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Image Search Results
Journal: Human Genetics
Article Title: Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity
doi: 10.1007/s00439-010-0879-3
Figure Lengend Snippet: Detection of copy number changes by oligo array-based genomic hybridization for patient 1. The Y axis represents the log2 ratio of the intensities of patient and reference DNA. On the X axis oligos are ordered by Mb position. The lower panel shows the observed log2 ratios on chromosome (Chr) 1. The spikes outside the selected area are known copy number variants in the human DNA. The upper panel shows a magnified view of the selected area in the lower panel for the probes located in DPYD and flanking regions. The genes located in the flanking region of DPYD are indicated on the X axis. The grey box represents the minimal deleted region for patient 1
Article Snippet: Fluorescent labelling of DNA was performed using the CGH labelling kit for
Techniques: Hybridization