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    Sino Biological sars cov 2 2019 ncov spike s1 his recombinant protein hplc verified covid 19 spike s1 research
    The predicted linear B-cell epitopes in the Spike protein of <t>SARS-CoV-2.</t> a , The number of linear B-cell epitopes shared among the distinct methods and literature mining. The pink, green and light blue represent epitopes with antigenicity scores > 0.9, 0.4 and 0.9, and
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    The predicted linear B-cell epitopes in the Spike protein of SARS-CoV-2. a , The number of linear B-cell epitopes shared among the distinct methods and literature mining. The pink, green and light blue represent epitopes with antigenicity scores > 0.9, 0.4 and 0.9, and

    Journal: bioRxiv

    Article Title: Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies

    doi: 10.1101/2020.12.13.422550

    Figure Lengend Snippet: The predicted linear B-cell epitopes in the Spike protein of SARS-CoV-2. a , The number of linear B-cell epitopes shared among the distinct methods and literature mining. The pink, green and light blue represent epitopes with antigenicity scores > 0.9, 0.4 and 0.9, and

    Article Snippet: The horses were inoculated subcutaneously with SARS-CoV-2 Spike Protein (S1 Subunit, His tag) (Sino Biological, China, cat no:40591-V08H) antigens containing 1.0mg, 1.5mg, 2.0mg and 3.0mg on day 0, 14, 28 and 42, respectively, or Freund′s adjuvant as a control.

    Techniques:

    Measurements of the selected Linear B cell epitope binding to antibody and neutralization efficiency of selected epitopes against SARS-CoV-2. a-d, The binding affinity assessed by ELISA between linear B-cell epitopes and serum antibodies from immunized horse with S1-based vaccines (a), immunized mouse with RBD-based vaccines (b), immunized monkey with RBD-based vaccines (c), and a patient recovering from COVID-19 (d). e, The binding affinity assessed by ELISA between the linear B-cell epitopes and serum antibodies from immunized mice with corresponding epitopes of ‘YNSASFSTFKCYGVSPTKLNDLCFT’, ‘GDEVRQIAPGQTGKIADYNYKLP’, ‘YQPYRVVVLSFELLH’, and ‘CVNFNFNGL’. f, Neutralization assay against SARS-CoV-2 pseudovirus in ‘YNSASFSTFKCYGVSPTKLNDLCFT’, ‘GDEVRQIAPGQTGKIADYNYKLP’, ‘YQPYRVVVLSFELLH’, and ‘CVNFNFNGL’. y-axis is the value of EC 50 . g, Neutralization assay against SARS-CoV-2 live virus in ‘YNSASFSTFKCYGVSPTKLNDLCFT’, ‘GDEVRQIAPGQTGKIADYNYKLP’, ‘YQPYRVVVLSFELLH’, and ‘CVNFNFNGL’. y-axis is the value of NT 50 .

    Journal: bioRxiv

    Article Title: Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies

    doi: 10.1101/2020.12.13.422550

    Figure Lengend Snippet: Measurements of the selected Linear B cell epitope binding to antibody and neutralization efficiency of selected epitopes against SARS-CoV-2. a-d, The binding affinity assessed by ELISA between linear B-cell epitopes and serum antibodies from immunized horse with S1-based vaccines (a), immunized mouse with RBD-based vaccines (b), immunized monkey with RBD-based vaccines (c), and a patient recovering from COVID-19 (d). e, The binding affinity assessed by ELISA between the linear B-cell epitopes and serum antibodies from immunized mice with corresponding epitopes of ‘YNSASFSTFKCYGVSPTKLNDLCFT’, ‘GDEVRQIAPGQTGKIADYNYKLP’, ‘YQPYRVVVLSFELLH’, and ‘CVNFNFNGL’. f, Neutralization assay against SARS-CoV-2 pseudovirus in ‘YNSASFSTFKCYGVSPTKLNDLCFT’, ‘GDEVRQIAPGQTGKIADYNYKLP’, ‘YQPYRVVVLSFELLH’, and ‘CVNFNFNGL’. y-axis is the value of EC 50 . g, Neutralization assay against SARS-CoV-2 live virus in ‘YNSASFSTFKCYGVSPTKLNDLCFT’, ‘GDEVRQIAPGQTGKIADYNYKLP’, ‘YQPYRVVVLSFELLH’, and ‘CVNFNFNGL’. y-axis is the value of NT 50 .

    Article Snippet: The horses were inoculated subcutaneously with SARS-CoV-2 Spike Protein (S1 Subunit, His tag) (Sino Biological, China, cat no:40591-V08H) antigens containing 1.0mg, 1.5mg, 2.0mg and 3.0mg on day 0, 14, 28 and 42, respectively, or Freund′s adjuvant as a control.

    Techniques: Binding Assay, Neutralization, Enzyme-linked Immunosorbent Assay, Mouse Assay

    The characteristics of the 18 selected linear B cell epitopes. a , The sequences of 18 selected linear B-cell epitopes. The bold is the mutated site in less than ten of 118,694 virus strains; The red is the predicted discontinuous residues. The bars on the right side are the Wilcoxon test p value for the comparisons of IgG or IgA antibody enrichment scores associated with each linear B-cell epitope between COVID-19 patients and negative controls. b , The digesting enzymes profile of the epitope sequence. Red indicated not digest, blue indicated digest. c-d , The localization of the 18 selected epitopes mapped on SARS-CoV-2 S (PDB: 6VSB) protein (c) and ACE-RBD complex (d). e-f , The localizations of B cell discontinuous epitopes on SARS-CoV-2 S (PDB: 6VSB) protein (e) and ACE-RBD complex (f). The spike protein is grey, the RBD region is wheat color, the selected epitopes are green, the mutation sites are red, the human ACE domain is blue, and the discontinuous B-cell epitopes are purple.

    Journal: bioRxiv

    Article Title: Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies

    doi: 10.1101/2020.12.13.422550

    Figure Lengend Snippet: The characteristics of the 18 selected linear B cell epitopes. a , The sequences of 18 selected linear B-cell epitopes. The bold is the mutated site in less than ten of 118,694 virus strains; The red is the predicted discontinuous residues. The bars on the right side are the Wilcoxon test p value for the comparisons of IgG or IgA antibody enrichment scores associated with each linear B-cell epitope between COVID-19 patients and negative controls. b , The digesting enzymes profile of the epitope sequence. Red indicated not digest, blue indicated digest. c-d , The localization of the 18 selected epitopes mapped on SARS-CoV-2 S (PDB: 6VSB) protein (c) and ACE-RBD complex (d). e-f , The localizations of B cell discontinuous epitopes on SARS-CoV-2 S (PDB: 6VSB) protein (e) and ACE-RBD complex (f). The spike protein is grey, the RBD region is wheat color, the selected epitopes are green, the mutation sites are red, the human ACE domain is blue, and the discontinuous B-cell epitopes are purple.

    Article Snippet: The horses were inoculated subcutaneously with SARS-CoV-2 Spike Protein (S1 Subunit, His tag) (Sino Biological, China, cat no:40591-V08H) antigens containing 1.0mg, 1.5mg, 2.0mg and 3.0mg on day 0, 14, 28 and 42, respectively, or Freund′s adjuvant as a control.

    Techniques: Sequencing, Mutagenesis