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  • 99
    Cell Signaling Technology Inc phospho erk1 2
    Phospho Erk1 2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospho erk1 2/product/Cell Signaling Technology Inc
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    phospho erk1 2 - by Bioz Stars, 2021-06
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    Cell Signaling Technology Inc anti erk1 2
    Schematic representation of MDM2 antagonist-induced phosphorylation of <t>ERK1/2</t> through mitochondrial p53. MDM2 antagonists activate p53, which translocates into the mitochondria and causes elevated production of reactive oxygen species (ROS). The ROS produced inhibits the protein tyrosine phosphatases (PTPs), resulting in phosphorylation of receptor tyrosine kinases (RTKs) like PDGFR, IGF-1R, and DDR1. The activated RTKs then activate the ERK pathway.
    Anti Erk1 2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti erk1 2/product/Cell Signaling Technology Inc
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti erk1 2 - by Bioz Stars, 2021-06
    97/100 stars
      Buy from Supplier

    99
    Cell Signaling Technology Inc erk1 2
    RAS and MAPK are the downstream pathways of miR-518b and Rap1b. (A–C) Western blotting to measure the phosphorylation level of Raf-1 and <t>ERK1/2</t> after transfected with miR-518b or scramble negative control (NC) and Rap1b-encoding plasmid (Rap1b) or control plasmid (Ctrl). (B,C) represent the statistical results of p-Raf-1 and p-ERK1/2 shown in (A) . (D) Change in miR-518b upon hypoxia condition (2% O 2 ). Each of the tests was replicated for three times. Data are presented as mean ± SEM. * P
    Erk1 2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/erk1 2/product/Cell Signaling Technology Inc
    Average 99 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    erk1 2 - by Bioz Stars, 2021-06
    99/100 stars
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    ERK1 2 Phospho Regulation Immunocytochemistry Kit
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    Rabbit polyclonal Phospho Erk1 2 antibody
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    Rabbit polyclonal antibody to ERK1 2 Isotype Note IgG Host Note Rabbit Conjugation Note Unconjugated Reactivity Note Human Mouse Rat Application Note WB
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    N/A
    Rabbit polyclonal antibody to ERK1 2 Isotype Note IgG Host Note Rabbit Conjugation Note Unconjugated Reactivity Note Human Mouse Rat Guinea Pig Application Note WB IHC P P ELISA
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    Image Search Results


    Schematic representation of MDM2 antagonist-induced phosphorylation of ERK1/2 through mitochondrial p53. MDM2 antagonists activate p53, which translocates into the mitochondria and causes elevated production of reactive oxygen species (ROS). The ROS produced inhibits the protein tyrosine phosphatases (PTPs), resulting in phosphorylation of receptor tyrosine kinases (RTKs) like PDGFR, IGF-1R, and DDR1. The activated RTKs then activate the ERK pathway.

    Journal: Cancers

    Article Title: MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies

    doi: 10.3390/cancers12082253

    Figure Lengend Snippet: Schematic representation of MDM2 antagonist-induced phosphorylation of ERK1/2 through mitochondrial p53. MDM2 antagonists activate p53, which translocates into the mitochondria and causes elevated production of reactive oxygen species (ROS). The ROS produced inhibits the protein tyrosine phosphatases (PTPs), resulting in phosphorylation of receptor tyrosine kinases (RTKs) like PDGFR, IGF-1R, and DDR1. The activated RTKs then activate the ERK pathway.

    Article Snippet: The primary antibodies used were: anti-p53 (1:200, Santa Cruz sc-126); anti-p-ERK1/2 thr202/tyr204 (1:1000, CST 4370); anti-ERK1/2 (1:1000 ab17942); anti-IGF-1R (1:1000 CST 3027), anti-Actin (1:1000 Sigma Aldrich A3853); anti-COX IV (1:1000, CST 4844) and anti-GAPDH (1:1000, Santa Cruz sc-51907).

    Techniques: Produced

    RAS and MAPK are the downstream pathways of miR-518b and Rap1b. (A–C) Western blotting to measure the phosphorylation level of Raf-1 and ERK1/2 after transfected with miR-518b or scramble negative control (NC) and Rap1b-encoding plasmid (Rap1b) or control plasmid (Ctrl). (B,C) represent the statistical results of p-Raf-1 and p-ERK1/2 shown in (A) . (D) Change in miR-518b upon hypoxia condition (2% O 2 ). Each of the tests was replicated for three times. Data are presented as mean ± SEM. * P

    Journal: Frontiers in Endocrinology

    Article Title: miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal

    doi: 10.3389/fendo.2018.00100

    Figure Lengend Snippet: RAS and MAPK are the downstream pathways of miR-518b and Rap1b. (A–C) Western blotting to measure the phosphorylation level of Raf-1 and ERK1/2 after transfected with miR-518b or scramble negative control (NC) and Rap1b-encoding plasmid (Rap1b) or control plasmid (Ctrl). (B,C) represent the statistical results of p-Raf-1 and p-ERK1/2 shown in (A) . (D) Change in miR-518b upon hypoxia condition (2% O 2 ). Each of the tests was replicated for three times. Data are presented as mean ± SEM. * P

    Article Snippet: The membrane was blocked with 5% BSA, then incubated with specific primary antibodies which included rabbit anti-Rap1b (SAB2700792, Sigma-Aldrich, Shanghai, China), rabbit anti-p-Raf-1 and Raf-1 (#9421 & #9422, Cell Signaling Technology, Shanghai, China), mouse anti-p-ERK1/2, and ERK1/2 (#4376 & #4696, Cell Signaling Technology, Shanghai, China) at 4°C overnight.

    Techniques: Western Blot, Transfection, Negative Control, Plasmid Preparation