g12d Search Results


k ras lsl g12d  (Addgene inc)
94
Addgene inc k ras lsl g12d
K Ras Lsl G12d, supplied by Addgene inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti g12dras  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc anti g12dras
Anti G12dras, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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plex ha bira k ras g12d ires puro  (Addgene inc)
92
Addgene inc plex ha bira k ras g12d ires puro
Plex Ha Bira K Ras G12d Ires Puro, supplied by Addgene inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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kras g12d  (Addgene inc)
94
Addgene inc kras g12d
Kras G12d, supplied by Addgene inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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pat15484 hf abe8e  (Addgene inc)
91
Addgene inc pat15484 hf abe8e
a The heatmap shows mean on-target activity of three parallel transfections normalised to the active splice donor site plasmid. A set of 34 previously used targets (Fig. ) were used to determine on-target editing efficiencies of dABE8e, nABE8e and 6 increased fidelity <t>ABE8e</t> base editors. b Mismatch tolerance of ABE8e and its increased fidelity variants were compared utilising the exact same matching sgRNA (target 1 in Fig. ) and 50 sgRNAs mismatching in one, two, three, four or five positions as indicated as red letters. Blue and yellow heatmaps show the mean normalised activity (off-target/on-target) derived from three parallel transfections. White and red heatmaps show the mean on-target activity (percentages of GFP positive cells) derived from three parallel transfections. For source data see the Source Data file.
Pat15484 Hf Abe8e, supplied by Addgene inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


a The heatmap shows mean on-target activity of three parallel transfections normalised to the active splice donor site plasmid. A set of 34 previously used targets (Fig. ) were used to determine on-target editing efficiencies of dABE8e, nABE8e and 6 increased fidelity ABE8e base editors. b Mismatch tolerance of ABE8e and its increased fidelity variants were compared utilising the exact same matching sgRNA (target 1 in Fig. ) and 50 sgRNAs mismatching in one, two, three, four or five positions as indicated as red letters. Blue and yellow heatmaps show the mean normalised activity (off-target/on-target) derived from three parallel transfections. White and red heatmaps show the mean on-target activity (percentages of GFP positive cells) derived from three parallel transfections. For source data see the Source Data file.

Journal: Nature Communications

Article Title: BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors

doi: 10.1038/s41467-021-26461-y

Figure Lengend Snippet: a The heatmap shows mean on-target activity of three parallel transfections normalised to the active splice donor site plasmid. A set of 34 previously used targets (Fig. ) were used to determine on-target editing efficiencies of dABE8e, nABE8e and 6 increased fidelity ABE8e base editors. b Mismatch tolerance of ABE8e and its increased fidelity variants were compared utilising the exact same matching sgRNA (target 1 in Fig. ) and 50 sgRNAs mismatching in one, two, three, four or five positions as indicated as red letters. Blue and yellow heatmaps show the mean normalised activity (off-target/on-target) derived from three parallel transfections. White and red heatmaps show the mean on-target activity (percentages of GFP positive cells) derived from three parallel transfections. For source data see the Source Data file.

Article Snippet: The following plasmids developed in this study are available from Addgene: pAT9624-BEAR-cloning (#162986), pAT9658-sgRNA-mCherry (#162987), pAT9679-sgRNA-BFP (#162988), pAT9651-BEAR-GFP (#162989), pAT9750-BEAR-mCherry (#162990), pAT9752-BEAR-mScarlet (#162991), pAT9650-BEAR-GFP-active (#162992), pAT9751-BEAR-mCherry-active (#162993), pAT9753-BEAR-mScarlet-active (#162994), pAT15415-BEAR-GFP-target-mCherry (#162995), pAT15416-BEAR-mScarlet-target-BFP (#162996), pAT9676-ABE (#162997), pAT9749-dABE (#162998), pAT9991-eABE (#162999), pAT9992-HF-ABE (#163000), pAT9993-Hypa-ABE (#163001), pAT9994-HypaR661A-ABE (#163002), pAT9995-evoABE (#163003), pAT9996-HeF-ABE (#163004), pAT9675-CBE (#163007), pAT9748-dCBE (#163008), pAT15064-eCBE (#163009), pAT15065-HF-CBE (#163010), pAT15066-Hypa-CBE (#163011), pAT15067-HypaA-CBE (#163012), pAT15068-evoCBE (#163013), pAT15069-HeF-CBE (#163014), pAT15516-BEAR-GFP-2in1 (#174082), pAT15482_ABE8e (#174120), pAT15483_e-ABE8e (#174121), pAT15484_HF-ABE8e (#174122), pAT15485_Hypa-ABE8e (#174123), pAT15486_HypaR661A-ABE8e (#174124), pAT15487_evo-ABE8e (#174125), pAT15488_HeF-ABE8e (#174126), pAT15489_dABE8e (#174127).

Techniques: Activity Assay, Transfection, Plasmid Preparation, Derivative Assay