fundus autofluorescence Search Results


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  • 90
    heidelberg engineering fundus autofluorescence
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 115 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Carl Zeiss fundus autofluorescence
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 91/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Canon inc fundus autofluorescence faf
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence Faf, supplied by Canon inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    heidelberg engineering short wave blue 488nm fundus autofluorescence fundus autofluorescence faf
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Short Wave Blue 488nm Fundus Autofluorescence Fundus Autofluorescence Faf, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    heidelberg engineering fundus autofluorescence imaging
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence Imaging, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 70 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    89
    Carl Zeiss fundus autofluorescence imaging
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence Imaging, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 89/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    topcon fundus autofluorescence
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence, supplied by topcon, used in various techniques. Bioz Stars score: 91/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Optos plc fundus autofluorescence
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence, supplied by Optos plc, used in various techniques. Bioz Stars score: 91/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fundus autofluorescence/product/Optos plc
    Average 91 stars, based on 5 article reviews
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    90
    heidelberg engineering fundus autofluoresence
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluoresence, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    adobe systems fundus autofluorescence images
    Images of patient 2. Fundus autofluorescence <t>(FAF)</t> images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography <t>(SD-OCT)</t> images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively
    Fundus Autofluorescence Images, supplied by adobe systems, used in various techniques. Bioz Stars score: 90/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    heidelberg engineering fundus autofluorescence faf imaging
    (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of <t>SW-FAF</t> and NIR-FAF imaging are shown as insets. (B) <t>SD-OCT</t> horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.
    Fundus Autofluorescence Faf Imaging, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 88/100, based on 48 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Optos plc fundus autofluorescence imaging
    (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of <t>SW-FAF</t> and NIR-FAF imaging are shown as insets. (B) <t>SD-OCT</t> horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.
    Fundus Autofluorescence Imaging, supplied by Optos plc, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Optos plc ultra widefield fundus autofluorescence
    (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of <t>SW-FAF</t> and NIR-FAF imaging are shown as insets. (B) <t>SD-OCT</t> horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.
    Ultra Widefield Fundus Autofluorescence, supplied by Optos plc, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Carl Zeiss fundus autofluorescence faf imaging
    (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of <t>SW-FAF</t> and NIR-FAF imaging are shown as insets. (B) <t>SD-OCT</t> horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.
    Fundus Autofluorescence Faf Imaging, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 88/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Nidek fundus autofluorescence faf imaging
    (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of <t>SW-FAF</t> and NIR-FAF imaging are shown as insets. (B) <t>SD-OCT</t> horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.
    Fundus Autofluorescence Faf Imaging, supplied by Nidek, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Images of patient 2. Fundus autofluorescence (FAF) images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography (SD-OCT) images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively

    Journal: Molecular Vision

    Article Title: Familial discordance in Stargardt disease

    doi:

    Figure Lengend Snippet: Images of patient 2. Fundus autofluorescence (FAF) images C and D correspond with the white square regions in images A and B , respectively. The horizontal white dashed lines represent the position of the spectral domain-optical coherence tomography (SD-OCT) images E and F on the corresponding en face image. FAF revealed widespread retinal disease. Relative foveal sparing was present bilaterally as evidenced by a uniform autofluorescence pattern at the foveae (black arrows). The corresponding SD-OCT images revealed relative preservation of the inner segment–outer segment junctions of the photoreceptors (IS/OS), external limiting membrane (ELM), and outer nuclear layer (ONL) in this region. The horizontal borders of the regions with preserved IS/OS are indicated by the vertical white dashed lines on the corresponding FAF and SD-OCT images. Outside these regions, absence of IS/OS was associated with functionally preserved retinal pigment epithelium (RPE), at least as identified by FAF ( C , D ). Qualitatively normal thickness RPE was also observed in regions with loss of IS/OS ( F , white arrow).Corresponding size bars for A and B , C and D , and E and F are included in A , C and E , respectively

    Article Snippet: Clinical examination, fundus photography, fundus autofluorescence (FAF), and spectral domain-optical coherence tomography (SD-OCT; Heidelberg Spectralis HRA+OCT; Heidelberg Engineering, Dossenheim, Germany) were performed using standard acquisition protocols following pupil dilation with Guttae Tropicamide Minims 1% (Bausch and Lomb, Surrey, UK).

    Techniques: Preserving

    Color fundus photo ( top ), FAF ( middle ), and SD-OCT images ( bottom two rows ) in female CHM carriers. Outlines on color fundus photo and FAF images : location of AOSLO images. Black lines : horizontal SD-OCT scan locations; the span of the lower magnified

    Journal: Investigative Ophthalmology & Visual Science

    Article Title: High-Resolution Images of Retinal Structure in Patients with Choroideremia

    doi: 10.1167/iovs.12-10707

    Figure Lengend Snippet: Color fundus photo ( top ), FAF ( middle ), and SD-OCT images ( bottom two rows ) in female CHM carriers. Outlines on color fundus photo and FAF images : location of AOSLO images. Black lines : horizontal SD-OCT scan locations; the span of the lower magnified

    Article Snippet: SD-OCT and fundus autofluorescence (FAF) images were obtained (Spectralis HRA + OCT Laser Scanning Camera; Heidelberg Engineering, Vista, CA) in all members from families A, B, and D as previously described.

    Techniques:

    Color fundus photo ( top ), FAF ( middle ), and SD-OCT images in male CHM patients. In the most severely affected patient (B-IV-2, [ D ]), AOSLO images did not reveal unambiguous cone mosaics, although an island of hyperautofluorescent RPE and outer retinal

    Journal: Investigative Ophthalmology & Visual Science

    Article Title: High-Resolution Images of Retinal Structure in Patients with Choroideremia

    doi: 10.1167/iovs.12-10707

    Figure Lengend Snippet: Color fundus photo ( top ), FAF ( middle ), and SD-OCT images in male CHM patients. In the most severely affected patient (B-IV-2, [ D ]), AOSLO images did not reveal unambiguous cone mosaics, although an island of hyperautofluorescent RPE and outer retinal

    Article Snippet: SD-OCT and fundus autofluorescence (FAF) images were obtained (Spectralis HRA + OCT Laser Scanning Camera; Heidelberg Engineering, Vista, CA) in all members from families A, B, and D as previously described.

    Techniques:

    (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of SW-FAF and NIR-FAF imaging are shown as insets. (B) SD-OCT horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.

    Journal: Ophthalmic genetics

    Article Title: Detailed Functional and Structural Phenotype of Bietti Crystalline Dystrophy Associated with Mutations in CYP4V2 Complicated by Choroidal Neovascularization

    doi: 10.3109/13816810.2015.1126616

    Figure Lengend Snippet: (A) Fundus photography, fundus reflectance and autofluorescence imaging in the patient. Normal appearance of SW-FAF and NIR-FAF imaging are shown as insets. (B) SD-OCT horizontal, 9 mm cross sections through the fovea of the patient compared to a representative normal subject. Nuclear layers are labeled: outer nuclear layer = ONL, inner nuclear layer = INL, ganglion cell layer = GCL. Outer retinal layers are labeled ( diagonal arrows 1. OLM, 2. Ellipsoid, 3. Photoreceptor outer segment/RPE interdigitation, 4. RPE. Vertical arrow in the patient denotes boundary region where the retina transitions from a near normal appearance on FAF imaging in temporal (T) retina to a clearly abnormal signal nasally (N). (C) Horizontal sensitivity profiles measured with achromatic, light-adapted ( top panel ), and dark-adapted, chromatic (500 nm), automatic static perimetry in the patient compared to the normal range (g ray band = mean ± 2SD). Dark adapted photoreceptor mediation estimated with two color (500 nm and 650 nm) dark adapted perimetry is shown above the dark-adapted sensitivity profile (R = rod; M = mixed cone-rod; C = cone mediation). Gap in the dark-adapted, rod-mediated sensitivity profile corresponds to the rod free region near fixation. Hatched bar: blind spot.

    Article Snippet: SD-OCT, en face near infrared (NIR) reflectance (REF) and fundus autofluorescence (FAF) imaging to NIR and short-wavelength (SW) excitation lights was performed using a Spectralis-HRA system (Heidelberg Engineering GmbH, Heidelberg, Germany).

    Techniques: Imaging, Labeling

    (A) Magnified NIR-REF and SW-FAF from the patient. Arrows in the NIR-REF image denote regions sampled with SD-OCT and orientation of the magnified (B) cross-sections. (B) Magnified SD-OCT horizontal cross-section through the fovea into nasal retina in the patient compared with a normal subject. Scans are split at the fovea and flipped horizontally in the normal subject to facilitate comparisons of the details of the outer retinal lamination. Scans are vertically aligned by the RPE/Bruch's layers (C) Magnified SD-OCT scans from regions ‘ii’ (left panel) and ‘i’ (right panel) compared with sections from a normal subject. Stars denote RPE hyperreflectivities that correspond to yellow-white dots; arrow points to gap in the ellipsoid layer.

    Journal: Ophthalmic genetics

    Article Title: Detailed Functional and Structural Phenotype of Bietti Crystalline Dystrophy Associated with Mutations in CYP4V2 Complicated by Choroidal Neovascularization

    doi: 10.3109/13816810.2015.1126616

    Figure Lengend Snippet: (A) Magnified NIR-REF and SW-FAF from the patient. Arrows in the NIR-REF image denote regions sampled with SD-OCT and orientation of the magnified (B) cross-sections. (B) Magnified SD-OCT horizontal cross-section through the fovea into nasal retina in the patient compared with a normal subject. Scans are split at the fovea and flipped horizontally in the normal subject to facilitate comparisons of the details of the outer retinal lamination. Scans are vertically aligned by the RPE/Bruch's layers (C) Magnified SD-OCT scans from regions ‘ii’ (left panel) and ‘i’ (right panel) compared with sections from a normal subject. Stars denote RPE hyperreflectivities that correspond to yellow-white dots; arrow points to gap in the ellipsoid layer.

    Article Snippet: SD-OCT, en face near infrared (NIR) reflectance (REF) and fundus autofluorescence (FAF) imaging to NIR and short-wavelength (SW) excitation lights was performed using a Spectralis-HRA system (Heidelberg Engineering GmbH, Heidelberg, Germany).

    Techniques: