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  • cnqx  (Tocris)
    98
    Tocris cnqx
    Cnqx, supplied by Tocris, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Tocris
    Average 98 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cnqx - by Bioz Stars, 2022-09
    98/100 stars
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    97
    Millipore cnqx
    Activity-dependent [Cl − ] i gradient in the superficial dorsal horn. a MQAE fluorescence in the SDH of a transverse spinal cord slice ( left ) and pseudocolor image ( right ) show heterogeneous Cl − concentrations across the SDH. b Representative patch clamp recordings from SDH neurons illustrate the strong increase in the frequency of spontaneous inhibitory (left) and excitatory (right) post-synaptic currents upon capsaicin administration (2 µM). c Estimated [Cl − ] i from MQAE fluorescence lifetime of SDH neurons is not correlated to the distance from the dorsal white matter in the presence of <t>TTX</t> (1 µM), bicuculline (20 µM), strychnine (1 µM), <t>CNQX</t> (10 µM), AP5 (40 µM) to block synaptic activity ( black; slope −0.007 mM µm –1 ; n cells per point = 20–43, total = 179 cells; F = 0.4, P = 0.6), while the correlation is significant in presence of capsaicin to enhance synaptic activity ( red; slope = –0.027 mM µm –1 ; n cells per point = 24–49, total = 209 cells; F = 4.8, P = 0.03). Two-way-ANOVA, F treatment = 17.2, P
    Cnqx, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Millipore
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cnqx - by Bioz Stars, 2022-09
    97/100 stars
      Buy from Supplier

    cnqx  (Abcam)
    93
    Abcam cnqx
    Activity-dependent [Cl − ] i gradient in the superficial dorsal horn. a MQAE fluorescence in the SDH of a transverse spinal cord slice ( left ) and pseudocolor image ( right ) show heterogeneous Cl − concentrations across the SDH. b Representative patch clamp recordings from SDH neurons illustrate the strong increase in the frequency of spontaneous inhibitory (left) and excitatory (right) post-synaptic currents upon capsaicin administration (2 µM). c Estimated [Cl − ] i from MQAE fluorescence lifetime of SDH neurons is not correlated to the distance from the dorsal white matter in the presence of <t>TTX</t> (1 µM), bicuculline (20 µM), strychnine (1 µM), <t>CNQX</t> (10 µM), AP5 (40 µM) to block synaptic activity ( black; slope −0.007 mM µm –1 ; n cells per point = 20–43, total = 179 cells; F = 0.4, P = 0.6), while the correlation is significant in presence of capsaicin to enhance synaptic activity ( red; slope = –0.027 mM µm –1 ; n cells per point = 24–49, total = 209 cells; F = 4.8, P = 0.03). Two-way-ANOVA, F treatment = 17.2, P
    Cnqx, supplied by Abcam, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Abcam
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cnqx - by Bioz Stars, 2022-09
    93/100 stars
      Buy from Supplier

    Image Search Results


    Activity-dependent [Cl − ] i gradient in the superficial dorsal horn. a MQAE fluorescence in the SDH of a transverse spinal cord slice ( left ) and pseudocolor image ( right ) show heterogeneous Cl − concentrations across the SDH. b Representative patch clamp recordings from SDH neurons illustrate the strong increase in the frequency of spontaneous inhibitory (left) and excitatory (right) post-synaptic currents upon capsaicin administration (2 µM). c Estimated [Cl − ] i from MQAE fluorescence lifetime of SDH neurons is not correlated to the distance from the dorsal white matter in the presence of TTX (1 µM), bicuculline (20 µM), strychnine (1 µM), CNQX (10 µM), AP5 (40 µM) to block synaptic activity ( black; slope −0.007 mM µm –1 ; n cells per point = 20–43, total = 179 cells; F = 0.4, P = 0.6), while the correlation is significant in presence of capsaicin to enhance synaptic activity ( red; slope = –0.027 mM µm –1 ; n cells per point = 24–49, total = 209 cells; F = 4.8, P = 0.03). Two-way-ANOVA, F treatment = 17.2, P

    Journal: Nature Communications

    Article Title: Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

    doi: 10.1038/s41467-020-17824-y

    Figure Lengend Snippet: Activity-dependent [Cl − ] i gradient in the superficial dorsal horn. a MQAE fluorescence in the SDH of a transverse spinal cord slice ( left ) and pseudocolor image ( right ) show heterogeneous Cl − concentrations across the SDH. b Representative patch clamp recordings from SDH neurons illustrate the strong increase in the frequency of spontaneous inhibitory (left) and excitatory (right) post-synaptic currents upon capsaicin administration (2 µM). c Estimated [Cl − ] i from MQAE fluorescence lifetime of SDH neurons is not correlated to the distance from the dorsal white matter in the presence of TTX (1 µM), bicuculline (20 µM), strychnine (1 µM), CNQX (10 µM), AP5 (40 µM) to block synaptic activity ( black; slope −0.007 mM µm –1 ; n cells per point = 20–43, total = 179 cells; F = 0.4, P = 0.6), while the correlation is significant in presence of capsaicin to enhance synaptic activity ( red; slope = –0.027 mM µm –1 ; n cells per point = 24–49, total = 209 cells; F = 4.8, P = 0.03). Two-way-ANOVA, F treatment = 17.2, P

    Article Snippet: Lifetime values of SDH neurons were measured under two conditions: (i) TTX (1 μM), bicuculline (20 μM, sigma), strychnine (1 μM, sigma), CNQX (10 μM, sigma), APV (40 μM, sigma) to block synaptic activity (N = 14 slices from two rats) and (ii) capsaicin (2 μM, Sigma) to enhance synaptic activity (N = 14 slices, from three rats).

    Techniques: Activity Assay, Fluorescence, Patch Clamp, Blocking Assay