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  • 86
    Millipore herg blockers
    ( A ) Blocking SEI channel activity in ppk29 mutants with the <t>hERG</t> channel <t>blocker</t> <t>Cisapride</t> eliminate the protective effect in a dose dependent manner (n = 8 per genotype, p<0.01, two-way ANOVA; genotype, dose, and genotype by dose showed significant effects, p =<0.001). ( B ) Schematic representation of transgenic constructs. ( C ) Neuronal expression of ppk29 -3′UTR is sufficient to rescue the majority of the protective effect of the ppk29 mutation (n = 12, p<0.01, one-way ANOVA). Data are presented as mean ± SEM. Different letters above bars represent significantly different groups (Tukey post hoc analysis, p<0.05). ( D ) Neuronal expression of sei cDNA with or without its endogenous 3′UTR, but not the 3′UTR alone , is sufficient to rescue the sei mutation (n = 12, p<0.001, one-way ANOVA). DOI: http://dx.doi.org/10.7554/eLife.01849.015
    Herg Blockers, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Trinity Biotech herg blockers
    Expression analysis as measured by RT–qPCR of cardiac ion channel genes and sarcomeric protein TNNT2 gene in undifferentiated hiPSCs and hiPSC‐CMs. Data are expressed as fold change versus. RPL37A . N = 3. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. QT intervals (left), RR intervals (right) and QTcB intervals measured with MEA in CMs derived from all the control hPSC lines under baseline conditions. N = 17. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. Data Information: (A) Kruskal–Wallis test with Dunn's multiple comparisons test: <t>hERG</t> 1a/b: JLNS R594Q versus Undiff.: <t>0.0296;</t> <t>LQT2</t> corr versus Undiff.: 0.0011. hERG 1a: JLNS R594Q versus Undiff.: 0.0088; LQT2 corr versus Undiff.: 0.0012. KCNE2: LQT2 corr versus Undiff.: 0.0012; LQT2 N996I versus Undiff.: 0.0468. TNNT2: WT versus Undiff.: 0.0458; LQT1 R594Q versus Undiff.: 0.0320; JLNS R594Q versus Undiff.: 0.0052; LQT2 corr versus Undiff.: 0.0444. LQT2 N996I versus Undiff.: 0.0468. LQT1 corr versus Undiff.: 0.0444. LQT1 R190Q versus Undiff.: 0.0493. CACNA1c: LQT1 R594Q versus Undiff.: 0.0076; JLNS R594Q versus Undiff.: 0.0429; LQT2 corr versus Undiff.: 0.0164. KCNJ12: LQT2 corr versus Undiff.: 0.0024; LQT2 corr versus LQT1 corr : 0.0060. (B) One‐way ANOVA with Holm–Sidak's multiple comparison test: QT intervals: WT versus LQT1 corr : < 0.0001; LQT2 corr versus LQT1 corr : 0.0006; LQT1 corr versus hESC WT : < 0.0001. RR intervals: WT versus LQT1 corr : < 0.0001; WT versus LQT2 corr : 0.0009; WT versus hESC WT : < 0.0001. QTc B : WT versus LQT1 corr : 0.0475; LQT1 corr versus LQT2 corr : 0.0432; LQT1 corr versus hESC WT : < 0.0001. LQT2 corr versus hESC WT : 0.0432. (A, B) Data are expressed and plotted as the mean ± SEM. Source data are available online for this figure.
    Herg Blockers, supplied by Trinity Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Thermo Fisher herg blockers
    Expression analysis as measured by RT–qPCR of cardiac ion channel genes and sarcomeric protein TNNT2 gene in undifferentiated hiPSCs and hiPSC‐CMs. Data are expressed as fold change versus. RPL37A . N = 3. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. QT intervals (left), RR intervals (right) and QTcB intervals measured with MEA in CMs derived from all the control hPSC lines under baseline conditions. N = 17. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. Data Information: (A) Kruskal–Wallis test with Dunn's multiple comparisons test: <t>hERG</t> 1a/b: JLNS R594Q versus Undiff.: <t>0.0296;</t> <t>LQT2</t> corr versus Undiff.: 0.0011. hERG 1a: JLNS R594Q versus Undiff.: 0.0088; LQT2 corr versus Undiff.: 0.0012. KCNE2: LQT2 corr versus Undiff.: 0.0012; LQT2 N996I versus Undiff.: 0.0468. TNNT2: WT versus Undiff.: 0.0458; LQT1 R594Q versus Undiff.: 0.0320; JLNS R594Q versus Undiff.: 0.0052; LQT2 corr versus Undiff.: 0.0444. LQT2 N996I versus Undiff.: 0.0468. LQT1 corr versus Undiff.: 0.0444. LQT1 R190Q versus Undiff.: 0.0493. CACNA1c: LQT1 R594Q versus Undiff.: 0.0076; JLNS R594Q versus Undiff.: 0.0429; LQT2 corr versus Undiff.: 0.0164. KCNJ12: LQT2 corr versus Undiff.: 0.0024; LQT2 corr versus LQT1 corr : 0.0060. (B) One‐way ANOVA with Holm–Sidak's multiple comparison test: QT intervals: WT versus LQT1 corr : < 0.0001; LQT2 corr versus LQT1 corr : 0.0006; LQT1 corr versus hESC WT : < 0.0001. RR intervals: WT versus LQT1 corr : < 0.0001; WT versus LQT2 corr : 0.0009; WT versus hESC WT : < 0.0001. QTc B : WT versus LQT1 corr : 0.0475; LQT1 corr versus LQT2 corr : 0.0432; LQT1 corr versus hESC WT : < 0.0001. LQT2 corr versus hESC WT : 0.0432. (A, B) Data are expressed and plotted as the mean ± SEM. Source data are available online for this figure.
    Herg Blockers, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Cayman Chemical herg channel blocker
    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
    Herg Channel Blocker, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Eli Lilly herg blocker fluoxetine
    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
    Herg Blocker Fluoxetine, supplied by Eli Lilly, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    ( A ) Blocking SEI channel activity in ppk29 mutants with the hERG channel blocker Cisapride eliminate the protective effect in a dose dependent manner (n = 8 per genotype, p<0.01, two-way ANOVA; genotype, dose, and genotype by dose showed significant effects, p =<0.001). ( B ) Schematic representation of transgenic constructs. ( C ) Neuronal expression of ppk29 -3′UTR is sufficient to rescue the majority of the protective effect of the ppk29 mutation (n = 12, p<0.01, one-way ANOVA). Data are presented as mean ± SEM. Different letters above bars represent significantly different groups (Tukey post hoc analysis, p<0.05). ( D ) Neuronal expression of sei cDNA with or without its endogenous 3′UTR, but not the 3′UTR alone , is sufficient to rescue the sei mutation (n = 12, p<0.001, one-way ANOVA). DOI: http://dx.doi.org/10.7554/eLife.01849.015

    Journal: eLife

    Article Title: Natural antisense transcripts regulate the neuronal stress response and excitability

    doi: 10.7554/eLife.01849

    Figure Lengend Snippet: ( A ) Blocking SEI channel activity in ppk29 mutants with the hERG channel blocker Cisapride eliminate the protective effect in a dose dependent manner (n = 8 per genotype, p<0.01, two-way ANOVA; genotype, dose, and genotype by dose showed significant effects, p =<0.001). ( B ) Schematic representation of transgenic constructs. ( C ) Neuronal expression of ppk29 -3′UTR is sufficient to rescue the majority of the protective effect of the ppk29 mutation (n = 12, p<0.01, one-way ANOVA). Data are presented as mean ± SEM. Different letters above bars represent significantly different groups (Tukey post hoc analysis, p<0.05). ( D ) Neuronal expression of sei cDNA with or without its endogenous 3′UTR, but not the 3′UTR alone , is sufficient to rescue the sei mutation (n = 12, p<0.001, one-way ANOVA). DOI: http://dx.doi.org/10.7554/eLife.01849.015

    Article Snippet: Stock solutions of hERG blockers were kept as 10 mM Cisapride (Sigma-Aldrich, St. Louis, MO, USA) in DMSO and 100 mM E 4301 (Alomone labs, Jerusalem, Israel) in distilled water.

    Techniques: Blocking Assay, Activity Assay, Transgenic Assay, Construct, Expressing, Mutagenesis

    Treating ppk29 mutants flies with hERG inhibitors cisapride ( A ) and E−4301 ( B ) lead to a significantly faster heat-induced seizures and paralyses in all tested genotypes (n = 8 for each genotype, two-way ANOVA with a Tukey's post-hoc test; the interaction between genotype and concentration is significant for both drugs, p =<0.001). Average data are presented as mean ± SEM. Different letters above bars represent significantly different groups. DOI: http://dx.doi.org/10.7554/eLife.01849.016

    Journal: eLife

    Article Title: Natural antisense transcripts regulate the neuronal stress response and excitability

    doi: 10.7554/eLife.01849

    Figure Lengend Snippet: Treating ppk29 mutants flies with hERG inhibitors cisapride ( A ) and E−4301 ( B ) lead to a significantly faster heat-induced seizures and paralyses in all tested genotypes (n = 8 for each genotype, two-way ANOVA with a Tukey's post-hoc test; the interaction between genotype and concentration is significant for both drugs, p =<0.001). Average data are presented as mean ± SEM. Different letters above bars represent significantly different groups. DOI: http://dx.doi.org/10.7554/eLife.01849.016

    Article Snippet: Stock solutions of hERG blockers were kept as 10 mM Cisapride (Sigma-Aldrich, St. Louis, MO, USA) in DMSO and 100 mM E 4301 (Alomone labs, Jerusalem, Israel) in distilled water.

    Techniques: Concentration Assay

    Expression analysis as measured by RT–qPCR of cardiac ion channel genes and sarcomeric protein TNNT2 gene in undifferentiated hiPSCs and hiPSC‐CMs. Data are expressed as fold change versus. RPL37A . N = 3. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. QT intervals (left), RR intervals (right) and QTcB intervals measured with MEA in CMs derived from all the control hPSC lines under baseline conditions. N = 17. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. Data Information: (A) Kruskal–Wallis test with Dunn's multiple comparisons test: hERG 1a/b: JLNS R594Q versus Undiff.: 0.0296; LQT2 corr versus Undiff.: 0.0011. hERG 1a: JLNS R594Q versus Undiff.: 0.0088; LQT2 corr versus Undiff.: 0.0012. KCNE2: LQT2 corr versus Undiff.: 0.0012; LQT2 N996I versus Undiff.: 0.0468. TNNT2: WT versus Undiff.: 0.0458; LQT1 R594Q versus Undiff.: 0.0320; JLNS R594Q versus Undiff.: 0.0052; LQT2 corr versus Undiff.: 0.0444. LQT2 N996I versus Undiff.: 0.0468. LQT1 corr versus Undiff.: 0.0444. LQT1 R190Q versus Undiff.: 0.0493. CACNA1c: LQT1 R594Q versus Undiff.: 0.0076; JLNS R594Q versus Undiff.: 0.0429; LQT2 corr versus Undiff.: 0.0164. KCNJ12: LQT2 corr versus Undiff.: 0.0024; LQT2 corr versus LQT1 corr : 0.0060. (B) One‐way ANOVA with Holm–Sidak's multiple comparison test: QT intervals: WT versus LQT1 corr : < 0.0001; LQT2 corr versus LQT1 corr : 0.0006; LQT1 corr versus hESC WT : < 0.0001. RR intervals: WT versus LQT1 corr : < 0.0001; WT versus LQT2 corr : 0.0009; WT versus hESC WT : < 0.0001. QTc B : WT versus LQT1 corr : 0.0475; LQT1 corr versus LQT2 corr : 0.0432; LQT1 corr versus hESC WT : < 0.0001. LQT2 corr versus hESC WT : 0.0432. (A, B) Data are expressed and plotted as the mean ± SEM. Source data are available online for this figure.

    Journal: EMBO Molecular Medicine

    Article Title: A new hERG allosteric modulator rescues genetic and drug‐induced long‐ QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

    doi: 10.15252/emmm.201606260

    Figure Lengend Snippet: Expression analysis as measured by RT–qPCR of cardiac ion channel genes and sarcomeric protein TNNT2 gene in undifferentiated hiPSCs and hiPSC‐CMs. Data are expressed as fold change versus. RPL37A . N = 3. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. QT intervals (left), RR intervals (right) and QTcB intervals measured with MEA in CMs derived from all the control hPSC lines under baseline conditions. N = 17. * P < 0.05. The colour of the asterisks indicates comparisons and relative statistical significance. Data Information: (A) Kruskal–Wallis test with Dunn's multiple comparisons test: hERG 1a/b: JLNS R594Q versus Undiff.: 0.0296; LQT2 corr versus Undiff.: 0.0011. hERG 1a: JLNS R594Q versus Undiff.: 0.0088; LQT2 corr versus Undiff.: 0.0012. KCNE2: LQT2 corr versus Undiff.: 0.0012; LQT2 N996I versus Undiff.: 0.0468. TNNT2: WT versus Undiff.: 0.0458; LQT1 R594Q versus Undiff.: 0.0320; JLNS R594Q versus Undiff.: 0.0052; LQT2 corr versus Undiff.: 0.0444. LQT2 N996I versus Undiff.: 0.0468. LQT1 corr versus Undiff.: 0.0444. LQT1 R190Q versus Undiff.: 0.0493. CACNA1c: LQT1 R594Q versus Undiff.: 0.0076; JLNS R594Q versus Undiff.: 0.0429; LQT2 corr versus Undiff.: 0.0164. KCNJ12: LQT2 corr versus Undiff.: 0.0024; LQT2 corr versus LQT1 corr : 0.0060. (B) One‐way ANOVA with Holm–Sidak's multiple comparison test: QT intervals: WT versus LQT1 corr : < 0.0001; LQT2 corr versus LQT1 corr : 0.0006; LQT1 corr versus hESC WT : < 0.0001. RR intervals: WT versus LQT1 corr : < 0.0001; WT versus LQT2 corr : 0.0009; WT versus hESC WT : < 0.0001. QTc B : WT versus LQT1 corr : 0.0475; LQT1 corr versus LQT2 corr : 0.0432; LQT1 corr versus hESC WT : < 0.0001. LQT2 corr versus hESC WT : 0.0432. (A, B) Data are expressed and plotted as the mean ± SEM. Source data are available online for this figure.

    Article Snippet: Asymptomatic or borderline LQTS mutation carriers are highly represented in the LQTS population [36 and 19%, respectively, for LQT1 and LQT2 (Schwartz et al , )], and they are particularly susceptible to hERG blockers (Fitzgerald & Ackerman, ).

    Techniques: Expressing, Quantitative RT-PCR, Derivative Assay

    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a hERG channel blocker (E-4031), calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.

    Journal: bioRxiv

    Article Title: hiPSC-CM Electrophysiology: Impact of Temporal Changes and Study Parameters on Experimental Reproducibility

    doi: 10.1101/2023.10.02.560475

    Figure Lengend Snippet: hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a hERG channel blocker (E-4031), calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.

    Article Snippet: A hERG channel blocker (50 nM E-4031, #15203 Cayman Chemical) was tested for its ability to prolong FPD and APD( , , ).

    Techniques: Whisker Assay, Two Tailed Test