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  • 93
    Millipore pahs
    Pahs, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 114 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pahs/product/Millipore
    Average 93 stars, based on 114 article reviews
    Price from $9.99 to $1999.99
    pahs - by Bioz Stars, 2020-11
    93/100 stars
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    99
    Agilent technologies gc ms ms pah analyzer
    Gc Ms Ms Pah Analyzer, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 99/100, based on 43 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gc ms ms pah analyzer/product/Agilent technologies
    Average 99 stars, based on 43 article reviews
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    gc ms ms pah analyzer - by Bioz Stars, 2020-11
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    92
    Xenobiotics pahs
    Pahs, supplied by Xenobiotics, used in various techniques. Bioz Stars score: 92/100, based on 128 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 128 article reviews
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    pah  (Sugen)
    93
    Sugen pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pah, supplied by Sugen, used in various techniques. Bioz Stars score: 93/100, based on 54 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pah/product/Sugen
    Average 93 stars, based on 54 article reviews
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    pah - by Bioz Stars, 2020-11
    93/100 stars
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    99
    Millipore pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pah, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 194 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 99 stars, based on 194 article reviews
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    pah - by Bioz Stars, 2020-11
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    92
    Supelco pahs
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pahs, supplied by Supelco, used in various techniques. Bioz Stars score: 92/100, based on 52 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 52 article reviews
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    pahs - by Bioz Stars, 2020-11
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    93
    Millipore para aminohippuric acid pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Para Aminohippuric Acid Pah, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 37 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 37 article reviews
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    89
    Xenobiotics polycyclic aromatic hydrocarbons pahs
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Polycyclic Aromatic Hydrocarbons Pahs, supplied by Xenobiotics, used in various techniques. Bioz Stars score: 89/100, based on 30 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 89 stars, based on 30 article reviews
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    92
    Merck & Co pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pah, supplied by Merck & Co, used in various techniques. Bioz Stars score: 92/100, based on 21 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 21 article reviews
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    88
    Sugen sugen hypoxia induced pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Sugen Hypoxia Induced Pah, supplied by Sugen, used in various techniques. Bioz Stars score: 88/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Millipore poly allylamine hydrochloride pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Poly Allylamine Hydrochloride Pah, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 3 article reviews
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    poly allylamine hydrochloride pah - by Bioz Stars, 2020-11
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    88
    Xenobiotics polycyclic aromatic hydrocarbons pah
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Polycyclic Aromatic Hydrocarbons Pah, supplied by Xenobiotics, used in various techniques. Bioz Stars score: 88/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Agilent technologies pahs
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pahs, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 93/100, based on 380 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pahs/product/Agilent technologies
    Average 93 stars, based on 380 article reviews
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    pahs - by Bioz Stars, 2020-11
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    90
    Cambridge Isotope Laboratories deuterated pahs
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Deuterated Pahs, supplied by Cambridge Isotope Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Agilent technologies polycyclic aromatic hydrocarbons pahs
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Polycyclic Aromatic Hydrocarbons Pahs, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 91/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    89
    Waters Corporation pah c18 column
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pah C18 Column, supplied by Waters Corporation, used in various techniques. Bioz Stars score: 89/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pah c18 column/product/Waters Corporation
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    85
    Sugen pah rat model
    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx <t>PAH</t> rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between <t>miR-31</t> levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P
    Pah Rat Model, supplied by Sugen, used in various techniques. Bioz Stars score: 85/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Merck KGaA anti pah
    Overview of the <t>DNAJC12,</t> <t>PAH,</t> TH, and TPH2 Protein Interaction Network, as Determined by Immunoprecipitation-Mass Spectrometry Analysis C-terminally tagged DNAJC12, PAH, TH, and TPH2 were immunopurified from HEK293 cells, and protein complexes were analyzed by liquid chromatography-mass spectrometry. CompPASS analysis was performed in technical duplicates. Proteins with NWD scores > 1, ASPM > 2, and entropy values > 0.7 that were reproducibly detected in the two CompPASS analyses were considered high-confidence interactors. Baits are represented in red. High-confidence interacting proteins (HCIPs) are represented in gray.
    Anti Pah, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 92/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Sugen sugen 5416 hypoxia induced pah rats
    Animal models of <t>PAH:</t> (A) monocrotaline-induced PAH for the acute efficacy study and (B) <t>SUGEN-5416/hypoxia-induced</t> PAH for the chronic efficacy study.
    Sugen 5416 Hypoxia Induced Pah Rats, supplied by Sugen, used in various techniques. Bioz Stars score: 91/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Sugen sugen 5416 hypoxia induced pah
    Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with <t>Sugen-5416</t> (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce <t>PAH.</t> Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.
    Sugen 5416 Hypoxia Induced Pah, supplied by Sugen, used in various techniques. Bioz Stars score: 88/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Cambridge Isotope Laboratories c labeled pahs
    Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with <t>Sugen-5416</t> (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce <t>PAH.</t> Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.
    C Labeled Pahs, supplied by Cambridge Isotope Laboratories, used in various techniques. Bioz Stars score: 93/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    c labeled pahs - by Bioz Stars, 2020-11
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    85
    Sugen hypoxia induced pah rat models
    Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with <t>Sugen-5416</t> (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce <t>PAH.</t> Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.
    Hypoxia Induced Pah Rat Models, supplied by Sugen, used in various techniques. Bioz Stars score: 85/100, based on 20 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    United Therapeutics Inc pah
    Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with <t>Sugen-5416</t> (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce <t>PAH.</t> Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.
    Pah, supplied by United Therapeutics Inc, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pah/product/United Therapeutics Inc
    Average 90 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    pah - by Bioz Stars, 2020-11
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    91
    Dr Ehrenstorfer GmbH deuterated pahs
    Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with <t>Sugen-5416</t> (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce <t>PAH.</t> Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.
    Deuterated Pahs, supplied by Dr Ehrenstorfer GmbH, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/deuterated pahs/product/Dr Ehrenstorfer GmbH
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    Image Search Results


    Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx PAH rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

    doi: 10.1152/ajpheart.00264.2016

    Figure Lengend Snippet: Expression of c-kit is upregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of c-kit from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx PAH rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of c-kit in RV normalized by LV-c-kit. C : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-31 levels and the relative expression levels of c-kit in RV of 13-wk Su/Hx/Nx PAH rats. * P

    Article Snippet: While a recent study did not find miR-208b in the failing RV of the Sugen/hypoxia model of PAH , miR-208b and MYH7 have been reported to be upregulated in the mouse model of PA banding-induced RV failure ( ).

    Techniques: Expressing, Western Blot

    Expression of MFN1 is downregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of MFN1 from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx PAH rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of MFN1 in RV normalized by LV-MFN1. C : Spearman correlation between RVSP and the relative expression levels of MFN1 in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of MFN1 in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between miR-140 levels and the relative expression levels of MFN1 in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of MFN1 in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of MFN1 in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-140 levels and the relative expression levels of MFN1 in RV of 13-wk Su/Hx/Nx PAH rats. * P

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

    doi: 10.1152/ajpheart.00264.2016

    Figure Lengend Snippet: Expression of MFN1 is downregulated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : representative Western blot of MFN1 from RV and LV of normoxic control, 8-wk, and 13-wk Su/Hx/Nx PAH rats. Blots were extracted from different lanes of the same gel to compare side by side. B : quantitative determination of relative expression of MFN1 in RV normalized by LV-MFN1. C : Spearman correlation between RVSP and the relative expression levels of MFN1 in RV of 8-wk Su/Hx/Nx PAH rats. D : Spearman correlation between RV hypertrophy and the relative expression levels of MFN1 in RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between miR-140 levels and the relative expression levels of MFN1 in RV of 8-wk Su/Hx/Nx PAH rats. F : Spearman correlation between RVSP and the relative expression levels of MFN1 in RV of 13-wk Su/Hx/Nx PAH rats. G : Spearman correlation between RV hypertrophy and the relative expression levels of MFN1 in RV of 13-wk Su/Hx/Nx PAH rats. H : Pearson correlation between miR-140 levels and the relative expression levels of MFN1 in RV of 13-wk Su/Hx/Nx PAH rats. * P

    Article Snippet: While a recent study did not find miR-208b in the failing RV of the Sugen/hypoxia model of PAH , miR-208b and MYH7 have been reported to be upregulated in the mouse model of PA banding-induced RV failure ( ).

    Techniques: Expressing, Western Blot

    MiroRNA-140 is elevated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : a subset of microRNA determined by unbiased microRNA microarrays that are differentially regulated more than 1 logFC between normal right ventricle (Nx RV) and hypertrophied RV at 8-wk Su/Hx/Nx PAH rats. B : qPCR validation of increase in miR-140 in the RV of the Su/Hx/Nx PAH rat. C : Pearson correlation between RVSP and miR-140 in the RV of 8-wk Su/Hx/Nx PAH rats. D : Pearson correlation between RV hypertrophy (Fulton's index) and miR-140 in the RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between RVSP and miR-140 in the RV of 13-wk Su/Hx/Nx PAH rats. F : Pearson correlation between RV hypertrophy (Fulton's index) and miR-140 in the RV of 13-wk Su/Hx/Nx PAH rats. * P

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

    doi: 10.1152/ajpheart.00264.2016

    Figure Lengend Snippet: MiroRNA-140 is elevated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : a subset of microRNA determined by unbiased microRNA microarrays that are differentially regulated more than 1 logFC between normal right ventricle (Nx RV) and hypertrophied RV at 8-wk Su/Hx/Nx PAH rats. B : qPCR validation of increase in miR-140 in the RV of the Su/Hx/Nx PAH rat. C : Pearson correlation between RVSP and miR-140 in the RV of 8-wk Su/Hx/Nx PAH rats. D : Pearson correlation between RV hypertrophy (Fulton's index) and miR-140 in the RV of 8-wk Su/Hx/Nx PAH rats. E : Pearson correlation between RVSP and miR-140 in the RV of 13-wk Su/Hx/Nx PAH rats. F : Pearson correlation between RV hypertrophy (Fulton's index) and miR-140 in the RV of 13-wk Su/Hx/Nx PAH rats. * P

    Article Snippet: While a recent study did not find miR-208b in the failing RV of the Sugen/hypoxia model of PAH , miR-208b and MYH7 have been reported to be upregulated in the mouse model of PA banding-induced RV failure ( ).

    Techniques: Real-time Polymerase Chain Reaction

    MicroRNA 208b is elevated in LV of Su/Hx/Nx rats compared with LV normoxic rats. A subset of microRNAs determined by unbiased microRNA microarrays that are differentially regulated more than 1 logFC between left ventricle (LV) of normoxic (Nx) and 8-wk Su/Hx/Nx PAH rats.

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

    doi: 10.1152/ajpheart.00264.2016

    Figure Lengend Snippet: MicroRNA 208b is elevated in LV of Su/Hx/Nx rats compared with LV normoxic rats. A subset of microRNAs determined by unbiased microRNA microarrays that are differentially regulated more than 1 logFC between left ventricle (LV) of normoxic (Nx) and 8-wk Su/Hx/Nx PAH rats.

    Article Snippet: While a recent study did not find miR-208b in the failing RV of the Sugen/hypoxia model of PAH , miR-208b and MYH7 have been reported to be upregulated in the mouse model of PA banding-induced RV failure ( ).

    Techniques:

    MiroRNA-31 is elevated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : qPCR validation of increase in miR-31 in the RV of the Su/Hx/Nx PAH rat. B : Pearson correlation between RVSP and miR-31 in the RV of 8-wk Su/Hx/Nx PAH rats. C : Pearson correlation between RV hypertrophy (Fulton's index) and miR-31 in the RV of 8-wk Su/Hx/Nx PAH rats. D : Pearson correlation between RVSP and miR-31 in the RV of 13-wk Su/Hx/Nx PAH rats. E : Pearson correlation between RV hypertrophy (Fulton's index) and miR-31 in the RV of 13-wk Su/Hx/Nx PAH rats. * P

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

    doi: 10.1152/ajpheart.00264.2016

    Figure Lengend Snippet: MiroRNA-31 is elevated in RV Su/Hx/Nx rats compared with RV normoxic rats. A : qPCR validation of increase in miR-31 in the RV of the Su/Hx/Nx PAH rat. B : Pearson correlation between RVSP and miR-31 in the RV of 8-wk Su/Hx/Nx PAH rats. C : Pearson correlation between RV hypertrophy (Fulton's index) and miR-31 in the RV of 8-wk Su/Hx/Nx PAH rats. D : Pearson correlation between RVSP and miR-31 in the RV of 13-wk Su/Hx/Nx PAH rats. E : Pearson correlation between RV hypertrophy (Fulton's index) and miR-31 in the RV of 13-wk Su/Hx/Nx PAH rats. * P

    Article Snippet: While a recent study did not find miR-208b in the failing RV of the Sugen/hypoxia model of PAH , miR-208b and MYH7 have been reported to be upregulated in the mouse model of PA banding-induced RV failure ( ).

    Techniques: Real-time Polymerase Chain Reaction

    Overview of the DNAJC12, PAH, TH, and TPH2 Protein Interaction Network, as Determined by Immunoprecipitation-Mass Spectrometry Analysis C-terminally tagged DNAJC12, PAH, TH, and TPH2 were immunopurified from HEK293 cells, and protein complexes were analyzed by liquid chromatography-mass spectrometry. CompPASS analysis was performed in technical duplicates. Proteins with NWD scores > 1, ASPM > 2, and entropy values > 0.7 that were reproducibly detected in the two CompPASS analyses were considered high-confidence interactors. Baits are represented in red. High-confidence interacting proteins (HCIPs) are represented in gray.

    Journal: American Journal of Human Genetics

    Article Title: Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability

    doi: 10.1016/j.ajhg.2017.01.002

    Figure Lengend Snippet: Overview of the DNAJC12, PAH, TH, and TPH2 Protein Interaction Network, as Determined by Immunoprecipitation-Mass Spectrometry Analysis C-terminally tagged DNAJC12, PAH, TH, and TPH2 were immunopurified from HEK293 cells, and protein complexes were analyzed by liquid chromatography-mass spectrometry. CompPASS analysis was performed in technical duplicates. Proteins with NWD scores > 1, ASPM > 2, and entropy values > 0.7 that were reproducibly detected in the two CompPASS analyses were considered high-confidence interactors. Baits are represented in red. High-confidence interacting proteins (HCIPs) are represented in gray.

    Article Snippet: The blots were blocked with 5% non-fat milk in Tris-buffered saline and Tween 20 (TBST) and then incubated with primary antibody solution: anti-PAH (Merck Millipore), anti-DNAJC12 (Abcam), and anti-β-actin overnight at 4°C.

    Techniques: Immunoprecipitation, Mass Spectrometry, Liquid Chromatography

    Phenylalanine Hydroxylase Enzyme Activity Is Reduced in the Presence of DNAJC12 Mutations (A) PAH activity was measured using liquid chromatography-electrospray ionization tandem mass spectrometry in fibroblasts with the homozygous missense variant (c.215G > C, individual C-II-4) and in fibroblasts from an unaffected age-matched healthy control after 5 μg or 10 μg PAH plasmids transfection. (B) Western blot assay of PAH, DNAJC12, and β-actin proteins in individual C-II-4 and control fibroblasts after 5 μg or 10 μg PAH plasmids transfection.

    Journal: American Journal of Human Genetics

    Article Title: Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability

    doi: 10.1016/j.ajhg.2017.01.002

    Figure Lengend Snippet: Phenylalanine Hydroxylase Enzyme Activity Is Reduced in the Presence of DNAJC12 Mutations (A) PAH activity was measured using liquid chromatography-electrospray ionization tandem mass spectrometry in fibroblasts with the homozygous missense variant (c.215G > C, individual C-II-4) and in fibroblasts from an unaffected age-matched healthy control after 5 μg or 10 μg PAH plasmids transfection. (B) Western blot assay of PAH, DNAJC12, and β-actin proteins in individual C-II-4 and control fibroblasts after 5 μg or 10 μg PAH plasmids transfection.

    Article Snippet: The blots were blocked with 5% non-fat milk in Tris-buffered saline and Tween 20 (TBST) and then incubated with primary antibody solution: anti-PAH (Merck Millipore), anti-DNAJC12 (Abcam), and anti-β-actin overnight at 4°C.

    Techniques: Activity Assay, Liquid Chromatography, Mass Spectrometry, Variant Assay, Transfection, Western Blot

    Animal models of PAH: (A) monocrotaline-induced PAH for the acute efficacy study and (B) SUGEN-5416/hypoxia-induced PAH for the chronic efficacy study.

    Journal: Molecular pharmaceutics

    Article Title: Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency

    doi: 10.1021/acs.molpharmaceut.6b01061

    Figure Lengend Snippet: Animal models of PAH: (A) monocrotaline-induced PAH for the acute efficacy study and (B) SUGEN-5416/hypoxia-induced PAH for the chronic efficacy study.

    Article Snippet: We evaluated the effect of the formulations on pulmonary hemodynamics in monocrotaline-induced PAH rats (MCT-induced PAH) and assessed the formulation’s efficacy in slowing the disease progression in Sugen-5416/hypoxia-induced PAH rats (SU/hypoxia-induced PAH).

    Techniques:

    Treatment protocol for (A) acute efficacy studies in monocrotaline-induced PAH model. (B) chronic efficacy studies in SUGEN-5416/hypoxia-induced PAH model. The doses of super dismutase (SOD) and fasudil were 5 and 3 mg/kg, respectively. In case of formulations, formulations containing 5 mg/kg SOD and 3 mg/kg fasudil were administered.

    Journal: Molecular pharmaceutics

    Article Title: Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency

    doi: 10.1021/acs.molpharmaceut.6b01061

    Figure Lengend Snippet: Treatment protocol for (A) acute efficacy studies in monocrotaline-induced PAH model. (B) chronic efficacy studies in SUGEN-5416/hypoxia-induced PAH model. The doses of super dismutase (SOD) and fasudil were 5 and 3 mg/kg, respectively. In case of formulations, formulations containing 5 mg/kg SOD and 3 mg/kg fasudil were administered.

    Article Snippet: We evaluated the effect of the formulations on pulmonary hemodynamics in monocrotaline-induced PAH rats (MCT-induced PAH) and assessed the formulation’s efficacy in slowing the disease progression in Sugen-5416/hypoxia-induced PAH rats (SU/hypoxia-induced PAH).

    Techniques:

    Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with Sugen-5416 (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce PAH. Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.

    Journal: Journal of controlled release : official journal of the Controlled Release Society

    Article Title: Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

    doi: 10.1016/j.jconrel.2015.05.261

    Figure Lengend Snippet: Experimental Approach On day 0, Adult male Sprague Dawley rats were injected with Sugen-5416 (20 mg/kg, SC), exposed to normobaric hypoxia (10 % O 2 ) for three weeks, and returned to room air an additional 10 weeks to induce PAH. Animals were randomized to treatments and received intravenous injections at week 8, 10, and 12. Evaluation of therapeutic effects occurred at week 13 and tissues were collected for molecular analysis.

    Article Snippet: We performed a series of experiments testing the in vivo distribution, toxicity, and efficacy of Star:Star-mPEG mediated delivery of antimiR-145 in rats with Sugen-5416/Hypoxia induced PAH.

    Techniques: Injection