Journal: Neuroscience

Article Title: Promoter Specific Alterations of BDNF mRNA in Schizophrenia

doi: 10.1016/j.neuroscience.2010.05.037

Figure Lengend Snippet: Expression of the 4 major BDNF transcripts: I–IX (black bars), II–IX (white bars), IV–IX (grey bars) and VI–IX (hatched bars) were measured by qPCR. (A) CBDB cohort and (B) TRC cohort. Data is expressed as percent change relative to the control group and presented as mean −/+ SEM. Significance between groups was *p<0.05 or lower. Note: BDNF transcript I–IX was significant by ANCOVA- CBDB: F=4.59, df=1, 62, p=0.04 and TRC: F=4.42, df=1, 66, p=0.04.

Article Snippet: The transcripts arising from the 4 best characterized BDNF exons ( 13 ) were targeted by the following ABI probes: BDNF I–IX (Cat# hs00538277-m1), BDNF II–IX (Cat# hs00538278-m1), BDNF IV–IX (Cat# hs00380947-m1) and BDNF VI–IX (Cat# hs00156058-m1).

Techniques: Expressing

Journal: Neuroscience

Article Title: Promoter Specific Alterations of BDNF mRNA in Schizophrenia

doi: 10.1016/j.neuroscience.2010.05.037

Figure Lengend Snippet: (A) A representative western blot containing both control and schizophrenic cases was immunoprobed for the ~14kDa mature BDNF protein. β-actin was probed as a loading control and an internal control (I) was used for normalization between western blots. (B) Bands were quantitated by densitometry. Expression of the mature BDNF protein is expressed as percent change relative to the control group and presented as mean −/+ SEM.

Article Snippet: The transcripts arising from the 4 best characterized BDNF exons ( 13 ) were targeted by the following ABI probes: BDNF I–IX (Cat# hs00538277-m1), BDNF II–IX (Cat# hs00538278-m1), BDNF IV–IX (Cat# hs00380947-m1) and BDNF VI–IX (Cat# hs00156058-m1).

Techniques: Western Blot, Expressing

Journal: Neuroscience

Article Title: Promoter Specific Alterations of BDNF mRNA in Schizophrenia

doi: 10.1016/j.neuroscience.2010.05.037

Figure Lengend Snippet: Expression of the 4 major BDNF transcripts: I–IX (black bars), II–IX (white bars), IV–IX (grey bars) and VI–IX (hatched bars) in (A) the parietal cortex and (B) hippocampus were measured by qPCR. Data is expressed as percent change relative to the control group and presented as mean −/+ SEM.

Article Snippet: The transcripts arising from the 4 best characterized BDNF exons ( 13 ) were targeted by the following ABI probes: BDNF I–IX (Cat# hs00538277-m1), BDNF II–IX (Cat# hs00538278-m1), BDNF IV–IX (Cat# hs00380947-m1) and BDNF VI–IX (Cat# hs00156058-m1).

Techniques: Expressing

Journal: Neuroscience

Article Title: Promoter Specific Alterations of BDNF mRNA in Schizophrenia

doi: 10.1016/j.neuroscience.2010.05.037

Figure Lengend Snippet: Expression of the 4 major BDNF transcripts: I–IX (black bars), II–IX (white bars), IV–IX (grey bars) and VI–IX (hatched bars) in the (A) DLPFC, (B) parietal cortex and (C) hippocampus were measured by qPCR. For the DLPFC, data for the TRC and CBDB cohorts were pooled for analysis. For the parietal cortex and hippocampus, the CBDB cohort was used. Data is expressed as percent change relative to the control group and presented as mean + SEM. Significance between groups was *p<0.05 or lower.

Article Snippet: The transcripts arising from the 4 best characterized BDNF exons ( 13 ) were targeted by the following ABI probes: BDNF I–IX (Cat# hs00538277-m1), BDNF II–IX (Cat# hs00538278-m1), BDNF IV–IX (Cat# hs00380947-m1) and BDNF VI–IX (Cat# hs00156058-m1).

Techniques: Expressing

Journal: Biomolecules

Article Title: Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans

doi: 10.3390/biom11050641

Figure Lengend Snippet: PANSS cognitive subscale scores in control subjects and subjects with PTSD depending on BDNF rs6265 ( A , C ) and BDNF rs56164415 ( B , D ) genotypes and alleles. Results are shown using the box and whiskers plot, where the central box represents the interquartile range (IQR), middle line the median, whiskers 1.5 IQR, dots the outliers and grey asterix extreme values. The differences between groups were analyzed using Kruskal–Wallis ANOVA, followed by the Dunn’s test, or Mann–Whitney U test.

Article Snippet: Assay IDs were C_11592758_10 for rs6265 and C_89097201_10 for rs56164415.

Techniques: MANN-WHITNEY

Journal: Biomolecules

Article Title: Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans

doi: 10.3390/biom11050641

Figure Lengend Snippet: PANSS cognitive subscale scores in control subjects and subjects with PTSD, divided by smoking status, depending on BDNF rs6265 ( A , C , E , G ) and BDNF rs56164415 ( B , D , F , H ) polymorphisms. Results are shown using the box and whiskers plot, where the central box represents the interquartile range (IQR), middle line the median, whiskers 1.5 IQR, dots the outliers, and grey asterix presents extreme values. The differences between groups were analyzed using Kruskal–Wallis ANOVA, followed by the Dunn’s test, or Mann–Whitney U test.

Article Snippet: Assay IDs were C_11592758_10 for rs6265 and C_89097201_10 for rs56164415.

Techniques: MANN-WHITNEY