Journal: Optics Express

Article Title: High quality factor silica microspheres functionalized with self-assembled nanomaterials

doi: 10.1364/OE.21.020601

Figure Lengend Snippet: (a) Total Q factors of the functional microsphere versus the self-assembled polymer layer thickness (t). The experimental data are shown as triangles (for PAH/PB) and dots (for PAH/PCBS). The theoretical fittings are performed using 1/ Q = 1/ Q coupling + A × t α , where Q coupling , A , and α are fitting constants. (b) The relationship between film thickness t and Q film . The fitted values are given by1/ Q film = A × t α . The experimental data are obtained using 1/ Q film = 1/ Q - 1/ Q coupling. .

Article Snippet: For this experimental study, PAH, PCBS and PB were purchased from Sigma-Aldrich.

Techniques: Functional Assay

Journal: Environmental science & technology

Article Title: HUMAN CYP2A6, CYP2B6 AND CYP2E1 ATROPSELECTIVELY METABOLIZE POLYCHLORINATED BIPHENYLS TO HYDROXYLATED METABOLITES

doi: 10.1021/acs.est.8b05250

Figure Lengend Snippet: I n silico predictions and in vitro incubations show that chiral PCBs are metabolized to hydroxylated metabolites by human CYP2A6, CYP2B6, and CYP2E1. ADMET Predictor and Metadrug software packages were initially used to predict human P450 isoforms involved in the metabolism of chiral PCBs. Metabolism studies with recombinant human P450 enzymes were performed to assess if the P450 isoforms identified in silico indeed form OH-PCBs. In vitro Data are presented as mean ± standard deviation, n = 3. a ✓ indicates that the OH-PCB metabolite was predicted to be formed. b In vitro metabolite formation rate (+) below 80 fmol/pmol P450/min, (++) between 80 and 180 fmol/pmol P450/min, (+++) between 180 and 420 fmol/pmol P450/min and (++++) above 420 fmol/pmol P450/min. c Experimental data for incubation with CYP2E1 for 60 min are shown. d Peak corresponding to this metabolite was below the limit of detection (LOD).

Article Snippet: In addition, MetaDrug predicted the oxidation of chiral PCBs to arene oxide, dihydrodiol, and other metabolites, thus suggesting more complex metabolic pathways for PCBs than predicted by ADMET Predictor.

Techniques: In Vitro, Software, Recombinant, In Silico, Standard Deviation, Incubation

Journal: PLoS ONE

Article Title: Assessment of the Polychlorinated Biphenyl (PCB) Occurrence in Copper Sulfates and the Influential Role of PCB Levels on Grapes

doi: 10.1371/journal.pone.0144896

Figure Lengend Snippet: Concentrations of Σ 17 PCDD/Fs and Σ 19 PCBs in agricultural-grade (n = 10) and analytical-grade (n = 4) CuSO 4 . The box upper and under lines represent the 25th and 75th percentiles, respectively, and the three horizontal bars represent the 5th, 50th, and 95th percentiles. * represent the 1% and 99%, □ represent mean values.

Article Snippet: Reagents and Materials 13 C-labeled surrogate standards for PCDD/Fs (EPA 1613-LCS) and PCBs (EPA 68A-LCS) and 13 C-labeled injection standards for PCDD/Fs (EPA 1613-IS) and PCBs (EPA 68A-IS) were all purchased from Wellington Laboratories (Guelph, Canada).

Techniques: