hy-p1323a Search Results


lp npy  (MedChemExpress)
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MedChemExpress lp npy
A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection <t>with</t> <t>NPY</t> (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY <t>(LP-NPY)</t> (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
Lp Npy, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection with NPY (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY (LP-NPY) (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

doi: 10.1038/s41467-025-62382-w

Figure Lengend Snippet: A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection with NPY (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY (LP-NPY) (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.

Article Snippet: The drugs included Morphine hydrochloride (China National Accord Medicines Corporation Ltd), Clozapine N-oxide (CNO; 16882, Cayman), NPY (MedChemExpress, HY-P0198A), BIBO3304 (MedChemExpress, HY-107725), Nalfurafine (MedChemExpress, HY-12745A), LP-NPY (MedChemExpress, HY-P1323A) EM-1 (MedChemExpress, HY-P0185), Naloxone (MedChemExpress, HY-17417), Diphtheria toxin (Sigma, D0564), PD176252 (MedChemExpress, HY-103286).

Techniques: Injection, Two Tailed Test