Journal: Data in Brief
Article Title: Integrated dataset on acute phase protein response in chicken challenged with Escherichia coli lipopolysaccharide endotoxin
Figure Lengend Snippet: Interactome of pathways differentially expressed among time in chicken challenged with Escherichia coli lipopolysaccharide (LPS group) and their intermediate proteins. Gene ontology analysed pathways over-represented in the list of 19 proteins differentially expressed among time in LPS group. This analyse have been done with the Cytoscape application ClueGO and the REVIGO tool for GO terms selection. GO terms in bold represent GO terms selected to be the most representative of their GO group defined by the REVIGO tool. For each proteins, 4 fold changes among the 5 different time points have been represented using colour intensity to figure fold change value. Positive fold changes are in green, negative are in red, fold change values close to 0 are in white. Proteins have been gather in 3 groups defined by their fold changes pattern. The A pattern correspond to a quick increase of a protein, then go back to the initial situation, while the pattern B correspond to a quick decrease of a protein and then a go back to the initial situation. The C pattern correspond to a decrease which happen later in the infection process. For each pattern, evolution of one protein mean among time has been represented with histogram to illustrate the pattern properties.
Article Snippet: Twenty four birds were injected subcutaneously (SC) at time point 0, with Escherichia coli lipopolysaccharide (LPS from E. coli O111:B4 purified by phenol extraction, L2630-25MG; Sigma-Aldrich, Dorset, UK) (2 mg/kg body weight) in a volume of 0.5 mL as the treatment group and another 24 birds injected SC by sterile normal saline (0.5 mL) as a control group.
Techniques: Selection, Infection