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Image Search Results
Journal: Cell
Article Title: p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
doi: 10.1016/j.cell.2018.11.011
Figure Lengend Snippet: (A) HCT116 cells were cultured for 24 hr in medium plus fetal bovine serum (FBS; gray bars), delipidated FBS (DL-FBS; black bars), or delipidated FBS plus 25-hydroxycholesterol (DL-FBS+25-HC; white bars). Expression of HMGCR, HMGCS1, and SREBF-2 was assessed by qRT-PCR (n = 3; *p < 0.01; n.s., not significant). Error bars represent SD of the means.
Article Snippet: Reagents The reagents used and working concentrations were as follows: Nutlin-3 (10 μM, Sigma-Aldrich, catalog #N6287), {"type":"entrez-nucleotide","attrs":{"text":"LG100268","term_id":"1041422930","term_text":"LG100268"}} LG100268 (Sigma-Aldrich, catalog #SML0279), T0901317 (Sigma-Aldrich, catalog #T2320),
Techniques: Cell Culture, Expressing, Quantitative RT-PCR