ldl-cholesterol ldl-c Search Results


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  • 93
    Thermo Fisher ldl cholesterol ldl c
    Ldl Cholesterol Ldl C, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore low density lipoprotein cholesterol ldl c
    Low Density Lipoprotein Cholesterol Ldl C, supplied by Millipore, used in various techniques. Bioz Stars score: 96/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abcam ldl cholesterol ldl c
    Serum lipid profiles of mice treated with atorvastatin for 4 weeks. Serum concentrations of (A) <t>LDL,</t> (B) <t>HDL,</t> (C) TC, (D) TG and (E) pre-β HDL. Data are presented as the mean ± standard deviation. n=4. *P
    Ldl Cholesterol Ldl C, supplied by Abcam, used in various techniques. Bioz Stars score: 99/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    FUJIFILM low density lipoprotein cholesterol ldl c
    Cyp27a1 expression and the antiatherosclerotic effect of RIF in mice The effect of Cyp3a11 induction by RIF on atherosclerosis development was analyzed in ApoE KO mice with normal Cyp27a1 expression and 27-OHC plasma concentration, and in het mice with reduced Cyp27a1 expression and 27-OHC plasma concentration. RIF induced hepatic Cyp3a11 mRNA 3-fold and had no effect on intestinal Cyp3a11 expression in both genotypes. In ApoE KO mice, RIF increased hepatic Cyp27a1 mRNA, leading to an increase in CYP27A1 activity measured by the 27-OHC/Cholesterol ratio in plasma. RIF also decreased TC and <t>LDL-C</t> and increased <t>HDL-C.</t> In het mice, RIF reduced Cyp27a1 mRNA levels in the intestine and had no effect on plasma lipids, despite reduced cholesterol absorption. The different effect of RIF on atherosclerosis development in ApoE KO and het mice underline the importance of Cyp27a1 expression in the protection of atherosclerosis.
    Low Density Lipoprotein Cholesterol Ldl C, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 92/100, based on 57 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abbott Laboratories low density lipoprotein cholesterol ldl c
    Cyp27a1 expression and the antiatherosclerotic effect of RIF in mice The effect of Cyp3a11 induction by RIF on atherosclerosis development was analyzed in ApoE KO mice with normal Cyp27a1 expression and 27-OHC plasma concentration, and in het mice with reduced Cyp27a1 expression and 27-OHC plasma concentration. RIF induced hepatic Cyp3a11 mRNA 3-fold and had no effect on intestinal Cyp3a11 expression in both genotypes. In ApoE KO mice, RIF increased hepatic Cyp27a1 mRNA, leading to an increase in CYP27A1 activity measured by the 27-OHC/Cholesterol ratio in plasma. RIF also decreased TC and <t>LDL-C</t> and increased <t>HDL-C.</t> In het mice, RIF reduced Cyp27a1 mRNA levels in the intestine and had no effect on plasma lipids, despite reduced cholesterol absorption. The different effect of RIF on atherosclerosis development in ApoE KO and het mice underline the importance of Cyp27a1 expression in the protection of atherosclerosis.
    Low Density Lipoprotein Cholesterol Ldl C, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 93/100, based on 84 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    KALEN BIOMEDICAL human ldl cholesterol ldl c
    Regulation of miR-27a in HepG2 cells The level of miR-27a was assessed by TaqMan qPCR in HepG2 cells treated for 24 h with (A) Bay-11 (an inhibitor of NF-KB), <t>LDL-C,</t> simvastatin (commonly used statin that inhibits cholesterol synthesis), insulin and glucose; (B) 200 μM fatty acids (Sigma) conjugated with 0.2% BSA (30 mM) in 1% ethanol; different concentrations of simvastatin (C) or human LDL-C (D) . Data are mean of three independent experiments ± S.D. The significance is indicated only for samples that are significantly different from all the others. * P
    Human Ldl Cholesterol Ldl C, supplied by KALEN BIOMEDICAL, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    IDEXX non fasting direct serum ldl cholesterol ldl c
    Regulation of miR-27a in HepG2 cells The level of miR-27a was assessed by TaqMan qPCR in HepG2 cells treated for 24 h with (A) Bay-11 (an inhibitor of NF-KB), <t>LDL-C,</t> simvastatin (commonly used statin that inhibits cholesterol synthesis), insulin and glucose; (B) 200 μM fatty acids (Sigma) conjugated with 0.2% BSA (30 mM) in 1% ethanol; different concentrations of simvastatin (C) or human LDL-C (D) . Data are mean of three independent experiments ± S.D. The significance is indicated only for samples that are significantly different from all the others. * P
    Non Fasting Direct Serum Ldl Cholesterol Ldl C, supplied by IDEXX, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Roche low density lipoprotein cholesterol ldl c
    Blood biochemical results for young and old mice. (a) Crea: creatinine. (b) <t>BUN:</t> blood urea nitrogen. (c) CHOL: total cholesterol. (d) TG: triglycerides. (e) <t>LDL-C:</t> low-density lipoprotein. (f) HDL-C: high-density lipoprotein. Values are mean ± SE. P
    Low Density Lipoprotein Cholesterol Ldl C, supplied by Roche, used in various techniques. Bioz Stars score: 93/100, based on 575 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BioSino low density lipoprotein cholesterol ldl c
    Blocking TLR2 activity does not affect plasma lipid levels. The total cholesterol (A), triglyceride (B), <t>LDL-C</t> (C), and <t>HDL-C</t> (D) levels were determined in 58-week-old ApoE −/− mice treated with saline, IgG or a TLR2ab iv for 18 weeks and in TLR2-deficient ApoE −/− mice (DK) fed a chow diet. The data are shown as the mean±SEM ( n =12 mice/group).
    Low Density Lipoprotein Cholesterol Ldl C, supplied by BioSino, used in various techniques. Bioz Stars score: 92/100, based on 140 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Shanghai Fosun Long March Medical Science low density lipoprotein cholesterol ldl c kits
    The effect of serum TC, TG, <t>HDL-C</t> and <t>LDL-C</t> concentrations after SCU treatment.Under high-fat diet and chronic stress, rats were treated with different concentrations of SCU (50, 100, 300 mg/kg) for 4 weeks, and serum biochemistry was determined by clinical chemistry analyzer. All data were represented as means±standard deviation (n=8).Statistical analysis of TC, TG, HDL-C and LDL-C (* P
    Low Density Lipoprotein Cholesterol Ldl C Kits, supplied by Shanghai Fosun Long March Medical Science, used in various techniques. Bioz Stars score: 91/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Hitachi Ltd low density cholesterol ldl c
    The effect of serum TC, TG, <t>HDL-C</t> and <t>LDL-C</t> concentrations after SCU treatment.Under high-fat diet and chronic stress, rats were treated with different concentrations of SCU (50, 100, 300 mg/kg) for 4 weeks, and serum biochemistry was determined by clinical chemistry analyzer. All data were represented as means±standard deviation (n=8).Statistical analysis of TC, TG, HDL-C and LDL-C (* P
    Low Density Cholesterol Ldl C, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 88/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Roche low density cholesterol ldl c
    The effect of serum TC, TG, <t>HDL-C</t> and <t>LDL-C</t> concentrations after SCU treatment.Under high-fat diet and chronic stress, rats were treated with different concentrations of SCU (50, 100, 300 mg/kg) for 4 weeks, and serum biochemistry was determined by clinical chemistry analyzer. All data were represented as means±standard deviation (n=8).Statistical analysis of TC, TG, HDL-C and LDL-C (* P
    Low Density Cholesterol Ldl C, supplied by Roche, used in various techniques. Bioz Stars score: 91/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BioSino low density lipoprotein cholesterol ldl c kits
    The effect of GLC, COS1 and COS2 on serum <t>CHO,</t> TG, HDL-C and <t>LDL-C</t> in rats ( n = 10, means ± SD). ( A ) GLC, COS1 and COS2 could reduce the CHO in the serum, which were better than Orlistat; ( B ) Compared with the HF group, the TG in the serum was decreased in GLC, COS1 and COS2; ( C ) COS2-H and COS2-M significantly increased the HDL-C in the serum, and it appeared dose dependent in the COS1 group; ( D ) GLC, COS1 and COS2 reduced the LDL-C in the serum more effectively than Orlistat. Note: Compared with HF, * P
    Low Density Lipoprotein Cholesterol Ldl C Kits, supplied by BioSino, used in various techniques. Bioz Stars score: 89/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Thermo Fisher low density lipoprotein cholesterol ldl c
    BBR ameliorates hepatic steatosis in HFD-fed rats. (A) The livers isolated from rats fed with a normal diet (ND), high-fat diet (HFD) or HFD plus Berberine (HFD + BBR)were stained with hematoxylin and eosin. Photographs are at 200 × magnification. A large magnification is shown in the white box. Ballooning cells and Mallory bodiesare shown in black and red arrows, respectively. (B) Hepatic TG contents, and (C) serum TC and <t>LDL-c</t> levels were measured in the experimental animals as described in “ Methods ”. Data are mean ± SEM. * p
    Low Density Lipoprotein Cholesterol Ldl C, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 44 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BioSino low density cholesterol ldl c
    BBR ameliorates hepatic steatosis in HFD-fed rats. (A) The livers isolated from rats fed with a normal diet (ND), high-fat diet (HFD) or HFD plus Berberine (HFD + BBR)were stained with hematoxylin and eosin. Photographs are at 200 × magnification. A large magnification is shown in the white box. Ballooning cells and Mallory bodiesare shown in black and red arrows, respectively. (B) Hepatic TG contents, and (C) serum TC and <t>LDL-c</t> levels were measured in the experimental animals as described in “ Methods ”. Data are mean ± SEM. * p
    Low Density Cholesterol Ldl C, supplied by BioSino, used in various techniques. Bioz Stars score: 91/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Hitachi Ltd low density lipoprotein cholesterol ldl c
    Serum lipid levels were significantly improved by SD-FRE treatment. (A–E) Effects of SD-FRE on TC, TG, <t>HDL-C,</t> <t>LDL-C,</t> and FFA levels in the serum. Data are mean ± SEM ( n = 8). +++ p
    Low Density Lipoprotein Cholesterol Ldl C, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 93/100, based on 1086 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens AG low density lipoprotein cholesterol ldl c
    Serum lipid levels were significantly improved by SD-FRE treatment. (A–E) Effects of SD-FRE on TC, TG, <t>HDL-C,</t> <t>LDL-C,</t> and FFA levels in the serum. Data are mean ± SEM ( n = 8). +++ p
    Low Density Lipoprotein Cholesterol Ldl C, supplied by Siemens AG, used in various techniques. Bioz Stars score: 92/100, based on 48 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    FUJIFILM ldl cholesterol
    Lipoprotein cholesterol levels are affected by loss of CAV1 in the intestinal epithelia. (A,B) Male CAV1 IEC-KO (IKO) mice are protected from HFD-induced increase in fasted plasma <t>LDL</t> cholesterol ( n =6-10, mean±s.e.m, two-way ANOVA, significant interaction between diet and genotype) (A), but female mice are not ( n =8-9) (B). Female CAV1 IEC-KO , but not WT, mice have higher fasted plasma <t>HDL</t> cholesterol on HFD than LFD. Mean±s.e.m, two-way ANOVA, groups with different letters are significantly different by post hoc testing. (C) CAV1 IEC-KO mice on CD have higher postprandial plasma LDL cholesterol than WT mice. Mean±s.e.m, Student's t -test, * P
    Ldl Cholesterol, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 92/100, based on 150 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Serum lipid profiles of mice treated with atorvastatin for 4 weeks. Serum concentrations of (A) LDL, (B) HDL, (C) TC, (D) TG and (E) pre-β HDL. Data are presented as the mean ± standard deviation. n=4. *P

    Journal: Experimental and Therapeutic Medicine

    Article Title: Atorvastatin upregulates apolipoprotein M expression via attenuating LXRα expression in hyperlipidemic apoE-deficient mice

    doi: 10.3892/etm.2018.6694

    Figure Lengend Snippet: Serum lipid profiles of mice treated with atorvastatin for 4 weeks. Serum concentrations of (A) LDL, (B) HDL, (C) TC, (D) TG and (E) pre-β HDL. Data are presented as the mean ± standard deviation. n=4. *P

    Article Snippet: Serum was separated by centrifugation at 600 × g under 4°C for 20 min, following which HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), total cholesterol (TC; all cat. no. ab65390), and triglyceride (TG; cat. no. ab65336) levels were measured ( ) with assay kits (Abcam).

    Techniques: Mouse Assay, Standard Deviation

    Cyp27a1 expression and the antiatherosclerotic effect of RIF in mice The effect of Cyp3a11 induction by RIF on atherosclerosis development was analyzed in ApoE KO mice with normal Cyp27a1 expression and 27-OHC plasma concentration, and in het mice with reduced Cyp27a1 expression and 27-OHC plasma concentration. RIF induced hepatic Cyp3a11 mRNA 3-fold and had no effect on intestinal Cyp3a11 expression in both genotypes. In ApoE KO mice, RIF increased hepatic Cyp27a1 mRNA, leading to an increase in CYP27A1 activity measured by the 27-OHC/Cholesterol ratio in plasma. RIF also decreased TC and LDL-C and increased HDL-C. In het mice, RIF reduced Cyp27a1 mRNA levels in the intestine and had no effect on plasma lipids, despite reduced cholesterol absorption. The different effect of RIF on atherosclerosis development in ApoE KO and het mice underline the importance of Cyp27a1 expression in the protection of atherosclerosis.

    Journal: Bioscience Reports

    Article Title: Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice

    doi: 10.1042/BSR20171162

    Figure Lengend Snippet: Cyp27a1 expression and the antiatherosclerotic effect of RIF in mice The effect of Cyp3a11 induction by RIF on atherosclerosis development was analyzed in ApoE KO mice with normal Cyp27a1 expression and 27-OHC plasma concentration, and in het mice with reduced Cyp27a1 expression and 27-OHC plasma concentration. RIF induced hepatic Cyp3a11 mRNA 3-fold and had no effect on intestinal Cyp3a11 expression in both genotypes. In ApoE KO mice, RIF increased hepatic Cyp27a1 mRNA, leading to an increase in CYP27A1 activity measured by the 27-OHC/Cholesterol ratio in plasma. RIF also decreased TC and LDL-C and increased HDL-C. In het mice, RIF reduced Cyp27a1 mRNA levels in the intestine and had no effect on plasma lipids, despite reduced cholesterol absorption. The different effect of RIF on atherosclerosis development in ApoE KO and het mice underline the importance of Cyp27a1 expression in the protection of atherosclerosis.

    Article Snippet: Triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) were quantified in plasma with a kit from Wako Chemicals GmbH (Neuss, Germany).

    Techniques: Expressing, Mouse Assay, Concentration Assay, Activity Assay

    Serum lipids: TG (a), TC (b), HDL-C (c), and LDL-C (d). NC and HF, abbreviations for “normal diet” and “high-fat diet,” represent the control and HFD-fed groups, respectively. Data are presented as the mean ± SE, n = 15 mice/group, * P

    Journal: International Journal of Endocrinology

    Article Title: Effect of High-Fat Diet on Peripheral Neuropathy in C57BL/6 Mice

    doi: 10.1155/2014/305205

    Figure Lengend Snippet: Serum lipids: TG (a), TC (b), HDL-C (c), and LDL-C (d). NC and HF, abbreviations for “normal diet” and “high-fat diet,” represent the control and HFD-fed groups, respectively. Data are presented as the mean ± SE, n = 15 mice/group, * P

    Article Snippet: Plasma Assays Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured using Wako kits (Wako Pure Chemical, Osaka, Japan) and a Beckman CX7 analyzer (Beckman Coulter, Brea, CA, USA).

    Techniques: Mouse Assay

    Regulation of miR-27a in HepG2 cells The level of miR-27a was assessed by TaqMan qPCR in HepG2 cells treated for 24 h with (A) Bay-11 (an inhibitor of NF-KB), LDL-C, simvastatin (commonly used statin that inhibits cholesterol synthesis), insulin and glucose; (B) 200 μM fatty acids (Sigma) conjugated with 0.2% BSA (30 mM) in 1% ethanol; different concentrations of simvastatin (C) or human LDL-C (D) . Data are mean of three independent experiments ± S.D. The significance is indicated only for samples that are significantly different from all the others. * P

    Journal: Atherosclerosis

    Article Title: MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis

    doi: 10.1016/j.atherosclerosis.2015.08.023

    Figure Lengend Snippet: Regulation of miR-27a in HepG2 cells The level of miR-27a was assessed by TaqMan qPCR in HepG2 cells treated for 24 h with (A) Bay-11 (an inhibitor of NF-KB), LDL-C, simvastatin (commonly used statin that inhibits cholesterol synthesis), insulin and glucose; (B) 200 μM fatty acids (Sigma) conjugated with 0.2% BSA (30 mM) in 1% ethanol; different concentrations of simvastatin (C) or human LDL-C (D) . Data are mean of three independent experiments ± S.D. The significance is indicated only for samples that are significantly different from all the others. * P

    Article Snippet: About 2 × 105 HepG2 cells were seeded per 6-cm plate and serum-starved for 24 h before the following treatments: 50, 100 or 200 μg/ml human LDL-cholesterol (LDL-C) (Kalen Biomedical; Montgomery Vlg, MD); 10, 30 or 90 μM simvastatin (Sigma; St Louis, MO); 100 nM insulin (Sigma); 30 nM glucose (Sigma); 5 μM Bay-11 (Cayman; Ann Arbor, MI); 200 μM fatty acids conjugated with 0.2% BSA (30 mM) in 1% ethanol.

    Techniques: Real-time Polymerase Chain Reaction

    Blood biochemical results for young and old mice. (a) Crea: creatinine. (b) BUN: blood urea nitrogen. (c) CHOL: total cholesterol. (d) TG: triglycerides. (e) LDL-C: low-density lipoprotein. (f) HDL-C: high-density lipoprotein. Values are mean ± SE. P

    Journal: Oxidative Medicine and Cellular Longevity

    Article Title: Protective Effects of Hydrogen Sulfide in the Ageing Kidney

    doi: 10.1155/2016/7570489

    Figure Lengend Snippet: Blood biochemical results for young and old mice. (a) Crea: creatinine. (b) BUN: blood urea nitrogen. (c) CHOL: total cholesterol. (d) TG: triglycerides. (e) LDL-C: low-density lipoprotein. (f) HDL-C: high-density lipoprotein. Values are mean ± SE. P

    Article Snippet: Plasma levels of creatinine (Crea), blood urea nitrogen (BUN), total cholesterol (CHOL), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were determined by automatic biochemical analyser (Cobas 6000, Roche, Basel, Switzerland).

    Techniques: Mouse Assay

    Adjusted relationship between plasma levels of OxPL/apoB (nM) and relative risk of PAD Data derive from a cubic spline conditional logistic regression model with age, race (women only), smoking status, fasting status and date of blood sampling as matching variables. The model is adjusted for triglycerides, HDL-C, LDL-C, hsCRP, HbA 1c , history of diabetes, history of hypertension, pack-years of smoking, parental history of MI before age 60, aspirin use, BMI, physical activity, postmenopausal hormone use (women only), and gender (pooled only). The 95% CI is indicated by the dashed lines.

    Journal: Journal of the American College of Cardiology

    Article Title: Oxidation-specific biomarkers and risk of peripheral artery disease

    doi: 10.1016/j.jacc.2013.02.047

    Figure Lengend Snippet: Adjusted relationship between plasma levels of OxPL/apoB (nM) and relative risk of PAD Data derive from a cubic spline conditional logistic regression model with age, race (women only), smoking status, fasting status and date of blood sampling as matching variables. The model is adjusted for triglycerides, HDL-C, LDL-C, hsCRP, HbA 1c , history of diabetes, history of hypertension, pack-years of smoking, parental history of MI before age 60, aspirin use, BMI, physical activity, postmenopausal hormone use (women only), and gender (pooled only). The 95% CI is indicated by the dashed lines.

    Article Snippet: The lab measured high-density lipoprotein cholesterol (HDL-C) and triglycerides enzymatically and low-density lipoprotein cholesterol (LDL-C) by a homogenous direct method from Roche Diagnostics (Indianapolis, IN).

    Techniques: Sampling, Activity Assay

    Blocking TLR2 activity does not affect plasma lipid levels. The total cholesterol (A), triglyceride (B), LDL-C (C), and HDL-C (D) levels were determined in 58-week-old ApoE −/− mice treated with saline, IgG or a TLR2ab iv for 18 weeks and in TLR2-deficient ApoE −/− mice (DK) fed a chow diet. The data are shown as the mean±SEM ( n =12 mice/group).

    Journal: Acta Pharmacologica Sinica

    Article Title: Blocking TLR2 activity diminishes and stabilizes advanced atherosclerotic lesions in apolipoprotein E-deficient mice

    doi: 10.1038/aps.2013.75

    Figure Lengend Snippet: Blocking TLR2 activity does not affect plasma lipid levels. The total cholesterol (A), triglyceride (B), LDL-C (C), and HDL-C (D) levels were determined in 58-week-old ApoE −/− mice treated with saline, IgG or a TLR2ab iv for 18 weeks and in TLR2-deficient ApoE −/− mice (DK) fed a chow diet. The data are shown as the mean±SEM ( n =12 mice/group).

    Article Snippet: Biochemical analysis The levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides in the plasma were determined using commercial kits (Biosino, Beijing, China) according to the manufacturers' instructions.

    Techniques: Blocking Assay, Activity Assay, Mouse Assay

    Gas improves dyslipidemia in DM rats. (A) Levels of TC in serum samples of rats after 5 weeks of treatment. (B) Levels of TG in serum samples of rats after 5 weeks of treatment. (C) Levels of LDL-C in serum samples of rats after 5 weeks of treatment. (D) Levels of HDL-C in serum samples of rats after 5 weeks of treatment. Values are represented as means ± SD for 10 rats in each group. # P

    Journal: Frontiers in Pharmacology

    Article Title: Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation

    doi: 10.3389/fphar.2018.01346

    Figure Lengend Snippet: Gas improves dyslipidemia in DM rats. (A) Levels of TC in serum samples of rats after 5 weeks of treatment. (B) Levels of TG in serum samples of rats after 5 weeks of treatment. (C) Levels of LDL-C in serum samples of rats after 5 weeks of treatment. (D) Levels of HDL-C in serum samples of rats after 5 weeks of treatment. Values are represented as means ± SD for 10 rats in each group. # P

    Article Snippet: The kits for detecting triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were purchased from Biosino Biotechnology & Science Inc. (Beijing, China).

    Techniques:

    The effect of serum TC, TG, HDL-C and LDL-C concentrations after SCU treatment.Under high-fat diet and chronic stress, rats were treated with different concentrations of SCU (50, 100, 300 mg/kg) for 4 weeks, and serum biochemistry was determined by clinical chemistry analyzer. All data were represented as means±standard deviation (n=8).Statistical analysis of TC, TG, HDL-C and LDL-C (* P

    Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

    Article Title: Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats

    doi: 10.12659/MSM.907530

    Figure Lengend Snippet: The effect of serum TC, TG, HDL-C and LDL-C concentrations after SCU treatment.Under high-fat diet and chronic stress, rats were treated with different concentrations of SCU (50, 100, 300 mg/kg) for 4 weeks, and serum biochemistry was determined by clinical chemistry analyzer. All data were represented as means±standard deviation (n=8).Statistical analysis of TC, TG, HDL-C and LDL-C (* P

    Article Snippet: Atorvastatin calcium tablets (Lipitor) were procured from Pfizer Inc. Total Cholesterol (TC) kits, Triglyceride (TG) kits, high-density lipoprotein cholesterol (HDL-C) kits, and low-density lipoprotein cholesterol (LDL-C) kits were purchased from Shanghai Fosun Long March Medical Science Co., Ltd, and lipid control was purchased from Randox laboratories Ltd. Glutathione kits (GSH), total superoxide dismutase kits (T-SOD), malonaldehyde kits (MDA), and total protein quantitative kits were acquired from Jian Cheng Bioengineering Institute (Nanjing, China).

    Techniques: Standard Deviation

    The effect of GLC, COS1 and COS2 on serum CHO, TG, HDL-C and LDL-C in rats ( n = 10, means ± SD). ( A ) GLC, COS1 and COS2 could reduce the CHO in the serum, which were better than Orlistat; ( B ) Compared with the HF group, the TG in the serum was decreased in GLC, COS1 and COS2; ( C ) COS2-H and COS2-M significantly increased the HDL-C in the serum, and it appeared dose dependent in the COS1 group; ( D ) GLC, COS1 and COS2 reduced the LDL-C in the serum more effectively than Orlistat. Note: Compared with HF, * P

    Journal: Marine Drugs

    Article Title: Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats

    doi: 10.3390/md13052732

    Figure Lengend Snippet: The effect of GLC, COS1 and COS2 on serum CHO, TG, HDL-C and LDL-C in rats ( n = 10, means ± SD). ( A ) GLC, COS1 and COS2 could reduce the CHO in the serum, which were better than Orlistat; ( B ) Compared with the HF group, the TG in the serum was decreased in GLC, COS1 and COS2; ( C ) COS2-H and COS2-M significantly increased the HDL-C in the serum, and it appeared dose dependent in the COS1 group; ( D ) GLC, COS1 and COS2 reduced the LDL-C in the serum more effectively than Orlistat. Note: Compared with HF, * P

    Article Snippet: Total cholesterol (CHO), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) kits were obtained from BioSino Biotechnology and Science Inc., Beijing, China.

    Techniques: Gas Chromatography

    BBR ameliorates hepatic steatosis in HFD-fed rats. (A) The livers isolated from rats fed with a normal diet (ND), high-fat diet (HFD) or HFD plus Berberine (HFD + BBR)were stained with hematoxylin and eosin. Photographs are at 200 × magnification. A large magnification is shown in the white box. Ballooning cells and Mallory bodiesare shown in black and red arrows, respectively. (B) Hepatic TG contents, and (C) serum TC and LDL-c levels were measured in the experimental animals as described in “ Methods ”. Data are mean ± SEM. * p

    Journal: Journal of Translational Medicine

    Article Title: Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

    doi: 10.1186/s12967-015-0383-6

    Figure Lengend Snippet: BBR ameliorates hepatic steatosis in HFD-fed rats. (A) The livers isolated from rats fed with a normal diet (ND), high-fat diet (HFD) or HFD plus Berberine (HFD + BBR)were stained with hematoxylin and eosin. Photographs are at 200 × magnification. A large magnification is shown in the white box. Ballooning cells and Mallory bodiesare shown in black and red arrows, respectively. (B) Hepatic TG contents, and (C) serum TC and LDL-c levels were measured in the experimental animals as described in “ Methods ”. Data are mean ± SEM. * p

    Article Snippet: Fasting serum levels of total cholesterol and low-density lipoprotein cholesterol (LDL-c) were measured using an Amplex Red Cholesterol Assay Kit (A12216, Molecular Probes Invitrogen Detection Technologies) according to the manufacturer’s protocol.

    Techniques: Isolation, Staining

    Serum lipid levels were significantly improved by SD-FRE treatment. (A–E) Effects of SD-FRE on TC, TG, HDL-C, LDL-C, and FFA levels in the serum. Data are mean ± SEM ( n = 8). +++ p

    Journal: Frontiers in Pharmacology

    Article Title: Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase

    doi: 10.3389/fphar.2018.00760

    Figure Lengend Snippet: Serum lipid levels were significantly improved by SD-FRE treatment. (A–E) Effects of SD-FRE on TC, TG, HDL-C, LDL-C, and FFA levels in the serum. Data are mean ± SEM ( n = 8). +++ p

    Article Snippet: The serum biochemical indexes including TC, TG, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and FFA were evaluated by an automatic biochemical analyzer (Hitachi 7180+ISE, Tokyo, Japan).

    Techniques:

    Lipoprotein cholesterol levels are affected by loss of CAV1 in the intestinal epithelia. (A,B) Male CAV1 IEC-KO (IKO) mice are protected from HFD-induced increase in fasted plasma LDL cholesterol ( n =6-10, mean±s.e.m, two-way ANOVA, significant interaction between diet and genotype) (A), but female mice are not ( n =8-9) (B). Female CAV1 IEC-KO , but not WT, mice have higher fasted plasma HDL cholesterol on HFD than LFD. Mean±s.e.m, two-way ANOVA, groups with different letters are significantly different by post hoc testing. (C) CAV1 IEC-KO mice on CD have higher postprandial plasma LDL cholesterol than WT mice. Mean±s.e.m, Student's t -test, * P

    Journal: Disease Models & Mechanisms

    Article Title: Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels

    doi: 10.1242/dmm.027300

    Figure Lengend Snippet: Lipoprotein cholesterol levels are affected by loss of CAV1 in the intestinal epithelia. (A,B) Male CAV1 IEC-KO (IKO) mice are protected from HFD-induced increase in fasted plasma LDL cholesterol ( n =6-10, mean±s.e.m, two-way ANOVA, significant interaction between diet and genotype) (A), but female mice are not ( n =8-9) (B). Female CAV1 IEC-KO , but not WT, mice have higher fasted plasma HDL cholesterol on HFD than LFD. Mean±s.e.m, two-way ANOVA, groups with different letters are significantly different by post hoc testing. (C) CAV1 IEC-KO mice on CD have higher postprandial plasma LDL cholesterol than WT mice. Mean±s.e.m, Student's t -test, * P

    Article Snippet: Kits were used to measure total cholesterol (Infinity Total Cholesterol, Fisher Scientific), free cholesterol (Free Cholesterol E, Wako Diagnostics, Richmond, VA), HDL cholesterol (HDL-C E, Wako Diagnostics), LDL cholesterol (LDL-C Reagent L-type, Wako Diagnostics), NEFAs [HR Series NEFA-HR(2), Wako Diagnostics], and TGs (Infinity Triglycerides, Fisher Scientific) according to the manufacturer's directions.

    Techniques: Mouse Assay