Journal: Chembiochem : a European journal of chemical biology

Article Title: A Reversible Protection Strategy to Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach

doi: 10.1002/cbic.201100472

Figure Lengend Snippet: RP-HPLC chromatogram (14–50% acetonitrile/0.1% TFA gradient) of C-terminal-Dbz H4 peptide without Alloc protection. C-terminal AA introduced as A) Fmoc-Gly-OH and B) Fmoc-(Dmb)Gly-OH. Peptide identities were confirmed by MALDI-TOF MS analysis;

Article Snippet: Fmoc-Rink amide MBHA LL resin (0.36 mmol/g), Fmoc-Rink linker, Boc-Gly-OH, Boc-Leu-OH·H2 O, Fmoc-(Dmb)Gly-OH, Fmoc- Nle-OH, Fmoc-Ser(tBu)-Thr(ΨMe,Mepro)-OH, and Fmoc-OSu were obtained from Novabiochem.

Techniques: High Performance Liquid Chromatography, Mass Spectrometry

Journal:

Article Title: Synthesis and In Vitro Characterization of Novel Dextran-Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and its Peptidyl Intermediates

doi: 10.1002/jps.21161

Figure Lengend Snippet: Synthesis of MPS-mGGGGG-OH and MPS-mGGGGG-dextran. Reagents: (i) Piperidine (20%), DMF, (ii) Fmoc-Gly-OH, HBTU, DMF, (iii) Fmoc-mGly-OH, HBTU, DMF, (iv) MPS, HBTU.

Article Snippet: Fmoc-Gly-Wang resin, coupling reagents, and Fmoc-amino acid building blocks, Fmoc-Gly-OH and Fmoc-methyl Gly (mGly)-OH, were purchased from Novabiochem (San Diego, CA).

Techniques:

Journal: Chembiochem : a European journal of chemical biology

Article Title: A Reversible Protection Strategy to Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach

doi: 10.1002/cbic.201100472

Figure Lengend Snippet: RP-HPLC chromatogram (14–50% acetonitrile/0.1% TFA gradient) of C-terminal-Dbz H4 peptide without Alloc protection. C-terminal AA introduced as A) Fmoc-Gly-OH and B) Fmoc-(Dmb)Gly-OH. Peptide identities were confirmed by MALDI-TOF MS analysis;

Article Snippet: Fmoc-Rink amide MBHA LL resin (0.36 mmol/g), Fmoc-Rink linker, Boc-Gly-OH, Boc-Leu-OH·H2 O, Fmoc-(Dmb)Gly-OH, Fmoc- Nle-OH, Fmoc-Ser(tBu)-Thr(ΨMe,Mepro)-OH, and Fmoc-OSu were obtained from Novabiochem.

Techniques: High Performance Liquid Chromatography, Mass Spectrometry

Journal: Molecular Diversity

Article Title: New method of peptide cleavage based on Edman degradation

doi: 10.1007/s11030-013-9453-y

Figure Lengend Snippet: Proposed peptide cleavage method based on Edman degradation. BOC tert -butyloxycarbonyl, Fmoc 9-fluorenylmethoxycarbonyl, Pg protecting group, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_1$$\end{document} – \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_5$$\end{document} amino acid residues, Ac acetyl group, PITC phenyl isothiocyanate. A gray ball represents a single resin bead

Article Snippet: Fmoc amino acid derivatives (Fmoc-Leu–OH, Fmoc-Tyr(Bu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH, Fmoc-Gln(Trt)–OH, Fmoc-Glu(OBu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH, Fmoc-Asp (OBu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH, Fmoc-Pro–OH, Fmoc-His(Trt)–OH, Fmoc-Lys (Mtt)–OH, Fmoc-Val–OH, Fmoc-Thr(Bu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH) and Boc-Lys(Fmoc)–OH were purchased from Novabiochem or IrisBiotech; TentaGel®HL–NH \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_{2}$$\end{document} resin (0.56 mmol/g, 110 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upmu $$\end{document} m particle size) was purchased from Rapp Polymere.

Techniques:

Journal: Molecular Diversity

Article Title: New method of peptide cleavage based on Edman degradation

doi: 10.1007/s11030-013-9453-y

Figure Lengend Snippet: Proposed peptide cleavage method based on Edman degradation. BOC tert -butyloxycarbonyl, Fmoc 9-fluorenylmethoxycarbonyl, Pg protecting group, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_1$$\end{document} – \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_5$$\end{document} amino acid residues, Ac acetyl group, PITC phenyl isothiocyanate. A gray ball represents a single resin bead

Article Snippet: Fmoc amino acid derivatives (Fmoc-Leu–OH, Fmoc-Tyr(Bu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH, Fmoc-Gln(Trt)–OH, Fmoc-Glu(OBu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH, Fmoc-Asp (OBu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH, Fmoc-Pro–OH, Fmoc-His(Trt)–OH, Fmoc-Lys (Mtt)–OH, Fmoc-Val–OH, Fmoc-Thr(Bu \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^\mathrm{t}$$\end{document} )–OH) and Boc-Lys(Fmoc)–OH were purchased from Novabiochem or IrisBiotech; TentaGel®HL–NH \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_{2}$$\end{document} resin (0.56 mmol/g, 110 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upmu $$\end{document} m particle size) was purchased from Rapp Polymere.

Techniques: