Journal: Nucleic Acids Research
Article Title: MACE: model based analysis of ChIP-exo
Figure Lengend Snippet: Comparing MACE with the method used by Rhee et al . (2011). ( A ) Bar-plot showing percent of putative binding regions (green areas) supported by CTCF canonical motif (RSYDMCMYCTRSTGK). The bar height indicates the number of total binding regions (exact numbers are superimposed on top). (B) Bar-plot showing percent of putative binding regions (red area) cross-validated by ENCODE CTCF ChIP-seq. ( C ) Comparing average conservation score (PhastCon) between regions identified by MACE and Rhee 2011. All binding regions identified by the two methods were combined and then divided into three groups: common border pair (black), MACE-unique (red) and Rhee et al .-unique (blue). ( D ) Cumulative curves used to compare spatial resolution between MACE and Rhee 2011. CTCF indicates CCCTC binding factor; MACE, model-based analysis of ChIP-exo.
Article Snippet: AVAILABILITY Raw and processed data of CTCF ChIP-exo, source code and documentation of MACE are available at http://chipexo.sourceforge.net/ .
Techniques: Binding Assay, Chromatin Immunoprecipitation