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lp npy  (MedChemExpress)


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    Structured Review

    MedChemExpress lp npy
    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection <t>with</t> <t>NPY</t> (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY <t>(LP-NPY)</t> (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
    Lp Npy, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p1323a/%5BLeu31%2CPro34%5D-Neuropeptide+Y/pmc12317128-335-25-26
    Average 93 stars, based on 2 article reviews
    lp npy - by Bioz Stars, 2026-10
    93/100 stars

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    1) Product Images from "Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord"

    Article Title: Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

    Journal: Nature Communications

    doi: 10.1038/s41467-025-62382-w

    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection with NPY (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY (LP-NPY) (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
    Figure Legend Snippet: A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection with NPY (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY (LP-NPY) (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.

    Techniques Used: Injection, Two Tailed Test

    Related Articles

    Saline:

    Article Title: Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor.
    Article Snippet: The injection cannula was connected to a 10 μl microsyringe (Hamilton, Nevada, USA) via a polyethylene tube driven by a syringe pump (KD Scientific, 788130, USA). .. NPY (2 μg/μl in saline, Tocris Bioscience, 1153, UK), Y1R agonist ([Leu31,Pro34]-NPY, 2 μg/μl in saline, MedChemExpress, HY-P1323A, Monmouth Junction, USA), Y2R agonist (Peptide YY, 2 μg/ μl in saline, MedChemExpress, HY-P1021A, Monmouth Junction, USA) or saline were infused bilaterally into the MHb at a flow rate of 100 nl/min (200 nl/side). ..

    Article Title: Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor
    Article Snippet: The injection cannula was connected to a 10 μl microsyringe (Hamilton, Nevada, USA) via a polyethylene tube driven by a syringe pump (KD Scientific, 788130, USA). .. NPY (2 μg/μl in saline, Tocris Bioscience, 1153, UK), Y1R agonist ([Leu31,Pro34]-NPY, 2 μg/μl in saline, MedChemExpress, HY-P1323A, Monmouth Junction, USA), Y2R agonist (Peptide YY, 2 μg/μl in saline, MedChemExpress, HY-P1021A, Monmouth Junction, USA) or saline were infused bilaterally into the MHb at a flow rate of 100 nl/min (200 nl/side). ..

    other:

    Article Title: Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord.
    Article Snippet: For intrathecal injections, lumbar puncture was made by a Hamilton microsyringe (Hamilton) fitted with a 30-G needle between the L5 and L6 spinal levels to deliver reagents (10μl) into CSF in non-anesthetized mice.



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    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection <t>with</t> <t>NPY</t> (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY <t>(LP-NPY)</t> (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
    Lp Npy, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p1323a/%5BLeu31%2CPro34%5D-Neuropeptide+Y/pmc12317128-335-25-26
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    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection <t>with</t> <t>NPY</t> (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY <t>(LP-NPY)</t> (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
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    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection <t>with</t> <t>NPY</t> (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY <t>(LP-NPY)</t> (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
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    hy p1323a  (MedChemExpress)
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    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection <t>with</t> <t>NPY</t> (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY <t>(LP-NPY)</t> (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.
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    Image Search Results


    A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection with NPY (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY (LP-NPY) (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

    doi: 10.1038/s41467-025-62382-w

    Figure Lengend Snippet: A Intrathecal morphine-induced scratching was dose-dependently inhibited by co-injection with NPY (1, 3, 10 μg), one-way ANOVA, Dunnett’s multiple comparisons. B Intrathecal morphine-induced scratching was significantly attenuated by co-injection with NPY1R selective agonist [Leu 31 , Pro 34 ] NPY (LP-NPY) (0.3, 1, 3 μg), one-way ANOVA, Dunnett’s multiple comparisons. C Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons. D Intrathecal co-injected morphine (0.3 nmol) and NPY (10 μg) in WT or Npy1r −/− mice, one-way ANOVA, Dunnett’s multiple comparisons. E Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 10 μg NPY, student’s unpaired two-tailed t -test. F Intrathecal EM-1 (10 nmol)-induced scratching was inhibited by 3 μg LP-NPY, student’s unpaired two-tailed t -test. Data are shown as means ± SEM. P values are indicated in the figures. Sample sizes are presented in parentheses. Source data are provided as a Source Data file.

    Article Snippet: The drugs included Morphine hydrochloride (China National Accord Medicines Corporation Ltd), Clozapine N-oxide (CNO; 16882, Cayman), NPY (MedChemExpress, HY-P0198A), BIBO3304 (MedChemExpress, HY-107725), Nalfurafine (MedChemExpress, HY-12745A), LP-NPY (MedChemExpress, HY-P1323A) EM-1 (MedChemExpress, HY-P0185), Naloxone (MedChemExpress, HY-17417), Diphtheria toxin (Sigma, D0564), PD176252 (MedChemExpress, HY-103286).

    Techniques: Injection, Two Tailed Test