high‐density lipoprotein hdl Search Results


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  • 90
    RayBiotech high density lipoprotein hdl
    High Density Lipoprotein Hdl, supplied by RayBiotech, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore high density lipoprotein hdl
    Effect of <t>VLDL,</t> LDL, and <t>HDL</t> on HCV-LP binding to Molt-4 cells. Cell-bound HCV-LPs were analyzed by flow cytometry by the indirect method (A and B) or the direct method (C). (A) Increasing concentrations of HCV-LPs with or without LDL (0.5 mg/ml) were added simultaneously to the cells. (B) Alternatively, HCV-LPs were preincubated with LDL for 2 h at 4°C before being added to the cells. (C) SYTO-labeled HCV-LPs were incubated with cells for 1 h at 4°C, and cell-bound HCV-LPs were analyzed as described in Materials and Methods (open bars). Cells were preincubated with VLDL, LDL, or HDL (0.5 mg/ml) or anti-human LDL-R IgG (20 μg/ml) for 2 h at 4°C before the addition of SYTO-labeled HCV-LPs (hatched bars). Alternatively, SYTO-labeled HCV-LPs were preincubated with VLDL, LDL, or HDL at 4°C before being added to the cells (solid bar).
    High Density Lipoprotein Hdl, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 54 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BioVision high density lipoprotein hdl
    Effect of <t>VLDL,</t> LDL, and <t>HDL</t> on HCV-LP binding to Molt-4 cells. Cell-bound HCV-LPs were analyzed by flow cytometry by the indirect method (A and B) or the direct method (C). (A) Increasing concentrations of HCV-LPs with or without LDL (0.5 mg/ml) were added simultaneously to the cells. (B) Alternatively, HCV-LPs were preincubated with LDL for 2 h at 4°C before being added to the cells. (C) SYTO-labeled HCV-LPs were incubated with cells for 1 h at 4°C, and cell-bound HCV-LPs were analyzed as described in Materials and Methods (open bars). Cells were preincubated with VLDL, LDL, or HDL (0.5 mg/ml) or anti-human LDL-R IgG (20 μg/ml) for 2 h at 4°C before the addition of SYTO-labeled HCV-LPs (hatched bars). Alternatively, SYTO-labeled HCV-LPs were preincubated with VLDL, LDL, or HDL at 4°C before being added to the cells (solid bar).
    High Density Lipoprotein Hdl, supplied by BioVision, used in various techniques. Bioz Stars score: 92/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Prospec high density lipoprotein hdl
    DBZ attenuates ox‐ LDL –induced foam cell formation and promotes cholesterol efflux in macrophages. A, THP ‐1 macrophages were cotreated with the indicated concentrations of DBZ (5, 10, and 20 μmol/L) and Ox LDL (50 μg/mL) for 48 h. Lipid accumulation was observed by Oil Red O staining (scale=20 μm). B, Intracellular cholesteryl ester levels were normalized to cellular protein content in THP ‐1 macrophages. Macrophages were treated with DBZ and <t>NBD</t> cholesterol. Cholesterol efflux to apoA‐1 (C) and <t>HDL</t> (D) from THP ‐1 macrophages. Cholesterol efflux was expressed as the percentage fluorescence in the medium relative to total fluorescence. E, THP ‐1 macrophages were treated with the indicated concentrations of DBZ for 24 h. The relative protein levels of ABCA 1 and ABCG 1 were determined by Western blot analysis. T1317 (1 μmol/L) was used as a positive control. F, The transcriptional activity of LXR α was assessed by the transactivation reporter assay in 293T cells. G and H, The model structure of the complex formed by the LXR α ligand‐binding pocket and DBZ by molecular docking. I, THP ‐1 macrophages were pretreated with GGPP (10 μmol/L) for 2 h and then treated with DBZ (20 μmol/L) for 24 h. The relative protein level of ABCA 1 was determined by Western blot analysis. Prior to treatment with DBZ (20 μmol/L), THP ‐1 macrophages were treated with GGPP for 2 h and then incubated with 50 μg/mL Ox LDL for 48 h. J, Representative Oil Red O staining of THP ‐1 macrophage foam cells (scale=20 μm). K, Intracellular cholesteryl ester levels that were normalized to cellular protein content in THP ‐1 macrophages. Values are presented as the mean± SEM of at least 3 experiments ( ### P
    High Density Lipoprotein Hdl, supplied by Prospec, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Dade Behring high density lipoprotein hdl
    DBZ attenuates ox‐ LDL –induced foam cell formation and promotes cholesterol efflux in macrophages. A, THP ‐1 macrophages were cotreated with the indicated concentrations of DBZ (5, 10, and 20 μmol/L) and Ox LDL (50 μg/mL) for 48 h. Lipid accumulation was observed by Oil Red O staining (scale=20 μm). B, Intracellular cholesteryl ester levels were normalized to cellular protein content in THP ‐1 macrophages. Macrophages were treated with DBZ and <t>NBD</t> cholesterol. Cholesterol efflux to apoA‐1 (C) and <t>HDL</t> (D) from THP ‐1 macrophages. Cholesterol efflux was expressed as the percentage fluorescence in the medium relative to total fluorescence. E, THP ‐1 macrophages were treated with the indicated concentrations of DBZ for 24 h. The relative protein levels of ABCA 1 and ABCG 1 were determined by Western blot analysis. T1317 (1 μmol/L) was used as a positive control. F, The transcriptional activity of LXR α was assessed by the transactivation reporter assay in 293T cells. G and H, The model structure of the complex formed by the LXR α ligand‐binding pocket and DBZ by molecular docking. I, THP ‐1 macrophages were pretreated with GGPP (10 μmol/L) for 2 h and then treated with DBZ (20 μmol/L) for 24 h. The relative protein level of ABCA 1 was determined by Western blot analysis. Prior to treatment with DBZ (20 μmol/L), THP ‐1 macrophages were treated with GGPP for 2 h and then incubated with 50 μg/mL Ox LDL for 48 h. J, Representative Oil Red O staining of THP ‐1 macrophage foam cells (scale=20 μm). K, Intracellular cholesteryl ester levels that were normalized to cellular protein content in THP ‐1 macrophages. Values are presented as the mean± SEM of at least 3 experiments ( ### P
    High Density Lipoprotein Hdl, supplied by Dade Behring, used in various techniques. Bioz Stars score: 92/100, based on 50 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Stanbio high density lipoprotein hdl cholesterol
    DBZ attenuates ox‐ LDL –induced foam cell formation and promotes cholesterol efflux in macrophages. A, THP ‐1 macrophages were cotreated with the indicated concentrations of DBZ (5, 10, and 20 μmol/L) and Ox LDL (50 μg/mL) for 48 h. Lipid accumulation was observed by Oil Red O staining (scale=20 μm). B, Intracellular cholesteryl ester levels were normalized to cellular protein content in THP ‐1 macrophages. Macrophages were treated with DBZ and <t>NBD</t> cholesterol. Cholesterol efflux to apoA‐1 (C) and <t>HDL</t> (D) from THP ‐1 macrophages. Cholesterol efflux was expressed as the percentage fluorescence in the medium relative to total fluorescence. E, THP ‐1 macrophages were treated with the indicated concentrations of DBZ for 24 h. The relative protein levels of ABCA 1 and ABCG 1 were determined by Western blot analysis. T1317 (1 μmol/L) was used as a positive control. F, The transcriptional activity of LXR α was assessed by the transactivation reporter assay in 293T cells. G and H, The model structure of the complex formed by the LXR α ligand‐binding pocket and DBZ by molecular docking. I, THP ‐1 macrophages were pretreated with GGPP (10 μmol/L) for 2 h and then treated with DBZ (20 μmol/L) for 24 h. The relative protein level of ABCA 1 was determined by Western blot analysis. Prior to treatment with DBZ (20 μmol/L), THP ‐1 macrophages were treated with GGPP for 2 h and then incubated with 50 μg/mL Ox LDL for 48 h. J, Representative Oil Red O staining of THP ‐1 macrophage foam cells (scale=20 μm). K, Intracellular cholesteryl ester levels that were normalized to cellular protein content in THP ‐1 macrophages. Values are presented as the mean± SEM of at least 3 experiments ( ### P
    High Density Lipoprotein Hdl Cholesterol, supplied by Stanbio, used in various techniques. Bioz Stars score: 90/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Genzyme high density lipoprotein hdl cholesterol
    DBZ attenuates ox‐ LDL –induced foam cell formation and promotes cholesterol efflux in macrophages. A, THP ‐1 macrophages were cotreated with the indicated concentrations of DBZ (5, 10, and 20 μmol/L) and Ox LDL (50 μg/mL) for 48 h. Lipid accumulation was observed by Oil Red O staining (scale=20 μm). B, Intracellular cholesteryl ester levels were normalized to cellular protein content in THP ‐1 macrophages. Macrophages were treated with DBZ and <t>NBD</t> cholesterol. Cholesterol efflux to apoA‐1 (C) and <t>HDL</t> (D) from THP ‐1 macrophages. Cholesterol efflux was expressed as the percentage fluorescence in the medium relative to total fluorescence. E, THP ‐1 macrophages were treated with the indicated concentrations of DBZ for 24 h. The relative protein levels of ABCA 1 and ABCG 1 were determined by Western blot analysis. T1317 (1 μmol/L) was used as a positive control. F, The transcriptional activity of LXR α was assessed by the transactivation reporter assay in 293T cells. G and H, The model structure of the complex formed by the LXR α ligand‐binding pocket and DBZ by molecular docking. I, THP ‐1 macrophages were pretreated with GGPP (10 μmol/L) for 2 h and then treated with DBZ (20 μmol/L) for 24 h. The relative protein level of ABCA 1 was determined by Western blot analysis. Prior to treatment with DBZ (20 μmol/L), THP ‐1 macrophages were treated with GGPP for 2 h and then incubated with 50 μg/mL Ox LDL for 48 h. J, Representative Oil Red O staining of THP ‐1 macrophage foam cells (scale=20 μm). K, Intracellular cholesteryl ester levels that were normalized to cellular protein content in THP ‐1 macrophages. Values are presented as the mean± SEM of at least 3 experiments ( ### P
    High Density Lipoprotein Hdl Cholesterol, supplied by Genzyme, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abcam high density lipoprotein hdl
    Effects of AngII infusion on plasma nitrite/nitrate, total cholesterol, high density lipoprotein <t>(HDL)</t> and very low density lipoprotein <t>(VLDL).</t> Box plots showing plasma (A) total cholesterol; (B) HDL, (C) VLDL and (D) total NO metabolites in saline-infused (Veh) and AngII -infused (AngII) ApoE −/− mice. Results are mean±SEM; n = 5; Statistical significance shown as *P
    High Density Lipoprotein Hdl, supplied by Abcam, used in various techniques. Bioz Stars score: 93/100, based on 47 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Kovalent high density lipoprotein hdl cholesterol
    Effects of AngII infusion on plasma nitrite/nitrate, total cholesterol, high density lipoprotein <t>(HDL)</t> and very low density lipoprotein <t>(VLDL).</t> Box plots showing plasma (A) total cholesterol; (B) HDL, (C) VLDL and (D) total NO metabolites in saline-infused (Veh) and AngII -infused (AngII) ApoE −/− mice. Results are mean±SEM; n = 5; Statistical significance shown as *P
    High Density Lipoprotein Hdl Cholesterol, supplied by Kovalent, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Asan Pharmaceuticals Co high density lipoprotein hdl cholesterol
    Effects of AngII infusion on plasma nitrite/nitrate, total cholesterol, high density lipoprotein <t>(HDL)</t> and very low density lipoprotein <t>(VLDL).</t> Box plots showing plasma (A) total cholesterol; (B) HDL, (C) VLDL and (D) total NO metabolites in saline-infused (Veh) and AngII -infused (AngII) ApoE −/− mice. Results are mean±SEM; n = 5; Statistical significance shown as *P
    High Density Lipoprotein Hdl Cholesterol, supplied by Asan Pharmaceuticals Co, used in various techniques. Bioz Stars score: 92/100, based on 23 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Olympus high density lipoprotein hdl
    Dependency network in schizophrenia and related psychoses . The network was constructed from the diagnostic, clinical, antipsychotic medication use, and metabolite cluster data. Node shapes represent different types of variables and platforms, node color corresponds to significance and direction of regulation (schizophrenia versus controls), and line width is proportional to strength of dependency. The two metabolic variables directly linked with schizophrenia and two other metabolic network hubs are highlighted with green squares. The cutoff for the presence of an edge was set at β = 0.25 by the average non-rejection rate, that is, an edge in the graph was tested positive in 25% of the 500 samplings. Abbreviations: BDI, Beck Depression Inventory [ 26 ]; BMI, body mass index; Chol, cholesterol; CRP, C-reactive protein; DiastBP, diastolic blood pressure; GGT, gamma-glutamyltransferase; <t>HDL,</t> high-density lipoprotein; HOMA-IR, homeostatic model assessment index; <t>LDL,</t> low-density lipoprotein; NIDDM, non-insulin-dependent diabetes mellitus; SystBP, systolic blood pressure; TG, total triglycerides; Tot, total.
    High Density Lipoprotein Hdl, supplied by Olympus, used in various techniques. Bioz Stars score: 93/100, based on 77 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Roche high density lipoprotein hdl
    Peripherally restricted CB 1 R antagonism restores liver function and cholesterol homeostasis in obese Magel2 -null mice . Both JD5037 and SLV319 (3 mg/kg/day for 28 d) treatment reduced the HFD-induced hepatic injury and steatosis in obese Magel2 -null mice, as manifested by the reduced serum levels of ALT ( A , B ), AST ( C , D ), and TG content in the liver ( E , F ). Both compounds were equally potent in normalizing serum cholesterol levels ( G , H ), but not in restoring the <t>HDL/LDL</t> cholesterol ratio in Magel2 -null mice ( I , J ). Similar patterns of results were obtained both in obese male ( left panels ) and female ( right panels ) mice. Legend: Vehicle, V; JD5037, J; SLV319, S. Data represent the mean ± SEM from 5 to 10 mice per group. * P
    High Density Lipoprotein Hdl, supplied by Roche, used in various techniques. Bioz Stars score: 93/100, based on 397 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agappe Diagnostic high density lipoprotein hdl
    Peripherally restricted CB 1 R antagonism restores liver function and cholesterol homeostasis in obese Magel2 -null mice . Both JD5037 and SLV319 (3 mg/kg/day for 28 d) treatment reduced the HFD-induced hepatic injury and steatosis in obese Magel2 -null mice, as manifested by the reduced serum levels of ALT ( A , B ), AST ( C , D ), and TG content in the liver ( E , F ). Both compounds were equally potent in normalizing serum cholesterol levels ( G , H ), but not in restoring the <t>HDL/LDL</t> cholesterol ratio in Magel2 -null mice ( I , J ). Similar patterns of results were obtained both in obese male ( left panels ) and female ( right panels ) mice. Legend: Vehicle, V; JD5037, J; SLV319, S. Data represent the mean ± SEM from 5 to 10 mice per group. * P
    High Density Lipoprotein Hdl, supplied by Agappe Diagnostic, used in various techniques. Bioz Stars score: 92/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Beckman Coulter high density lipoprotein hdl
    Bidirectional instrumental variable (IV) estimated association between 25(OH)D and NAFLD by unweighted GRSs. Data were presented as regression coefficient (β) or odds ratio (OR) and 95% confidence interval (CI). In this MR framework, the instrumental variable estimators are OR IV(VD-NAFLD) = exp (ln (OR VD_GRS-NAFLD )/β VD_GRS-25(OH)D ) and β IV(NAFLD-VD) = β NAFLD_GRS-25(OH)D /ln (OR NAFLD_GRS-NAFLD ). Data were adjusted for age, sex, BMI, current smoking, hypertension, diabetes, <t>HDL-cholesterol,</t> <t>LDL-cholesterol</t> and triglycerides. 25(OH)D, 25-hydroxyvitamin D; VD_GRS, vitamin D genetic risk score; NAFLD_GRS, nonalcoholic fatty liver disease genetic risk score; SD, standard deviation.
    High Density Lipoprotein Hdl, supplied by Beckman Coulter, used in various techniques. Bioz Stars score: 93/100, based on 175 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ERBA Diagnostics high density lipoprotein hdl
    Bidirectional instrumental variable (IV) estimated association between 25(OH)D and NAFLD by unweighted GRSs. Data were presented as regression coefficient (β) or odds ratio (OR) and 95% confidence interval (CI). In this MR framework, the instrumental variable estimators are OR IV(VD-NAFLD) = exp (ln (OR VD_GRS-NAFLD )/β VD_GRS-25(OH)D ) and β IV(NAFLD-VD) = β NAFLD_GRS-25(OH)D /ln (OR NAFLD_GRS-NAFLD ). Data were adjusted for age, sex, BMI, current smoking, hypertension, diabetes, <t>HDL-cholesterol,</t> <t>LDL-cholesterol</t> and triglycerides. 25(OH)D, 25-hydroxyvitamin D; VD_GRS, vitamin D genetic risk score; NAFLD_GRS, nonalcoholic fatty liver disease genetic risk score; SD, standard deviation.
    High Density Lipoprotein Hdl, supplied by ERBA Diagnostics, used in various techniques. Bioz Stars score: 92/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Hitachi Ltd high density lipoprotein hdl
    Inflammation increased lipid accumulation to accelerate tubulointerstitial injuries. Eight-week-old diabetic db/db mice were randomly assigned and received subcutaneous injections with either 0.5 mL distilled water ( db/db , n =10) or 0.5 mL 10% casein ( db/db +casein, n =10) every other day for 8 weeks. HK-2 cells were made quiescent using serum-free medium for 24 h, and treated with 30 mmol/L glucose (HG) or 30 mmol/L glucose plus 5 ng/mL IL-1β. TG, triglyceride; TC, total cholesterol; <t>LDL,</t> low-density lipoprotein; <t>HDL,</t> high-density lipoprotein (A). Filipin staining was used to examine lipid accumulation both in vivo and in vitro (B and D, original magnification ×200). The concentration of cholesterol ester was measured both in vivo (C, n =5) and in vitro (E). The results represent the mean±SD. * P
    High Density Lipoprotein Hdl, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 93/100, based on 387 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens Healthineers high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Siemens Healthineers, used in various techniques. Bioz Stars score: 93/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Stanbio high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Stanbio, used in various techniques. Bioz Stars score: 92/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Mimetics high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Mimetics, used in various techniques. Bioz Stars score: 92/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Shimadzu Corporation high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Shimadzu Corporation, used in various techniques. Bioz Stars score: 92/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens AG high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Siemens AG, used in various techniques. Bioz Stars score: 92/100, based on 65 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Pointe Scientific high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Pointe Scientific, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Pure Chemistry Scientific Inc high density lipoprotein hdl
    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for <t>LDL,</t> <t>HDL,</t> total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA
    High Density Lipoprotein Hdl, supplied by Pure Chemistry Scientific Inc, used in various techniques. Bioz Stars score: 92/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    FUJIFILM high density lipoprotein hdl
    Extended ACK treatment alters metabolic factors. (A) ACK-mediated effects on fasting and non-fasting blood glucose in WT mice. (B) ACK-mediated effects on fasting insulin in WT mice. (C) ACK-mediated effects on the oral glucose tolerance test (OGTT) (water-treated control, black line: ACK-treated, red line). (D) ACK-mediated effects on OGTT AUC (Area Under Curve). ACK-mediated effects on pancreatic islet gross cellular morphology (E) and islet size (F). Insulin-secreting beta cells (red fluorescence) and Glucagon-secreting alpha cells (green fluorescence). Effect of ACK on pancreatic islet size (E), beta cell percentage (G) alpha cell percentage (H). Effects of ACK treatment on levels of leptin (I), gastrointestinal inhibitory peptide (GIP: J), pancreatic polypeptide (PP: K) and peptide YY (PYY: L). ACK effects on total plasma cholesterol (M). ACK effects on plasma lipoproteins: low-density lipoprotein <t>(LDL:</t> N); high-density lipoprotein <t>(HDL:</t> O); LDL:HDL plasma level ratio is indicated in panel (P). ACK effects on plasma triglycerides and ketone bodies (Q) and (R). A Student’s t-test was used for comparisons between control and ACK treatment group. Data are means ± SEM. *p≤0.05, n = 6–8/group.
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    Effect of VLDL, LDL, and HDL on HCV-LP binding to Molt-4 cells. Cell-bound HCV-LPs were analyzed by flow cytometry by the indirect method (A and B) or the direct method (C). (A) Increasing concentrations of HCV-LPs with or without LDL (0.5 mg/ml) were added simultaneously to the cells. (B) Alternatively, HCV-LPs were preincubated with LDL for 2 h at 4°C before being added to the cells. (C) SYTO-labeled HCV-LPs were incubated with cells for 1 h at 4°C, and cell-bound HCV-LPs were analyzed as described in Materials and Methods (open bars). Cells were preincubated with VLDL, LDL, or HDL (0.5 mg/ml) or anti-human LDL-R IgG (20 μg/ml) for 2 h at 4°C before the addition of SYTO-labeled HCV-LPs (hatched bars). Alternatively, SYTO-labeled HCV-LPs were preincubated with VLDL, LDL, or HDL at 4°C before being added to the cells (solid bar).

    Journal: Journal of Virology

    Article Title: Interaction of Hepatitis C Virus-Like Particles and Cells: a Model System for Studying Viral Binding and Entry

    doi: 10.1128/JVI.76.18.9335-9344.2002

    Figure Lengend Snippet: Effect of VLDL, LDL, and HDL on HCV-LP binding to Molt-4 cells. Cell-bound HCV-LPs were analyzed by flow cytometry by the indirect method (A and B) or the direct method (C). (A) Increasing concentrations of HCV-LPs with or without LDL (0.5 mg/ml) were added simultaneously to the cells. (B) Alternatively, HCV-LPs were preincubated with LDL for 2 h at 4°C before being added to the cells. (C) SYTO-labeled HCV-LPs were incubated with cells for 1 h at 4°C, and cell-bound HCV-LPs were analyzed as described in Materials and Methods (open bars). Cells were preincubated with VLDL, LDL, or HDL (0.5 mg/ml) or anti-human LDL-R IgG (20 μg/ml) for 2 h at 4°C before the addition of SYTO-labeled HCV-LPs (hatched bars). Alternatively, SYTO-labeled HCV-LPs were preincubated with VLDL, LDL, or HDL at 4°C before being added to the cells (solid bar).

    Article Snippet: Bovine serum albumin (BSA), very-low-density lipoprotein (VLDL), LDL, and high-density lipoprotein (HDL) were obtained from Sigma (St. Louis, Mo.).

    Techniques: Binding Assay, Flow Cytometry, Cytometry, Labeling, Incubation

    DBZ attenuates ox‐ LDL –induced foam cell formation and promotes cholesterol efflux in macrophages. A, THP ‐1 macrophages were cotreated with the indicated concentrations of DBZ (5, 10, and 20 μmol/L) and Ox LDL (50 μg/mL) for 48 h. Lipid accumulation was observed by Oil Red O staining (scale=20 μm). B, Intracellular cholesteryl ester levels were normalized to cellular protein content in THP ‐1 macrophages. Macrophages were treated with DBZ and NBD cholesterol. Cholesterol efflux to apoA‐1 (C) and HDL (D) from THP ‐1 macrophages. Cholesterol efflux was expressed as the percentage fluorescence in the medium relative to total fluorescence. E, THP ‐1 macrophages were treated with the indicated concentrations of DBZ for 24 h. The relative protein levels of ABCA 1 and ABCG 1 were determined by Western blot analysis. T1317 (1 μmol/L) was used as a positive control. F, The transcriptional activity of LXR α was assessed by the transactivation reporter assay in 293T cells. G and H, The model structure of the complex formed by the LXR α ligand‐binding pocket and DBZ by molecular docking. I, THP ‐1 macrophages were pretreated with GGPP (10 μmol/L) for 2 h and then treated with DBZ (20 μmol/L) for 24 h. The relative protein level of ABCA 1 was determined by Western blot analysis. Prior to treatment with DBZ (20 μmol/L), THP ‐1 macrophages were treated with GGPP for 2 h and then incubated with 50 μg/mL Ox LDL for 48 h. J, Representative Oil Red O staining of THP ‐1 macrophage foam cells (scale=20 μm). K, Intracellular cholesteryl ester levels that were normalized to cellular protein content in THP ‐1 macrophages. Values are presented as the mean± SEM of at least 3 experiments ( ### P

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: DBZ (Danshensu Bingpian Zhi), a Novel Natural Compound Derivative, Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice

    doi: 10.1161/JAHA.117.006297

    Figure Lengend Snippet: DBZ attenuates ox‐ LDL –induced foam cell formation and promotes cholesterol efflux in macrophages. A, THP ‐1 macrophages were cotreated with the indicated concentrations of DBZ (5, 10, and 20 μmol/L) and Ox LDL (50 μg/mL) for 48 h. Lipid accumulation was observed by Oil Red O staining (scale=20 μm). B, Intracellular cholesteryl ester levels were normalized to cellular protein content in THP ‐1 macrophages. Macrophages were treated with DBZ and NBD cholesterol. Cholesterol efflux to apoA‐1 (C) and HDL (D) from THP ‐1 macrophages. Cholesterol efflux was expressed as the percentage fluorescence in the medium relative to total fluorescence. E, THP ‐1 macrophages were treated with the indicated concentrations of DBZ for 24 h. The relative protein levels of ABCA 1 and ABCG 1 were determined by Western blot analysis. T1317 (1 μmol/L) was used as a positive control. F, The transcriptional activity of LXR α was assessed by the transactivation reporter assay in 293T cells. G and H, The model structure of the complex formed by the LXR α ligand‐binding pocket and DBZ by molecular docking. I, THP ‐1 macrophages were pretreated with GGPP (10 μmol/L) for 2 h and then treated with DBZ (20 μmol/L) for 24 h. The relative protein level of ABCA 1 was determined by Western blot analysis. Prior to treatment with DBZ (20 μmol/L), THP ‐1 macrophages were treated with GGPP for 2 h and then incubated with 50 μg/mL Ox LDL for 48 h. J, Representative Oil Red O staining of THP ‐1 macrophage foam cells (scale=20 μm). K, Intracellular cholesteryl ester levels that were normalized to cellular protein content in THP ‐1 macrophages. Values are presented as the mean± SEM of at least 3 experiments ( ### P

    Article Snippet: NBD cholesterol (Cayman), apoA1, high‐density lipoprotein (HDL) (ProSpec), atorvastatin (Pfizer Ltd.), lipopolysaccharide, PMA (phorbol 12‐myristate 13‐acetate), T0901317 (hereafter referred to as T1317), and GGPP (geranylgeranyl pyrophosphate) were purchased from Sigma‐Aldrich.

    Techniques: Staining, Fluorescence, Western Blot, Positive Control, Activity Assay, Reporter Assay, Ligand Binding Assay, Incubation

    Effects of AngII infusion on plasma nitrite/nitrate, total cholesterol, high density lipoprotein (HDL) and very low density lipoprotein (VLDL). Box plots showing plasma (A) total cholesterol; (B) HDL, (C) VLDL and (D) total NO metabolites in saline-infused (Veh) and AngII -infused (AngII) ApoE −/− mice. Results are mean±SEM; n = 5; Statistical significance shown as *P

    Journal: PLoS ONE

    Article Title: Impaired Acetylcholine-Induced Endothelium-Dependent Aortic Relaxation by Caveolin-1 in Angiotensin II-Infused Apolipoprotein-E (ApoE−/−) Knockout Mice

    doi: 10.1371/journal.pone.0058481

    Figure Lengend Snippet: Effects of AngII infusion on plasma nitrite/nitrate, total cholesterol, high density lipoprotein (HDL) and very low density lipoprotein (VLDL). Box plots showing plasma (A) total cholesterol; (B) HDL, (C) VLDL and (D) total NO metabolites in saline-infused (Veh) and AngII -infused (AngII) ApoE −/− mice. Results are mean±SEM; n = 5; Statistical significance shown as *P

    Article Snippet: Plasma Nitrite/nitrate and Cholesterol Measurement Measurements of total plasma cholesterol, high density lipoprotein (HDL) and low density/very low density lipoprotein (LDL/VLDL) were performed in plasma in duplicate using a commercial kit in accordance with the manufacturers’ instructions (inter-assay coefficient of variation 3.4%) (Abcam).

    Techniques: Mouse Assay

    Dependency network in schizophrenia and related psychoses . The network was constructed from the diagnostic, clinical, antipsychotic medication use, and metabolite cluster data. Node shapes represent different types of variables and platforms, node color corresponds to significance and direction of regulation (schizophrenia versus controls), and line width is proportional to strength of dependency. The two metabolic variables directly linked with schizophrenia and two other metabolic network hubs are highlighted with green squares. The cutoff for the presence of an edge was set at β = 0.25 by the average non-rejection rate, that is, an edge in the graph was tested positive in 25% of the 500 samplings. Abbreviations: BDI, Beck Depression Inventory [ 26 ]; BMI, body mass index; Chol, cholesterol; CRP, C-reactive protein; DiastBP, diastolic blood pressure; GGT, gamma-glutamyltransferase; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment index; LDL, low-density lipoprotein; NIDDM, non-insulin-dependent diabetes mellitus; SystBP, systolic blood pressure; TG, total triglycerides; Tot, total.

    Journal: Genome Medicine

    Article Title: Metabolome in schizophrenia and other psychotic disorders: a general population-based study

    doi: 10.1186/gm233

    Figure Lengend Snippet: Dependency network in schizophrenia and related psychoses . The network was constructed from the diagnostic, clinical, antipsychotic medication use, and metabolite cluster data. Node shapes represent different types of variables and platforms, node color corresponds to significance and direction of regulation (schizophrenia versus controls), and line width is proportional to strength of dependency. The two metabolic variables directly linked with schizophrenia and two other metabolic network hubs are highlighted with green squares. The cutoff for the presence of an edge was set at β = 0.25 by the average non-rejection rate, that is, an edge in the graph was tested positive in 25% of the 500 samplings. Abbreviations: BDI, Beck Depression Inventory [ 26 ]; BMI, body mass index; Chol, cholesterol; CRP, C-reactive protein; DiastBP, diastolic blood pressure; GGT, gamma-glutamyltransferase; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment index; LDL, low-density lipoprotein; NIDDM, non-insulin-dependent diabetes mellitus; SystBP, systolic blood pressure; TG, total triglycerides; Tot, total.

    Article Snippet: Biochemical measures Total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, triglycerides and glucose were measured with an AU400 analyzer (Olympus, Japan).

    Techniques: Construct, Diagnostic Assay

    Peripherally restricted CB 1 R antagonism restores liver function and cholesterol homeostasis in obese Magel2 -null mice . Both JD5037 and SLV319 (3 mg/kg/day for 28 d) treatment reduced the HFD-induced hepatic injury and steatosis in obese Magel2 -null mice, as manifested by the reduced serum levels of ALT ( A , B ), AST ( C , D ), and TG content in the liver ( E , F ). Both compounds were equally potent in normalizing serum cholesterol levels ( G , H ), but not in restoring the HDL/LDL cholesterol ratio in Magel2 -null mice ( I , J ). Similar patterns of results were obtained both in obese male ( left panels ) and female ( right panels ) mice. Legend: Vehicle, V; JD5037, J; SLV319, S. Data represent the mean ± SEM from 5 to 10 mice per group. * P

    Journal: Molecular Metabolism

    Article Title: Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome

    doi: 10.1016/j.molmet.2016.10.004

    Figure Lengend Snippet: Peripherally restricted CB 1 R antagonism restores liver function and cholesterol homeostasis in obese Magel2 -null mice . Both JD5037 and SLV319 (3 mg/kg/day for 28 d) treatment reduced the HFD-induced hepatic injury and steatosis in obese Magel2 -null mice, as manifested by the reduced serum levels of ALT ( A , B ), AST ( C , D ), and TG content in the liver ( E , F ). Both compounds were equally potent in normalizing serum cholesterol levels ( G , H ), but not in restoring the HDL/LDL cholesterol ratio in Magel2 -null mice ( I , J ). Similar patterns of results were obtained both in obese male ( left panels ) and female ( right panels ) mice. Legend: Vehicle, V; JD5037, J; SLV319, S. Data represent the mean ± SEM from 5 to 10 mice per group. * P

    Article Snippet: 2.8 Blood biochemistry Serum levels of cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were determined using the Cobas C-111 chemistry analyzer (Roche, Switzerland).

    Techniques: Mouse Assay, AST Assay

    Bidirectional instrumental variable (IV) estimated association between 25(OH)D and NAFLD by unweighted GRSs. Data were presented as regression coefficient (β) or odds ratio (OR) and 95% confidence interval (CI). In this MR framework, the instrumental variable estimators are OR IV(VD-NAFLD) = exp (ln (OR VD_GRS-NAFLD )/β VD_GRS-25(OH)D ) and β IV(NAFLD-VD) = β NAFLD_GRS-25(OH)D /ln (OR NAFLD_GRS-NAFLD ). Data were adjusted for age, sex, BMI, current smoking, hypertension, diabetes, HDL-cholesterol, LDL-cholesterol and triglycerides. 25(OH)D, 25-hydroxyvitamin D; VD_GRS, vitamin D genetic risk score; NAFLD_GRS, nonalcoholic fatty liver disease genetic risk score; SD, standard deviation.

    Journal: EBioMedicine

    Article Title: Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis

    doi: 10.1016/j.ebiom.2017.12.027

    Figure Lengend Snippet: Bidirectional instrumental variable (IV) estimated association between 25(OH)D and NAFLD by unweighted GRSs. Data were presented as regression coefficient (β) or odds ratio (OR) and 95% confidence interval (CI). In this MR framework, the instrumental variable estimators are OR IV(VD-NAFLD) = exp (ln (OR VD_GRS-NAFLD )/β VD_GRS-25(OH)D ) and β IV(NAFLD-VD) = β NAFLD_GRS-25(OH)D /ln (OR NAFLD_GRS-NAFLD ). Data were adjusted for age, sex, BMI, current smoking, hypertension, diabetes, HDL-cholesterol, LDL-cholesterol and triglycerides. 25(OH)D, 25-hydroxyvitamin D; VD_GRS, vitamin D genetic risk score; NAFLD_GRS, nonalcoholic fatty liver disease genetic risk score; SD, standard deviation.

    Article Snippet: Fasting plasma glucose, triglycerides, total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were measured using the AU 680 (Beckman Coulter, Brea, USA).

    Techniques: Standard Deviation

    Bidirectional instrumental variable (IV) estimated association between 25(OH)D and NAFLD by weighted GRSs. Data were presented as regression coefficient (β) or odds ratio (OR) and 95% confidence interval (CI). In this MR framework, the instrumental variable estimators are OR IV(VD-NAFLD) = exp (ln (OR VD_GRS-NAFLD )/β VD_GRS-25(OH)D ) and β IV(NAFLD-VD) = β NAFLD_GRS-25(OH)D /ln (OR NAFLD_GRS-NAFLD ). Data were adjusted for age, sex, BMI, current smoking, hypertension, diabetes, HDL-cholesterol, LDL-cholesterol and triglycerides. 25(OH)D, 25-hydroxyvitamin D; VD_GRS, vitamin D genetic risk score; NAFLD_GRS, nonalcoholic fatty liver disease genetic risk score; SD, standard deviation.

    Journal: EBioMedicine

    Article Title: Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis

    doi: 10.1016/j.ebiom.2017.12.027

    Figure Lengend Snippet: Bidirectional instrumental variable (IV) estimated association between 25(OH)D and NAFLD by weighted GRSs. Data were presented as regression coefficient (β) or odds ratio (OR) and 95% confidence interval (CI). In this MR framework, the instrumental variable estimators are OR IV(VD-NAFLD) = exp (ln (OR VD_GRS-NAFLD )/β VD_GRS-25(OH)D ) and β IV(NAFLD-VD) = β NAFLD_GRS-25(OH)D /ln (OR NAFLD_GRS-NAFLD ). Data were adjusted for age, sex, BMI, current smoking, hypertension, diabetes, HDL-cholesterol, LDL-cholesterol and triglycerides. 25(OH)D, 25-hydroxyvitamin D; VD_GRS, vitamin D genetic risk score; NAFLD_GRS, nonalcoholic fatty liver disease genetic risk score; SD, standard deviation.

    Article Snippet: Fasting plasma glucose, triglycerides, total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were measured using the AU 680 (Beckman Coulter, Brea, USA).

    Techniques: Standard Deviation

    Inflammation increased lipid accumulation to accelerate tubulointerstitial injuries. Eight-week-old diabetic db/db mice were randomly assigned and received subcutaneous injections with either 0.5 mL distilled water ( db/db , n =10) or 0.5 mL 10% casein ( db/db +casein, n =10) every other day for 8 weeks. HK-2 cells were made quiescent using serum-free medium for 24 h, and treated with 30 mmol/L glucose (HG) or 30 mmol/L glucose plus 5 ng/mL IL-1β. TG, triglyceride; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein (A). Filipin staining was used to examine lipid accumulation both in vivo and in vitro (B and D, original magnification ×200). The concentration of cholesterol ester was measured both in vivo (C, n =5) and in vitro (E). The results represent the mean±SD. * P

    Journal: Acta Pharmacologica Sinica

    Article Title: Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy

    doi: 10.1038/aps.2017.177

    Figure Lengend Snippet: Inflammation increased lipid accumulation to accelerate tubulointerstitial injuries. Eight-week-old diabetic db/db mice were randomly assigned and received subcutaneous injections with either 0.5 mL distilled water ( db/db , n =10) or 0.5 mL 10% casein ( db/db +casein, n =10) every other day for 8 weeks. HK-2 cells were made quiescent using serum-free medium for 24 h, and treated with 30 mmol/L glucose (HG) or 30 mmol/L glucose plus 5 ng/mL IL-1β. TG, triglyceride; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein (A). Filipin staining was used to examine lipid accumulation both in vivo and in vitro (B and D, original magnification ×200). The concentration of cholesterol ester was measured both in vivo (C, n =5) and in vitro (E). The results represent the mean±SD. * P

    Article Snippet: Serum levels of triglycerides (TGs), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were measured by automatic analyzers (Hitachi, Tokyo, Japan).

    Techniques: Mouse Assay, Staining, In Vivo, In Vitro, Concentration Assay

    Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for LDL, HDL, total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA

    Journal: Thyroid

    Article Title: Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

    doi: 10.1089/thy.2014.0262

    Figure Lengend Snippet: Comparison between the whole and the euthyroid subsample. Top: Estimated mean levels for LDL, HDL, total cholesterol, total triglyceride, leptin, and vaspin with 95% confidence intervals by serum 3,5-diiodothyronine concentrations calculated by ANOVA

    Article Snippet: High-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were selectively precipitated and then determined by homogenous assays (Dimension VISTA, Siemens Healthcare Diagnostics).

    Techniques:

    Extended ACK treatment alters metabolic factors. (A) ACK-mediated effects on fasting and non-fasting blood glucose in WT mice. (B) ACK-mediated effects on fasting insulin in WT mice. (C) ACK-mediated effects on the oral glucose tolerance test (OGTT) (water-treated control, black line: ACK-treated, red line). (D) ACK-mediated effects on OGTT AUC (Area Under Curve). ACK-mediated effects on pancreatic islet gross cellular morphology (E) and islet size (F). Insulin-secreting beta cells (red fluorescence) and Glucagon-secreting alpha cells (green fluorescence). Effect of ACK on pancreatic islet size (E), beta cell percentage (G) alpha cell percentage (H). Effects of ACK treatment on levels of leptin (I), gastrointestinal inhibitory peptide (GIP: J), pancreatic polypeptide (PP: K) and peptide YY (PYY: L). ACK effects on total plasma cholesterol (M). ACK effects on plasma lipoproteins: low-density lipoprotein (LDL: N); high-density lipoprotein (HDL: O); LDL:HDL plasma level ratio is indicated in panel (P). ACK effects on plasma triglycerides and ketone bodies (Q) and (R). A Student’s t-test was used for comparisons between control and ACK treatment group. Data are means ± SEM. *p≤0.05, n = 6–8/group.

    Journal: PLoS ONE

    Article Title: Long-Term Artificial Sweetener Acesulfame Potassium Treatment Alters Neurometabolic Functions in C57BL/6J Mice

    doi: 10.1371/journal.pone.0070257

    Figure Lengend Snippet: Extended ACK treatment alters metabolic factors. (A) ACK-mediated effects on fasting and non-fasting blood glucose in WT mice. (B) ACK-mediated effects on fasting insulin in WT mice. (C) ACK-mediated effects on the oral glucose tolerance test (OGTT) (water-treated control, black line: ACK-treated, red line). (D) ACK-mediated effects on OGTT AUC (Area Under Curve). ACK-mediated effects on pancreatic islet gross cellular morphology (E) and islet size (F). Insulin-secreting beta cells (red fluorescence) and Glucagon-secreting alpha cells (green fluorescence). Effect of ACK on pancreatic islet size (E), beta cell percentage (G) alpha cell percentage (H). Effects of ACK treatment on levels of leptin (I), gastrointestinal inhibitory peptide (GIP: J), pancreatic polypeptide (PP: K) and peptide YY (PYY: L). ACK effects on total plasma cholesterol (M). ACK effects on plasma lipoproteins: low-density lipoprotein (LDL: N); high-density lipoprotein (HDL: O); LDL:HDL plasma level ratio is indicated in panel (P). ACK effects on plasma triglycerides and ketone bodies (Q) and (R). A Student’s t-test was used for comparisons between control and ACK treatment group. Data are means ± SEM. *p≤0.05, n = 6–8/group.

    Article Snippet: Plasma lipid levels including triglycerides, total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were assayed according to the manufacturer’s instructions (Wako Chemicals USA, Inc., Richmond, VA).

    Techniques: Mouse Assay, Fluorescence