hy-n6739 Search Results


beauvericin  (MedChemExpress)
94
MedChemExpress beauvericin
( A ) Cells were treated with the indicated concentrations of <t>beauvericin</t> for 24 h, and viability was measured using the CellTiter-Glo assay. ( B ) Cells were exposed to beauvericin (2 and 4 μM) for 14 days, and colonies were stained with 0.5% crystal violet. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control (one-way ANOVA with Tukey’s post hoc test).
Beauvericin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) Cells were treated with the indicated concentrations of beauvericin for 24 h, and viability was measured using the CellTiter-Glo assay. ( B ) Cells were exposed to beauvericin (2 and 4 μM) for 14 days, and colonies were stained with 0.5% crystal violet. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control (one-way ANOVA with Tukey’s post hoc test).

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: ( A ) Cells were treated with the indicated concentrations of beauvericin for 24 h, and viability was measured using the CellTiter-Glo assay. ( B ) Cells were exposed to beauvericin (2 and 4 μM) for 14 days, and colonies were stained with 0.5% crystal violet. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control (one-way ANOVA with Tukey’s post hoc test).

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Glo Assay, Staining, Control

HCT116 and SW480 cells were treated with beauvericin for 24 h. Cell-cycle distribution ( A ) and apoptosis ( B ) were analyzed using the Guava Muse Cell Analyzer. Data are presented as mean ± SD ( n = 3). * p < 0.05, *** p < 0.001 vs. vehicle control.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: HCT116 and SW480 cells were treated with beauvericin for 24 h. Cell-cycle distribution ( A ) and apoptosis ( B ) were analyzed using the Guava Muse Cell Analyzer. Data are presented as mean ± SD ( n = 3). * p < 0.05, *** p < 0.001 vs. vehicle control.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Control

Cells were treated with beauvericin (5 and 10 μM) for 24 h. ( A ) Nuclear condensation/fragmentation (red arrows) was assessed by DAPI staining. ( B ) Mitochondrial ROS was detected using MitoSOX™. ( C ) Mitochondrial membrane potential was measured using TMRE. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: Cells were treated with beauvericin (5 and 10 μM) for 24 h. ( A ) Nuclear condensation/fragmentation (red arrows) was assessed by DAPI staining. ( B ) Mitochondrial ROS was detected using MitoSOX™. ( C ) Mitochondrial membrane potential was measured using TMRE. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Staining, Membrane, Control

Cells were treated with beauvericin (5 and 10 μM) for 24 h. Apoptosis-related proteins were analyzed by Western blot and quantified by densitometry. β-Actin served as a loading control. Data are presented as mean ± SD ( n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle control.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: Cells were treated with beauvericin (5 and 10 μM) for 24 h. Apoptosis-related proteins were analyzed by Western blot and quantified by densitometry. β-Actin served as a loading control. Data are presented as mean ± SD ( n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle control.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Western Blot, Control

( A ) Wound closure assay after treatment with beauvericin (1 and 2 μM) for 30 h (HCT116) or 48 h (SW480). Quantification was normalized to the initial wound width. ( B ) Transwell migration assay using uncoated inserts (8.0 μm pore size) under serum-gradient conditions (upper: serum-free; lower: 10% FBS) for 6 h. ( C ) Transwell invasion through ECM-coated inserts was assessed after 18 h, and invaded cells were stained with H&E. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: ( A ) Wound closure assay after treatment with beauvericin (1 and 2 μM) for 30 h (HCT116) or 48 h (SW480). Quantification was normalized to the initial wound width. ( B ) Transwell migration assay using uncoated inserts (8.0 μm pore size) under serum-gradient conditions (upper: serum-free; lower: 10% FBS) for 6 h. ( C ) Transwell invasion through ECM-coated inserts was assessed after 18 h, and invaded cells were stained with H&E. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Wound Closure Assay, Transwell Migration Assay, Pore Size, Staining, Control

Cells were treated with beauvericin (2 and 4 μM) for 24 h. Phosphorylated FAK, Src, and ERK1/2 were quantified after normalization to the corresponding total proteins. EMT-associated markers were analyzed by Western blot and quantified by densitometry. β-Actin was used as a loading control. Data are presented as mean ± SD ( n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle control.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: Cells were treated with beauvericin (2 and 4 μM) for 24 h. Phosphorylated FAK, Src, and ERK1/2 were quantified after normalization to the corresponding total proteins. EMT-associated markers were analyzed by Western blot and quantified by densitometry. β-Actin was used as a loading control. Data are presented as mean ± SD ( n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle control.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Western Blot, Control

HCT116 and SW480 cells were treated with beauvericin (1 and 2 μM) for 24 h, and conditioned medium (CM) was collected. CM was applied to HUVECs for ( A ) proliferation and ( B ) invasion assays. ( C ) HUVEC tube formation on ECM gel was assessed using CM. ( D ) VEGF levels in CM were measured by ELISA. Data are presented as mean ± SD ( n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. untreated CM group.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: HCT116 and SW480 cells were treated with beauvericin (1 and 2 μM) for 24 h, and conditioned medium (CM) was collected. CM was applied to HUVECs for ( A ) proliferation and ( B ) invasion assays. ( C ) HUVEC tube formation on ECM gel was assessed using CM. ( D ) VEGF levels in CM were measured by ELISA. Data are presented as mean ± SD ( n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. untreated CM group.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Enzyme-linked Immunosorbent Assay

( A ) PPI network of overlapping genes between CRC-associated genes (NCBI Gene) and beauvericin-predicted targets (PharmMapper) constructed using STRING (minimum interaction score = 0.7). ( B ) Top hub genes ranked by node degree. ( C ) Phosphorylation levels of JAK2, STAT1, and STAT3 were assessed by Western blot after beauvericin treatment (2 and 4 μM, 24 h) and quantified after normalization to their respective total protein levels. β-Actin served as an additional loading control. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: ( A ) PPI network of overlapping genes between CRC-associated genes (NCBI Gene) and beauvericin-predicted targets (PharmMapper) constructed using STRING (minimum interaction score = 0.7). ( B ) Top hub genes ranked by node degree. ( C ) Phosphorylation levels of JAK2, STAT1, and STAT3 were assessed by Western blot after beauvericin treatment (2 and 4 μM, 24 h) and quantified after normalization to their respective total protein levels. β-Actin served as an additional loading control. Data are presented as mean ± SD ( n = 3). ** p < 0.01, *** p < 0.001 vs. vehicle control.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Construct, Phospho-proteomics, Western Blot, Control

Beauvericin induces mitochondrial apoptosis and is associated with attenuation of EMT-associated signaling, VEGF-dependent endothelial activation, and JAK/STAT pathway activation.

Journal: Journal of Microbiology and Biotechnology

Article Title: Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro

doi: 10.4014/jmb.2511.11035

Figure Lengend Snippet: Beauvericin induces mitochondrial apoptosis and is associated with attenuation of EMT-associated signaling, VEGF-dependent endothelial activation, and JAK/STAT pathway activation.

Article Snippet: Beauvericin was purchased from MedChemExpress (USA).

Techniques: Activation Assay