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    Millipore jak inhibitor i
    <t>JAK</t> <t>inhibitor</t> I effectively prevents IFN-γ-stimulated STAT1 activation in neurons
    Jak Inhibitor I, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak inhibitor i/product/Millipore
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    jak inhibitor i - by Bioz Stars, 2021-04
    94/100 stars
      Buy from Supplier

    97
    Millipore jak inhibitor
    Janus kinase <t>(JAK)/STAT</t> inhibitors blocked Interleukin (IL)-7-mediated osteoclast formation from peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs). PBMCs from healthy individuals (A,C) and SFMCs from rheumatoid arthritis patients (B,D) were cultured with M-CSF (20 ng/mL), RANKL (50 ng/mL), or IL-7 (2 ng/mL) in the presence or absence of <t>tofacitinib</t> [5 µM, (A,B) ] or signal transducer and activator of transcription 5 (STAT5) inhibitor [CAS 285986-31-4, 50 µM, (C,D) ] for 10 days, replacing the medium at 3-day intervals with fresh cytokines and osteoprotegerin. Tartrate-resistant acid phosphatase (TRAP) staining and enumeration were performed as described in Figure 1 . Representative images and quantification of TRAP + cells are shown. Results are representative of three or six independent experiments. Bars represent the mean and p values were obtained using the unpaired two-tailed Student’s t -test.
    Jak Inhibitor, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak inhibitor/product/Millipore
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    jak inhibitor - by Bioz Stars, 2021-04
    97/100 stars
      Buy from Supplier

    93
    Santa Cruz Biotechnology jak inhibitor i
    Janus kinase <t>(JAK)/STAT</t> inhibitors blocked Interleukin (IL)-7-mediated osteoclast formation from peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs). PBMCs from healthy individuals (A,C) and SFMCs from rheumatoid arthritis patients (B,D) were cultured with M-CSF (20 ng/mL), RANKL (50 ng/mL), or IL-7 (2 ng/mL) in the presence or absence of <t>tofacitinib</t> [5 µM, (A,B) ] or signal transducer and activator of transcription 5 (STAT5) inhibitor [CAS 285986-31-4, 50 µM, (C,D) ] for 10 days, replacing the medium at 3-day intervals with fresh cytokines and osteoprotegerin. Tartrate-resistant acid phosphatase (TRAP) staining and enumeration were performed as described in Figure 1 . Representative images and quantification of TRAP + cells are shown. Results are representative of three or six independent experiments. Bars represent the mean and p values were obtained using the unpaired two-tailed Student’s t -test.
    Jak Inhibitor I, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak inhibitor i/product/Santa Cruz Biotechnology
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    jak inhibitor i - by Bioz Stars, 2021-04
    93/100 stars
      Buy from Supplier

    N/A
    Janus associated kinases JAKs are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors JAK1 mostly activates IL 6 whereas JAK1 and
      Buy from Supplier

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    JAK inhibitor I effectively prevents IFN-γ-stimulated STAT1 activation in neurons

    Journal: Journal of neuroimmunology

    Article Title: Extended JAK Activation and Delayed STAT1 Dephosphorylation Contribute to the Distinct Signaling Profile of CNS Neurons Exposed to Interferon-Gamma

    doi: 10.1016/j.jneuroim.2012.06.006

    Figure Lengend Snippet: JAK inhibitor I effectively prevents IFN-γ-stimulated STAT1 activation in neurons

    Article Snippet: To confirm the activity of JAK inhibitor I, neurons and MEF were plated as described above and were treated with IFN-γ (100U/ml) in the presence of JAK inhibitor I (Calbiochem; 10μM), or vehicle only (DMSO).

    Techniques: Activation Assay

    Janus kinase (JAK)/STAT inhibitors blocked Interleukin (IL)-7-mediated osteoclast formation from peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs). PBMCs from healthy individuals (A,C) and SFMCs from rheumatoid arthritis patients (B,D) were cultured with M-CSF (20 ng/mL), RANKL (50 ng/mL), or IL-7 (2 ng/mL) in the presence or absence of tofacitinib [5 µM, (A,B) ] or signal transducer and activator of transcription 5 (STAT5) inhibitor [CAS 285986-31-4, 50 µM, (C,D) ] for 10 days, replacing the medium at 3-day intervals with fresh cytokines and osteoprotegerin. Tartrate-resistant acid phosphatase (TRAP) staining and enumeration were performed as described in Figure 1 . Representative images and quantification of TRAP + cells are shown. Results are representative of three or six independent experiments. Bars represent the mean and p values were obtained using the unpaired two-tailed Student’s t -test.

    Journal: Frontiers in Immunology

    Article Title: Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand

    doi: 10.3389/fimmu.2017.01376

    Figure Lengend Snippet: Janus kinase (JAK)/STAT inhibitors blocked Interleukin (IL)-7-mediated osteoclast formation from peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs). PBMCs from healthy individuals (A,C) and SFMCs from rheumatoid arthritis patients (B,D) were cultured with M-CSF (20 ng/mL), RANKL (50 ng/mL), or IL-7 (2 ng/mL) in the presence or absence of tofacitinib [5 µM, (A,B) ] or signal transducer and activator of transcription 5 (STAT5) inhibitor [CAS 285986-31-4, 50 µM, (C,D) ] for 10 days, replacing the medium at 3-day intervals with fresh cytokines and osteoprotegerin. Tartrate-resistant acid phosphatase (TRAP) staining and enumeration were performed as described in Figure 1 . Representative images and quantification of TRAP + cells are shown. Results are representative of three or six independent experiments. Bars represent the mean and p values were obtained using the unpaired two-tailed Student’s t -test.

    Article Snippet: The JAK inhibitor, tofacitinib, and a STAT5 inhibitor (CAS 285986-31-4; Sigma-Aldrich, St. Louis, MO, USA) were used to evaluate JAK/STAT signaling.

    Techniques: Cell Culture, Staining, Two Tailed Test