mx 1 cells Search Results


  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 90
    CLS Cell Lines Service GmbH mx 1 cells
    The combinatory effect of eribulin (ERI) and paclitaxel (PTX) on MDA-MB-231, Hs578T, MDA-MB-157, and <t>Mx-1</t> cells was tested using WST assays. ( A ) Sensitivity to PTX in the presence or absence of low doses of ERI (upper panels for each cell line) and sensitivity to ERI in the presence or absence of low doses of PTX (lower panels for each cell line). Closed circles (●) indicate control, closed triangles (▲) indicate 0.1 nM (MDA-MB-231 and Hs578T cells) or 0.05 nM (MDA-MB-157 and Mx-1 cells) of ERI, open circles (○) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of ERI, closed squares (■) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of PTX, and open squares (□) indicate 0.3 nM (MDA-MB-157 and Mx-1 cells), 0.5 nM (MDA-MB-231 cells), or 1.0 nM (Hs578T cells) of PTX. The error bars represent the standard deviations of the values obtained; experiments were performed in triplicate. ( B ) The experimental data were plotted on an isobologram. The dots located below, on, or above the diagonal line indicate synergistic, additive, and antagonistic effects, respectively.
    Mx 1 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mx 1 cells/product/CLS Cell Lines Service GmbH
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mx 1 cells - by Bioz Stars, 2024-06
    90/100 stars
      Buy from Supplier

    94
    Cell Signaling Technology Inc mx1
    The combinatory effect of eribulin (ERI) and paclitaxel (PTX) on MDA-MB-231, Hs578T, MDA-MB-157, and <t>Mx-1</t> cells was tested using WST assays. ( A ) Sensitivity to PTX in the presence or absence of low doses of ERI (upper panels for each cell line) and sensitivity to ERI in the presence or absence of low doses of PTX (lower panels for each cell line). Closed circles (●) indicate control, closed triangles (▲) indicate 0.1 nM (MDA-MB-231 and Hs578T cells) or 0.05 nM (MDA-MB-157 and Mx-1 cells) of ERI, open circles (○) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of ERI, closed squares (■) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of PTX, and open squares (□) indicate 0.3 nM (MDA-MB-157 and Mx-1 cells), 0.5 nM (MDA-MB-231 cells), or 1.0 nM (Hs578T cells) of PTX. The error bars represent the standard deviations of the values obtained; experiments were performed in triplicate. ( B ) The experimental data were plotted on an isobologram. The dots located below, on, or above the diagonal line indicate synergistic, additive, and antagonistic effects, respectively.
    Mx1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mx1/product/Cell Signaling Technology Inc
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mx1 - by Bioz Stars, 2024-06
    94/100 stars
      Buy from Supplier

    86
    Bioarray Inc mx 1 cells
    In vitro characterization of B7-H4 ADCs. A, The anti–B7-H4 antibody does not block the functional activity of B7-H4 ligand. HEK293 or HEK293-B7-H4 cells were incubated with 10 nmol/L antibody (B7-H4 or nonbinding control) prior to the addition of CellTrace Violet-labeled CD3 + T cells and CD3/CD28 T-cell Activator. T cell proliferation was determined after 4-day incubation. Data represent the mean (± standard deviation) of triplicate samples. B, Schematics of the B7-H4–targeted ADCs evaluated in this study: site-specific DS DAR 2 and DAR 6, and DF DAR 12. C, Binding of ADCs to HEK293-B7-H4 cells and <t>MX-1</t> breast cancer cells. Flow cytometry analysis was performed with B7-H4 ADCs, unconjugated antibody, and nonbinding control ADCs. D, Binding of ADCs to recombinant human B7-H4 protein. ELISA was performed with B7-H4 ADCs, unconjugated antibody, and non-binding control ADCs. E, B7-H4 ADCs elicit target-dependent cytotoxicity. HEK293-B7-H4 cells were incubated with test article for 3 days, and viability was measured with CellTiter-Glo.
    Mx 1 Cells, supplied by Bioarray Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mx 1 cells/product/Bioarray Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mx 1 cells - by Bioz Stars, 2024-06
    86/100 stars
      Buy from Supplier

    86
    Charles River Laboratories mx 1 cell line
    In vitro characterization of B7-H4 ADCs. A, The anti–B7-H4 antibody does not block the functional activity of B7-H4 ligand. HEK293 or HEK293-B7-H4 cells were incubated with 10 nmol/L antibody (B7-H4 or nonbinding control) prior to the addition of CellTrace Violet-labeled CD3 + T cells and CD3/CD28 T-cell Activator. T cell proliferation was determined after 4-day incubation. Data represent the mean (± standard deviation) of triplicate samples. B, Schematics of the B7-H4–targeted ADCs evaluated in this study: site-specific DS DAR 2 and DAR 6, and DF DAR 12. C, Binding of ADCs to HEK293-B7-H4 cells and <t>MX-1</t> breast cancer cells. Flow cytometry analysis was performed with B7-H4 ADCs, unconjugated antibody, and nonbinding control ADCs. D, Binding of ADCs to recombinant human B7-H4 protein. ELISA was performed with B7-H4 ADCs, unconjugated antibody, and non-binding control ADCs. E, B7-H4 ADCs elicit target-dependent cytotoxicity. HEK293-B7-H4 cells were incubated with test article for 3 days, and viability was measured with CellTiter-Glo.
    Mx 1 Cell Line, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mx 1 cell line/product/Charles River Laboratories
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mx 1 cell line - by Bioz Stars, 2024-06
    86/100 stars
      Buy from Supplier

    86
    CEM Corporation hl60 mx1 cell lines
    IC 50 determined on tested cell lines. Each dose is shown in micromolar concentration [µM] as Mean ± SD.
    Hl60 Mx1 Cell Lines, supplied by CEM Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hl60 mx1 cell lines/product/CEM Corporation
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    hl60 mx1 cell lines - by Bioz Stars, 2024-06
    86/100 stars
      Buy from Supplier

    Image Search Results


    The combinatory effect of eribulin (ERI) and paclitaxel (PTX) on MDA-MB-231, Hs578T, MDA-MB-157, and Mx-1 cells was tested using WST assays. ( A ) Sensitivity to PTX in the presence or absence of low doses of ERI (upper panels for each cell line) and sensitivity to ERI in the presence or absence of low doses of PTX (lower panels for each cell line). Closed circles (●) indicate control, closed triangles (▲) indicate 0.1 nM (MDA-MB-231 and Hs578T cells) or 0.05 nM (MDA-MB-157 and Mx-1 cells) of ERI, open circles (○) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of ERI, closed squares (■) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of PTX, and open squares (□) indicate 0.3 nM (MDA-MB-157 and Mx-1 cells), 0.5 nM (MDA-MB-231 cells), or 1.0 nM (Hs578T cells) of PTX. The error bars represent the standard deviations of the values obtained; experiments were performed in triplicate. ( B ) The experimental data were plotted on an isobologram. The dots located below, on, or above the diagonal line indicate synergistic, additive, and antagonistic effects, respectively.

    Journal: Oncotarget

    Article Title: Combination of two anti-tubulin agents, eribulin and paclitaxel, enhances anti-tumor effects on triple-negative breast cancer through mesenchymal-epithelial transition

    doi: 10.18632/oncotarget.25184

    Figure Lengend Snippet: The combinatory effect of eribulin (ERI) and paclitaxel (PTX) on MDA-MB-231, Hs578T, MDA-MB-157, and Mx-1 cells was tested using WST assays. ( A ) Sensitivity to PTX in the presence or absence of low doses of ERI (upper panels for each cell line) and sensitivity to ERI in the presence or absence of low doses of PTX (lower panels for each cell line). Closed circles (●) indicate control, closed triangles (▲) indicate 0.1 nM (MDA-MB-231 and Hs578T cells) or 0.05 nM (MDA-MB-157 and Mx-1 cells) of ERI, open circles (○) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of ERI, closed squares (■) indicate 0.1 nM (MDA-MB-157 and Mx-1 cells), 0.2 nM (MDA-MB-231 cells), or 0.5 nM (Hs578T cells) of PTX, and open squares (□) indicate 0.3 nM (MDA-MB-157 and Mx-1 cells), 0.5 nM (MDA-MB-231 cells), or 1.0 nM (Hs578T cells) of PTX. The error bars represent the standard deviations of the values obtained; experiments were performed in triplicate. ( B ) The experimental data were plotted on an isobologram. The dots located below, on, or above the diagonal line indicate synergistic, additive, and antagonistic effects, respectively.

    Article Snippet: Three TNBC cell lines (MDA-MB-231, Hs578T, and MDA-MB-157) were purchased from the American Type Cell Collection (Manassas, VA), and Mx-1 cells were purchased from CLS Cell Lines Service (Eppelheim, Germany) in 2016, and passaged in our laboratory for less than 6 months after receipt or resuscitation.

    Techniques:

    The expression of epithelial and mesenchymal markers was studied by western blotting. Representative results of western blot analyses are shown. β-Actin was used as a loading control. The experiments were performed independently at least three times, and one representative blot is provided in the figures. ( A ) Expression of EMT markers in MDA-MB-231, Hs578T, MDA-MB-157, and Mx-1 cells treated with eribulin (ERI; 0.1 and 0.2 nM), paclitaxel (PTX; 0.5 and 1 nM), or both (ERI; 0.2 nM and PTX; 1 nM) for 96 h. ( B ) Expression of EMT markers in MDA-MB-231, Hs578T cells treated with ERI (0.2 nM) or PTX (1 nM) for 24 h and 48 h.

    Journal: Oncotarget

    Article Title: Combination of two anti-tubulin agents, eribulin and paclitaxel, enhances anti-tumor effects on triple-negative breast cancer through mesenchymal-epithelial transition

    doi: 10.18632/oncotarget.25184

    Figure Lengend Snippet: The expression of epithelial and mesenchymal markers was studied by western blotting. Representative results of western blot analyses are shown. β-Actin was used as a loading control. The experiments were performed independently at least three times, and one representative blot is provided in the figures. ( A ) Expression of EMT markers in MDA-MB-231, Hs578T, MDA-MB-157, and Mx-1 cells treated with eribulin (ERI; 0.1 and 0.2 nM), paclitaxel (PTX; 0.5 and 1 nM), or both (ERI; 0.2 nM and PTX; 1 nM) for 96 h. ( B ) Expression of EMT markers in MDA-MB-231, Hs578T cells treated with ERI (0.2 nM) or PTX (1 nM) for 24 h and 48 h.

    Article Snippet: Three TNBC cell lines (MDA-MB-231, Hs578T, and MDA-MB-157) were purchased from the American Type Cell Collection (Manassas, VA), and Mx-1 cells were purchased from CLS Cell Lines Service (Eppelheim, Germany) in 2016, and passaged in our laboratory for less than 6 months after receipt or resuscitation.

    Techniques: Expressing, Western Blot

    In vitro characterization of B7-H4 ADCs. A, The anti–B7-H4 antibody does not block the functional activity of B7-H4 ligand. HEK293 or HEK293-B7-H4 cells were incubated with 10 nmol/L antibody (B7-H4 or nonbinding control) prior to the addition of CellTrace Violet-labeled CD3 + T cells and CD3/CD28 T-cell Activator. T cell proliferation was determined after 4-day incubation. Data represent the mean (± standard deviation) of triplicate samples. B, Schematics of the B7-H4–targeted ADCs evaluated in this study: site-specific DS DAR 2 and DAR 6, and DF DAR 12. C, Binding of ADCs to HEK293-B7-H4 cells and MX-1 breast cancer cells. Flow cytometry analysis was performed with B7-H4 ADCs, unconjugated antibody, and nonbinding control ADCs. D, Binding of ADCs to recombinant human B7-H4 protein. ELISA was performed with B7-H4 ADCs, unconjugated antibody, and non-binding control ADCs. E, B7-H4 ADCs elicit target-dependent cytotoxicity. HEK293-B7-H4 cells were incubated with test article for 3 days, and viability was measured with CellTiter-Glo.

    Journal: Molecular Cancer Therapeutics

    Article Title: Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer

    doi: 10.1158/1535-7163.MCT-22-0786

    Figure Lengend Snippet: In vitro characterization of B7-H4 ADCs. A, The anti–B7-H4 antibody does not block the functional activity of B7-H4 ligand. HEK293 or HEK293-B7-H4 cells were incubated with 10 nmol/L antibody (B7-H4 or nonbinding control) prior to the addition of CellTrace Violet-labeled CD3 + T cells and CD3/CD28 T-cell Activator. T cell proliferation was determined after 4-day incubation. Data represent the mean (± standard deviation) of triplicate samples. B, Schematics of the B7-H4–targeted ADCs evaluated in this study: site-specific DS DAR 2 and DAR 6, and DF DAR 12. C, Binding of ADCs to HEK293-B7-H4 cells and MX-1 breast cancer cells. Flow cytometry analysis was performed with B7-H4 ADCs, unconjugated antibody, and nonbinding control ADCs. D, Binding of ADCs to recombinant human B7-H4 protein. ELISA was performed with B7-H4 ADCs, unconjugated antibody, and non-binding control ADCs. E, B7-H4 ADCs elicit target-dependent cytotoxicity. HEK293-B7-H4 cells were incubated with test article for 3 days, and viability was measured with CellTiter-Glo.

    Article Snippet: Cell lines: MX-1 cells (RRID:CVCL_4774) (Creative Bioarray CSC-C0264) were cultured in DMEM:F12K with 10% FBS and 1% penicillin/streptomycin.

    Techniques: In Vitro, Blocking Assay, Functional Assay, Activity Assay, Incubation, Labeling, Standard Deviation, Binding Assay, Flow Cytometry, Recombinant, Enzyme-linked Immunosorbent Assay

    In vivo profile comparison of B7-H4 ADCs. A, Antitumor activity of B7-H4 ADCs in HBCx-24 PDX model. Inset, B7-H4 IHC. B, Antitumor activity of B7-H4 ADCs in MX-1 breast cancer cell line model. Inset, B7-H4 IHC. C, Plasma levels of conjugated drug in MX-1 tumor-bearing animals following a single administration of ADC at 0.15 mg/kg payload. Refer to legend in part B. D, Plasma levels of three analytes in cynomolgus monkeys following a single administration of ADC at 0.09 mg/kg payload. Blue, XMT-1660 DAR 6 DS; purple, DAR 2 DS.

    Journal: Molecular Cancer Therapeutics

    Article Title: Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer

    doi: 10.1158/1535-7163.MCT-22-0786

    Figure Lengend Snippet: In vivo profile comparison of B7-H4 ADCs. A, Antitumor activity of B7-H4 ADCs in HBCx-24 PDX model. Inset, B7-H4 IHC. B, Antitumor activity of B7-H4 ADCs in MX-1 breast cancer cell line model. Inset, B7-H4 IHC. C, Plasma levels of conjugated drug in MX-1 tumor-bearing animals following a single administration of ADC at 0.15 mg/kg payload. Refer to legend in part B. D, Plasma levels of three analytes in cynomolgus monkeys following a single administration of ADC at 0.09 mg/kg payload. Blue, XMT-1660 DAR 6 DS; purple, DAR 2 DS.

    Article Snippet: Cell lines: MX-1 cells (RRID:CVCL_4774) (Creative Bioarray CSC-C0264) were cultured in DMEM:F12K with 10% FBS and 1% penicillin/streptomycin.

    Techniques: In Vivo, Comparison, Activity Assay

    IC 50 determined on tested cell lines. Each dose is shown in micromolar concentration [µM] as Mean ± SD.

    Journal: Molecules

    Article Title: Imaging Flow Cytometric Analysis of Stilbene-Dependent Apoptosis in Drug Resistant Human Leukemic Cell Lines

    doi: 10.3390/molecules24101896

    Figure Lengend Snippet: IC 50 determined on tested cell lines. Each dose is shown in micromolar concentration [µM] as Mean ± SD.

    Article Snippet: To our knowledge, this is a first published report which presents induction of apoptosis after exposure to rhaponticin (in the presence and absence of mitoxantrone) in HL60, HL60/MX1, HL60/MX2, CCRF-CEM cell lines, deoxyrhaponticin (in the presence and absence of mitoxantrone) in CCRF-CEM and HL60/MX1 cell lines, piceatannol (in the presence and absence of mitoxantrone) in HL60/MX2 cell line, pterostilbene (in the presence and absence of mitoxantrone) in HL60/MX2 which may show a tendency of inhibiting MDR.

    Techniques: Concentration Assay

    Results of FlowSight analysis of HL60 cells treated with t-resveratrol in IC 50 (Columns: BF—BrightField, AnxV—Annexin V-FITC, PI—Propidium Iodide; AnxV/PI—Coexpression of Annexin V-FITC and Propidium Iodide; PhiPhiLux—Caspase3-FITC; PhiPhiLux/PI—coexpression of Caspase3-FITC and propidium iodide; Rows: A—viable cells (AnxV-/PI-); B—Early-apoptic cells (AnxV+/PI-); C—Late-apoptic cells (AnxV+/PI+); D—Necrotic cells (AnxV-/PI+); E—viable cells (Casp-/PI-); F— apoptic cells (Casp+/PI-, Casp+/PI+); G—necrotic cells (Casp-/PI+)).

    Journal: Molecules

    Article Title: Imaging Flow Cytometric Analysis of Stilbene-Dependent Apoptosis in Drug Resistant Human Leukemic Cell Lines

    doi: 10.3390/molecules24101896

    Figure Lengend Snippet: Results of FlowSight analysis of HL60 cells treated with t-resveratrol in IC 50 (Columns: BF—BrightField, AnxV—Annexin V-FITC, PI—Propidium Iodide; AnxV/PI—Coexpression of Annexin V-FITC and Propidium Iodide; PhiPhiLux—Caspase3-FITC; PhiPhiLux/PI—coexpression of Caspase3-FITC and propidium iodide; Rows: A—viable cells (AnxV-/PI-); B—Early-apoptic cells (AnxV+/PI-); C—Late-apoptic cells (AnxV+/PI+); D—Necrotic cells (AnxV-/PI+); E—viable cells (Casp-/PI-); F— apoptic cells (Casp+/PI-, Casp+/PI+); G—necrotic cells (Casp-/PI+)).

    Article Snippet: To our knowledge, this is a first published report which presents induction of apoptosis after exposure to rhaponticin (in the presence and absence of mitoxantrone) in HL60, HL60/MX1, HL60/MX2, CCRF-CEM cell lines, deoxyrhaponticin (in the presence and absence of mitoxantrone) in CCRF-CEM and HL60/MX1 cell lines, piceatannol (in the presence and absence of mitoxantrone) in HL60/MX2 cell line, pterostilbene (in the presence and absence of mitoxantrone) in HL60/MX2 which may show a tendency of inhibiting MDR.

    Techniques:

    Apoptosis analysis of HL60 cell line. Graphs taken from FlowSight cytometer. All axes are shown in a logarithmic scale. (Columns: 1—Annexin V-FITC and PhiPhiLux-G1D2-FITC histogram; 2—propidium iodide histogram; 3—Annexin V-FITC/propidium iodide dot plot and PhiPhiLux-G1D2-FITC/propidium iodide dot plot; Rows: A, B—IC 50 of pterostilbene; C, D—IC 50 of pterostilbene with mitoxantrone. Rows A, C—Annexin V-FITC/propidium iodide assay; B, D—PhiPhiLux-G1D2-FITC/propidium iodide assay).

    Journal: Molecules

    Article Title: Imaging Flow Cytometric Analysis of Stilbene-Dependent Apoptosis in Drug Resistant Human Leukemic Cell Lines

    doi: 10.3390/molecules24101896

    Figure Lengend Snippet: Apoptosis analysis of HL60 cell line. Graphs taken from FlowSight cytometer. All axes are shown in a logarithmic scale. (Columns: 1—Annexin V-FITC and PhiPhiLux-G1D2-FITC histogram; 2—propidium iodide histogram; 3—Annexin V-FITC/propidium iodide dot plot and PhiPhiLux-G1D2-FITC/propidium iodide dot plot; Rows: A, B—IC 50 of pterostilbene; C, D—IC 50 of pterostilbene with mitoxantrone. Rows A, C—Annexin V-FITC/propidium iodide assay; B, D—PhiPhiLux-G1D2-FITC/propidium iodide assay).

    Article Snippet: To our knowledge, this is a first published report which presents induction of apoptosis after exposure to rhaponticin (in the presence and absence of mitoxantrone) in HL60, HL60/MX1, HL60/MX2, CCRF-CEM cell lines, deoxyrhaponticin (in the presence and absence of mitoxantrone) in CCRF-CEM and HL60/MX1 cell lines, piceatannol (in the presence and absence of mitoxantrone) in HL60/MX2 cell line, pterostilbene (in the presence and absence of mitoxantrone) in HL60/MX2 which may show a tendency of inhibiting MDR.

    Techniques: Cytometry

    Apoptosis analysis of HL60 cell line. Graphs taken from FlowSight cytometer. All axes are shown in a logarithmic scale. (Columns: 1—Annexin V-FITC and PhiPhiLux-G1D2-FITC histogram; 2—propidium iodide histogram; 3—Annexin V-FITC/propidium iodide dot plot and PhiPhiLux-G1D2-FITC/propidium iodide dot plot; Rows: A, B—untreated HL60 cells; C, D—HL60 cells with mitoxantrone. Rows A, C—Annexin V-FITC/propidium iodide assay, B, D—PhiPhiLux-G1D2-FITC/propidium iodide assay).

    Journal: Molecules

    Article Title: Imaging Flow Cytometric Analysis of Stilbene-Dependent Apoptosis in Drug Resistant Human Leukemic Cell Lines

    doi: 10.3390/molecules24101896

    Figure Lengend Snippet: Apoptosis analysis of HL60 cell line. Graphs taken from FlowSight cytometer. All axes are shown in a logarithmic scale. (Columns: 1—Annexin V-FITC and PhiPhiLux-G1D2-FITC histogram; 2—propidium iodide histogram; 3—Annexin V-FITC/propidium iodide dot plot and PhiPhiLux-G1D2-FITC/propidium iodide dot plot; Rows: A, B—untreated HL60 cells; C, D—HL60 cells with mitoxantrone. Rows A, C—Annexin V-FITC/propidium iodide assay, B, D—PhiPhiLux-G1D2-FITC/propidium iodide assay).

    Article Snippet: To our knowledge, this is a first published report which presents induction of apoptosis after exposure to rhaponticin (in the presence and absence of mitoxantrone) in HL60, HL60/MX1, HL60/MX2, CCRF-CEM cell lines, deoxyrhaponticin (in the presence and absence of mitoxantrone) in CCRF-CEM and HL60/MX1 cell lines, piceatannol (in the presence and absence of mitoxantrone) in HL60/MX2 cell line, pterostilbene (in the presence and absence of mitoxantrone) in HL60/MX2 which may show a tendency of inhibiting MDR.

    Techniques: Cytometry