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  • 99
    Millipore bms 345541
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms 345541, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 440 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 99 stars, based on 440 article reviews
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    bms 345541 - by Bioz Stars, 2020-09
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    94
    Novartis bms
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms, supplied by Novartis, used in various techniques. Bioz Stars score: 94/100, based on 1960 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 1960 article reviews
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    bms  (Janssen)
    92
    Janssen bms
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms, supplied by Janssen, used in various techniques. Bioz Stars score: 92/100, based on 1979 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 1979 article reviews
    Price from $9.99 to $1999.99
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    92/100 stars
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    bms  (Celgene)
    92
    Celgene bms
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms, supplied by Celgene, used in various techniques. Bioz Stars score: 92/100, based on 1045 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 1045 article reviews
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    92/100 stars
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    94
    Pfizer Inc bms
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 94/100, based on 1569 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 1569 article reviews
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    94/100 stars
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    bms  (AbbVie)
    92
    AbbVie bms
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms, supplied by AbbVie, used in various techniques. Bioz Stars score: 92/100, based on 1120 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Boehringer Ingelheim bms
    VSV viral titer recovery by <t>BMS-345541</t> in B16 melanoma but not 5TGM1 myeloma cells
    Bms, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 94/100, based on 1061 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 1061 article reviews
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    93
    Bristol Myers bristol myers squibb bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bristol Myers Squibb Bms, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 93/100, based on 950 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 950 article reviews
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    93
    AstraZeneca bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by AstraZeneca, used in various techniques. Bioz Stars score: 93/100, based on 799 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Eli Lilly bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Eli Lilly, used in various techniques. Bioz Stars score: 92/100, based on 569 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Gilead Sciences bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 92/100, based on 436 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Merck & Co bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Merck & Co, used in various techniques. Bioz Stars score: 94/100, based on 907 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 907 article reviews
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    94
    Genentech bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Genentech, used in various techniques. Bioz Stars score: 94/100, based on 472 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 472 article reviews
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    bms  (Amgen)
    92
    Amgen bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Amgen, used in various techniques. Bioz Stars score: 92/100, based on 460 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    bms  (Eisai)
    92
    Eisai bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Eisai, used in various techniques. Bioz Stars score: 92/100, based on 269 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 269 article reviews
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    bms  (Sanofi)
    92
    Sanofi bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Sanofi, used in various techniques. Bioz Stars score: 92/100, based on 315 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 315 article reviews
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    97
    Miltenyi Biotec monocyte isolation kit
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Monocyte Isolation Kit, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 97/100, based on 1033 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Centocor bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Centocor, used in various techniques. Bioz Stars score: 93/100, based on 203 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    bms  (Takeda)
    94
    Takeda bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Takeda, used in various techniques. Bioz Stars score: 94/100, based on 262 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 262 article reviews
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    93
    Daiichi Sankyo bms
    Novel nucleoside analogs discovered at <t>Bristol-Myers</t> <t>Squibb</t> *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).
    Bms, supplied by Daiichi Sankyo, used in various techniques. Bioz Stars score: 93/100, based on 126 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    98
    Tocris bms493
    SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM <t>BMS493</t> (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P
    Bms493, supplied by Tocris, used in various techniques. Bioz Stars score: 98/100, based on 174 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    bms  (Chugai)
    94
    Chugai bms
    SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM <t>BMS493</t> (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P
    Bms, supplied by Chugai, used in various techniques. Bioz Stars score: 94/100, based on 175 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 175 article reviews
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    bms  (Incyte)
    92
    Incyte bms
    SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM <t>BMS493</t> (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P
    Bms, supplied by Incyte, used in various techniques. Bioz Stars score: 92/100, based on 72 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 92 stars, based on 72 article reviews
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    91
    Exelixis bms
    SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM <t>BMS493</t> (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P
    Bms, supplied by Exelixis, used in various techniques. Bioz Stars score: 91/100, based on 74 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91/100 stars
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    92
    Astellas bms
    SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM <t>BMS493</t> (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P
    Bms, supplied by Astellas, used in various techniques. Bioz Stars score: 92/100, based on 156 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    VSV viral titer recovery by BMS-345541 in B16 melanoma but not 5TGM1 myeloma cells

    Journal: Experimental hematology

    Article Title: Oncolytic vesicular stomatitis virus and bortezomib are antagonistic against myeloma cells in vitro but have additive anti-myeloma activity in vivo

    doi: 10.1016/j.exphem.2013.09.005

    Figure Lengend Snippet: VSV viral titer recovery by BMS-345541 in B16 melanoma but not 5TGM1 myeloma cells

    Article Snippet: Bortezomib (PS-431; Velcade®) was purchased from Millennium Pharmaceuticals (Cambridge, MA); BMS-345541 from Calbiochem (San Diego, CA); and murine and human IFNβ from PBL Interferon Source (Piscataway, NJ).

    Techniques:

    Novel nucleoside analogs discovered at Bristol-Myers Squibb *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).

    Journal: Journal of Clinical and Translational Hepatology

    Article Title: The Discovery and Development of a Potent Antiviral Drug, Entecavir, for the Treatment of Chronic Hepatitis B

    doi: 10.14218/JCTH.2013.00006

    Figure Lengend Snippet: Novel nucleoside analogs discovered at Bristol-Myers Squibb *Nucleoside analogs showing activity against varicella zoster virus (VZV) and herpes simplex virus (HSV).

    Article Snippet: Discovery On January 13, 1995, researchers from Bristol-Myers Squibb (BMS) discovered a compound showing a high potency against HBV, more potent than any previously tested drug.

    Techniques: Activity Assay

    SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM BMS493 (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P

    Journal: Development (Cambridge, England)

    Article Title: RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation

    doi: 10.1242/dev.164822

    Figure Lengend Snippet: SMG initiation is enhanced by addition of retinol and blocked by pharmacological inhibitor of RARs. (A-C) Mandibular explants were cultured with either vehicle control (A), 10 µM retinol (B) or 5 µM BMS493 (C), followed by whole-mount E-cadherin immunostaining and confocal microscopy. Bilateral patches of dense E-cadherin staining at base of tongue in control and retinol samples, but not in BMS493 samples, indicates that SMG initiation is blocked by RAR inhibitors. (D-I) Volume projections (D-F) and surface rendering (G-I) through the region of SMG gland initiation (rotated 90° from image plane for frontal view) are shown. (J) SMG epithelium volume quantitation indicates that retinol treatment increases initial bud size, whereas treatment with RAR inhibitor blocks initiation. Bar chart shows the average volume and standard error for each group ( n =8 glands from four mandibles for each condition). (K) Contingency table for the presence or absence of initiated glands (TRUE versus FALSE) for each prospective site in the experiment ( n =8 possible sites in four mandibles for each condition). (L-N) E-cadherin-stained frozen sections of cultured mandible explants reveal that inhibition of RAR blocks epithelial thickening (N). (O) qPCR of Fgf10 RNA in mandibles cultured on control or BMS493-treated medium reveals that treatment with RAR inhibitor causes a mild reduction in Fgf10 expression ( n =3 mandibles). Yellow arrowheads indicate epithelial invagination into underlying mesenchyme, yellow asterisks indicate absence of epithelial invagination. * P

    Article Snippet: For RAR inhibition experiments, cultures were treated with 5 µM of either BMS493, BMS614, LE135 or MM 11253 (Tocris, #3509, #3660, #2021 and #3822, respectively).

    Techniques: Cell Culture, Immunostaining, Confocal Microscopy, Staining, Quantitation Assay, Inhibition, Real-time Polymerase Chain Reaction, Expressing

    Treatment with a pan-RAR inhibitor blocks differentiation into SOX9 + salivary epithelium. (A-C‴) Mandibular explants were cultured on either 10 µM retinol, 5 µM BMS493, or vehicle control medium, whole-mount immunostained for E-cadherin and SOX9, and imaged by confocal microscopy. (A′-C′) Volume projections of E-cadherin staining in SMG initiation region, rotated for frontal view, show a bilateral pair of epithelial invaginations samples grown on control and retinol medium, but not on BMS493 medium. Control and retinol treated samples have a bilateral pair of SOX9 + expression domains that colocalize with the invaginated epithelium (A″,A‴,B″,B‴). The epithelial SOX9 expression domains are absent in BMS493-treated samples (C″,C‴). (D) SOX9 expression colocalized with epithelial buds was quantified by the intensity sum of the immunofluorescence signal. Average and standard error bars for each group are shown ( n =4). Yellow arrowheads indicate epithelium invaginated into underlying mesenchyme, yellow asterisks indicate the absence of epithelial invagination. * P

    Journal: Development (Cambridge, England)

    Article Title: RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation

    doi: 10.1242/dev.164822

    Figure Lengend Snippet: Treatment with a pan-RAR inhibitor blocks differentiation into SOX9 + salivary epithelium. (A-C‴) Mandibular explants were cultured on either 10 µM retinol, 5 µM BMS493, or vehicle control medium, whole-mount immunostained for E-cadherin and SOX9, and imaged by confocal microscopy. (A′-C′) Volume projections of E-cadherin staining in SMG initiation region, rotated for frontal view, show a bilateral pair of epithelial invaginations samples grown on control and retinol medium, but not on BMS493 medium. Control and retinol treated samples have a bilateral pair of SOX9 + expression domains that colocalize with the invaginated epithelium (A″,A‴,B″,B‴). The epithelial SOX9 expression domains are absent in BMS493-treated samples (C″,C‴). (D) SOX9 expression colocalized with epithelial buds was quantified by the intensity sum of the immunofluorescence signal. Average and standard error bars for each group are shown ( n =4). Yellow arrowheads indicate epithelium invaginated into underlying mesenchyme, yellow asterisks indicate the absence of epithelial invagination. * P

    Article Snippet: For RAR inhibition experiments, cultures were treated with 5 µM of either BMS493, BMS614, LE135 or MM 11253 (Tocris, #3509, #3660, #2021 and #3822, respectively).

    Techniques: Cell Culture, Confocal Microscopy, Staining, Expressing, Immunofluorescence