rnfl Search Results


  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94
    Carl Zeiss rnfl
    (A) An optical coherence tomography retinal nerve fiber layer scan in the left eye demonstrated retinal nerve fiber layer <t>(RNFL)</t> thickening of the superotemporal region (arrow) rather than RNFL thinning. (B) Optical coherence tomography <t>(OCT)</t> 3-D reconstruction imaging shows superotemporal peripapillary retinoschisis as a 3-D (arrow). (C) After 3 months of topical prostaglandin analogue medication, an OCT RNFL scan revealed a decrease in RNFL (arrow). (D) OCT 3-D reconstruction imaging shows the decreased peripapillary retinoschisis (arrow). TEMP=temporal; SUP = superior; NAS = nasal; INF = inferior.
    Rnfl, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 94/100, based on 279 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/Carl Zeiss
    Average 94 stars, based on 279 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    94/100 stars
      Buy from Supplier

    91
    GraphPad Prism Inc rnfl
    (A) An optical coherence tomography retinal nerve fiber layer scan in the left eye demonstrated retinal nerve fiber layer <t>(RNFL)</t> thickening of the superotemporal region (arrow) rather than RNFL thinning. (B) Optical coherence tomography <t>(OCT)</t> 3-D reconstruction imaging shows superotemporal peripapillary retinoschisis as a 3-D (arrow). (C) After 3 months of topical prostaglandin analogue medication, an OCT RNFL scan revealed a decrease in RNFL (arrow). (D) OCT 3-D reconstruction imaging shows the decreased peripapillary retinoschisis (arrow). TEMP=temporal; SUP = superior; NAS = nasal; INF = inferior.
    Rnfl, supplied by GraphPad Prism Inc, used in various techniques. Bioz Stars score: 91/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/GraphPad Prism Inc
    Average 91 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    91/100 stars
      Buy from Supplier

    93
    Optovue rnfl
    (A) An optical coherence tomography retinal nerve fiber layer scan in the left eye demonstrated retinal nerve fiber layer <t>(RNFL)</t> thickening of the superotemporal region (arrow) rather than RNFL thinning. (B) Optical coherence tomography <t>(OCT)</t> 3-D reconstruction imaging shows superotemporal peripapillary retinoschisis as a 3-D (arrow). (C) After 3 months of topical prostaglandin analogue medication, an OCT RNFL scan revealed a decrease in RNFL (arrow). (D) OCT 3-D reconstruction imaging shows the decreased peripapillary retinoschisis (arrow). TEMP=temporal; SUP = superior; NAS = nasal; INF = inferior.
    Rnfl, supplied by Optovue, used in various techniques. Bioz Stars score: 93/100, based on 56 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/Optovue
    Average 93 stars, based on 56 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    rnfl  (topcon)
    93
    topcon rnfl
    (A) An optical coherence tomography retinal nerve fiber layer scan in the left eye demonstrated retinal nerve fiber layer <t>(RNFL)</t> thickening of the superotemporal region (arrow) rather than RNFL thinning. (B) Optical coherence tomography <t>(OCT)</t> 3-D reconstruction imaging shows superotemporal peripapillary retinoschisis as a 3-D (arrow). (C) After 3 months of topical prostaglandin analogue medication, an OCT RNFL scan revealed a decrease in RNFL (arrow). (D) OCT 3-D reconstruction imaging shows the decreased peripapillary retinoschisis (arrow). TEMP=temporal; SUP = superior; NAS = nasal; INF = inferior.
    Rnfl, supplied by topcon, used in various techniques. Bioz Stars score: 93/100, based on 89 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/topcon
    Average 93 stars, based on 89 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    92
    heidelberg engineering rnfl
    Bivariate fit for <t>RNFL</t> thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and <t>ALSFRS-R</t> progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.
    Rnfl, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 92/100, based on 136 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/heidelberg engineering
    Average 92 stars, based on 136 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    91
    Mine Safety Appliances rnfl
    Bivariate fit for <t>RNFL</t> thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and <t>ALSFRS-R</t> progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.
    Rnfl, supplied by Mine Safety Appliances, used in various techniques. Bioz Stars score: 91/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/Mine Safety Appliances
    Average 91 stars, based on 9 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    91/100 stars
      Buy from Supplier

    94
    Cell Signaling Technology Inc rnfl
    Bivariate fit for <t>RNFL</t> thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and <t>ALSFRS-R</t> progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.
    Rnfl, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/Cell Signaling Technology Inc
    Average 94 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    94/100 stars
      Buy from Supplier

    rnfl  (Sony)
    92
    Sony rnfl
    Bivariate fit for <t>RNFL</t> thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and <t>ALSFRS-R</t> progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.
    Rnfl, supplied by Sony, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl/product/Sony
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rnfl - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    93
    heidelberg engineering rnfl export software
    Bivariate fit for <t>RNFL</t> thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and <t>ALSFRS-R</t> progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.
    Rnfl Export Software, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl export software/product/heidelberg engineering
    Average 93 stars, based on 6 article reviews
    Price from $9.99 to $1999.99
    rnfl export software - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    88
    heidelberg engineering circumpapillary rnfl
    Bivariate fit for <t>RNFL</t> thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and <t>ALSFRS-R</t> progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.
    Circumpapillary Rnfl, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 88/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/circumpapillary rnfl/product/heidelberg engineering
    Average 88 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    circumpapillary rnfl - by Bioz Stars, 2020-08
    88/100 stars
      Buy from Supplier

    90
    Carl Zeiss peripapillary rnfl
    <t>OCT</t> and SLP results for a patient with advanced glaucoma that illustrate the influence of the blood vessels on the OCT <t>RNFL</t> profile. A, Image of optic disc with circle of analysis and ITV (blue) and ITA (pink) indicated. B, Total deviation visual field
    Peripapillary Rnfl, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 65 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/peripapillary rnfl/product/Carl Zeiss
    Average 90 stars, based on 65 article reviews
    Price from $9.99 to $1999.99
    peripapillary rnfl - by Bioz Stars, 2020-08
    90/100 stars
      Buy from Supplier

    90
    heidelberg engineering peripapillary rnfl
    Example of automated segmentation errors resulting in an underestimation of <t>RNFL</t> thickness values. (Top) The circumpapillary <t>OCT</t> B-scan acquired at baseline is shown with automated segmentation of the anterior RNFL boundary in yellow and posterior RNFL boundary in red. There are two errors along the posterior boundary segmentation; one occurs at the crossing of the superior branch artery and vein (red arrows), resulting in RNFL thickness values that are 15–20% smaller than those for manually refined segmentations in sectors 3 and 4. The second error (red arrowhead) occurs at a vessel crossing in sector 9 (nasal inferior), resulting in values that are 10–15% below the manually refined values. A magnified view of the first error at baseline (inset) is shown persisting over time to the 4-year follow-up visit. (Bottom) The same scans are shown with manually refined segmentations. Long-term retinal nerve fiber layer segmentation study
    Peripapillary Rnfl, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 59 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/peripapillary rnfl/product/heidelberg engineering
    Average 90 stars, based on 59 article reviews
    Price from $9.99 to $1999.99
    peripapillary rnfl - by Bioz Stars, 2020-08
    90/100 stars
      Buy from Supplier

    93
    Optovue peripapillary rnfl
    Example of automated segmentation errors resulting in an underestimation of <t>RNFL</t> thickness values. (Top) The circumpapillary <t>OCT</t> B-scan acquired at baseline is shown with automated segmentation of the anterior RNFL boundary in yellow and posterior RNFL boundary in red. There are two errors along the posterior boundary segmentation; one occurs at the crossing of the superior branch artery and vein (red arrows), resulting in RNFL thickness values that are 15–20% smaller than those for manually refined segmentations in sectors 3 and 4. The second error (red arrowhead) occurs at a vessel crossing in sector 9 (nasal inferior), resulting in values that are 10–15% below the manually refined values. A magnified view of the first error at baseline (inset) is shown persisting over time to the 4-year follow-up visit. (Bottom) The same scans are shown with manually refined segmentations. Long-term retinal nerve fiber layer segmentation study
    Peripapillary Rnfl, supplied by Optovue, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/peripapillary rnfl/product/Optovue
    Average 93 stars, based on 6 article reviews
    Price from $9.99 to $1999.99
    peripapillary rnfl - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    88
    Carl Zeiss rnfl imaging
    Interpretation of optic disc center displacement in case of myelinated retinal nerve fiber. (A) Myelinated retinal nerve fibers (arrowheads) interfered with the optic disc margin detection (black irregular circle) in the superonasal region. In cases with structural obstacles around the optic disc, the <t>OCT</t> algorithm usually failed to identify optic disc margin. Manual delineation (blue irregular arc) was performed by extending the visible surrounding optic disc margin. The direction of optic disc center displacement was estimated to be superonasal (arrows). (B) The unreliable zone should be interpreted with caution in the displacement error-encoded map. In superonasal displacement, there was a possibility of underestimation of <t>RNFL</t> thickness in superior, superonasal, and inferonasal regions. Part of the red- or yellow-coded areas in the RNFL deviation map might indicate false-positive RNFL thinning. In contrast, the superotemporal region was likely overestimated. Further investigation is needed for potential glaucomatous damage in this region. OCT = optical coherence tomography
    Rnfl Imaging, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 88/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl imaging/product/Carl Zeiss
    Average 88 stars, based on 15 article reviews
    Price from $9.99 to $1999.99
    rnfl imaging - by Bioz Stars, 2020-08
    88/100 stars
      Buy from Supplier

    89
    Carl Zeiss circumpapillary rnfl
    Interpretation of optic disc center displacement in case of myelinated retinal nerve fiber. (A) Myelinated retinal nerve fibers (arrowheads) interfered with the optic disc margin detection (black irregular circle) in the superonasal region. In cases with structural obstacles around the optic disc, the <t>OCT</t> algorithm usually failed to identify optic disc margin. Manual delineation (blue irregular arc) was performed by extending the visible surrounding optic disc margin. The direction of optic disc center displacement was estimated to be superonasal (arrows). (B) The unreliable zone should be interpreted with caution in the displacement error-encoded map. In superonasal displacement, there was a possibility of underestimation of <t>RNFL</t> thickness in superior, superonasal, and inferonasal regions. Part of the red- or yellow-coded areas in the RNFL deviation map might indicate false-positive RNFL thinning. In contrast, the superotemporal region was likely overestimated. Further investigation is needed for potential glaucomatous damage in this region. OCT = optical coherence tomography
    Circumpapillary Rnfl, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 89/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/circumpapillary rnfl/product/Carl Zeiss
    Average 89 stars, based on 11 article reviews
    Price from $9.99 to $1999.99
    circumpapillary rnfl - by Bioz Stars, 2020-08
    89/100 stars
      Buy from Supplier

    88
    Cytoskeleton Inc rnfl retardance
    Interpretation of optic disc center displacement in case of myelinated retinal nerve fiber. (A) Myelinated retinal nerve fibers (arrowheads) interfered with the optic disc margin detection (black irregular circle) in the superonasal region. In cases with structural obstacles around the optic disc, the <t>OCT</t> algorithm usually failed to identify optic disc margin. Manual delineation (blue irregular arc) was performed by extending the visible surrounding optic disc margin. The direction of optic disc center displacement was estimated to be superonasal (arrows). (B) The unreliable zone should be interpreted with caution in the displacement error-encoded map. In superonasal displacement, there was a possibility of underestimation of <t>RNFL</t> thickness in superior, superonasal, and inferonasal regions. Part of the red- or yellow-coded areas in the RNFL deviation map might indicate false-positive RNFL thinning. In contrast, the superotemporal region was likely overestimated. Further investigation is needed for potential glaucomatous damage in this region. OCT = optical coherence tomography
    Rnfl Retardance, supplied by Cytoskeleton Inc, used in various techniques. Bioz Stars score: 88/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rnfl retardance/product/Cytoskeleton Inc
    Average 88 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    rnfl retardance - by Bioz Stars, 2020-08
    88/100 stars
      Buy from Supplier

    90
    topcon peripapillary rnfl
    Design of the study. The study comprised 3 steps. In the first step, an association study of known POAG-related loci was carried out using the genome-wide SNP data from SNP array (cases) and a previous genetic study (control).[ 25 – 27 ] In the second step, 3 candidate risk SNPs were genotyped in the cases and controls to test for the reproducibility. Then a clinical correlation study was performed in the third step. SNP, single nucleotide polymorphism; POAG, primary open-angle glaucoma, HFA, Humphrey Field Analyzer, <t>RNFL,</t> retinal nerve fiber layer thickness, <t>OCT,</t> optical coherence tomography, SFC, stereoscopic fundus camera, LSFG, laser speckle flowgraphy.
    Peripapillary Rnfl, supplied by topcon, used in various techniques. Bioz Stars score: 90/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/peripapillary rnfl/product/topcon
    Average 90 stars, based on 15 article reviews
    Price from $9.99 to $1999.99
    peripapillary rnfl - by Bioz Stars, 2020-08
    90/100 stars
      Buy from Supplier

    Image Search Results


    (A) An optical coherence tomography retinal nerve fiber layer scan in the left eye demonstrated retinal nerve fiber layer (RNFL) thickening of the superotemporal region (arrow) rather than RNFL thinning. (B) Optical coherence tomography (OCT) 3-D reconstruction imaging shows superotemporal peripapillary retinoschisis as a 3-D (arrow). (C) After 3 months of topical prostaglandin analogue medication, an OCT RNFL scan revealed a decrease in RNFL (arrow). (D) OCT 3-D reconstruction imaging shows the decreased peripapillary retinoschisis (arrow). TEMP=temporal; SUP = superior; NAS = nasal; INF = inferior.

    Journal: Korean Journal of Ophthalmology : KJO

    Article Title: Optic Disc Pit with Peripapillary Retinoschisis Presenting as a Localized Retinal Nerve Fiber Layer Defect

    doi: 10.3341/kjo.2011.25.6.455

    Figure Lengend Snippet: (A) An optical coherence tomography retinal nerve fiber layer scan in the left eye demonstrated retinal nerve fiber layer (RNFL) thickening of the superotemporal region (arrow) rather than RNFL thinning. (B) Optical coherence tomography (OCT) 3-D reconstruction imaging shows superotemporal peripapillary retinoschisis as a 3-D (arrow). (C) After 3 months of topical prostaglandin analogue medication, an OCT RNFL scan revealed a decrease in RNFL (arrow). (D) OCT 3-D reconstruction imaging shows the decreased peripapillary retinoschisis (arrow). TEMP=temporal; SUP = superior; NAS = nasal; INF = inferior.

    Article Snippet: However, optical coherence tomography (OCT) (Stratus OCT, Carl Zeiss Meditec) RNFL scan indicated RNFL thickening of the superotemporal region rather than RNFL thinning ( ).

    Techniques: Imaging

    Flowchart of the hypothetical spectrum of events that could imply false RNFL estimates owing to improper scan alignment. Careful overall assessment of sectoral and average OCT RNFL parameters can help identify scan alignment issues. Note: results are

    Journal: Journal of glaucoma

    Article Title: Effect of Improper Scan Alignment on Retinal Nerve Fiber Layer Thickness Measurements Using Stratus Optical Coherence Tomograph

    doi: 10.1097/IJG.0b013e31815c3aeb

    Figure Lengend Snippet: Flowchart of the hypothetical spectrum of events that could imply false RNFL estimates owing to improper scan alignment. Careful overall assessment of sectoral and average OCT RNFL parameters can help identify scan alignment issues. Note: results are

    Article Snippet: – For this study, the Fast RNFL thickness acquisition protocol using the Stratus OCT (software version 4.0.7; Carl Zeiss Meditec, Dublin CA) was used without pupil dilation.

    Techniques:

    A. The OCT RNFL profiles for all 50 individuals with the mean of these profiles shown in bold. The vertical dashed lines are the mean locations for the STva and ITva and the horizontal solid lines the range. B. The profiles from panel A positioned from top to bottom in order of the location of the STva. C. The same profiles as in panel B, but shifted by an amount equal to the relative locations of the STva.

    Journal: Journal of glaucoma

    Article Title: The Location of The Inferior and Superior Temporal Blood Vessels and Inter-Individual Variability of The Retinal Nerve Fiber Layer Thickness

    doi: 10.1097/IJG.0b013e3181af31ec

    Figure Lengend Snippet: A. The OCT RNFL profiles for all 50 individuals with the mean of these profiles shown in bold. The vertical dashed lines are the mean locations for the STva and ITva and the horizontal solid lines the range. B. The profiles from panel A positioned from top to bottom in order of the location of the STva. C. The same profiles as in panel B, but shifted by an amount equal to the relative locations of the STva.

    Article Snippet: RNFL thickness was measured using OCT and a fast RNFL circular scan protocol (Stratus OCT3, Zeiss Meditech, Dublin, CA) and scanning laser polarimetry (SLP) (GDx-VCC, Zeiss Meditech, Dublin, CA).

    Techniques:

    Two OCT RNFL thickness profiles that illustrate the variation in thickness possible across normal healthy eyes.

    Journal: Journal of glaucoma

    Article Title: The Location of The Inferior and Superior Temporal Blood Vessels and Inter-Individual Variability of The Retinal Nerve Fiber Layer Thickness

    doi: 10.1097/IJG.0b013e3181af31ec

    Figure Lengend Snippet: Two OCT RNFL thickness profiles that illustrate the variation in thickness possible across normal healthy eyes.

    Article Snippet: RNFL thickness was measured using OCT and a fast RNFL circular scan protocol (Stratus OCT3, Zeiss Meditech, Dublin, CA) and scanning laser polarimetry (SLP) (GDx-VCC, Zeiss Meditech, Dublin, CA).

    Techniques:

    The black dashed and solid horizontal lines indicate the regions included within the quadrant and Garway-Heath et al(G-H) sectors, respectively. The curves represent the average OCT RNFL profiles for all 50 eyes.

    Journal: Journal of glaucoma

    Article Title: The Location of The Inferior and Superior Temporal Blood Vessels and Inter-Individual Variability of The Retinal Nerve Fiber Layer Thickness

    doi: 10.1097/IJG.0b013e3181af31ec

    Figure Lengend Snippet: The black dashed and solid horizontal lines indicate the regions included within the quadrant and Garway-Heath et al(G-H) sectors, respectively. The curves represent the average OCT RNFL profiles for all 50 eyes.

    Article Snippet: RNFL thickness was measured using OCT and a fast RNFL circular scan protocol (Stratus OCT3, Zeiss Meditech, Dublin, CA) and scanning laser polarimetry (SLP) (GDx-VCC, Zeiss Meditech, Dublin, CA).

    Techniques:

    A. An OCT RNFL thickness profile from a healthy eye. B. Example of a SLP density plot used to export data for SLP analysis. C. SLP RNFL profile obtained around green ring in panel B. D. A fundus image from the SLP report used to identify the location of the major temporal vein and artery in the superior (STva) and inferior (ITva) disc regions. The red and blue lines show the location of STva and ITva and the black arcs show the range of locations for the individuals in this study.

    Journal: Journal of glaucoma

    Article Title: The Location of The Inferior and Superior Temporal Blood Vessels and Inter-Individual Variability of The Retinal Nerve Fiber Layer Thickness

    doi: 10.1097/IJG.0b013e3181af31ec

    Figure Lengend Snippet: A. An OCT RNFL thickness profile from a healthy eye. B. Example of a SLP density plot used to export data for SLP analysis. C. SLP RNFL profile obtained around green ring in panel B. D. A fundus image from the SLP report used to identify the location of the major temporal vein and artery in the superior (STva) and inferior (ITva) disc regions. The red and blue lines show the location of STva and ITva and the black arcs show the range of locations for the individuals in this study.

    Article Snippet: RNFL thickness was measured using OCT and a fast RNFL circular scan protocol (Stratus OCT3, Zeiss Meditech, Dublin, CA) and scanning laser polarimetry (SLP) (GDx-VCC, Zeiss Meditech, Dublin, CA).

    Techniques:

    Bivariate fit for RNFL thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and ALSFRS-R progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.

    Journal: PLoS ONE

    Article Title: Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease

    doi: 10.1371/journal.pone.0185242

    Figure Lengend Snippet: Bivariate fit for RNFL thickness and ALFRS-R progression rate. No significant correlation between mean RNFL thickness and ALSFRS-R progression rate was found. Again, data shown are from right eyes only, but the same result was obtained from left eyes.

    Article Snippet: ALS disease severity, determined through the ALS Functional Rating Scale (ALSFRS-R); mean and six sector RNFL thickness values compared to age-adjusted values in the normative database provided by Heidelberg Engineering; RNFL thickness correlation with ALSFRS-R, ALSFRS-R progression rate, forced vital capacity (FVC), and visual acuity.

    Techniques:

    Bivariate fit for RNFL thickness and ALFRS-R score. No significant correlation between mean RNFL thickness and ALSFRS-R score was found. Please note that most ALSFRS-R scores were relatively high, indicating mild ALS disease severity. Data shown are from right eyes only, but we obtained the same result from left eyes: there was no correlation observed between ALSFRS-R and RNFL thinning.

    Journal: PLoS ONE

    Article Title: Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease

    doi: 10.1371/journal.pone.0185242

    Figure Lengend Snippet: Bivariate fit for RNFL thickness and ALFRS-R score. No significant correlation between mean RNFL thickness and ALSFRS-R score was found. Please note that most ALSFRS-R scores were relatively high, indicating mild ALS disease severity. Data shown are from right eyes only, but we obtained the same result from left eyes: there was no correlation observed between ALSFRS-R and RNFL thinning.

    Article Snippet: ALS disease severity, determined through the ALS Functional Rating Scale (ALSFRS-R); mean and six sector RNFL thickness values compared to age-adjusted values in the normative database provided by Heidelberg Engineering; RNFL thickness correlation with ALSFRS-R, ALSFRS-R progression rate, forced vital capacity (FVC), and visual acuity.

    Techniques:

    OCT and SLP results for a patient with advanced glaucoma that illustrate the influence of the blood vessels on the OCT RNFL profile. A, Image of optic disc with circle of analysis and ITV (blue) and ITA (pink) indicated. B, Total deviation visual field

    Journal:

    Article Title: Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography

    doi: 10.1097/IJG.0b013e3181629a02

    Figure Lengend Snippet: OCT and SLP results for a patient with advanced glaucoma that illustrate the influence of the blood vessels on the OCT RNFL profile. A, Image of optic disc with circle of analysis and ITV (blue) and ITA (pink) indicated. B, Total deviation visual field

    Article Snippet: The thickness of the peripapillary RNFL was measured with the Stratus OCT (Carl Zeiss Meditec Inc, Dublin, CA) using version 4.0 software and the fast scan protocol.

    Techniques:

    A, The OCT RNFL thickness profiles from 16 controls (gray) with the mean of these 16 profiles (black). B, The RNFL profiles in (A) normalized by dividing each by its mean RNFL thickness. C, The OCT RNFL profiles from the 6 controls (black) with the largest

    Journal:

    Article Title: Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography

    doi: 10.1097/IJG.0b013e3181629a02

    Figure Lengend Snippet: A, The OCT RNFL thickness profiles from 16 controls (gray) with the mean of these 16 profiles (black). B, The RNFL profiles in (A) normalized by dividing each by its mean RNFL thickness. C, The OCT RNFL profiles from the 6 controls (black) with the largest

    Article Snippet: The thickness of the peripapillary RNFL was measured with the Stratus OCT (Carl Zeiss Meditec Inc, Dublin, CA) using version 4.0 software and the fast scan protocol.

    Techniques:

    Each row (A–E) shows the OCT and SLP results for a single control. The left column shows the OCT RNFL profiles for the individual (solid) along with the mean (dashed) for all 16 controls. The center column is the fundus image from the SLP scan

    Journal:

    Article Title: Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography

    doi: 10.1097/IJG.0b013e3181629a02

    Figure Lengend Snippet: Each row (A–E) shows the OCT and SLP results for a single control. The left column shows the OCT RNFL profiles for the individual (solid) along with the mean (dashed) for all 16 controls. The center column is the fundus image from the SLP scan

    Article Snippet: The thickness of the peripapillary RNFL was measured with the Stratus OCT (Carl Zeiss Meditec Inc, Dublin, CA) using version 4.0 software and the fast scan protocol.

    Techniques:

    Example of automated segmentation errors resulting in an underestimation of RNFL thickness values. (Top) The circumpapillary OCT B-scan acquired at baseline is shown with automated segmentation of the anterior RNFL boundary in yellow and posterior RNFL boundary in red. There are two errors along the posterior boundary segmentation; one occurs at the crossing of the superior branch artery and vein (red arrows), resulting in RNFL thickness values that are 15–20% smaller than those for manually refined segmentations in sectors 3 and 4. The second error (red arrowhead) occurs at a vessel crossing in sector 9 (nasal inferior), resulting in values that are 10–15% below the manually refined values. A magnified view of the first error at baseline (inset) is shown persisting over time to the 4-year follow-up visit. (Bottom) The same scans are shown with manually refined segmentations. Long-term retinal nerve fiber layer segmentation study

    Journal: Journal of glaucoma

    Article Title: Optical coherence tomography segmentation errors of the retinal nerve fiber layer persist over time

    doi: 10.1097/IJG.0000000000001222

    Figure Lengend Snippet: Example of automated segmentation errors resulting in an underestimation of RNFL thickness values. (Top) The circumpapillary OCT B-scan acquired at baseline is shown with automated segmentation of the anterior RNFL boundary in yellow and posterior RNFL boundary in red. There are two errors along the posterior boundary segmentation; one occurs at the crossing of the superior branch artery and vein (red arrows), resulting in RNFL thickness values that are 15–20% smaller than those for manually refined segmentations in sectors 3 and 4. The second error (red arrowhead) occurs at a vessel crossing in sector 9 (nasal inferior), resulting in values that are 10–15% below the manually refined values. A magnified view of the first error at baseline (inset) is shown persisting over time to the 4-year follow-up visit. (Bottom) The same scans are shown with manually refined segmentations. Long-term retinal nerve fiber layer segmentation study

    Article Snippet: Trained operators used a spectral domain OCT to obtain peripapillary RNFL thickness measurements (Spectralis, Heidelberg Engineering, Heidelberg, Germany).

    Techniques:

    Example of automated segmentation errors resulting in an overestimation of RNFL thickness values. (Top) The circumpapillary OCT B-scan acquired at baseline is shown with automated segmentation of the anterior RNFL boundary in yellow and posterior RNFL boundary in red. There is an error along the posterior boundary segmentation (red arrow), resulting in RNFL thickness values that are 10–25% larger than those for manually refined segmentations in sector 12. A magnified view of this error at baseline (inset) is shown persisting over time to the 4-year follow-up visit. (Bottom) The same scans are shown with manually refined segmentations. Long-term retinal nerve fiber layer segmentation study

    Journal: Journal of glaucoma

    Article Title: Optical coherence tomography segmentation errors of the retinal nerve fiber layer persist over time

    doi: 10.1097/IJG.0000000000001222

    Figure Lengend Snippet: Example of automated segmentation errors resulting in an overestimation of RNFL thickness values. (Top) The circumpapillary OCT B-scan acquired at baseline is shown with automated segmentation of the anterior RNFL boundary in yellow and posterior RNFL boundary in red. There is an error along the posterior boundary segmentation (red arrow), resulting in RNFL thickness values that are 10–25% larger than those for manually refined segmentations in sector 12. A magnified view of this error at baseline (inset) is shown persisting over time to the 4-year follow-up visit. (Bottom) The same scans are shown with manually refined segmentations. Long-term retinal nerve fiber layer segmentation study

    Article Snippet: Trained operators used a spectral domain OCT to obtain peripapillary RNFL thickness measurements (Spectralis, Heidelberg Engineering, Heidelberg, Germany).

    Techniques:

    Interpretation of optic disc center displacement in case of myelinated retinal nerve fiber. (A) Myelinated retinal nerve fibers (arrowheads) interfered with the optic disc margin detection (black irregular circle) in the superonasal region. In cases with structural obstacles around the optic disc, the OCT algorithm usually failed to identify optic disc margin. Manual delineation (blue irregular arc) was performed by extending the visible surrounding optic disc margin. The direction of optic disc center displacement was estimated to be superonasal (arrows). (B) The unreliable zone should be interpreted with caution in the displacement error-encoded map. In superonasal displacement, there was a possibility of underestimation of RNFL thickness in superior, superonasal, and inferonasal regions. Part of the red- or yellow-coded areas in the RNFL deviation map might indicate false-positive RNFL thinning. In contrast, the superotemporal region was likely overestimated. Further investigation is needed for potential glaucomatous damage in this region. OCT = optical coherence tomography

    Journal: PLoS ONE

    Article Title: The Effect of Optic Disc Center Displacement on Retinal Nerve Fiber Layer Measurement Determined by Spectral Domain Optical Coherence Tomography

    doi: 10.1371/journal.pone.0165538

    Figure Lengend Snippet: Interpretation of optic disc center displacement in case of myelinated retinal nerve fiber. (A) Myelinated retinal nerve fibers (arrowheads) interfered with the optic disc margin detection (black irregular circle) in the superonasal region. In cases with structural obstacles around the optic disc, the OCT algorithm usually failed to identify optic disc margin. Manual delineation (blue irregular arc) was performed by extending the visible surrounding optic disc margin. The direction of optic disc center displacement was estimated to be superonasal (arrows). (B) The unreliable zone should be interpreted with caution in the displacement error-encoded map. In superonasal displacement, there was a possibility of underestimation of RNFL thickness in superior, superonasal, and inferonasal regions. Part of the red- or yellow-coded areas in the RNFL deviation map might indicate false-positive RNFL thinning. In contrast, the superotemporal region was likely overestimated. Further investigation is needed for potential glaucomatous damage in this region. OCT = optical coherence tomography

    Article Snippet: All subjects underwent a comprehensive ophthalmic examination, including a visual acuity test, applanation tonometry, anterior segment examination, refraction, optic disc photography, standard automated perimetry (Humphrey Field analyzer with SITA standard 30–2 test; Carl Zeiss Meditec), and RNFL imaging with a SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec).

    Techniques:

    Optic disc center displacement and data sampling positional variation. (A) Cirrus HD-OCT’s built-in algorithm automatically calculated the optic disc center (central light-blue dot) and 3.46-mm circumpapillary scan location (purple circle). The optic disc center displacement (arrow, 0.42 mm superotemporal movement) caused a sampling position change (outer red circle) in circumpapillary RNFL thickness. In this study, we manipulated the optic disc center (green and black dots) from 0 to 0.3 mm at 0.03-mm intervals in horizontal (temporal and nasal) and vertical (superior and inferior) directions and 0 to 0.42 mm at 0.042-mm intervals in diagonal (superotemporal, superonasal, inferonasal, and inferotemporal) directions. This 0.03-mm (equal to 1 pixel) or 0.042-mm (equal to 1 diagonal pixel) interval was the minimum evaluable scale in Cirrus HD-OCT. (B) In RNFL thickness map, RNFL thickness data were resampled between a 2.5-mm diameter circle and a 5.4-mm square. According to optic disc center displacement, the original scan area (black circle and square) was adjusted to a new scan area (red circle and square). OCT = optical coherence tomography; RNFL = retinal nerve fiber layer; T = temporal; ST = superotemporal; S = superior; SN = superonasal; N = nasal; IN = inferonasal; I = inferior; IT = inferotemporal; px = pixel

    Journal: PLoS ONE

    Article Title: The Effect of Optic Disc Center Displacement on Retinal Nerve Fiber Layer Measurement Determined by Spectral Domain Optical Coherence Tomography

    doi: 10.1371/journal.pone.0165538

    Figure Lengend Snippet: Optic disc center displacement and data sampling positional variation. (A) Cirrus HD-OCT’s built-in algorithm automatically calculated the optic disc center (central light-blue dot) and 3.46-mm circumpapillary scan location (purple circle). The optic disc center displacement (arrow, 0.42 mm superotemporal movement) caused a sampling position change (outer red circle) in circumpapillary RNFL thickness. In this study, we manipulated the optic disc center (green and black dots) from 0 to 0.3 mm at 0.03-mm intervals in horizontal (temporal and nasal) and vertical (superior and inferior) directions and 0 to 0.42 mm at 0.042-mm intervals in diagonal (superotemporal, superonasal, inferonasal, and inferotemporal) directions. This 0.03-mm (equal to 1 pixel) or 0.042-mm (equal to 1 diagonal pixel) interval was the minimum evaluable scale in Cirrus HD-OCT. (B) In RNFL thickness map, RNFL thickness data were resampled between a 2.5-mm diameter circle and a 5.4-mm square. According to optic disc center displacement, the original scan area (black circle and square) was adjusted to a new scan area (red circle and square). OCT = optical coherence tomography; RNFL = retinal nerve fiber layer; T = temporal; ST = superotemporal; S = superior; SN = superonasal; N = nasal; IN = inferonasal; I = inferior; IT = inferotemporal; px = pixel

    Article Snippet: All subjects underwent a comprehensive ophthalmic examination, including a visual acuity test, applanation tonometry, anterior segment examination, refraction, optic disc photography, standard automated perimetry (Humphrey Field analyzer with SITA standard 30–2 test; Carl Zeiss Meditec), and RNFL imaging with a SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec).

    Techniques: Sampling

    Design of the study. The study comprised 3 steps. In the first step, an association study of known POAG-related loci was carried out using the genome-wide SNP data from SNP array (cases) and a previous genetic study (control).[ 25 – 27 ] In the second step, 3 candidate risk SNPs were genotyped in the cases and controls to test for the reproducibility. Then a clinical correlation study was performed in the third step. SNP, single nucleotide polymorphism; POAG, primary open-angle glaucoma, HFA, Humphrey Field Analyzer, RNFL, retinal nerve fiber layer thickness, OCT, optical coherence tomography, SFC, stereoscopic fundus camera, LSFG, laser speckle flowgraphy.

    Journal: PLoS ONE

    Article Title: Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7

    doi: 10.1371/journal.pone.0186678

    Figure Lengend Snippet: Design of the study. The study comprised 3 steps. In the first step, an association study of known POAG-related loci was carried out using the genome-wide SNP data from SNP array (cases) and a previous genetic study (control).[ 25 – 27 ] In the second step, 3 candidate risk SNPs were genotyped in the cases and controls to test for the reproducibility. Then a clinical correlation study was performed in the third step. SNP, single nucleotide polymorphism; POAG, primary open-angle glaucoma, HFA, Humphrey Field Analyzer, RNFL, retinal nerve fiber layer thickness, OCT, optical coherence tomography, SFC, stereoscopic fundus camera, LSFG, laser speckle flowgraphy.

    Article Snippet: Peripapillary RNFL thickness was measured by OCT (3D OCT 2000, Topcon, Tokyo, Japan) together with axial length (IOLMaster, Carl Zeiss, Oberkochen, Germany).

    Techniques: Genome Wide