Journal: Antimicrobial Agents and Chemotherapy
Article Title: Role of a Mutation at Position 167 of CTX-M-19 in Ceftazidime Hydrolysis
Figure Lengend Snippet: The active site of CTX-M-type β-lactamase with aztreonam (A and B), ceftazidime (C and D), or cefotaxime (E and F). (A, C, and E) CTX-M-18; (B, D, and F) CTX-M-19. Red broken lines indicate hydrogen bonds. Black thin double arrow indicates an interatomic distance longer than hydrogen bond. Blue broken double arrow indicates a steric interaction with the hydroxyl group of S167 and the thiazole ring.
Article Snippet: Reference powders of the following antibiotics were kindly provided by their manufacturers: piperacillin (Toyama Chemical Co., Ltd., Tokyo, Japan), cefoxitin and imipenem (Banyu Pharmaceutical Co., Ltd., Tokyo, Japan), cefepime (Bristol Pharmaceutical Co., Tokyo, Japan), ceftizoxime (Fujisawa Pharmaceutical Co., Ltd., Tokyo, Japan), clavulanate and ceftazidime (Glaxo Smith Kline, Tokyo, Japan), cefotaxime (Aventis Pharma, Tokyo, Japan), aztreonam (Eisai Co., Ltd., Tokyo, Japan), and faropenem (Suntory, Ltd., Tokyo, Japan).