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human aβ  (MedChemExpress)
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MedChemExpress human aβ
Effects of REST on the expression of synaptic genes. ( <t>A</t> ) REST was successfully knocked down <t>in</t> <t>SH-SY5Y</t> cells. n = 3. ( B ) REST knockdown increased GRIA1 and GRIN2A expression, while declined GRIN1 expression in SH-SY5Y cells. n = 3. ( C ) 10 μM Aβ increased the mRNA expression of GRIA1 and GRIN2A, and decreased GRIN1 mRNA expression. n = 3. ( D ) REST over-expression significantly increased the mRNA expression of GRIN1, which was decreased by 10 μM Aβ in SH-SY5Y cells. n = 3. Independent experiments were performed three times. Data are expressed as mean ± SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs the corresponding control group.
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Effects of REST on the expression of synaptic genes. ( A ) REST was successfully knocked down in SH-SY5Y cells. n = 3. ( B ) REST knockdown increased GRIA1 and GRIN2A expression, while declined GRIN1 expression in SH-SY5Y cells. n = 3. ( C ) 10 μM Aβ increased the mRNA expression of GRIA1 and GRIN2A, and decreased GRIN1 mRNA expression. n = 3. ( D ) REST over-expression significantly increased the mRNA expression of GRIN1, which was decreased by 10 μM Aβ in SH-SY5Y cells. n = 3. Independent experiments were performed three times. Data are expressed as mean ± SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs the corresponding control group.

Journal: Aging (Albany NY)

Article Title: Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity

doi: 10.18632/aging.203118

Figure Lengend Snippet: Effects of REST on the expression of synaptic genes. ( A ) REST was successfully knocked down in SH-SY5Y cells. n = 3. ( B ) REST knockdown increased GRIA1 and GRIN2A expression, while declined GRIN1 expression in SH-SY5Y cells. n = 3. ( C ) 10 μM Aβ increased the mRNA expression of GRIA1 and GRIN2A, and decreased GRIN1 mRNA expression. n = 3. ( D ) REST over-expression significantly increased the mRNA expression of GRIN1, which was decreased by 10 μM Aβ in SH-SY5Y cells. n = 3. Independent experiments were performed three times. Data are expressed as mean ± SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs the corresponding control group.

Article Snippet: For the Aβ treatment, cells were incubated with 10 μM human Aβ 1-42 (MCE, China) for 48 h. For transfection, SH-SY5Y cells or primary mouse hippocampal neurons were plated in 6-well plates at the density of 3 × 10 5 cells/well.

Techniques: Expressing, Knockdown, Over Expression, Control

Effects of REST on IEGs. ( A ) REST knockdown declined ARC expression, while increased NPAS4 and BDNF expression in SH-SY5Y cells. n = 3. ( B ) 10 μM Aβ decreased ARC mRNA expression. n = 3. ( C ) Over-expression of REST significantly increased ARC mRNA expression, which was decreased by 10 μM Aβ. n = 3. ( D ) The ARC protein expression showed a similar trend to its mRNA expression. n = 3. Independent experiments were performed three times. Data are expressed as mean ± SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs the corresponding control group.

Journal: Aging (Albany NY)

Article Title: Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity

doi: 10.18632/aging.203118

Figure Lengend Snippet: Effects of REST on IEGs. ( A ) REST knockdown declined ARC expression, while increased NPAS4 and BDNF expression in SH-SY5Y cells. n = 3. ( B ) 10 μM Aβ decreased ARC mRNA expression. n = 3. ( C ) Over-expression of REST significantly increased ARC mRNA expression, which was decreased by 10 μM Aβ. n = 3. ( D ) The ARC protein expression showed a similar trend to its mRNA expression. n = 3. Independent experiments were performed three times. Data are expressed as mean ± SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs the corresponding control group.

Article Snippet: For the Aβ treatment, cells were incubated with 10 μM human Aβ 1-42 (MCE, China) for 48 h. For transfection, SH-SY5Y cells or primary mouse hippocampal neurons were plated in 6-well plates at the density of 3 × 10 5 cells/well.

Techniques: Knockdown, Expressing, Over Expression, Control