Journal: PLoS ONE

Article Title: Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review

doi: 10.1371/journal.pone.0266974

Figure Lengend Snippet: Figure presents the number of studies identifying specific retinal biomarkers as associated with each CSVD disorder of interest for the present systematic review. For each CSVD disorder, the number of individuals included in studies reporting association of a specific biomarker is reported (denoted as n). Abbreviations: CAA = Cerebral Amyloid Angiopathy, CADASIL = Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, CSVD = Cerebral Small Vessel Disease, ERG = Electroretinography, GCL = Ganglion Cell Layer, MELAS = Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes syndrome, RNFL = Retinal Nerve Fiber Layer, VEP = Visual Evoked Potentials, VF = Visual Field.

Article Snippet: Rufa et al. , 2011 , Case-control , CADASIL , 17 subjects 20 controls , OCT , Zeiss Stratus 3000 OCT , Peripapillary fast RNFL program (v 3.0) , Yes , • RNFL thickness.

Techniques: Biomarker Discovery

Journal: PLoS ONE

Article Title: Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review

doi: 10.1371/journal.pone.0266974

Figure Lengend Snippet: Summary of design, patient characteristics, methodology and results for studies of CADASIL.

Article Snippet: Rufa et al. , 2011 , Case-control , CADASIL , 17 subjects 20 controls , OCT , Zeiss Stratus 3000 OCT , Peripapillary fast RNFL program (v 3.0) , Yes , • RNFL thickness.

Techniques: Imaging, Software

Journal: BMC Ophthalmology

Article Title: Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

doi: 10.1186/s12886-017-0652-7

Figure Lengend Snippet: Demonstrates the typical infra-red (IR) images pre and post refinement of the automated segmentation. 1 a -1 c is a case of mild disc swelling: 1 a , IR image of optic nerve head; 1 b , Cross section of the peripapillary RNFL scan as autosegmented; 1 c , Cross section of the peripapillary RNFL scan following refinement of the segmentation manually. 1 d -1 f is a case of moderate to severe disc swelling: 1 d , IR image of optic nerve head; 1 e , Cross section of the peripapillary RNFL scan as autosegmented; 1 f , Cross section of the peripapillary RNFL scan following refinement of the segmentation manually

Article Snippet: SDOCT RNFL thickness peripapillary circular scans were acquired from all subjects using Heidelberg Engineering SPECTRALIS HRA + OCT (Heidelberg Engineering, Heidelberg, Germany).

Techniques:

Journal: BMC Ophthalmology

Article Title: Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

doi: 10.1186/s12886-017-0652-7

Figure Lengend Snippet: This figure presents the IR image of the optic nerve head and the cross-sectional peripapillary circle scan for three subjects ( ab , cd , ef ). The figure demonstrates that in moderate to severe optic nerve head swelling the RNFL boundary as delineated by autosegmentation (blue line) is variable and not accurate. The average RNFL thickness values in these cases will be very inaccurate in these patients. In subject CD the height of the elevation of the optic nerve head is truncated by the image width and hence any values obtained from this scan are inaccurate. All the cases presented in these images were not manually segmented and were excluded from the study

Article Snippet: SDOCT RNFL thickness peripapillary circular scans were acquired from all subjects using Heidelberg Engineering SPECTRALIS HRA + OCT (Heidelberg Engineering, Heidelberg, Germany).

Techniques: