hy-p0201 Search Results


substance p  (MedChemExpress)
94
MedChemExpress substance p
(A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), <t>substance</t> <t>P</t> (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).
Substance P, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0201/Substance+P/pmc13189246-260-16-19
Average 94 stars, based on 1 article reviews
substance p - by Bioz Stars, 2026-10
94/100 stars
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substance p sp  (MedChemExpress)
94
MedChemExpress substance p sp
(A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), <t>substance</t> <t>P</t> (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).
Substance P Sp, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0201/Substance+P/pmc10315577-72-59-64
Average 94 stars, based on 1 article reviews
substance p sp - by Bioz Stars, 2026-10
94/100 stars
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sp hy p0201  (MedChemExpress)
94
MedChemExpress sp hy p0201
(A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), <t>substance</t> <t>P</t> (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).
Sp Hy P0201, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0201/Calcitonin%2FCALCA%2C+Mouse/pm40209863-110-23-24
Average 94 stars, based on 1 article reviews
sp hy p0201 - by Bioz Stars, 2026-10
94/100 stars
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sp hyp0201  (MedChemExpress)
94
MedChemExpress sp hyp0201
(A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), <t>substance</t> <t>P</t> (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).
Sp Hyp0201, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0201/%CE%B1-CGRP/pm42442600-295-15-17
Average 94 stars, based on 1 article reviews
sp hyp0201 - by Bioz Stars, 2026-10
94/100 stars
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substance p, fam-labeled  (MedChemExpress)
N/A
Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The
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Image Search Results


(A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).

Journal: Cell reports

Article Title: Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity

doi: 10.1016/j.celrep.2025.116613

Figure Lengend Snippet: (A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).

Article Snippet: For certain experiments, cultures were treated with 100 nM of CGRPα (Bachem, 4025897 or MedChemExpress, HY-P0203), substance P (SP; MedChemExpress, HY-P0201), neuropeptide Y (NPY; MedChemExpress, HY-P0198), or norepinephrine (NE; Sigma, A7256) during the differentiation process or for ten hours (see corresponding figure legend), unless otherwise indicated.

Techniques: RNA Sequencing, Control

(A) Representative images of differentiated adipocytes treated throughout differentiation with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control (green: BODIPY, red: DAPI; all images were taken on day 8 of differentiation). Scale bar: 100 μm. (B and C) Quantification of (B) adipocyte and (C) nuclei counts from (A). (D) Principal-component analysis (PCA) of RNA sequencing data from preadipocytes treated with 100 nM CGRPα for 10 h. (E) Heatmap of the 500 most variable genes across treatment groups from (D). (F) Volcano plot of differentially expressed genes (DEGs) with log2 fold change (L2FC) > 0.5 and adjusted p value ( p adj) < 0.05. (G) Heatmap of the top 10 DEGs, ranked by p adj. (H) UpSet plot illustrating the overlap of DEGs with a p adj <0.05 between adipocytes and preadipocytes treated with CGRPα. (I) Gene set enrichment analysis (GSEA) highlighting significantly enriched pathways in preadipocytes treated with CGRPα. (J) Expression of the different receptor components in preadipocytes and adipocytes. Statistical analysis was performed using an unpaired one-way ANOVA (B and C; Dunnett correction comparing all groups to vehicle). p values are limited to 3 decimal places for clarity. Data are presented as mean ± SD ( n = 3–5 independent replicates).

Journal: Cell reports

Article Title: Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity

doi: 10.1016/j.celrep.2025.116613

Figure Lengend Snippet: (A) Representative images of differentiated adipocytes treated throughout differentiation with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control (green: BODIPY, red: DAPI; all images were taken on day 8 of differentiation). Scale bar: 100 μm. (B and C) Quantification of (B) adipocyte and (C) nuclei counts from (A). (D) Principal-component analysis (PCA) of RNA sequencing data from preadipocytes treated with 100 nM CGRPα for 10 h. (E) Heatmap of the 500 most variable genes across treatment groups from (D). (F) Volcano plot of differentially expressed genes (DEGs) with log2 fold change (L2FC) > 0.5 and adjusted p value ( p adj) < 0.05. (G) Heatmap of the top 10 DEGs, ranked by p adj. (H) UpSet plot illustrating the overlap of DEGs with a p adj <0.05 between adipocytes and preadipocytes treated with CGRPα. (I) Gene set enrichment analysis (GSEA) highlighting significantly enriched pathways in preadipocytes treated with CGRPα. (J) Expression of the different receptor components in preadipocytes and adipocytes. Statistical analysis was performed using an unpaired one-way ANOVA (B and C; Dunnett correction comparing all groups to vehicle). p values are limited to 3 decimal places for clarity. Data are presented as mean ± SD ( n = 3–5 independent replicates).

Article Snippet: For certain experiments, cultures were treated with 100 nM of CGRPα (Bachem, 4025897 or MedChemExpress, HY-P0203), substance P (SP; MedChemExpress, HY-P0201), neuropeptide Y (NPY; MedChemExpress, HY-P0198), or norepinephrine (NE; Sigma, A7256) during the differentiation process or for ten hours (see corresponding figure legend), unless otherwise indicated.

Techniques: Control, RNA Sequencing, Expressing