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notch inhibitor sahm1  (MedChemExpress)
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MedChemExpress notch inhibitor sahm1
Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or <t>SAHM1</t> (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)
Notch Inhibitor Sahm1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)

Journal: BMC cancer

Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.

doi: 10.1186/s12885-022-09645-7

Figure Lengend Snippet: Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)

Article Snippet: Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).

Techniques: Activation Assay, Expressing, Cell Culture, Western Blot, Clone Assay, Luciferase, Plasmid Preparation, Activity Assay

Fig. 5 Blockade of Notch signals improved tumor suppressive effects in an orthotopic bladder cancer model. A, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment (HC + SA). B, the tumor weight (day 12) of mice treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). The H&E staining were presented and the scale bar was 2 mm. C, the overall survival of tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment. D, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS or laminin (1 μg per mouse). E, the tumor weight (day 12) of mice treated with PBS or laminin (1 μg per mouse). F, immunofluorescence of Notch1 in tumor tissues from (E). The scale bar was 25 μm. G, the tumor weight (day 12) of mice (laminin treatment) treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). H, the overall survival of tumor bearing mice (laminin treatment) treated with PBS, HCPT, SAHM1 or combining treatment

Journal: BMC cancer

Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.

doi: 10.1186/s12885-022-09645-7

Figure Lengend Snippet: Fig. 5 Blockade of Notch signals improved tumor suppressive effects in an orthotopic bladder cancer model. A, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment (HC + SA). B, the tumor weight (day 12) of mice treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). The H&E staining were presented and the scale bar was 2 mm. C, the overall survival of tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment. D, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS or laminin (1 μg per mouse). E, the tumor weight (day 12) of mice treated with PBS or laminin (1 μg per mouse). F, immunofluorescence of Notch1 in tumor tissues from (E). The scale bar was 25 μm. G, the tumor weight (day 12) of mice (laminin treatment) treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). H, the overall survival of tumor bearing mice (laminin treatment) treated with PBS, HCPT, SAHM1 or combining treatment

Article Snippet: Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).

Techniques: Staining, Immunofluorescence