cgp46381 Search Results


tpmpa  (Tocris)
94
Tocris tpmpa
GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A <t>)</t> <t>bicuculline</t> (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) <t>TPMPA</t> (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.
Tpmpa, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tpmpa/product/Tocris
Average 94 stars, based on 1 article reviews
tpmpa - by Bioz Stars, 2026-02
94/100 stars
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gaba b r antagonist cgp 46381  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology gaba b r antagonist cgp 46381
GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A <t>)</t> <t>bicuculline</t> (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) <t>TPMPA</t> (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.
Gaba B R Antagonist Cgp 46381, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gaba b r antagonist cgp 46381/product/Santa Cruz Biotechnology
Average 94 stars, based on 1 article reviews
gaba b r antagonist cgp 46381 - by Bioz Stars, 2026-02
94/100 stars
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cgp46381  (Tocris)
93
Tocris cgp46381
GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A <t>)</t> <t>bicuculline</t> (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) <t>TPMPA</t> (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.
Cgp46381, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cgp46381/product/Tocris
Average 93 stars, based on 1 article reviews
cgp46381 - by Bioz Stars, 2026-02
93/100 stars
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cgp 46381  (Koma Biotech)
90
Koma Biotech cgp 46381
GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A <t>)</t> <t>bicuculline</t> (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) <t>TPMPA</t> (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.
Cgp 46381, supplied by Koma Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cgp 46381/product/Koma Biotech
Average 90 stars, based on 1 article reviews
cgp 46381 - by Bioz Stars, 2026-02
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cgp 46381  (Ciba Geigy)
90
Ciba Geigy cgp 46381
GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A <t>)</t> <t>bicuculline</t> (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) <t>TPMPA</t> (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.
Cgp 46381, supplied by Ciba Geigy, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cgp 46381/product/Ciba Geigy
Average 90 stars, based on 1 article reviews
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3-amino-propyl)(cyclohexylmethyl)phosphinic acid cgp46381  (Novartis)
90
Novartis 3-amino-propyl)(cyclohexylmethyl)phosphinic acid cgp46381
Summary of saturation studies of <t>[3H]-CGP54626A</t> binding to GABAB(1a,2) and GABAB(1b,2) receptors
3 Amino Propyl)(Cyclohexylmethyl)Phosphinic Acid Cgp46381, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/3-amino-propyl)(cyclohexylmethyl)phosphinic acid cgp46381/product/Novartis
Average 90 stars, based on 1 article reviews
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Image Search Results


GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A ) bicuculline (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) TPMPA (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.

Journal: International Journal of Molecular Sciences

Article Title: Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABA A and GABA B Receptors

doi: 10.3390/ijms222011254

Figure Lengend Snippet: GABA A and GABA B receptors are responsible for GABA-mediated growth promotion in zebrafish larvae. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were pretreated with 10 µM each of ( A ) bicuculline (GABA A antagonist), ( B ) CGP 46381 (GABA B antagonist), and ( C ) TPMPA (GABA C antagonist) 2 h before treatment with 25 mM GABA. The media were replaced at 6 dpf with GABA, and total body length was measured at 9 dpf. Graphs represent the total body length ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (** p < 0.01 and *** p < 0.001). N.S., non-significant.

Article Snippet: Bicuculline, CGP 46381, and TPMPA were purchased from Tocris Bioscience (Bristol, United Kingdom).

Techniques:

GABA upregulates growth-stimulating gene expression via GABA A and GABA B receptors. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were treated with 10 µM of each ( A ) bicuculline, ( B ) CGP 46381, and ( C ) TPMPA 2 h before treatment with 25 mM GABA, and total RNA was extracted at 9 dpf. The RNA was reverse-transcribed, and synthetic cDNA was amplified to determine expression of the genes for insulin-like growth factor 1 ( zIGF-1) , growth hormone 1 ( zGH-1 ), growth hormone receptor 1 ( zGHR-1 ), and cholecystokinin A ( zCCKA ). z β-Actin was used as an internal control. Densitometry analysis was conducted to determine the expression level of each gene relative to that of β-actin and illustrated ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (*** p < 0.001). N.S., non-significant.

Journal: International Journal of Molecular Sciences

Article Title: Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABA A and GABA B Receptors

doi: 10.3390/ijms222011254

Figure Lengend Snippet: GABA upregulates growth-stimulating gene expression via GABA A and GABA B receptors. Zebrafish larvae ( n = 20) at three days post-fertilization (dpf) were treated with 10 µM of each ( A ) bicuculline, ( B ) CGP 46381, and ( C ) TPMPA 2 h before treatment with 25 mM GABA, and total RNA was extracted at 9 dpf. The RNA was reverse-transcribed, and synthetic cDNA was amplified to determine expression of the genes for insulin-like growth factor 1 ( zIGF-1) , growth hormone 1 ( zGH-1 ), growth hormone receptor 1 ( zGHR-1 ), and cholecystokinin A ( zCCKA ). z β-Actin was used as an internal control. Densitometry analysis was conducted to determine the expression level of each gene relative to that of β-actin and illustrated ( bottom ). Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (*** p < 0.001). N.S., non-significant.

Article Snippet: Bicuculline, CGP 46381, and TPMPA were purchased from Tocris Bioscience (Bristol, United Kingdom).

Techniques: Gene Expression, Reverse Transcription, Amplification, Expressing, Control

Inhibition of GABA A and GABA B receptors downregulates GABA-mediated IGF-1 and IGF-1R expression in preosteoblast MC3T3-E1 cells. MC3T3-E1 cells (1 × 10 4 cells/mL) were treated with 5 µM each of ( A , D ) bicuculline, ( B , E ) CGP 46381, and ( C , F ) TPMPA 2 h before treatment with 10 mM GABA for seven days. Total RNA was extracted, and RT-PCR was performed to determine the expression level of IGF-1 and IGF-1R . Glyceraldehyde 3-phosphate dehydrogenase gene ( GAPDH ) was used as an internal control. The expression of IGF-1 and IGF-1R relative to that of GAPDH level was determined ( bottom ). In a parallel experiment, cell-free supernatants were collected, and ELISA was conducted. Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (*** p < 0.001). N.S., non-significant.

Journal: International Journal of Molecular Sciences

Article Title: Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABA A and GABA B Receptors

doi: 10.3390/ijms222011254

Figure Lengend Snippet: Inhibition of GABA A and GABA B receptors downregulates GABA-mediated IGF-1 and IGF-1R expression in preosteoblast MC3T3-E1 cells. MC3T3-E1 cells (1 × 10 4 cells/mL) were treated with 5 µM each of ( A , D ) bicuculline, ( B , E ) CGP 46381, and ( C , F ) TPMPA 2 h before treatment with 10 mM GABA for seven days. Total RNA was extracted, and RT-PCR was performed to determine the expression level of IGF-1 and IGF-1R . Glyceraldehyde 3-phosphate dehydrogenase gene ( GAPDH ) was used as an internal control. The expression of IGF-1 and IGF-1R relative to that of GAPDH level was determined ( bottom ). In a parallel experiment, cell-free supernatants were collected, and ELISA was conducted. Significant differences among the groups were determined using Student’s t -test. All data are presented as mean ± standard error of the mean (*** p < 0.001). N.S., non-significant.

Article Snippet: Bicuculline, CGP 46381, and TPMPA were purchased from Tocris Bioscience (Bristol, United Kingdom).

Techniques: Inhibition, Expressing, Reverse Transcription Polymerase Chain Reaction, Control, Enzyme-linked Immunosorbent Assay

Summary of saturation studies of [3H]-CGP54626A binding to GABAB(1a,2) and GABAB(1b,2) receptors

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Summary of saturation studies of [3H]-CGP54626A binding to GABAB(1a,2) and GABAB(1b,2) receptors

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Representative saturation curve data for [3H]-CGP54626A binding to GABAB(1a,2) (A) and GABAB(1b,2) (B). Each point represents mean of duplicate determinations from a single experiment.

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Representative saturation curve data for [3H]-CGP54626A binding to GABAB(1a,2) (A) and GABAB(1b,2) (B). Each point represents mean of duplicate determinations from a single experiment.

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Summary of affinity values for the displacement of [3H]-CGP54626A binding to GABAB(1a,2) and GABAB(1b,2) receptors

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Summary of affinity values for the displacement of [3H]-CGP54626A binding to GABAB(1a,2) and GABAB(1b,2) receptors

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Competition studies of [3H]-CGP54626A binding to GABAB(1a,2) receptors. Displacement of [3H]-CGP546262A binding by GABAB agonists (A) and antagonists (B) is represented as per cent specific binding. Each curve represents mean±s.e.mean from n=3 experiments.

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Competition studies of [3H]-CGP54626A binding to GABAB(1a,2) receptors. Displacement of [3H]-CGP546262A binding by GABAB agonists (A) and antagonists (B) is represented as per cent specific binding. Each curve represents mean±s.e.mean from n=3 experiments.

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Competition studies of [3H]-CGP54626A binding to GABAB(1b,2) receptors. Displacement of [3H]-CGP546262A binding by GABAB agonists (A) and antagonists (B) is represented as per cent specific binding. Each curve represents mean±s.e.mean from n=3 experiments.

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Competition studies of [3H]-CGP54626A binding to GABAB(1b,2) receptors. Displacement of [3H]-CGP546262A binding by GABAB agonists (A) and antagonists (B) is represented as per cent specific binding. Each curve represents mean±s.e.mean from n=3 experiments.

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Summary of whole cell binding saturation studies of [3H]-CGP54626A binding to GABAB(1a,2) and GABAB(1b,2) receptors

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Summary of whole cell binding saturation studies of [3H]-CGP54626A binding to GABAB(1a,2) and GABAB(1b,2) receptors

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Representative saturation curve data for [3H]-CGP54626A binding to GABAB(1a,2) Each point represents the mean of duplicate determinations from a single experiment.

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Representative saturation curve data for [3H]-CGP54626A binding to GABAB(1a,2) Each point represents the mean of duplicate determinations from a single experiment.

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay

Competition studies of [3H]-CGP54626A binding to GABAB receptors. Displacement of [3H]-CGP546262A whole cell binding at GABAB(1a,2) (A) and GABAB(1b,2) (B) is represented as per cent specific binding. Each curve represents mean±s.e.mean from n=3 experiments.

Journal:

Article Title: Characterization of [ 3 H]-CGP54626A binding to heterodimeric GABA B receptors stably expressed in mammalian cells

doi: 10.1038/sj.bjp.0703755

Figure Lengend Snippet: Competition studies of [3H]-CGP54626A binding to GABAB receptors. Displacement of [3H]-CGP546262A whole cell binding at GABAB(1a,2) (A) and GABAB(1b,2) (B) is represented as per cent specific binding. Each curve represents mean±s.e.mean from n=3 experiments.

Article Snippet: 3-Aminopropylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP27492","term_id":"875036195","term_text":"CGP27492"}} CGP27492 ); ((3-Aminopropyl)(diethoxymethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP35348","term_id":"875599329","term_text":"CGP35348"}} CGP35348 ); [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)phosphinic acid (CGP 52432); [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP55845","term_id":"875097176","term_text":"CGP55845"}} CGP55845 ); [S-(R*,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid (CGP54626A); ((3-Amino-propyl)(cyclohexylmethyl)phosphinic acid) ( {"type":"entrez-protein","attrs":{"text":"CGP46381","term_id":"874689346","term_text":"CGP46381"}} CGP46381 ); [(2R)-3-Amino-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP51176","term_id":"875489595","term_text":"CGP51176"}} CGP51176 ) and (3-aminopropyl)butylphosphinic acid ( {"type":"entrez-protein","attrs":{"text":"CGP36742","term_id":"877561962","term_text":"CGP36742"}} CGP36742 ) are Novartis compounds but were synthesized in house.

Techniques: Binding Assay