n 6 - Search Results


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  • 94
    Thermo Fisher n 6 biotinamido hexyl
    N 6 Biotinamido Hexyl, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n6 cyclopentyladenosine
    Conspectus of protocols and groups. The pivot of all protocols was the construction of two  E / c  curves with an in vitro treatment inserted into them. The  inner  and  outer annuli  of the pie chart represent the  E / c  curves (showing the agonist used), and the medium annulus symbolizes the in vitro treatment (indicating the applied chemicals in  italic ).  Sectors  of the pie chart denote the particular protocols that progressed from the inside out. The names of the experimental groups, which underwent the protocols, are listed  outside  of the sectors. Two groups belong to one protocol (one sector): one group including solvent-treated atria and another one involving T 4 -treated atria.  Ado  adenosine,  CPA  N 6 -cyclopentyladenosine,  MC  methacholine,  S  solvent treatment,  T  T 4  (thyroxine) treatment,  Co  control,  Krebs  Krebs solution,  CPX  8-cyclopentyl-1,3-dipropylxanthine,  DMSO  dimethyl-sulfoxide,  NBTI  nitrobenzylthioinosine,  DCF  2′-deoxycoformycin
    N6 Cyclopentyladenosine, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Tocris n 6 cyclopentyladenosine
    Conspectus of protocols and groups. The pivot of all protocols was the construction of two  E / c  curves with an in vitro treatment inserted into them. The  inner  and  outer annuli  of the pie chart represent the  E / c  curves (showing the agonist used), and the medium annulus symbolizes the in vitro treatment (indicating the applied chemicals in  italic ).  Sectors  of the pie chart denote the particular protocols that progressed from the inside out. The names of the experimental groups, which underwent the protocols, are listed  outside  of the sectors. Two groups belong to one protocol (one sector): one group including solvent-treated atria and another one involving T 4 -treated atria.  Ado  adenosine,  CPA  N 6 -cyclopentyladenosine,  MC  methacholine,  S  solvent treatment,  T  T 4  (thyroxine) treatment,  Co  control,  Krebs  Krebs solution,  CPX  8-cyclopentyl-1,3-dipropylxanthine,  DMSO  dimethyl-sulfoxide,  NBTI  nitrobenzylthioinosine,  DCF  2′-deoxycoformycin
    N 6 Cyclopentyladenosine, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Selleck Chemicals n 6 methyladenosine
    Conspectus of protocols and groups. The pivot of all protocols was the construction of two  E / c  curves with an in vitro treatment inserted into them. The  inner  and  outer annuli  of the pie chart represent the  E / c  curves (showing the agonist used), and the medium annulus symbolizes the in vitro treatment (indicating the applied chemicals in  italic ).  Sectors  of the pie chart denote the particular protocols that progressed from the inside out. The names of the experimental groups, which underwent the protocols, are listed  outside  of the sectors. Two groups belong to one protocol (one sector): one group including solvent-treated atria and another one involving T 4 -treated atria.  Ado  adenosine,  CPA  N 6 -cyclopentyladenosine,  MC  methacholine,  S  solvent treatment,  T  T 4  (thyroxine) treatment,  Co  control,  Krebs  Krebs solution,  CPX  8-cyclopentyl-1,3-dipropylxanthine,  DMSO  dimethyl-sulfoxide,  NBTI  nitrobenzylthioinosine,  DCF  2′-deoxycoformycin
    N 6 Methyladenosine, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore 2 chloro n 6 cyclopentyladenosine
    Line graph illustrates changes in renal perfusion pressure in response to exogenous norepinephrine (NE) in 28 kidneys from C57BL/6 mice both before and during treatment with 2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA; highly selective A 1 receptor agonist).
    2 Chloro N 6 Cyclopentyladenosine, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 21 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    OlChemIm h6 n 6
    Line graph illustrates changes in renal perfusion pressure in response to exogenous norepinephrine (NE) in 28 kidneys from C57BL/6 mice both before and during treatment with 2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA; highly selective A 1 receptor agonist).
    H6 N 6, supplied by OlChemIm, used in various techniques. Bioz Stars score: 85/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n 6 aminohexyl l napthalenesulfonamide
    Line graph illustrates changes in renal perfusion pressure in response to exogenous norepinephrine (NE) in 28 kidneys from C57BL/6 mice both before and during treatment with 2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA; highly selective A 1 receptor agonist).
    N 6 Aminohexyl L Napthalenesulfonamide, supplied by Millipore, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Tocris 2 chloro n 6 cyclopentyladenosine
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    2 Chloro N 6 Cyclopentyladenosine, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 23 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    GE Healthcare mr750w n 6 scanner
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    Mr750w N 6 Scanner, supplied by GE Healthcare, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Boehringer Mannheim n 6 random hexamers
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Random Hexamers, supplied by Boehringer Mannheim, used in various techniques. Bioz Stars score: 85/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Cayman Chemical n 6 methyl ester
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Methyl Ester, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Nu-Chek Prep n 6 methyl ester
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Methyl Ester, supplied by Nu-Chek Prep, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n 6 methyl 2 deoxyadenosine
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Methyl 2 Deoxyadenosine, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n 6 2 phenylisopropyl adenosine
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 2 Phenylisopropyl Adenosine, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BIOLOG Life Science Institute n 6 camp n 6 1 methyl 2 phenylethyl adenosine 3
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Camp N 6 1 Methyl 2 Phenylethyl Adenosine 3, supplied by BIOLOG Life Science Institute, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n 6 aminohexyl 5 chloro 1 naphthalenesulfonamide hydrochloride
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Aminohexyl 5 Chloro 1 Naphthalenesulfonamide Hydrochloride, supplied by Millipore, used in various techniques. Bioz Stars score: 92/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BIOLOG Life Science Institute n 6 ethenoadenine dinucleotide enad
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Ethenoadenine Dinucleotide Enad, supplied by BIOLOG Life Science Institute, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Synaptic Systems n 6 ma antibodies
    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 <t>-cyclopentyladenosine</t> (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P
    N 6 Ma Antibodies, supplied by Synaptic Systems, used in various techniques. Bioz Stars score: 92/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n 6 methyladenine
    Birefringence decay profiles for the gapped duplex, 100 dT 24 , in the presence (filled circle) or absence (square) of <t>N</t> 6 <t>-methyladenine.</t> Decay profiles for full-duplex molecules are also displayed (circle). Solid lines represent two-exponential fits to the data for the gapped duplex (see Materials and Methods); dashed lines represent fits to the data for the full duplex species. ( A ) Na + of 40 mM, no magnesium; ( B ) Na + of 60 mM, 2 mM Mg 2+ .
    N 6 Methyladenine, supplied by Millipore, used in various techniques. Bioz Stars score: 88/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore n 6 benzoyladenosine 3
    Birefringence decay profiles for the gapped duplex, 100 dT 24 , in the presence (filled circle) or absence (square) of <t>N</t> 6 <t>-methyladenine.</t> Decay profiles for full-duplex molecules are also displayed (circle). Solid lines represent two-exponential fits to the data for the gapped duplex (see Materials and Methods); dashed lines represent fits to the data for the full duplex species. ( A ) Na + of 40 mM, no magnesium; ( B ) Na + of 60 mM, 2 mM Mg 2+ .
    N 6 Benzoyladenosine 3, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Taconic Biosciences nude mice n 6
    Birefringence decay profiles for the gapped duplex, 100 dT 24 , in the presence (filled circle) or absence (square) of <t>N</t> 6 <t>-methyladenine.</t> Decay profiles for full-duplex molecules are also displayed (circle). Solid lines represent two-exponential fits to the data for the gapped duplex (see Materials and Methods); dashed lines represent fits to the data for the full duplex species. ( A ) Na + of 40 mM, no magnesium; ( B ) Na + of 60 mM, 2 mM Mg 2+ .
    Nude Mice N 6, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 88/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    80
    DuPont de Nemours n 6 phenylisopropyl adenosine
    Birefringence decay profiles for the gapped duplex, 100 dT 24 , in the presence (filled circle) or absence (square) of <t>N</t> 6 <t>-methyladenine.</t> Decay profiles for full-duplex molecules are also displayed (circle). Solid lines represent two-exponential fits to the data for the gapped duplex (see Materials and Methods); dashed lines represent fits to the data for the full duplex species. ( A ) Na + of 40 mM, no magnesium; ( B ) Na + of 60 mM, 2 mM Mg 2+ .
    N 6 Phenylisopropyl Adenosine, supplied by DuPont de Nemours, used in various techniques. Bioz Stars score: 80/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Conspectus of protocols and groups. The pivot of all protocols was the construction of two  E / c  curves with an in vitro treatment inserted into them. The  inner  and  outer annuli  of the pie chart represent the  E / c  curves (showing the agonist used), and the medium annulus symbolizes the in vitro treatment (indicating the applied chemicals in  italic ).  Sectors  of the pie chart denote the particular protocols that progressed from the inside out. The names of the experimental groups, which underwent the protocols, are listed  outside  of the sectors. Two groups belong to one protocol (one sector): one group including solvent-treated atria and another one involving T 4 -treated atria.  Ado  adenosine,  CPA  N 6 -cyclopentyladenosine,  MC  methacholine,  S  solvent treatment,  T  T 4  (thyroxine) treatment,  Co  control,  Krebs  Krebs solution,  CPX  8-cyclopentyl-1,3-dipropylxanthine,  DMSO  dimethyl-sulfoxide,  NBTI  nitrobenzylthioinosine,  DCF  2′-deoxycoformycin

    Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

    Article Title: The effect of adenosine deaminase inhibition on the A1 adenosinergic and M2 muscarinergic control of contractility in eu- and hyperthyroid guinea pig atria

    doi: 10.1007/s00210-015-1121-6

    Figure Lengend Snippet: Conspectus of protocols and groups. The pivot of all protocols was the construction of two E / c curves with an in vitro treatment inserted into them. The inner and outer annuli of the pie chart represent the E / c curves (showing the agonist used), and the medium annulus symbolizes the in vitro treatment (indicating the applied chemicals in italic ). Sectors of the pie chart denote the particular protocols that progressed from the inside out. The names of the experimental groups, which underwent the protocols, are listed outside of the sectors. Two groups belong to one protocol (one sector): one group including solvent-treated atria and another one involving T 4 -treated atria. Ado adenosine, CPA N 6 -cyclopentyladenosine, MC methacholine, S solvent treatment, T T 4 (thyroxine) treatment, Co control, Krebs Krebs solution, CPX 8-cyclopentyl-1,3-dipropylxanthine, DMSO dimethyl-sulfoxide, NBTI nitrobenzylthioinosine, DCF 2′-deoxycoformycin

    Article Snippet: Materials The following chemicals were used: l -thyroxine sodium salt pentahydrate (T4 ), adenosine (non-selective adenosine receptor full agonist), acetyl-β-methylcholine chloride (methacholine: MC; non-selective muscarinic receptor full agonist with high affinity for the M2 muscarinic receptor (M2 receptor)), N6 -cyclopentyladenosine (CPA; selective A1 adenosine receptor full agonist), 8-cyclopentyl-1,3-dipropylxanthine (CPX; selective, competitive A1 adenosine receptor antagonist), and S -(2-hydroxy-5-nitrobenzyl)-6-thioinosine (NBTI; selective inhibitor of nucleoside transporter type ENT1) from Sigma (St. Louis, MO, USA) and pentostatin (2′-deoxycoformycin: DCF; selective inhibitor of adenosine deaminase) in Nipent™ , which was the generous gift of Wyeth Pharmaceuticals (Collegeville, PA, USA).

    Techniques: In Vitro

    Effects on HR of GD 13 rat embryo in 95% oxygen after 1 hour. Notes: ( A ) 2,4-Dinitrophenol induced a concentration-dependent decrease in embryonic HR. ( B ) N6-cyclopentyladenosine (CPA) induced a concentration-dependent decrease in embryonic HR. ( C ) Aminoimidazole-4-carboxyamide ribonucleoside (AICAR) induced a decrease in embryonic HR. ( D ) Pinacidil induced a concentration-dependent decrease in embryonic HR. Changes in HR (expressed as percent change from starting HR). Data are presented as mean ± SEM. * P

    Journal: Hypoxia

    Article Title: Control of the heart rate of rat embryos during the organogenic period

    doi: 10.2147/HP.S115050

    Figure Lengend Snippet: Effects on HR of GD 13 rat embryo in 95% oxygen after 1 hour. Notes: ( A ) 2,4-Dinitrophenol induced a concentration-dependent decrease in embryonic HR. ( B ) N6-cyclopentyladenosine (CPA) induced a concentration-dependent decrease in embryonic HR. ( C ) Aminoimidazole-4-carboxyamide ribonucleoside (AICAR) induced a decrease in embryonic HR. ( D ) Pinacidil induced a concentration-dependent decrease in embryonic HR. Changes in HR (expressed as percent change from starting HR). Data are presented as mean ± SEM. * P

    Article Snippet: All other reagents were sourced from Sigma-Aldrich Co. AICAR, N6-cyclopentyladenosine (CPA), 1,3-dipropyl-8-cyclopentylxanthine (CPX), pinacidil monohydrate, glibenclamide, IOX2, BAY 87-2243, atropine and atenolol were dissolved in dimethyl sulfoxide (Sigma-Aldrich Co.), and all other chemicals were dissolved in water.

    Techniques: Concentration Assay

    Line graph illustrates changes in renal perfusion pressure in response to exogenous norepinephrine (NE) in 28 kidneys from C57BL/6 mice both before and during treatment with 2-chloro- N 6 -cyclopentyladenosine (CCPA; highly selective A 1 receptor agonist).

    Journal: American Journal of Physiology - Renal Physiology

    Article Title: Role of A1 receptors in renal sympathetic neurotransmission in the mouse kidney

    doi: 10.1152/ajprenal.00363.2012

    Figure Lengend Snippet: Line graph illustrates changes in renal perfusion pressure in response to exogenous norepinephrine (NE) in 28 kidneys from C57BL/6 mice both before and during treatment with 2-chloro- N 6 -cyclopentyladenosine (CCPA; highly selective A 1 receptor agonist).

    Article Snippet: 1,3-Dipropyl-8-p-sulfophenylxanthine [DPSPX; adenosine receptor antagonist that does not penetrate cell membranes ( )] and 2-chloro- N 6 -cyclopentyladenosine [CCPA; a highly selective A1 receptor agonist ( )] were obtained from Sigma (St. Louis, MO).

    Techniques: Mouse Assay

    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Journal: American Journal of Physiology - Renal Physiology

    Article Title: A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury

    doi: 10.1152/ajprenal.00157.2012

    Figure Lengend Snippet: Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Article Snippet: 2-Amino-4,5-dimethyl-3-thienyl-[3-(trifluoromethyl)phenyl] methanone (PD-81723; a selective allosteric enhancer for the A1 AR; ), 2-chloro- N 6 -cyclopentyladenosine (CCPA; a selective A1 AR agonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; a selective antagonist for the A1 AR) and 4-{[4-(4-chlorophenyl)-2-thiazolyl]amino}phenol [SKI-II, a selective nonlipid inhibitor of sphingosine kinase (SK)] were purchased from Tocris (Minneapolis, MN).

    Techniques: Mouse Assay, Injection

    Birefringence decay profiles for the gapped duplex, 100 dT 24 , in the presence (filled circle) or absence (square) of N 6 -methyladenine. Decay profiles for full-duplex molecules are also displayed (circle). Solid lines represent two-exponential fits to the data for the gapped duplex (see Materials and Methods); dashed lines represent fits to the data for the full duplex species. ( A ) Na + of 40 mM, no magnesium; ( B ) Na + of 60 mM, 2 mM Mg 2+ .

    Journal: Nucleic Acids Research

    Article Title: Origin of the intrinsic rigidity of DNA

    doi: 10.1093/nar/gkh740

    Figure Lengend Snippet: Birefringence decay profiles for the gapped duplex, 100 dT 24 , in the presence (filled circle) or absence (square) of N 6 -methyladenine. Decay profiles for full-duplex molecules are also displayed (circle). Solid lines represent two-exponential fits to the data for the gapped duplex (see Materials and Methods); dashed lines represent fits to the data for the full duplex species. ( A ) Na + of 40 mM, no magnesium; ( B ) Na + of 60 mM, 2 mM Mg 2+ .

    Article Snippet: Saturated solutions of N 6 -methyladenine (Sigma) were mixed with small aliquots of 100 dT24 at room temperature (3- to 5-fold molar excess of me A over thymidylate monomer in the gap region).

    Techniques: