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    Millipore 6 paradol
    Effect of Harvest time on the key phytochemicals. The key phytochemicals in ginger samples were quantified for (a) 6‐gingerol, (b) <t>6‐paradol,</t> and (c) 6‐shogaol using a HPLC system. Individual phenolic compounds were identified using authentic external standards and are expressed as mg/g dry weight. Data are expressed as mean ± SD for at least 3 samples. The data were analyzed by one way ANOVA with Tukey's HSD post hoc test. * represents a significant difference at p
    6 Paradol, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/6 paradol/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    6 paradol - by Bioz Stars, 2022-08
    86/100 stars
      Buy from Supplier

    86
    Chromadex 6 paradol 6p
    Effect of Harvest time on the key phytochemicals. The key phytochemicals in ginger samples were quantified for (a) 6‐gingerol, (b) <t>6‐paradol,</t> and (c) 6‐shogaol using a HPLC system. Individual phenolic compounds were identified using authentic external standards and are expressed as mg/g dry weight. Data are expressed as mean ± SD for at least 3 samples. The data were analyzed by one way ANOVA with Tukey's HSD post hoc test. * represents a significant difference at p
    6 Paradol 6p, supplied by Chromadex, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/6 paradol 6p/product/Chromadex
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    6 paradol 6p - by Bioz Stars, 2022-08
    86/100 stars
      Buy from Supplier

    86
    MedChemExpress paradol
    <t>6-Paradol-mediated</t> ubiquitination degradation of EGFR leads to inactivate PI3K/AKT signaling pathway. A The effect of 6-Paradol on EGFR mRNA by PCR analysis. B , C The effect of 6-Paradol on protein stability of EGFR was measured using 293 T cells treated with CHX for 1 h or 2 h. D A proteasome inhibitor, MG-132 (5 μM), was used to evaluate whether 6-Paradol was involved in EGFR degradation by a proteasome-dependent route. E Co-immunoprecipitation and SDS-gel electrophoresis were performed to evaluate the levels of EGFR ubiquitination in 293 T cells. F , G Western blot assay was performed to measure the protein expression levels of PI3K/AKT signaling in MIA PaCa-2 and SW1990 cells treated with 6-Paradol and EGFR overexpressed plasmid. H Immunofluorescence analysis of p-AKT levels in the 6-P and NC groups in MIA PaCa-2 and SW1990 cells. ** p
    Paradol, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/paradol/product/MedChemExpress
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    paradol - by Bioz Stars, 2022-08
    86/100 stars
      Buy from Supplier

    Image Search Results


    Effect of Harvest time on the key phytochemicals. The key phytochemicals in ginger samples were quantified for (a) 6‐gingerol, (b) 6‐paradol, and (c) 6‐shogaol using a HPLC system. Individual phenolic compounds were identified using authentic external standards and are expressed as mg/g dry weight. Data are expressed as mean ± SD for at least 3 samples. The data were analyzed by one way ANOVA with Tukey's HSD post hoc test. * represents a significant difference at p

    Journal: Food Science & Nutrition

    Article Title: Phytochemical profile and anti‐oxidation activity changes during ginger (Zingiber officinale) harvest: Baby ginger attenuates lipid accumulation and ameliorates glucose uptake in HepG2 cells). Phytochemical profile and anti‐oxidation activity changes during ginger (Zingiber officinale) harvest: Baby ginger attenuates lipid accumulation and ameliorates glucose uptake in HepG2 cells

    doi: 10.1002/fsn3.2654

    Figure Lengend Snippet: Effect of Harvest time on the key phytochemicals. The key phytochemicals in ginger samples were quantified for (a) 6‐gingerol, (b) 6‐paradol, and (c) 6‐shogaol using a HPLC system. Individual phenolic compounds were identified using authentic external standards and are expressed as mg/g dry weight. Data are expressed as mean ± SD for at least 3 samples. The data were analyzed by one way ANOVA with Tukey's HSD post hoc test. * represents a significant difference at p

    Article Snippet: 2.1 Materials2,2‐Diphenyl‐1‐picrylhydrazyl radical (DPPH), Folin–Ciocalteu reagent, gallic acid, and 6‐hydroxy‐2,5,7, 8‐tetramethylchroman‐2‐carboxylic acid (Trolox), Roche Cell Proliferation Reagent WST‐1, 6‐gingerol, 6‐shogaol, and 6‐paradol were purchased from Sigma‐Aldrich.

    Techniques: High Performance Liquid Chromatography

    6-Paradol-mediated ubiquitination degradation of EGFR leads to inactivate PI3K/AKT signaling pathway. A The effect of 6-Paradol on EGFR mRNA by PCR analysis. B , C The effect of 6-Paradol on protein stability of EGFR was measured using 293 T cells treated with CHX for 1 h or 2 h. D A proteasome inhibitor, MG-132 (5 μM), was used to evaluate whether 6-Paradol was involved in EGFR degradation by a proteasome-dependent route. E Co-immunoprecipitation and SDS-gel electrophoresis were performed to evaluate the levels of EGFR ubiquitination in 293 T cells. F , G Western blot assay was performed to measure the protein expression levels of PI3K/AKT signaling in MIA PaCa-2 and SW1990 cells treated with 6-Paradol and EGFR overexpressed plasmid. H Immunofluorescence analysis of p-AKT levels in the 6-P and NC groups in MIA PaCa-2 and SW1990 cells. ** p

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: 6-Paradol-mediated ubiquitination degradation of EGFR leads to inactivate PI3K/AKT signaling pathway. A The effect of 6-Paradol on EGFR mRNA by PCR analysis. B , C The effect of 6-Paradol on protein stability of EGFR was measured using 293 T cells treated with CHX for 1 h or 2 h. D A proteasome inhibitor, MG-132 (5 μM), was used to evaluate whether 6-Paradol was involved in EGFR degradation by a proteasome-dependent route. E Co-immunoprecipitation and SDS-gel electrophoresis were performed to evaluate the levels of EGFR ubiquitination in 293 T cells. F , G Western blot assay was performed to measure the protein expression levels of PI3K/AKT signaling in MIA PaCa-2 and SW1990 cells treated with 6-Paradol and EGFR overexpressed plasmid. H Immunofluorescence analysis of p-AKT levels in the 6-P and NC groups in MIA PaCa-2 and SW1990 cells. ** p

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: Polymerase Chain Reaction, Immunoprecipitation, SDS-Gel, Electrophoresis, Western Blot, Expressing, Plasmid Preparation, Immunofluorescence

    Schematic diagram of mechanism. [6]-Paradol inhibited pancreatic cancer cell proliferation and migration and inhibited the activation of PI3K/AKT signaling by targeting EGFR and enhancing EGFR degradation via a proteasome-dependent route

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: Schematic diagram of mechanism. [6]-Paradol inhibited pancreatic cancer cell proliferation and migration and inhibited the activation of PI3K/AKT signaling by targeting EGFR and enhancing EGFR degradation via a proteasome-dependent route

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: Migration, Activation Assay

    EGFR inhibitor enhanced 6-Paradol mediated-inhibition effect on PI3K/AKT signaling activity. A , B Western blot assay was performed to measure the protein expression levels of PI3K/AKT signaling in MIA PaCa-2 and SW1990 cells treated with 6-Paradol, EGFR overexpressed plasmid and Erlotinib (2 nM). C – F Gain- or Lose-Functional experiments were performed to measure the proliferation and migration abilities of pancreatic cancer cells, which were respectively treated with 6-Paradol, EGFR overexpressed plasmid and (or) Erlotinib (2 nM). G , H The protein expression changes of E-cadherin, N-cadherin and Vimentin in Control, 6-P, 6-P + Erlotinib and 6-P + Erlotinib + EGFR groups, respectively. * p

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: EGFR inhibitor enhanced 6-Paradol mediated-inhibition effect on PI3K/AKT signaling activity. A , B Western blot assay was performed to measure the protein expression levels of PI3K/AKT signaling in MIA PaCa-2 and SW1990 cells treated with 6-Paradol, EGFR overexpressed plasmid and Erlotinib (2 nM). C – F Gain- or Lose-Functional experiments were performed to measure the proliferation and migration abilities of pancreatic cancer cells, which were respectively treated with 6-Paradol, EGFR overexpressed plasmid and (or) Erlotinib (2 nM). G , H The protein expression changes of E-cadherin, N-cadherin and Vimentin in Control, 6-P, 6-P + Erlotinib and 6-P + Erlotinib + EGFR groups, respectively. * p

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: Inhibition, Activity Assay, Western Blot, Expressing, Plasmid Preparation, Functional Assay, Migration

    6-Paradol significantly suppressed tumor growth in vivo. A Tumor photographs of the subcutaneous xenografts in Control and 6-Paradol treatment groups, n = 5, cell line: SW1990. B Tumor volume of the subcutaneous xenografts in Control and 6-Paradol treatment groups. C Weight change curve in Control and 6-Paradol treatment groups. D IHC staining for Ki67, PCNA, EMT markers, EGFR, p-AKT and p-PI3K, and representative images of two pairs of subcutaneous xenograft tissue (100 ×). (Scale bar: 100 μm) * p

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: 6-Paradol significantly suppressed tumor growth in vivo. A Tumor photographs of the subcutaneous xenografts in Control and 6-Paradol treatment groups, n = 5, cell line: SW1990. B Tumor volume of the subcutaneous xenografts in Control and 6-Paradol treatment groups. C Weight change curve in Control and 6-Paradol treatment groups. D IHC staining for Ki67, PCNA, EMT markers, EGFR, p-AKT and p-PI3K, and representative images of two pairs of subcutaneous xenograft tissue (100 ×). (Scale bar: 100 μm) * p

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: In Vivo, Immunohistochemistry, Staining

    The chemical structural formulas of extracts of ginger. A [6]-Paradol. B [6]-Shogaol. C [6]-Gingerol

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: The chemical structural formulas of extracts of ginger. A [6]-Paradol. B [6]-Shogaol. C [6]-Gingerol

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques:

    Inhibition of 6-Paradol on proliferation of pancreatic cancer cells. A , B CCK-8 assays were performed to measure proliferation ability of MIA PaCa-2 ( A ) and SW1990 ( B ), which were treated with different concentrations of 6-Paradol (0, 20, 40, 80 μM). C , D Colony formation assay was performed to test the cell colony ability in MIA PaCa-2 ( C ) and SW1990 ( D ), which were treated with different concentrations of 6-Paradol (0, 20, 40, 80 μM). E , F The pancreatic cancer cells were treated with different concentrations of 6-P for 48 h (0, 20, 40, 80 μM) or the same concentration of 6-P for different time frames (0, 24, 48, 72 h). And the morphological changes of MIA PaCa-2 E and SW1990 F were captured using a phase contrast microscope (scale bar: 200 μm). * p

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: Inhibition of 6-Paradol on proliferation of pancreatic cancer cells. A , B CCK-8 assays were performed to measure proliferation ability of MIA PaCa-2 ( A ) and SW1990 ( B ), which were treated with different concentrations of 6-Paradol (0, 20, 40, 80 μM). C , D Colony formation assay was performed to test the cell colony ability in MIA PaCa-2 ( C ) and SW1990 ( D ), which were treated with different concentrations of 6-Paradol (0, 20, 40, 80 μM). E , F The pancreatic cancer cells were treated with different concentrations of 6-P for 48 h (0, 20, 40, 80 μM) or the same concentration of 6-P for different time frames (0, 24, 48, 72 h). And the morphological changes of MIA PaCa-2 E and SW1990 F were captured using a phase contrast microscope (scale bar: 200 μm). * p

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: Inhibition, CCK-8 Assay, Colony Assay, Concentration Assay, Microscopy

    6-Paradol interacts with EGFR to exert suppression functions on proliferation and metastasis of pancreatic cancer cells. A PI3K-AKT signaling pathway and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance were correlated with 6-Paradol using KEGG pathway enrichment analysis. B The 3D structure of molecular docking between 6-Paradol and EGFR. C , D Western blot assays were performed to measure the effect of 6-Paradol (80 μM) on EGFR protein levels. E – G Gain-Functional experiment was performed to measure the effect of 6-Paradol (80 μM) on proliferation and migration of 6-P + EGFR group in MIA PaCa-2 and SW1990 (scale bar: 100 μm). H , I Western blot was applied to investigate effect of 6-P combined with EGFR on EMT transition in MIA PaCa-2 and PANC-1. ** p

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: 6-Paradol interacts with EGFR to exert suppression functions on proliferation and metastasis of pancreatic cancer cells. A PI3K-AKT signaling pathway and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance were correlated with 6-Paradol using KEGG pathway enrichment analysis. B The 3D structure of molecular docking between 6-Paradol and EGFR. C , D Western blot assays were performed to measure the effect of 6-Paradol (80 μM) on EGFR protein levels. E – G Gain-Functional experiment was performed to measure the effect of 6-Paradol (80 μM) on proliferation and migration of 6-P + EGFR group in MIA PaCa-2 and SW1990 (scale bar: 100 μm). H , I Western blot was applied to investigate effect of 6-P combined with EGFR on EMT transition in MIA PaCa-2 and PANC-1. ** p

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: Western Blot, Functional Assay, Migration

    Inhibition of 6-Paradol on migration and invasion of pancreatic cancer cells. A – D Transwell assays were performed to evaluate the migration and invasion abilities of pancreatic cancer cells and the cells were treated with different concentrations of 6-Paradol (0, 20, 40, 80 μM). Migration abilities were evaluated without Matrigel ( A ) and invasion abilities were evaluated with Matrigel ( B ) (scale bar: 100 μm). The statistical chart of migration cells ( C ) and invasion cells ( D ) in different concentrations of 6-Paradol. E – G Wound healing assays were performed to further measure the migrated abilities in MIA PaCa-2 and SW1990 (scale bar: 400 μm). H , I Western blot assays were used to analyze the effect of 6-Paradol on EMT. * p

    Journal: Cancer Cell International

    Article Title: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

    doi: 10.1186/s12935-021-02118-0

    Figure Lengend Snippet: Inhibition of 6-Paradol on migration and invasion of pancreatic cancer cells. A – D Transwell assays were performed to evaluate the migration and invasion abilities of pancreatic cancer cells and the cells were treated with different concentrations of 6-Paradol (0, 20, 40, 80 μM). Migration abilities were evaluated without Matrigel ( A ) and invasion abilities were evaluated with Matrigel ( B ) (scale bar: 100 μm). The statistical chart of migration cells ( C ) and invasion cells ( D ) in different concentrations of 6-Paradol. E – G Wound healing assays were performed to further measure the migrated abilities in MIA PaCa-2 and SW1990 (scale bar: 400 μm). H , I Western blot assays were used to analyze the effect of 6-Paradol on EMT. * p

    Article Snippet: P (No. HY-14617), MG-132 (No.HY-13259) and erlotinib (No. HY-50896) were purchased from the MedChemExpress (MCE, USA).

    Techniques: Inhibition, Migration, Western Blot