Journal: Clinical and Developmental Immunology
Article Title: LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice
Figure Lengend Snippet: LMW heparin treatment does not affect chemokine mRNA expression within the kidneys of B/W mice. The mRNA expression of CCL2 (a), CCL7 (b), CCL20 (c), CXCL1 (d), and CXCL2 (e) was significantly increased in Group 3 mice and were not significantly reduced in heparin-treated mice. The mRNA expression of CCL2 (f), CCL7 (g), and CXCL1 (h) was also analyzed in age-matched BALB/c mice. Data is given as Log 2 of mean ± SEM of fold change values normalized against 4-week-old mice ( n = 3). P values are calculated using one-way ANOVA followed by Bonferroni posttest. * P
Article Snippet: The Effect of LMW Heparin on In Vivo mRNA Expression Levels of Cytokines, Chemokines, Chemokine Receptor, and TLRs To measure the effect of LMW heparin treatment on cytokine and chemokine expression individual TaqMan real time PCR assays (qPCR) on a selection of cytokine and chemokine genes were performed.
Techniques: Expressing, Mouse Assay