Article Title: (2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice
Figure Lengend Snippet: Effects of ( R )-ketamine (( R )-Ket), ( R )-norketamine (( R )-NK), and (2 R ,6 R )-hydroxynorketamine ((2 R ,6 R )-HNK) in the lipopolysaccharide (LPS)-induced inflammation model and the pharmacokinetic profiles of these compounds. a Experimental schedules for the evaluation of the pharmacological effects of ( R )-Ket, ( R )-NK, and (2 R ,6 R )-HNK. The compounds were administered intraperitoneally (i.p.). b Effects of ( R )-Ket, ( R )-NK, and (2 R ,6 R )-HNK on the LPS-induced increase in the immobility time during the forced swimming test (FST; one-way analysis of variance, F 4,35 = 5.553, P = 0.001). c Effects of ( R )-Ket, ( R )-NK, and (2 R ,6 R )-HNK in the locomotion test (LMT; F 4,35 = 0.356, P = 0.838). b , c Data are represented as the mean ± SEM ( n = 8/group). ** P
Article Snippet: The effects of ( R )-ketamine, ( R )-norketamine, and (2 R ,6 R )-HNK at 3 h after administration were investigated in the LPS-induced inflammation model.