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notch inhibitor sahm1  (MedChemExpress)


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    MedChemExpress notch inhibitor sahm1
    Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or <t>SAHM1</t> (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)
    Notch Inhibitor Sahm1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p2203/SAHM1/pm35585515-54-0-7
    Average 90 stars, based on 1 article reviews
    notch inhibitor sahm1 - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development."

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.

    Journal: BMC cancer

    doi: 10.1186/s12885-022-09645-7

    Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)
    Figure Legend Snippet: Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)

    Techniques Used: Activation Assay, Expressing, Cell Culture, Western Blot, Clone Assay, Luciferase, Plasmid Preparation, Activity Assay

    Fig. 5 Blockade of Notch signals improved tumor suppressive effects in an orthotopic bladder cancer model. A, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment (HC + SA). B, the tumor weight (day 12) of mice treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). The H&E staining were presented and the scale bar was 2 mm. C, the overall survival of tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment. D, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS or laminin (1 μg per mouse). E, the tumor weight (day 12) of mice treated with PBS or laminin (1 μg per mouse). F, immunofluorescence of Notch1 in tumor tissues from (E). The scale bar was 25 μm. G, the tumor weight (day 12) of mice (laminin treatment) treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). H, the overall survival of tumor bearing mice (laminin treatment) treated with PBS, HCPT, SAHM1 or combining treatment
    Figure Legend Snippet: Fig. 5 Blockade of Notch signals improved tumor suppressive effects in an orthotopic bladder cancer model. A, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment (HC + SA). B, the tumor weight (day 12) of mice treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). The H&E staining were presented and the scale bar was 2 mm. C, the overall survival of tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment. D, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS or laminin (1 μg per mouse). E, the tumor weight (day 12) of mice treated with PBS or laminin (1 μg per mouse). F, immunofluorescence of Notch1 in tumor tissues from (E). The scale bar was 25 μm. G, the tumor weight (day 12) of mice (laminin treatment) treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). H, the overall survival of tumor bearing mice (laminin treatment) treated with PBS, HCPT, SAHM1 or combining treatment

    Techniques Used: Staining, Immunofluorescence

    Related Articles

    Activation Assay:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Expressing:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Cell Culture:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Western Blot:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Clone Assay:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Luciferase:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Plasmid Preparation:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Activity Assay:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Staining:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig

    Immunofluorescence:

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.
    Article Snippet: HCPT was purchased from Sangon (Shanghai, China).HCPT was purchased from Sangon (Shanghai, China).. Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).. Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).Laminin-1 for cell culture was purchased from Sigma-Aldrich (L4544, MA, USA).

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development
    Article Snippet: was purchased from Sangon (Shanghai, China). .. Notch inhibitor SAHM1 (C 94 H 162 N 36 O 23 S) was purchased from MedChemExpress (MA, USA). .. Laminin-1 for cell culture was purchased from Sig



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    notch inhibitor sahm1  (MedChemExpress)
    90
    MedChemExpress notch inhibitor sahm1
    Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or <t>SAHM1</t> (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)
    Notch Inhibitor Sahm1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p2203/SAHM1/pm35585515-54-0-7
    Average 90 stars, based on 1 article reviews
    notch inhibitor sahm1 - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)

    Journal: BMC cancer

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.

    doi: 10.1186/s12885-022-09645-7

    Figure Lengend Snippet: Fig. 3 Integrin α6β4 promoted Notch signals activation. A, relative expression of AKT1, STAT3, Wnt3A, Notch1, c-Myc and SOX2 in Biu-87 cells cultured on dish and 2D laminin/collagen gels. B, western blotting of cleaved intracellular domain of Notch1 in Biu-87 and MB49 cells cultured on dish or 2D laminin/collagen gels. C, western blotting of cleaved intracellular domain of Notch1 in Biu-87 cells cultured on 2D laminin/collagen gels (treated with scrambled siRNA, ITGA6 siRNA and ITGB4 siRNA). D, the full length human Notch1 promoter was cloned into the luciferase reporter vector. Notch1 transcription activity was examined after dish or 2D collagen/laminin culture (3 days) in Biu-87 and MB49 cells. E, cell proliferation of dish and 2D laminin/collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). F, relative migrating cells of dish and 2D laminin/ collagen cultured Biu-87/MB49 cells treated with PBS or SAHM1 (10 nM). G, survival analysis of bladder cancer patients with high/low Notch1 expression using TCGA database (n = 405)

    Article Snippet: Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).

    Techniques: Activation Assay, Expressing, Cell Culture, Western Blot, Clone Assay, Luciferase, Plasmid Preparation, Activity Assay

    Fig. 5 Blockade of Notch signals improved tumor suppressive effects in an orthotopic bladder cancer model. A, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment (HC + SA). B, the tumor weight (day 12) of mice treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). The H&E staining were presented and the scale bar was 2 mm. C, the overall survival of tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment. D, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS or laminin (1 μg per mouse). E, the tumor weight (day 12) of mice treated with PBS or laminin (1 μg per mouse). F, immunofluorescence of Notch1 in tumor tissues from (E). The scale bar was 25 μm. G, the tumor weight (day 12) of mice (laminin treatment) treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). H, the overall survival of tumor bearing mice (laminin treatment) treated with PBS, HCPT, SAHM1 or combining treatment

    Journal: BMC cancer

    Article Title: Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development.

    doi: 10.1186/s12885-022-09645-7

    Figure Lengend Snippet: Fig. 5 Blockade of Notch signals improved tumor suppressive effects in an orthotopic bladder cancer model. A, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment (HC + SA). B, the tumor weight (day 12) of mice treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). The H&E staining were presented and the scale bar was 2 mm. C, the overall survival of tumor bearing mice treated with PBS, HCPT, SAHM1 or combining treatment. D, the rates of hematuresis (day 10) in tumor bearing mice treated with PBS or laminin (1 μg per mouse). E, the tumor weight (day 12) of mice treated with PBS or laminin (1 μg per mouse). F, immunofluorescence of Notch1 in tumor tissues from (E). The scale bar was 25 μm. G, the tumor weight (day 12) of mice (laminin treatment) treated PBS, HCPT, SAHM1 or combining treatment (HC + SA). H, the overall survival of tumor bearing mice (laminin treatment) treated with PBS, HCPT, SAHM1 or combining treatment

    Article Snippet: Notch inhibitor SAHM1 (C94H162N36O23S) was purchased from MedChemExpress (MA, USA).

    Techniques: Staining, Immunofluorescence