaling module. ( a ) Immunoblot analysis for activating phosphorylations of proteins of the MKK3/6-p38 MAPK-ATF2 signaling module in primary brown adipocytes pre-treated with 10 μM SB216763 for 1 h before stimulation with 0.1 μM ISO for 1 h. ( b ) Immunoblot analysis of total and phosphorylated p38 MAPK in immortalized brown adipocytes overexpressing GSK3β mutants or empty vector. Cells were treated with 0.1 μM ISO for 1 h. ( c ) Fgf21 expression in primary brown adipocytes pre-treated with 10 μM SB202190 (p38 MAPK inhibitor) for 1 h before treatment with 10 μM SB216763 (GSK3 inhibitor) for 1 h, followed by stimulation with 0.1 μM ISO for additional 6 h. ( d ) Schematic presentation of the proposed mechanism through which GSK3 regulates the thermogenic gene program in brown adipocytes. Data presented as mean of means +SEM (n = 3). Statistical significance was determined by two-way ANOVA with repeated measures and Tukey’s post hoc test for multiple comparisons. *p

    Article Snippet: SB415286, SB216763, BIO, H89 and SB202190 were obtained from Tocris Bioscience.

    Techniques: Inhibition, Activation Assay, Plasmid Preparation, Expressing

    FSTL1 modulates myofibroblast differentiation by facilitating p38/JNK signaling. (a and b) Primary lung fibroblasts from Fstl1+/− and their WT littermates were treated with 5 ng/ml TGF-β1. (a) Immunofluorescence staining of α-SMA in lung fibroblasts. (b) Protein expression levels of α-SMA and type I collagen. (c-e) MLgs were pretreated with U0126, SB202190, and SP600125. Protein expression levels of α-SMA and type I collagen were detected by Western blotting. n = 4; Bars = 100 μm. * P

    Journal: Chinese Medical Journal

    Article Title: Follistatin-Like 1 Promotes Bleomycin-Induced Pulmonary Fibrosis through the Transforming Growth Factor Beta 1/Mitogen-Activated Protein Kinase Signaling Pathway

    doi: 10.4103/0366-6999.238151

    Figure Lengend Snippet: FSTL1 modulates myofibroblast differentiation by facilitating p38/JNK signaling. (a and b) Primary lung fibroblasts from Fstl1+/− and their WT littermates were treated with 5 ng/ml TGF-β1. (a) Immunofluorescence staining of α-SMA in lung fibroblasts. (b) Protein expression levels of α-SMA and type I collagen. (c-e) MLgs were pretreated with U0126, SB202190, and SP600125. Protein expression levels of α-SMA and type I collagen were detected by Western blotting. n = 4; Bars = 100 μm. * P

    Article Snippet: MLgs were cultured in 96-well plates for 24 h, and serum starved for 24 h. The cells were preincubated for 1 h with U0126 (ERK inhibitor, Cell Signaling Technology, MA, USA), SB202190 (p38 inhibitor, Cell Signaling Technology, MA, USA), SP600125 (JNK inhibitor, Cell Signaling Technology, MA, USA), and SB525334 (Smad2/3 inhibitor, R and D Systems, MN, USA) before treatment with 5 ng/ml TGF-β1 (R and D Systems, MN, USA) in the presence or absence of 100 ng/ml recombinant human FSTL1 protein (R and D Systems, MN, USA) for 24 h and finally incubated with MTT (final concentration of 0.5 mg/ml) for 4 h. The supernatant was removed, and 150 ml/well of dimethylsulfoxide (DMSO, Sigma-Aldrich, St. Louis, MO, USA) was added to dissolve the blue formazan crystals by shaking the plates for 15 min on an orbital shaker at 25°C.

    Techniques: Immunofluorescence, Staining, Expressing, Western Blot