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  • 99
    Lonza penicillin streptomycin amphotericin b
    Penicillin Streptomycin Amphotericin B, supplied by Lonza, used in various techniques. Bioz Stars score: 99/100, based on 285 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Thermo Fisher fungizone
    Fungizone, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 9206 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    97
    Millipore fungizone
    Fungizone, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 1271 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Gilead Sciences liposomal amphotericin b
    Liposomal Amphotericin B, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 92/100, based on 363 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Thermo Fisher penicillin streptomycin amphotericin b
    Penicillin Streptomycin Amphotericin B, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 759 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Gilead Sciences fungizone
    Size distribution and morphology of AmB–PGA nanoparticles. Notes: ( A ) The Z-average diameter of the AmB–PGA nanoparticles determined by dynamic light scattering measurements was 107±0.7 nm. ( B ) Transmission electron microscopy showed that the AmB–PGA nanoparticles were spherical in shape with an average size of 98±2 nm. ( C ) Particle size distribution of AmB–PGA nanoparticles assessed by photon correlation spectroscopy. ( D1 ) Phase contrast light and ( D2 ) fluorescence micrographs of normal peritoneal macrophages after their interaction with calcein (fluorescent probe)-loaded PGA nanoparticles. Abbreviations: AmB, <t>amphotericin</t> B; PGA, polyglutamic acid.
    Fungizone, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bristol Myers fungizone
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Fungizone, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 92/100, based on 388 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Astellas liposomal amphotericin b
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Liposomal Amphotericin B, supplied by Astellas, used in various techniques. Bioz Stars score: 92/100, based on 74 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Millipore penicillin streptomycin amphotericin b
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Penicillin Streptomycin Amphotericin B, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 174 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Lonza fungizone
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Fungizone, supplied by Lonza, used in various techniques. Bioz Stars score: 99/100, based on 289 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    97
    Lonza gentamicin amphotericin
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Gentamicin Amphotericin, supplied by Lonza, used in various techniques. Bioz Stars score: 97/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Gemini Bio fungizone
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Fungizone, supplied by Gemini Bio, used in various techniques. Bioz Stars score: 92/100, based on 182 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    GE Healthcare fungizone
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Fungizone, supplied by GE Healthcare, used in various techniques. Bioz Stars score: 99/100, based on 82 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Thermo Fisher gentamicin amphotericin solution
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Gentamicin Amphotericin Solution, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 71 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Corning Life Sciences amphotericin b
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Amphotericin B, supplied by Corning Life Sciences, used in various techniques. Bioz Stars score: 93/100, based on 66 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    89
    Bristol Myers amphotericin b deoxycholate
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Amphotericin B Deoxycholate, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 89/100, based on 46 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Millipore amphotericin b solution
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Amphotericin B Solution, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 35 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Cambrex fungizone
    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, <t>amphotericin</t> B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.
    Fungizone, supplied by Cambrex, used in various techniques. Bioz Stars score: 92/100, based on 110 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Size distribution and morphology of AmB–PGA nanoparticles. Notes: ( A ) The Z-average diameter of the AmB–PGA nanoparticles determined by dynamic light scattering measurements was 107±0.7 nm. ( B ) Transmission electron microscopy showed that the AmB–PGA nanoparticles were spherical in shape with an average size of 98±2 nm. ( C ) Particle size distribution of AmB–PGA nanoparticles assessed by photon correlation spectroscopy. ( D1 ) Phase contrast light and ( D2 ) fluorescence micrographs of normal peritoneal macrophages after their interaction with calcein (fluorescent probe)-loaded PGA nanoparticles. Abbreviations: AmB, amphotericin B; PGA, polyglutamic acid.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Size distribution and morphology of AmB–PGA nanoparticles. Notes: ( A ) The Z-average diameter of the AmB–PGA nanoparticles determined by dynamic light scattering measurements was 107±0.7 nm. ( B ) Transmission electron microscopy showed that the AmB–PGA nanoparticles were spherical in shape with an average size of 98±2 nm. ( C ) Particle size distribution of AmB–PGA nanoparticles assessed by photon correlation spectroscopy. ( D1 ) Phase contrast light and ( D2 ) fluorescence micrographs of normal peritoneal macrophages after their interaction with calcein (fluorescent probe)-loaded PGA nanoparticles. Abbreviations: AmB, amphotericin B; PGA, polyglutamic acid.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: Transmission Assay, Electron Microscopy, Spectroscopy, Fluorescence

    In vitro killing assay. Notes: Intracellular antifungal activity of the AmB–PGA formulation against Candida albicans inside RAW 264.7 cells. Macrophages were infected with C. albicans and treated with AmB–PGA nanoparticles. Percentage of infection was calculated by lysing macrophages (after 24 hours of treatment) with Triton X-100 (0.2%), subculturing in Sabouraud agar plates, and comparing with an untreated control. Experiments were carried out in triplicate. Each datum point represents the mean ± standard deviation. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; CFU, colony forming units; PGA, polyglutamic acid.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: In vitro killing assay. Notes: Intracellular antifungal activity of the AmB–PGA formulation against Candida albicans inside RAW 264.7 cells. Macrophages were infected with C. albicans and treated with AmB–PGA nanoparticles. Percentage of infection was calculated by lysing macrophages (after 24 hours of treatment) with Triton X-100 (0.2%), subculturing in Sabouraud agar plates, and comparing with an untreated control. Experiments were carried out in triplicate. Each datum point represents the mean ± standard deviation. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; CFU, colony forming units; PGA, polyglutamic acid.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: In Vitro, Activity Assay, Infection, Subculturing Assay, Standard Deviation

    Absorption spectra of the AmB–PGA nanoparticle formulation and commercially available formulations of AmB (AmB-L, AmB-D) in ( A ) aqueous medium and ( B ) organic solvent. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; PGA, polyglutamic acid.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Absorption spectra of the AmB–PGA nanoparticle formulation and commercially available formulations of AmB (AmB-L, AmB-D) in ( A ) aqueous medium and ( B ) organic solvent. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; PGA, polyglutamic acid.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques:

    Scanning electron micrographs of inhibition of Candida albicans biofilm mediated by the AmB–PGA formulation. Notes: ( A ) Untreated control image of biofilm, ( B ) AmB-L treated biofilm, ( C ) biofilm treated with AmB-D, and ( D ) biofilm treated with AmB–PGA. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; PGA, polyglutamic acid.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Scanning electron micrographs of inhibition of Candida albicans biofilm mediated by the AmB–PGA formulation. Notes: ( A ) Untreated control image of biofilm, ( B ) AmB-L treated biofilm, ( C ) biofilm treated with AmB-D, and ( D ) biofilm treated with AmB–PGA. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; PGA, polyglutamic acid.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: Inhibition

    In vitro cytotoxicity assay. Dose–response effects of AmB–PGA formulation on cytotoxicity against ( A ) KB cells and ( B ) RAW 264.7 cells. Notes: The cells were exposed for 24 hours to various AmB formulations at different drug concentrations. MTT values were normalized to the control cells. The data are reported as the mean ± standard deviation of four experiments. Free drug is pure AmB used in preparation of the complex. Abbreviations: AmB, amphotericin B; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PGA, polyglutamic acid; AmB-D, Fungizone ® ; AmB-L, Ambisome ® .

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: In vitro cytotoxicity assay. Dose–response effects of AmB–PGA formulation on cytotoxicity against ( A ) KB cells and ( B ) RAW 264.7 cells. Notes: The cells were exposed for 24 hours to various AmB formulations at different drug concentrations. MTT values were normalized to the control cells. The data are reported as the mean ± standard deviation of four experiments. Free drug is pure AmB used in preparation of the complex. Abbreviations: AmB, amphotericin B; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PGA, polyglutamic acid; AmB-D, Fungizone ® ; AmB-L, Ambisome ® .

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: In Vitro, Cytotoxicity Assay, MTT Assay, Standard Deviation

    Semiquantitative measure of antibiofilm activity of PGA nanoparticles. Notes: Growth percentage was analyzed by comparing relative metabolic activity obtained by XTT metabolic assay taking the untreated control as 100%. The data represent the mean ± standard deviation of three determinants and are representative of three different experiments (ie, the experiment was done in triplicate) with similar observations. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; PGA, polyglutamic acid; XTT, 2, 3-bis(2-methoxy-4-nitro-5-sulfoph enyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Semiquantitative measure of antibiofilm activity of PGA nanoparticles. Notes: Growth percentage was analyzed by comparing relative metabolic activity obtained by XTT metabolic assay taking the untreated control as 100%. The data represent the mean ± standard deviation of three determinants and are representative of three different experiments (ie, the experiment was done in triplicate) with similar observations. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; PGA, polyglutamic acid; XTT, 2, 3-bis(2-methoxy-4-nitro-5-sulfoph enyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: Activity Assay, Metabolic Assay, Standard Deviation

    Hemolytic activity of AmB and AmB–PGA nanoparticles. The extent of damage caused to red blood cells by the AmB formulation was measured as percent lysis of total erythrocytes used in the individual sample. Notes: ( A ) Hemolysis caused by the AmB–PGA formulation after 1 hour of incubation with human red blood cells. ( B ) Hemolysis after a 24-hour incubation period. AmB-D, AmB-L and pure AmB used in preparation of the complex were used as controls. Data are pooled from three different experiments. Each datum point is a mean ± standard deviation. Abbreviations: AmB, amphotericin B; DMSO, dimethyl sulfoxide; PGA, polyglutamic acid; AmB-D, Fungizone ® ; AmB-L, Ambisome ® .

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Hemolytic activity of AmB and AmB–PGA nanoparticles. The extent of damage caused to red blood cells by the AmB formulation was measured as percent lysis of total erythrocytes used in the individual sample. Notes: ( A ) Hemolysis caused by the AmB–PGA formulation after 1 hour of incubation with human red blood cells. ( B ) Hemolysis after a 24-hour incubation period. AmB-D, AmB-L and pure AmB used in preparation of the complex were used as controls. Data are pooled from three different experiments. Each datum point is a mean ± standard deviation. Abbreviations: AmB, amphotericin B; DMSO, dimethyl sulfoxide; PGA, polyglutamic acid; AmB-D, Fungizone ® ; AmB-L, Ambisome ® .

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: Activity Assay, Lysis, Incubation, Standard Deviation

    Time course of AmB release from PGA formulation over a period of 10 days. Notes: AmB-loaded PGA nanoparticles were incubated in ( A ) sterile 20 mM phosphate-buffered saline (pH 7.4) and ( B ) serum. The amount of AmB released at different time points was spectrophotometrically analyzed at 405 nm. Each time point represents mean of triplicate readings ± standard deviation. Abbreviations: AmB, amphotericin B; PGA, polyglutamic acid.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Time course of AmB release from PGA formulation over a period of 10 days. Notes: AmB-loaded PGA nanoparticles were incubated in ( A ) sterile 20 mM phosphate-buffered saline (pH 7.4) and ( B ) serum. The amount of AmB released at different time points was spectrophotometrically analyzed at 405 nm. Each time point represents mean of triplicate readings ± standard deviation. Abbreviations: AmB, amphotericin B; PGA, polyglutamic acid.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: Incubation, Standard Deviation

    Representative time-kill curve plot for Candida albicans in the presence of AmB-D, AmB-L, or AmB–PGA at 4× minimum inhibitory concentration. Notes: Wells containing no antibiotic were taken as the control. Assays were performed in quadruplicate. Each result is representative of at least three separate experiments. All values are shown as the mean ± standard deviation. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; CFU, colony forming units; PGA, polyglutamic acid.

    Journal: International Journal of Nanomedicine

    Article Title: Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

    doi: 10.2147/IJN.S63155

    Figure Lengend Snippet: Representative time-kill curve plot for Candida albicans in the presence of AmB-D, AmB-L, or AmB–PGA at 4× minimum inhibitory concentration. Notes: Wells containing no antibiotic were taken as the control. Assays were performed in quadruplicate. Each result is representative of at least three separate experiments. All values are shown as the mean ± standard deviation. Abbreviations: AmB, amphotericin B; AmB-D, Fungizone ® ; AmB-L, Ambisome ® ; CFU, colony forming units; PGA, polyglutamic acid.

    Article Snippet: AmB-bearing PGA nanoparticles prepared in-house were investigated for their physical characteristics, stability, safety (both in vitro and in vivo), and in vitro antifungal efficacy in comparison with two commonly used formulations of AmB, ie, AmBisome and Fungizone.

    Techniques: Concentration Assay, Standard Deviation

    The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, amphotericin B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: The release profiles of AmB from buccal tablets using different dissolution apparatuses. Notes: ( A ) USP dissolution apparatus (in 0.5% SDS solution) and ( B ) the dissolution rate test apparatus (in pH 5.8 and pH 6.8 medium). T1, AmB+DOC; T2, AmB+MPP; T3, AmB/MPP micelles. Abbreviations: AmB, amphotericin B; SDS, sodium dodecyl sulfate; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; USP, United States Pharmacopeia.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques:

    Release profile of AmB-loaded micelles and redissolved micelles in different mediums. Abbreviations: AmB, amphotericin B; SDS, sodium dodecyl sulfate.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: Release profile of AmB-loaded micelles and redissolved micelles in different mediums. Abbreviations: AmB, amphotericin B; SDS, sodium dodecyl sulfate.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques:

    Histopathological observation of oral buccal tissues through injection with 5% dextrose solution, Fungizone (AmB+DOC), AmB/MPP micelles, and MPP blank micelles under a light microscope (400×) after dosing for 5, 15, and 30 days. Abbreviations: AmB, amphotericin B; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; d, days.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: Histopathological observation of oral buccal tissues through injection with 5% dextrose solution, Fungizone (AmB+DOC), AmB/MPP micelles, and MPP blank micelles under a light microscope (400×) after dosing for 5, 15, and 30 days. Abbreviations: AmB, amphotericin B; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; d, days.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques: Injection, Light Microscopy

    Cytotoxicity of AmB, Fungizone (AmB+DOC), AmB/MPP micelles, and MPP blank micelles incubation for ( A ) 24 h and ( B ) 12 h. Abbreviations: AmB, amphotericin B; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: Cytotoxicity of AmB, Fungizone (AmB+DOC), AmB/MPP micelles, and MPP blank micelles incubation for ( A ) 24 h and ( B ) 12 h. Abbreviations: AmB, amphotericin B; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques: Incubation

    Ultrastructure observation of oral buccal tissues through injection with 5% dextrose solution, Fungizone (AmB+DOC), AmB/MPP micelles, and MPP blank micelles after dosing for 30 days under transmission electron microscope. Notes: ( A ) Epithelial surface layer of the oral buccal tissues (10,000×); ( B ) epithelial middle layer containing prickle cells (10,000×); ( C ) basement membrane (30,000×, orange arrows pointed to the disappeared parts in the basement membrane of the AMB+DOC group); ( D ) desmosome junctions between epithelial cells (30,000×, orange arrows pointed to the residual desmosome junctions in AmB+DOC group). Abbreviations: AmB, amphotericin B; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: Ultrastructure observation of oral buccal tissues through injection with 5% dextrose solution, Fungizone (AmB+DOC), AmB/MPP micelles, and MPP blank micelles after dosing for 30 days under transmission electron microscope. Notes: ( A ) Epithelial surface layer of the oral buccal tissues (10,000×); ( B ) epithelial middle layer containing prickle cells (10,000×); ( C ) basement membrane (30,000×, orange arrows pointed to the disappeared parts in the basement membrane of the AMB+DOC group); ( D ) desmosome junctions between epithelial cells (30,000×, orange arrows pointed to the residual desmosome junctions in AmB+DOC group). Abbreviations: AmB, amphotericin B; DOC, sodium deoxycholate; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques: Injection, Transmission Assay, Microscopy

    ( A ) MIC values of AmB/MPP and AmB; ( B ) observation of Candida albicans mature biofilms under SEM; ( C ) C. albicans BBU, concentrations of drugs were μg/mL. Notes: *Statistical difference at P ,0.05. All data represent the mean ± SD (n=6). Abbreviations: MIC, minimum inhibitory concentration; AmB, amphotericin B; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; SEM, scanning electron microscope; BBU, biofilm biomass unit; SD, standard deviation; C.A., Candida albicans .

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: ( A ) MIC values of AmB/MPP and AmB; ( B ) observation of Candida albicans mature biofilms under SEM; ( C ) C. albicans BBU, concentrations of drugs were μg/mL. Notes: *Statistical difference at P ,0.05. All data represent the mean ± SD (n=6). Abbreviations: MIC, minimum inhibitory concentration; AmB, amphotericin B; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; SEM, scanning electron microscope; BBU, biofilm biomass unit; SD, standard deviation; C.A., Candida albicans .

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques: Concentration Assay, Microscopy, Standard Deviation

    ( A ) Spontaneous AmB-loaded micelles formation from amphiphilic molecules in aqueous media; ( B ) the chemical formula and the 1 H-NMR spectra (400 MHz, CDCl 3 ) of MPEG-PCL-g-PEI; ( C ) buccal tablets containing AmB+DOC (T1), AmB+MPEG-PCL-g-PEI physical mixtures (T2), and AmB/MPEG-PCL-g-PEI micelles (T3). Abbreviations: AmB, amphotericin B; MPEG-PCL-g-PEI, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; DOC, sodium deoxycholate.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: ( A ) Spontaneous AmB-loaded micelles formation from amphiphilic molecules in aqueous media; ( B ) the chemical formula and the 1 H-NMR spectra (400 MHz, CDCl 3 ) of MPEG-PCL-g-PEI; ( C ) buccal tablets containing AmB+DOC (T1), AmB+MPEG-PCL-g-PEI physical mixtures (T2), and AmB/MPEG-PCL-g-PEI micelles (T3). Abbreviations: AmB, amphotericin B; MPEG-PCL-g-PEI, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine; DOC, sodium deoxycholate.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques: Nuclear Magnetic Resonance

    ( A ) The particle size distribution spectrum of blank micelles and AmB-loaded micelles; ( B ) zeta potential of blank micelles and AmB-loaded micelles; ( C ) morphology of AmB-loaded micelles determined by TEM (scale bar 100 nm); ( D ) DSC analysis of (a) MPP, (b) AmB, (c) AmB/MPP micelles, and (d) AmB and MPP physical mixtures. Abbreviations: AmB, amphotericin B; TEM, transmission electron microscopy; DSC, differential scanning calorimetry; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine.

    Journal: International Journal of Nanomedicine

    Article Title: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans

    doi: 10.2147/IJN.S124264

    Figure Lengend Snippet: ( A ) The particle size distribution spectrum of blank micelles and AmB-loaded micelles; ( B ) zeta potential of blank micelles and AmB-loaded micelles; ( C ) morphology of AmB-loaded micelles determined by TEM (scale bar 100 nm); ( D ) DSC analysis of (a) MPP, (b) AmB, (c) AmB/MPP micelles, and (d) AmB and MPP physical mixtures. Abbreviations: AmB, amphotericin B; TEM, transmission electron microscopy; DSC, differential scanning calorimetry; MPP, monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine.

    Article Snippet: Thus, much effort has been expended to increase the water solubility of AmB., – Fungizone® (Bristol-Myers Squibb, Rueil-Malmaison, France) has been launched first as a colloidal dispersion combined with sodium deoxycholate (DOC) to develop a micellar dispersion for encapsulating AmB, which improves the solubility of AmB.

    Techniques: Transmission Electron Microscopy, Transmission Assay, Electron Microscopy