substance p (MedChemExpress)

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MedChemExpress substance p

(A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), <t>substance</t> <t>P</t> (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).

Substance P, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0201/Substance+P/pmc13189246-260-16-19
Average 94 stars, based on 26 article reviews

substance p - by Bioz Stars, 2026-10

94/100 stars

Images

1) Product Images from "Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity"

Article Title: Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity

Journal: Cell reports

doi: 10.1016/j.celrep.2025.116613

Figure Legend Snippet: (A) Principal-component analysis of RNA sequencing data from adipocytes treated for 10 h with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control ( n = 3 independent replicates). (B) UpSet plot illustrating the overlap of differentially expressed genes (DEGs) with an adjusted p value ( p adj) < 0.05. (C) Number of DEGs in the positive and negative directions for each group from (B). (D) Volcano plots depicting DEGs with log2 fold change (L2FC) > 0.5 and p adj <0.05. (E) Heatmaps of the top 10 DEGs for each treatment group, sorted by p adj, compared to vehicle control. (F–H) Gene Ontology (GO) pathway overrepresentation analysis of DEGs ( p adj < 0.05), displaying the top 10 pathways sorted by p adj, for (F) NPY (L2FC > 0), (G) CGRPα (L2FC > 0), and (H) CGRPα (all DEGs; BP, biological process).

Techniques Used: RNA Sequencing, Control

(A) Representative images of differentiated adipocytes treated throughout differentiation with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control (green: BODIPY, red: DAPI; all images were taken on day 8 of differentiation). Scale bar: 100 μm. (B and C) Quantification of (B) adipocyte and (C) nuclei counts from (A). (D) Principal-component analysis (PCA) of RNA sequencing data from preadipocytes treated with 100 nM CGRPα for 10 h. (E) Heatmap of the 500 most variable genes across treatment groups from (D). (F) Volcano plot of differentially expressed genes (DEGs) with log2 fold change (L2FC) > 0.5 and adjusted p value ( p adj) < 0.05. (G) Heatmap of the top 10 DEGs, ranked by p adj. (H) UpSet plot illustrating the overlap of DEGs with a p adj <0.05 between adipocytes and preadipocytes treated with CGRPα. (I) Gene set enrichment analysis (GSEA) highlighting significantly enriched pathways in preadipocytes treated with CGRPα. (J) Expression of the different receptor components in preadipocytes and adipocytes. Statistical analysis was performed using an unpaired one-way ANOVA (B and C; Dunnett correction comparing all groups to vehicle). p values are limited to 3 decimal places for clarity. Data are presented as mean ± SD ( n = 3–5 independent replicates).

Figure Legend Snippet: (A) Representative images of differentiated adipocytes treated throughout differentiation with 100 nM norepinephrine (NE), α-calcitonin gene-related peptide (CGRPα), neuropeptide Y (NPY), substance P (SP), or vehicle control (green: BODIPY, red: DAPI; all images were taken on day 8 of differentiation). Scale bar: 100 μm. (B and C) Quantification of (B) adipocyte and (C) nuclei counts from (A). (D) Principal-component analysis (PCA) of RNA sequencing data from preadipocytes treated with 100 nM CGRPα for 10 h. (E) Heatmap of the 500 most variable genes across treatment groups from (D). (F) Volcano plot of differentially expressed genes (DEGs) with log2 fold change (L2FC) > 0.5 and adjusted p value ( p adj) < 0.05. (G) Heatmap of the top 10 DEGs, ranked by p adj. (H) UpSet plot illustrating the overlap of DEGs with a p adj <0.05 between adipocytes and preadipocytes treated with CGRPα. (I) Gene set enrichment analysis (GSEA) highlighting significantly enriched pathways in preadipocytes treated with CGRPα. (J) Expression of the different receptor components in preadipocytes and adipocytes. Statistical analysis was performed using an unpaired one-way ANOVA (B and C; Dunnett correction comparing all groups to vehicle). p values are limited to 3 decimal places for clarity. Data are presented as mean ± SD ( n = 3–5 independent replicates).

Techniques Used: Control, RNA Sequencing, Expressing

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Article Title: Identification of glicentin as a low-potency glucose-dependent insulinotropic polypeptide receptor agonist.
Article Snippet: nscript (55-102) MedChemExpress HY-P1304 0.001 dH2O CCK-33 Cholecystokinin (1-33) MedChemExpress HY-P2932 0.001 DMSO Oxytocin Oxytocic hormone MedChemExpress HY-17571 0.01 dH2O Vasopressin Vasopressin MedChemExpress HY-B1811 0.01 dH2O PHM-27 Prepro-vasoactive intestinal polypeptide (1- 27) MedChemExpress HY-P1072 0.001 DMSO Neurokinin P Substance P MedChemExpress HY-P0201 0.01 dH2O IP1 Intervening

Article Title: Metapanax delavayi extract as a neurocutaneous modulator via CRHR1/POMC/MC1R signaling.
Article Snippet: The plant material was authenticated by Dr. Wenguang Yang from the Kunming Institute of Botany as the leaves of Metapanax delavayi (voucher number JY20230612).The plant material was authenticated by Dr. Wenguang Yang from the Kunming Institute of Botany as the leaves of Metapanax delavayi (voucher number JY20230612).. The specimen (BTN-JY-20230612) was deposited in the herbarium at Shanghai Jiyan Biomedical Development Co., Ltd. Hyperoside (Catalogue Numbers: B20631), chlorogenic acid (Catalogue Numbers: B20782), isochlorogenic acid A (Catalogue Numbers: B21539) and isochlorogenic acid C (Catalogue Numbers: B21541) were procured from Shanghai Yuanye Bio-Technology Co., Ltd. Capsaicin (Catalogue Numbers: HY-10448), capsazepine (Catalogue Numbers: HY-15640), substance P (Catalogue Numbers: HY-P0201), and aprepitant (Catalogue Numbers: HY-10052) were purchased from MedChem Express (USA).. 4-tert-butylcyclohexanol (TTBC) (Catalogue Numbers: T102225) was purchased from Aladdin (Shanghai, China).4-tert-butylcyclohexanol (TTBC) (Catalogue Numbers: T102225) was purchased from Aladdin (Shanghai, China).

Article Title: Metapanax delavayi extract as a neurocutaneous modulator via CRHR1/POMC/MC1R signaling
Article Snippet: The plant material was authenticated by Dr. Wenguang Yang from the Kunming Institute of Botany as the leaves of Metapanax delavayi (voucher number JY20230612).The plant material was authenticated by Dr. Wenguang Yang from the Kunming Institute of Botany as the leaves of Metapanax delavayi (voucher number JY20230612).. The specimen (BTN-JY-20230612) was deposited in the herbarium at Shanghai Jiyan Biomedical Development Co., Ltd. Hyperoside (Catalogue Numbers: B20631 ), chlorogenic acid (Catalogue Numbers: B20782 ), isochlorogenic acid A (Catalogue Numbers: B21539 ) and isochlorogenic acid C (Catalogue Numbers: B21541 ) were procured from Shanghai Yuanye Bio-Technology Co., Ltd. Capsaicin (Catalogue Numbers: HY-10448), capsazepine (Catalogue Numbers: HY-15640), substance P (Catalogue Numbers: HY-P0201), and aprepitant (Catalogue Numbers: HY-10052) were purchased from MedChem Express (USA).. 4-tert-butylcyclohexanol (TTBC) (Catalogue Numbers: T102225) was purchased from Aladdin (Shanghai, China).4-tert-butylcyclohexanol (TTBC) (Catalogue Numbers: T102225) was purchased from Aladdin (Shanghai, China).

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substance p (MedChemExpress)

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Images

1) Product Images from "Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity"

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