c-reactive protein Search Results


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  • 96
    Thermo Fisher c reactive protein crp
    Relative expression of fetal liver acute phase protein mRNA levels measured with quantitative PCR. <t>CRP,</t> C-reactive protein; SAA3, Serum amyloid A 3; HEP, <t>Hepcidin.</t> Values of CRP and SAA3 are presented as bar charts with the group mean normalised expression vs . the value for Control group, with error bars representing SD. Values of HEP are presented as box plots with the group median normalised expression vs . the value for Control group, with whiskers representing maximum and minimum values. Significant differences vs . value for Control group are indicated: ‡ , p
    C Reactive Protein Crp, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 96/100, based on 105 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore c reactive protein crp
    Plasma <t>biomarkers</t> of systemic inflammation, anti-inflammatory, vascular and lipid mediators, and extracellular matrix breakdown in normal subjects and e-cigarette (e-cig) users. IL: interleukin; GM-CSF: granulocyte−macrophage colony-stimulating factor; MMP: matrix metalloproteinase; MCP: monocyte chemoattractant protein; MIP: macrophage inflammatory protein; TNF: tumour necrosis factor; IFN: interferon; <t>CRP:</t> C-reactive protein; PAI: plasminogen activator inhibitor; ICAM: intracellular adhesion molecule. Data are presented as mean± sem (n=4–20). *: p
    C Reactive Protein Crp, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 115 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    ProteinCT crp c reactive protein
    (A) Computerized axial tomography of chest (left panel) and abdomen-pelvis (right panel) during the acute event and (B) C-reactive protein and D-dimers changes during the acute event and in the days after therapy was started. (A) Bilateral pleural effusions (continuous arrows) associated to atelectasis (dashed arrow); cardiomegaly and pericardial effusion (dotted arrow); edema of the intestinal wall and of perivisceral adipose tissue (dashed-dotted arrows). (B) <t>CRP</t> and D-dimers are expressed as time fold increase above normal reference values. CRP = C-reactive protein, IVIG = high-dose intravenous immunoglobulins, MPD = methylprednisolone, PD = prednisolone.
    Crp C Reactive Protein, supplied by ProteinCT, used in various techniques. Bioz Stars score: 91/100, based on 590 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    R&D Systems c reactive protein crp
    Plasma levels of IL-RA, IL-17, IL-6, <t>CRP</t> and PGE 2 are higher in BMI > 35 than control volunteers. ( A ) Blood samples were collected in heparin for all cytokines/chemokines except G-CSF (which was collected in EDTA) and subjected to Luminex analysis. ● = healthy controls; Each volunteer with a BMI > 35 is identified with a unique symbol. All men are identified by squares. Results are expressed as the mean ± SEM. ( B ) MesoScale analyses of plasma samples from BMI > 35 and control volunteers for IL-17, VEGF and IL-6 levels. ( C ) CRP levels in the left panel and PGE 2 levels in the right.
    C Reactive Protein Crp, supplied by R&D Systems, used in various techniques. Bioz Stars score: 99/100, based on 469 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Dade Behring c reactive protein crp
    Biomarkers and mediators of the inflammatory response. Abbr.: <t>CRP</t> = C Reactive Protein, <t>RBP=</t> Retinol Binding Protein, MCP-1= Monocyte Chemoattractant Protein 1, IL-6 = Interleukin 6.
    C Reactive Protein Crp, supplied by Dade Behring, used in various techniques. Bioz Stars score: 93/100, based on 433 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    ProteinCT c reactive protein
    Biomarkers and mediators of the inflammatory response. Abbr.: <t>CRP</t> = C Reactive Protein, <t>RBP=</t> Retinol Binding Protein, MCP-1= Monocyte Chemoattractant Protein 1, IL-6 = Interleukin 6.
    C Reactive Protein, supplied by ProteinCT, used in various techniques. Bioz Stars score: 92/100, based on 245 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Protein Potential high sensitivity c reactive protein
    ROC curve of high-sensitivity C-reactive protein (hsCRP) in predicting severe microvascular dysfunction (MVD) (index of microvascular resistance  >  30).
    High Sensitivity C Reactive Protein, supplied by Protein Potential, used in various techniques. Bioz Stars score: 92/100, based on 74 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Dade Behring c reactive protein
    Baseline Lp‐ PLA 2  activity (μmol/min per liter) quartile groups in relation to outcomes in (A) all patients, (B) in women, and (C) in men, adjusted for demographics, baseline characteristics, routine biochemical variables, and prognostic biomarkers. The  x ‐axis presents a logarithmic scale. MACE indicates  CV  death, MI, or stroke;  MCE  indicates coronary heart disease death, MI, or urgent coronary revascularization. Event rates are Kaplan–Meier rates. Adjustment variables: randomized treatment, geographic region, age, sex, body mass index, current smoking, hypertension, diabetes mellitus, prior MI, prior coronary revascularization, multivessel coronary heart disease, polyvascular disease, significant renal dysfunction, routine biochemical variables (hemoglobin, white blood cell count, estimated glomerular filtration rate [Chronic Kidney Disease Epidemiology Collaboration], low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and triglycerides), and prognostic biomarkers (N‐terminal proB‐type natriuretic peptide, high‐sensitivity cardiac troponin T, cystatin C, high‐sensitivity C‐reactive protein, and interleukin 6). CV indicates cardiovascular; HR, hazard ratio; Lp‐PLA 2 , lipoprotein‐associated phospholipase A 2 ; MACE, major adverse cardiac events; MCE, major coronary events; MI, myocardial infarction; Q, quartile.
    C Reactive Protein, supplied by Dade Behring, used in various techniques. Bioz Stars score: 93/100, based on 191 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Dade Behring high sensitivity c reactive protein hscrp
    Changes in serum TBARS, <t>hsCRP,</t> and adiponectin levels. Serum levels of thiobarbituric acid-reacting substance (TBARS) (A) , high-sensitivity C-reactive protein (hsCRP) (B) , and adiponectin (C) . Data are mean ± SEM of 10 subjects of the control group and 16 subjects of the sitagliptin group. NS; not significant.
    High Sensitivity C Reactive Protein Hscrp, supplied by Dade Behring, used in various techniques. Bioz Stars score: 92/100, based on 151 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Siemens AG c reactive protein crp
    Epigenetic down-regulation of estrogen receptors ESR1 and ESR2 in <t>CP/CPPS</t> and deterioration of CP/CPPS symptoms in patients with advanced age ( A ) A significant decrease of expression of both estrogen receptor genes ( ESR1 and ESR2 ) was detected in somatic cells isolated from ejaculates of CP/CPPS patients in comparison to controls ( A.1 ). By analyzing the promoter methylation of ESR1 and ESR2 in ejaculated somatic cells, a highly significant increase of cells having methylated ESR1 and ESR2 promoters was found in the CP/CPPS group ( A.2 ). In contrast, androgen receptor ( AR ) gene expression and promoter methylation did not differ much between controls and patients ( A.1 and A.1 ); ( B ) Leukocytes isolated from blood of CP/CPPS and controls did not differ in gene expression of ESR1 ( B.1 ). CP/CPPS patients exhibited a reduced ESR2 and AR expression, whereby for ESR2 the difference was statistically significant (B.1). Methylation data showed a significant decrease of cells with methylated ESR1 promoter in CP/CPPS patients’ blood leukocytes, whereas ESR2 and AR promoters were comparable between patients and controls ( B.2 ); ( C ) Prostate cancer cell lines LNCaP, DU145 and PC3 were analyzed by COBRA in ESR1 and ESR2 promoters. PC3 cells exhibited methylation (m) in ESR1 promoter (Bsh1236i (CGCG)-specific restriction bands visible under “+”), whereas the other two were unmethylated (u) ( C.1 , upper gel picture). ESR2 promoter was methylated in LNCaP cells and unmethylated in DU145 and PC3 (C.1, bottom gel picture). Treatment with 5-aza-2′-deoxycytidine (+AZA) led to re-expression of ESR1 in PC3 cells and of ESR2 in LNCaP cells ( C.2 ); ( C ) Older CP/CPPS patients (≥40 years) exhibited extremely increased levels of <t>CRP</t> (C reactive protein) ( D.1 ) and significantly higher IPSS (international prostate symptom score) than younger patients (
    C Reactive Protein Crp, supplied by Siemens AG, used in various techniques. Bioz Stars score: 93/100, based on 144 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Hitachi Ltd c reactive protein crp
    (a–i) Receiver operating characteristic curves were presented for different screen tests with the date derived at 16–18 weeks of gestation. <t>CRP</t> , C‐reactive protein; FFA s, free fatty acids; <t>RBP</t> ‐4, retinol‐binding protein‐4; ROC , receiver operating characteristic.
    C Reactive Protein Crp, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 92/100, based on 108 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens Healthineers c reactive protein crp
    Survival curves for the ratio of patients with abnormal disease activity indicators and serum MMP-3 between non-progressive and progressive patients. P values were determined by log-rank tests between non-progressive and progressive groups. Pain VAS pain visual analogue scale, 28TJC 28-joint tender joint count, 28SJC 28-joint swollen joint count, PtGA patient global assessment of disease activity, PrGA provider global assessment of disease activity, HAQ health assessment questionnaire, <t>CRP</t> C-reactive protein, <t>ESR</t> erythrocyte sedimentation rate, DAS28 Disease Activity Score 28-joint assessment, SDAI simplified disease activity index, CDAI clinical disease activity index, MMP-3 matrix metalloproteinase-3, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide antibody
    C Reactive Protein Crp, supplied by Siemens Healthineers, used in various techniques. Bioz Stars score: 93/100, based on 178 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abbott Laboratories c reactive protein crp
    Survival curves for the ratio of patients with abnormal disease activity indicators and serum MMP-3 between non-progressive and progressive patients. P values were determined by log-rank tests between non-progressive and progressive groups. Pain VAS pain visual analogue scale, 28TJC 28-joint tender joint count, 28SJC 28-joint swollen joint count, PtGA patient global assessment of disease activity, PrGA provider global assessment of disease activity, HAQ health assessment questionnaire, <t>CRP</t> C-reactive protein, <t>ESR</t> erythrocyte sedimentation rate, DAS28 Disease Activity Score 28-joint assessment, SDAI simplified disease activity index, CDAI clinical disease activity index, MMP-3 matrix metalloproteinase-3, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide antibody
    C Reactive Protein Crp, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 93/100, based on 116 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Hitachi Ltd c reactive protein
    Survival curves for the ratio of patients with abnormal disease activity indicators and serum MMP-3 between non-progressive and progressive patients. P values were determined by log-rank tests between non-progressive and progressive groups. Pain VAS pain visual analogue scale, 28TJC 28-joint tender joint count, 28SJC 28-joint swollen joint count, PtGA patient global assessment of disease activity, PrGA provider global assessment of disease activity, HAQ health assessment questionnaire, <t>CRP</t> C-reactive protein, <t>ESR</t> erythrocyte sedimentation rate, DAS28 Disease Activity Score 28-joint assessment, SDAI simplified disease activity index, CDAI clinical disease activity index, MMP-3 matrix metalloproteinase-3, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide antibody
    C Reactive Protein, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 92/100, based on 68 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Olympus c reactive protein crp
    Complement <t>C3</t> and total IgE serum levels values according to low grade inflammation in both atopic (A) and not atopic (B) children affected by allergic disease. <t>CRP</t> values
    C Reactive Protein Crp, supplied by Olympus, used in various techniques. Bioz Stars score: 93/100, based on 71 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens AG c reactive protein
    Complement <t>C3</t> and total IgE serum levels values according to low grade inflammation in both atopic (A) and not atopic (B) children affected by allergic disease. <t>CRP</t> values
    C Reactive Protein, supplied by Siemens AG, used in various techniques. Bioz Stars score: 93/100, based on 103 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens Healthineers c reactive protein
    Complement <t>C3</t> and total IgE serum levels values according to low grade inflammation in both atopic (A) and not atopic (B) children affected by allergic disease. <t>CRP</t> values
    C Reactive Protein, supplied by Siemens Healthineers, used in various techniques. Bioz Stars score: 93/100, based on 70 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abbott Laboratories c reactive protein
    Complement <t>C3</t> and total IgE serum levels values according to low grade inflammation in both atopic (A) and not atopic (B) children affected by allergic disease. <t>CRP</t> values
    C Reactive Protein, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 92/100, based on 70 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Relative expression of fetal liver acute phase protein mRNA levels measured with quantitative PCR. CRP, C-reactive protein; SAA3, Serum amyloid A 3; HEP, Hepcidin. Values of CRP and SAA3 are presented as bar charts with the group mean normalised expression vs . the value for Control group, with error bars representing SD. Values of HEP are presented as box plots with the group median normalised expression vs . the value for Control group, with whiskers representing maximum and minimum values. Significant differences vs . value for Control group are indicated: ‡ , p

    Journal: PLoS ONE

    Article Title: Ex-Vivo Uterine Environment (EVE) Therapy Induced Limited Fetal Inflammation in a Premature Lamb Model

    doi: 10.1371/journal.pone.0140701

    Figure Lengend Snippet: Relative expression of fetal liver acute phase protein mRNA levels measured with quantitative PCR. CRP, C-reactive protein; SAA3, Serum amyloid A 3; HEP, Hepcidin. Values of CRP and SAA3 are presented as bar charts with the group mean normalised expression vs . the value for Control group, with error bars representing SD. Values of HEP are presented as box plots with the group median normalised expression vs . the value for Control group, with whiskers representing maximum and minimum values. Significant differences vs . value for Control group are indicated: ‡ , p

    Article Snippet: Ovine-specific PCR primers and hydrolysis probes for SP-A, B, C, D, interleukin (IL)-1β, IL-6, IL-8, TNF-α, MCP-2, C-reactive protein (CRP), Serum amyloid A (SAA) 3, and Hepcidin (all Life Technologies) were used to perform quantitative PCR.

    Techniques: Expressing, Real-time Polymerase Chain Reaction

    Plasma biomarkers of systemic inflammation, anti-inflammatory, vascular and lipid mediators, and extracellular matrix breakdown in normal subjects and e-cigarette (e-cig) users. IL: interleukin; GM-CSF: granulocyte−macrophage colony-stimulating factor; MMP: matrix metalloproteinase; MCP: monocyte chemoattractant protein; MIP: macrophage inflammatory protein; TNF: tumour necrosis factor; IFN: interferon; CRP: C-reactive protein; PAI: plasminogen activator inhibitor; ICAM: intracellular adhesion molecule. Data are presented as mean± sem (n=4–20). *: p

    Journal: ERJ Open Research

    Article Title: Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries

    doi: 10.1183/23120541.00182-2019

    Figure Lengend Snippet: Plasma biomarkers of systemic inflammation, anti-inflammatory, vascular and lipid mediators, and extracellular matrix breakdown in normal subjects and e-cigarette (e-cig) users. IL: interleukin; GM-CSF: granulocyte−macrophage colony-stimulating factor; MMP: matrix metalloproteinase; MCP: monocyte chemoattractant protein; MIP: macrophage inflammatory protein; TNF: tumour necrosis factor; IFN: interferon; CRP: C-reactive protein; PAI: plasminogen activator inhibitor; ICAM: intracellular adhesion molecule. Data are presented as mean± sem (n=4–20). *: p

    Article Snippet: Measurement of biomarkers by ELISA Plasma levels of biomarkers were measured using commercially available ELISA kits: C-reactive protein (CRP) (Sigma, St Louis, MO, USA), desmosine (MyBiosource, San Diego, CA, USA), 8-isoprostane, prostaglandin E2 , thromboxane B2 , resolvin D1 , resolvin D2 , resolvin E1 , leukotriene E4 (Cayman, Ann Arbor, MI, USA), fibrinogen (Abcam, Cambridge, MA, USA), intracellular adhesion molecule (ICAM)-1 (R & D Systems), 4-hydroxynonenal, malondialdehyde (Cell Biolabs, San Diego, CA, USA) and lipoxin A4 (TSZ ELISA, Waltham, MA, USA).

    Techniques:

    (A) Computerized axial tomography of chest (left panel) and abdomen-pelvis (right panel) during the acute event and (B) C-reactive protein and D-dimers changes during the acute event and in the days after therapy was started. (A) Bilateral pleural effusions (continuous arrows) associated to atelectasis (dashed arrow); cardiomegaly and pericardial effusion (dotted arrow); edema of the intestinal wall and of perivisceral adipose tissue (dashed-dotted arrows). (B) CRP and D-dimers are expressed as time fold increase above normal reference values. CRP = C-reactive protein, IVIG = high-dose intravenous immunoglobulins, MPD = methylprednisolone, PD = prednisolone.

    Journal: Medicine

    Article Title: Antiphospholipids Syndrome Complicated by a Systemic Capillary Leak-Like Syndrome Treated With Steroids and Intravenous Immunoglobulins

    doi: 10.1097/MD.0000000000002648

    Figure Lengend Snippet: (A) Computerized axial tomography of chest (left panel) and abdomen-pelvis (right panel) during the acute event and (B) C-reactive protein and D-dimers changes during the acute event and in the days after therapy was started. (A) Bilateral pleural effusions (continuous arrows) associated to atelectasis (dashed arrow); cardiomegaly and pericardial effusion (dotted arrow); edema of the intestinal wall and of perivisceral adipose tissue (dashed-dotted arrows). (B) CRP and D-dimers are expressed as time fold increase above normal reference values. CRP = C-reactive protein, IVIG = high-dose intravenous immunoglobulins, MPD = methylprednisolone, PD = prednisolone.

    Article Snippet: Abbreviations: aCL = anticardiolipin antibodies, ANA = antinuclear antibodies, APS = antiphospholipid syndrome, CAPS = catastrophic antiphospholipid syndrome, CRP = C-reactive protein, CT = computed tomography, ENA = extractable nuclear antigen, ESR = erythrocyte sedimentation rate, IVIG = intravenous immunoglobulins, SCL = systemic capillary leak, sPAP = systolic pulmonary arterial pressure.

    Techniques:

    Plasma levels of IL-RA, IL-17, IL-6, CRP and PGE 2 are higher in BMI > 35 than control volunteers. ( A ) Blood samples were collected in heparin for all cytokines/chemokines except G-CSF (which was collected in EDTA) and subjected to Luminex analysis. ● = healthy controls; Each volunteer with a BMI > 35 is identified with a unique symbol. All men are identified by squares. Results are expressed as the mean ± SEM. ( B ) MesoScale analyses of plasma samples from BMI > 35 and control volunteers for IL-17, VEGF and IL-6 levels. ( C ) CRP levels in the left panel and PGE 2 levels in the right.

    Journal: PLoS ONE

    Article Title: Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk

    doi: 10.1371/journal.pone.0228633

    Figure Lengend Snippet: Plasma levels of IL-RA, IL-17, IL-6, CRP and PGE 2 are higher in BMI > 35 than control volunteers. ( A ) Blood samples were collected in heparin for all cytokines/chemokines except G-CSF (which was collected in EDTA) and subjected to Luminex analysis. ● = healthy controls; Each volunteer with a BMI > 35 is identified with a unique symbol. All men are identified by squares. Results are expressed as the mean ± SEM. ( B ) MesoScale analyses of plasma samples from BMI > 35 and control volunteers for IL-17, VEGF and IL-6 levels. ( C ) CRP levels in the left panel and PGE 2 levels in the right.

    Article Snippet: PGE2 and CRP measurements ELISAs for prostaglandin E2 (PGE2 ) (Cat #514010, Cayman Chemical Company, Ann Arbor, MI), using EDTA-containing blood and C-reactive protein (CRP) (Cat # DCRP00, R & D Systems, Minneapolis, MN), using heparin-containing blood [ ] were performed according to the manufacturers’ instructions.

    Techniques: Luminex

    Biomarkers and mediators of the inflammatory response. Abbr.: CRP = C Reactive Protein, RBP= Retinol Binding Protein, MCP-1= Monocyte Chemoattractant Protein 1, IL-6 = Interleukin 6.

    Journal: Burns : journal of the International Society for Burn Injuries

    Article Title: Bacterial Respiratory Tract Infections are Promoted by Systemic Hyperglycemia after Severe Burn Injury in Pediatric Patients

    doi: 10.1016/j.burns.2013.07.007

    Figure Lengend Snippet: Biomarkers and mediators of the inflammatory response. Abbr.: CRP = C Reactive Protein, RBP= Retinol Binding Protein, MCP-1= Monocyte Chemoattractant Protein 1, IL-6 = Interleukin 6.

    Article Snippet: Serum insulin, C-reactive protein (CRP), and retinol binding protein (RBP) were determined using HPLC [ ], nephelometry (BNII, Plasma Protein Analyzer Dade Behring, MD), and ELISA techniques.

    Techniques: Binding Assay

    Levels for oxidative stress, inflammatory markers, and antioxidant enzyme activities based on areca nut use. CAT, catalase activity; MDA, malondialdehyde; GPx, glutathione peroxidase; hs-CRP, high-sensitivity C-reactive protein; SOD, superoxide dismutase. ∗ Values were significantly different from subjects who never chewed areca nut. (Blue-colored bar) current chewers, (striped bar) former chewers, and (white bar) never chewers.

    Journal: Oxidative Medicine and Cellular Longevity

    Article Title: Relationship of Oxidative Stress, Inflammation, and the Risk of Metabolic Syndrome in Patients with Oral Cancer

    doi: 10.1155/2018/9303094

    Figure Lengend Snippet: Levels for oxidative stress, inflammatory markers, and antioxidant enzyme activities based on areca nut use. CAT, catalase activity; MDA, malondialdehyde; GPx, glutathione peroxidase; hs-CRP, high-sensitivity C-reactive protein; SOD, superoxide dismutase. ∗ Values were significantly different from subjects who never chewed areca nut. (Blue-colored bar) current chewers, (striped bar) former chewers, and (white bar) never chewers.

    Article Snippet: Serum level of high-sensitivity C-reactive protein (hs-CRP) was quantified by particle-enhanced immunonephelometry with an image analyzer (Dade Behring, Deerfield, IL, USA).

    Techniques: Activity Assay, Multiple Displacement Amplification

    ROC curve of high-sensitivity C-reactive protein (hsCRP) in predicting severe microvascular dysfunction (MVD) (index of microvascular resistance  >  30).

    Journal: Frontiers in Cardiovascular Medicine

    Article Title: High-Sensitivity C-Reactive Protein Is a Predictor of Coronary Microvascular Dysfunction in Patients with Ischemic Heart Disease

    doi: 10.3389/fcvm.2017.00081

    Figure Lengend Snippet: ROC curve of high-sensitivity C-reactive protein (hsCRP) in predicting severe microvascular dysfunction (MVD) (index of microvascular resistance  >  30).

    Article Snippet: High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease .

    Techniques:

    Baseline Lp‐ PLA 2  activity (μmol/min per liter) quartile groups in relation to outcomes in (A) all patients, (B) in women, and (C) in men, adjusted for demographics, baseline characteristics, routine biochemical variables, and prognostic biomarkers. The  x ‐axis presents a logarithmic scale. MACE indicates  CV  death, MI, or stroke;  MCE  indicates coronary heart disease death, MI, or urgent coronary revascularization. Event rates are Kaplan–Meier rates. Adjustment variables: randomized treatment, geographic region, age, sex, body mass index, current smoking, hypertension, diabetes mellitus, prior MI, prior coronary revascularization, multivessel coronary heart disease, polyvascular disease, significant renal dysfunction, routine biochemical variables (hemoglobin, white blood cell count, estimated glomerular filtration rate [Chronic Kidney Disease Epidemiology Collaboration], low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and triglycerides), and prognostic biomarkers (N‐terminal proB‐type natriuretic peptide, high‐sensitivity cardiac troponin T, cystatin C, high‐sensitivity C‐reactive protein, and interleukin 6). CV indicates cardiovascular; HR, hazard ratio; Lp‐PLA 2 , lipoprotein‐associated phospholipase A 2 ; MACE, major adverse cardiac events; MCE, major coronary events; MI, myocardial infarction; Q, quartile.

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Lipoprotein‐Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease

    doi: 10.1161/JAHA.116.003407

    Figure Lengend Snippet: Baseline Lp‐ PLA 2 activity (μmol/min per liter) quartile groups in relation to outcomes in (A) all patients, (B) in women, and (C) in men, adjusted for demographics, baseline characteristics, routine biochemical variables, and prognostic biomarkers. The x ‐axis presents a logarithmic scale. MACE indicates CV death, MI, or stroke; MCE indicates coronary heart disease death, MI, or urgent coronary revascularization. Event rates are Kaplan–Meier rates. Adjustment variables: randomized treatment, geographic region, age, sex, body mass index, current smoking, hypertension, diabetes mellitus, prior MI, prior coronary revascularization, multivessel coronary heart disease, polyvascular disease, significant renal dysfunction, routine biochemical variables (hemoglobin, white blood cell count, estimated glomerular filtration rate [Chronic Kidney Disease Epidemiology Collaboration], low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and triglycerides), and prognostic biomarkers (N‐terminal proB‐type natriuretic peptide, high‐sensitivity cardiac troponin T, cystatin C, high‐sensitivity C‐reactive protein, and interleukin 6). CV indicates cardiovascular; HR, hazard ratio; Lp‐PLA 2 , lipoprotein‐associated phospholipase A 2 ; MACE, major adverse cardiac events; MCE, major coronary events; MI, myocardial infarction; Q, quartile.

    Article Snippet: High‐sensitivity C‐reactive protein was analyzed using the CardioPhase high‐sensitivity C‐reactive protein (Dade Behring) 2‐site particle‐enhanced immunonephelometry sandwich assay.

    Techniques: Proximity Ligation Assay, Activity Assay, Cell Counting, Filtration

    Changes in serum TBARS, hsCRP, and adiponectin levels. Serum levels of thiobarbituric acid-reacting substance (TBARS) (A) , high-sensitivity C-reactive protein (hsCRP) (B) , and adiponectin (C) . Data are mean ± SEM of 10 subjects of the control group and 16 subjects of the sitagliptin group. NS; not significant.

    Journal: Cardiovascular Diabetology

    Article Title: A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus- a randomized controlled trial START-J study

    doi: 10.1186/1475-2840-13-96

    Figure Lengend Snippet: Changes in serum TBARS, hsCRP, and adiponectin levels. Serum levels of thiobarbituric acid-reacting substance (TBARS) (A) , high-sensitivity C-reactive protein (hsCRP) (B) , and adiponectin (C) . Data are mean ± SEM of 10 subjects of the control group and 16 subjects of the sitagliptin group. NS; not significant.

    Article Snippet: All frozen samples were thawed on ice and subjected to measurements for adiponectin (Adiponectin ELISA Kit, Otsuka Pharmaceutical Co., Tokushima, Japan) [ ], high-sensitivity C-reactive protein (hsCRP) (N-Latex CRP II, Dade Behring Inc, Marburg, Germany), and thiobarbituric acid reactive substances (TBARS) [ ] (Japan Institute for the Control of Aging, Nikken SEIL Co., Shizuoka, Japan).

    Techniques:

    Epigenetic down-regulation of estrogen receptors ESR1 and ESR2 in CP/CPPS and deterioration of CP/CPPS symptoms in patients with advanced age ( A ) A significant decrease of expression of both estrogen receptor genes ( ESR1 and ESR2 ) was detected in somatic cells isolated from ejaculates of CP/CPPS patients in comparison to controls ( A.1 ). By analyzing the promoter methylation of ESR1 and ESR2 in ejaculated somatic cells, a highly significant increase of cells having methylated ESR1 and ESR2 promoters was found in the CP/CPPS group ( A.2 ). In contrast, androgen receptor ( AR ) gene expression and promoter methylation did not differ much between controls and patients ( A.1 and A.1 ); ( B ) Leukocytes isolated from blood of CP/CPPS and controls did not differ in gene expression of ESR1 ( B.1 ). CP/CPPS patients exhibited a reduced ESR2 and AR expression, whereby for ESR2 the difference was statistically significant (B.1). Methylation data showed a significant decrease of cells with methylated ESR1 promoter in CP/CPPS patients’ blood leukocytes, whereas ESR2 and AR promoters were comparable between patients and controls ( B.2 ); ( C ) Prostate cancer cell lines LNCaP, DU145 and PC3 were analyzed by COBRA in ESR1 and ESR2 promoters. PC3 cells exhibited methylation (m) in ESR1 promoter (Bsh1236i (CGCG)-specific restriction bands visible under “+”), whereas the other two were unmethylated (u) ( C.1 , upper gel picture). ESR2 promoter was methylated in LNCaP cells and unmethylated in DU145 and PC3 (C.1, bottom gel picture). Treatment with 5-aza-2′-deoxycytidine (+AZA) led to re-expression of ESR1 in PC3 cells and of ESR2 in LNCaP cells ( C.2 ); ( C ) Older CP/CPPS patients (≥40 years) exhibited extremely increased levels of CRP (C reactive protein) ( D.1 ) and significantly higher IPSS (international prostate symptom score) than younger patients (

    Journal: Oncotarget

    Article Title: Elevated seminal plasma estradiol and epigenetic inactivation of ESR1 and ESR2 is associated with CP/CPPS

    doi: 10.18632/oncotarget.24714

    Figure Lengend Snippet: Epigenetic down-regulation of estrogen receptors ESR1 and ESR2 in CP/CPPS and deterioration of CP/CPPS symptoms in patients with advanced age ( A ) A significant decrease of expression of both estrogen receptor genes ( ESR1 and ESR2 ) was detected in somatic cells isolated from ejaculates of CP/CPPS patients in comparison to controls ( A.1 ). By analyzing the promoter methylation of ESR1 and ESR2 in ejaculated somatic cells, a highly significant increase of cells having methylated ESR1 and ESR2 promoters was found in the CP/CPPS group ( A.2 ). In contrast, androgen receptor ( AR ) gene expression and promoter methylation did not differ much between controls and patients ( A.1 and A.1 ); ( B ) Leukocytes isolated from blood of CP/CPPS and controls did not differ in gene expression of ESR1 ( B.1 ). CP/CPPS patients exhibited a reduced ESR2 and AR expression, whereby for ESR2 the difference was statistically significant (B.1). Methylation data showed a significant decrease of cells with methylated ESR1 promoter in CP/CPPS patients’ blood leukocytes, whereas ESR2 and AR promoters were comparable between patients and controls ( B.2 ); ( C ) Prostate cancer cell lines LNCaP, DU145 and PC3 were analyzed by COBRA in ESR1 and ESR2 promoters. PC3 cells exhibited methylation (m) in ESR1 promoter (Bsh1236i (CGCG)-specific restriction bands visible under “+”), whereas the other two were unmethylated (u) ( C.1 , upper gel picture). ESR2 promoter was methylated in LNCaP cells and unmethylated in DU145 and PC3 (C.1, bottom gel picture). Treatment with 5-aza-2′-deoxycytidine (+AZA) led to re-expression of ESR1 in PC3 cells and of ESR2 in LNCaP cells ( C.2 ); ( C ) Older CP/CPPS patients (≥40 years) exhibited extremely increased levels of CRP (C reactive protein) ( D.1 ) and significantly higher IPSS (international prostate symptom score) than younger patients (

    Article Snippet: Blood samples from CP/CPPS patients were routinely analyzed for total testosterone, C-reactive protein (CRP) and prostate specific antigen (PSA) levels in the central laboratory of our university hospital (ADIVA, Siemens Health Care, Erlangen, Germany).

    Techniques: Expressing, Isolation, Methylation, Combined Bisulfite Restriction Analysis Assay

    (a–i) Receiver operating characteristic curves were presented for different screen tests with the date derived at 16–18 weeks of gestation. CRP , C‐reactive protein; FFA s, free fatty acids; RBP ‐4, retinol‐binding protein‐4; ROC , receiver operating characteristic.

    Journal: Journal of Diabetes Investigation

    Article Title: Ficolin‐3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women

    doi: 10.1111/jdi.12688

    Figure Lengend Snippet: (a–i) Receiver operating characteristic curves were presented for different screen tests with the date derived at 16–18 weeks of gestation. CRP , C‐reactive protein; FFA s, free fatty acids; RBP ‐4, retinol‐binding protein‐4; ROC , receiver operating characteristic.

    Article Snippet: Fasting glucose, lipids, free fatty acids (FFAs), C‐reactive protein (CRP) and RBP‐4 were measured by an automatic biochemical analyzer (Hitachi 7180; Hitachi, Ibaraki‐ken, Japan) using commercial kits (Wako Pure Chemical Industries, Osaka, Japan).

    Techniques: Derivative Assay, Binding Assay

    Survival curves for the ratio of patients with abnormal disease activity indicators and serum MMP-3 between non-progressive and progressive patients. P values were determined by log-rank tests between non-progressive and progressive groups. Pain VAS pain visual analogue scale, 28TJC 28-joint tender joint count, 28SJC 28-joint swollen joint count, PtGA patient global assessment of disease activity, PrGA provider global assessment of disease activity, HAQ health assessment questionnaire, CRP C-reactive protein, ESR erythrocyte sedimentation rate, DAS28 Disease Activity Score 28-joint assessment, SDAI simplified disease activity index, CDAI clinical disease activity index, MMP-3 matrix metalloproteinase-3, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide antibody

    Journal: Arthritis Research & Therapy

    Article Title: Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

    doi: 10.1186/s13075-015-0803-2

    Figure Lengend Snippet: Survival curves for the ratio of patients with abnormal disease activity indicators and serum MMP-3 between non-progressive and progressive patients. P values were determined by log-rank tests between non-progressive and progressive groups. Pain VAS pain visual analogue scale, 28TJC 28-joint tender joint count, 28SJC 28-joint swollen joint count, PtGA patient global assessment of disease activity, PrGA provider global assessment of disease activity, HAQ health assessment questionnaire, CRP C-reactive protein, ESR erythrocyte sedimentation rate, DAS28 Disease Activity Score 28-joint assessment, SDAI simplified disease activity index, CDAI clinical disease activity index, MMP-3 matrix metalloproteinase-3, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide antibody

    Article Snippet: Clinical assessments All patients were followed up at regular intervals including the same predefined assessment points (0, 1st, 3rd, 6th, and 12th month) and the following indicators were assessed: 28-joint tender and swollen joint count (28TJC and 28SJC, both 0–28), Patient global assessment of disease activity (PtGA, 0–10 cm, 10 = worst status), Provider global assessment of disease activity (PrGA, 0–10 cm, 10 = worst status), Pain visual analogue scale (Pain VAS, 0–10 cm, 10 = most pain), Chinese language version of the Stanford health assessment questionnaire (HAQ, 0–3, 3 = most functional disability) [ ], erythrocyte sedimentation rate [(ESR) mm/h, normal range: 0–20 mm/h (female), 0–15 mm/h (male)], C-reactive protein [(CRP), mg/dl, normal range: 0–0.5 mg/dl], RF (mg/L, determined by nephelometry, Siemens Healthcare Diagnostics, Munich, Germany, normal range: 0–20 mg/L), and anti-CCP [U/ml, measured by enzyme-linked immunosorbent assay (ELISA), Aesku Diagnostics, Wendelsheim, Germany, normal range: 0–18 U/ml].

    Techniques: Activity Assay, Electron Paramagnetic Resonance, Sedimentation

    Age- and sex-adjusted mean HOMA2-IR ( a ), HOMA2-%B ( b ), HS-CRP ( c ), and adiponectin ( d ) concentration according to the lifestyle score. HS-CRP high sensitivity C-reactive protein, HOMA2-IR homeostasis model assessment of insulin resistance, HOMA2-%B homeostasis model assessment of β-cell function. HOMA2-IR, HOMA2-%B, HS-CRP, and adiponectin levels are presented as geometric means. Bars represent 95% confidence intervals. * p

    Journal: Diabetology international

    Article Title: Joint impact of modifiable lifestyle behaviors on glycemic control and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry

    doi: 10.1007/s13340-017-0310-6

    Figure Lengend Snippet: Age- and sex-adjusted mean HOMA2-IR ( a ), HOMA2-%B ( b ), HS-CRP ( c ), and adiponectin ( d ) concentration according to the lifestyle score. HS-CRP high sensitivity C-reactive protein, HOMA2-IR homeostasis model assessment of insulin resistance, HOMA2-%B homeostasis model assessment of β-cell function. HOMA2-IR, HOMA2-%B, HS-CRP, and adiponectin levels are presented as geometric means. Bars represent 95% confidence intervals. * p

    Article Snippet: Determination of serum adiponectin (Mitsubishi Chemical Medience, Tokyo, Japan) and high-sensitivity C-reactive protein (HS-CRP) (Siemens Healthcare Diagnostics, Tokyo, Japan) were by latex immunonephelometry in 4869 and 4326 patients, respectively.

    Techniques: Concentration Assay, Cell Function Assay

    Complement C3 and total IgE serum levels values according to low grade inflammation in both atopic (A) and not atopic (B) children affected by allergic disease. CRP values

    Journal: World Journal of Clinical Pediatrics

    Article Title: Subclinical hypothyroidism in atopic South Italian children

    doi: 10.5409/wjcp.v5.i3.306

    Figure Lengend Snippet: Complement C3 and total IgE serum levels values according to low grade inflammation in both atopic (A) and not atopic (B) children affected by allergic disease. CRP values

    Article Snippet: In all patients, after an overnight fasting, a blood sample was obtained to evaluate C-reactive protein (CRP) and Complement C3 serum levels, measured using an Olympus AU 560 apparatus by an enzymatic colorimetric method, total and specific IgE by a fluorenzymeimmunoassay (ImmunoCap and ImmunoCap 0-100), thyroid hormones (TSH, fT3, and fT4) and anti-thyroid peroxidase antibodies (TPO-Ab) and anti-thyroglobulin antibodies (Tg-Ab), determined by high-specific solid-phase technique-chemiluminescence immunoassays (Perkinelmer, Turku, Finland).

    Techniques: