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  • 93
    Alomone Labs anti kv1 3
    <t>Kv1.3</t> and cell cycle marker expression in sham operated (sham) and advanced CRF rat kidneys. (A) Kv1.3 expression. (a) KCNA3 mRNA abundance in the renal cortex of sham operated (sham) and advanced CRF (CRF) rat kidneys. (b) and (c) Immunohistochemistry using antibody for Kv1.3 (brown) in sham operated and advanced CRF rat kidneys. High-power views of cortical interstitium. Magnification, ×60. (B) Cell cycle marker expression. The mRNA abundance of cyclin-dependent kinase 4 (Cdk4) (left) and p21 (right) in the renal cortex of sham operated and advanced CRF rat kidneys. # P < 0.05 versus sham operated rats. Values are means ± SEM ( n = 6). Differences were analyzed by ANOVA followed by Dunnett's or Student's t -test.
    Anti Kv1 3, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Santa Cruz Biotechnology kcna3
    Increased protein levels of ( a ) KCNA1, ( b ) <t>KCNA3,</t> and ( c ) KCNN1 in the NAc of SM rats. Data are presented as means ± SEM of fold changes relative to the controls. Key to statistics: * P < 0.05, ** P < 0.01, *** P < 0.001 in comparison to controls (SS group); # P < 0.05, ## P < 0.01 in comparison to SM rats
    Kcna3, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    95
    Alomone Labs anti kv1 3 polyclonal serum
    Increased protein levels of ( a ) KCNA1, ( b ) <t>KCNA3,</t> and ( c ) KCNN1 in the NAc of SM rats. Data are presented as means ± SEM of fold changes relative to the controls. Key to statistics: * P < 0.05, ** P < 0.01, *** P < 0.001 in comparison to controls (SS group); # P < 0.05, ## P < 0.01 in comparison to SM rats
    Anti Kv1 3 Polyclonal Serum, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Proteintech anti kv1 3
    The <t>CXCR4-Kv1.3</t> axis is implicated in gp120 LAV-induced NLRP3 inflammasome activation. a–f ELISA of IL-1β in supernatants of BV2 cells stimulated by gp120 LAV (0.5 μg/ml) in the presence of increasing doses of KCl (50–200 mM), the K+ efflux inhibitor glyburide (50–200 μM) (a); the ROS inhibitor ADPC (5–50 μM), NAC (5–25 μM) (b); MitoTEMPO (100–500 μM) (c); the actin polymerization inhibitor cytochalasin D (1–25 μM) (d); the lysosome inhibitor bafilomycin A (10–200 nM) (e); and the cathepsin B inhibitor CA-074Me (5–20 μM) (f). g Western blot (upper panel) and densitometric analysis (lower panel) of Kv1.3 in lysates of BV2 cells stimulated with increasing doses of gp120 LAV (0.01–0.5 μg/ml). h, i ELISA of IL-1β in supernatants of BV2 cells stimulated with gp120 LAV (0.5 μg/ml) in the presence of increasing doses of a Kv1.3-specific inhibitor (PAP-1, 0.1–2 μM) (h) or CXCR4-specific inhibitor (AMD3100, 0.1–10 μM) (i). j, k Immunoblot analysis of Casp-1-p20 and IL-1β-p17 (j) and ELISA of IL-1β (k) in supernatants (Sup) of BV2 cells transfected with control siRNA, CXCR4 or Kv1.3-specific siRNA and treated with or without gp120 LAV (0.5 μg/ml). CXCR4, Kv1.3, NLRP3, pro-casp-1, and pro-IL-1β in lysates (Lys) of these cells were also detected. l–n Western blots (l) and densitometric analysis of Kv1.3 (m) and p38-MAPK phosphorylation (P-p38, n) in lysates of BV2 cells transfected with siRNA control or CXCR4-specific siRNA and stimulated with or without gp120 LAV (0.5 μg/ml). The data are displayed as the mean ± SEM (n = 5) from three independent experiments (a–i, k, m, n). The Western blot results are representative of three (j) and five (g, l) independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001
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    Image Search Results


    Kv1.3 and cell cycle marker expression in sham operated (sham) and advanced CRF rat kidneys. (A) Kv1.3 expression. (a) KCNA3 mRNA abundance in the renal cortex of sham operated (sham) and advanced CRF (CRF) rat kidneys. (b) and (c) Immunohistochemistry using antibody for Kv1.3 (brown) in sham operated and advanced CRF rat kidneys. High-power views of cortical interstitium. Magnification, ×60. (B) Cell cycle marker expression. The mRNA abundance of cyclin-dependent kinase 4 (Cdk4) (left) and p21 (right) in the renal cortex of sham operated and advanced CRF rat kidneys. # P < 0.05 versus sham operated rats. Values are means ± SEM ( n = 6). Differences were analyzed by ANOVA followed by Dunnett's or Student's t -test.

    Journal: International Journal of Nephrology

    Article Title: Overexpression of Delayed Rectifier K + Channels Promotes In situ Proliferation of Leukocytes in Rat Kidneys with Advanced Chronic Renal Failure

    doi: 10.1155/2012/581581

    Figure Lengend Snippet: Kv1.3 and cell cycle marker expression in sham operated (sham) and advanced CRF rat kidneys. (A) Kv1.3 expression. (a) KCNA3 mRNA abundance in the renal cortex of sham operated (sham) and advanced CRF (CRF) rat kidneys. (b) and (c) Immunohistochemistry using antibody for Kv1.3 (brown) in sham operated and advanced CRF rat kidneys. High-power views of cortical interstitium. Magnification, ×60. (B) Cell cycle marker expression. The mRNA abundance of cyclin-dependent kinase 4 (Cdk4) (left) and p21 (right) in the renal cortex of sham operated and advanced CRF rat kidneys. # P < 0.05 versus sham operated rats. Values are means ± SEM ( n = 6). Differences were analyzed by ANOVA followed by Dunnett's or Student's t -test.

    Article Snippet: Primary antibodies were as follows: rabbit anti-Ki-67 (1 : 100; Lab Vision Co., Fremont, CA, USA), anti-Kv1.3 (1 : 100; Alomone Labs Ltd., Jerusalem, Israel), and mouse anticollagen type III (1 : 100; Abnova, Taipei City, Taiwan).

    Techniques: Marker, Expressing, Immunohistochemistry

    Increased protein levels of ( a ) KCNA1, ( b ) KCNA3, and ( c ) KCNN1 in the NAc of SM rats. Data are presented as means ± SEM of fold changes relative to the controls. Key to statistics: * P < 0.05, ** P < 0.01, *** P < 0.001 in comparison to controls (SS group); # P < 0.05, ## P < 0.01 in comparison to SM rats

    Journal: Molecular Neurobiology

    Article Title: A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens

    doi: 10.1007/s12035-019-01830-3

    Figure Lengend Snippet: Increased protein levels of ( a ) KCNA1, ( b ) KCNA3, and ( c ) KCNN1 in the NAc of SM rats. Data are presented as means ± SEM of fold changes relative to the controls. Key to statistics: * P < 0.05, ** P < 0.01, *** P < 0.001 in comparison to controls (SS group); # P < 0.05, ## P < 0.01 in comparison to SM rats

    Article Snippet: Subsequently, the membranes were incubated overnight at 4 °C with specific antibodies against KCNA1(Abcam, catalog # ab32433), KCNA3 (Santa Cruz, catalog # sc-398,855) and KCNN1 (Abcam, catalog # ab66624).

    Techniques:

    METH SA caused decreased DNA methylation in the NAc of SM rats. (a) DNA methylation at CpG-rich sites near the promoter of Kcna1 voltage-gated K + channels in the NAc of SM and MM rats. ( b ) DNA methylation at the Kcna3 promoter showed a decreasing trend ( p = 0.0548) in the NAc of SM rats in comparison to control rats; pre-exposure to METH normalized DNA methylation. ( c ) Decreased DNA methylation of calcium-activated K + channel, Kcnn1, in the NAc of SM rats and this was also reversed in the MM rats. Key to statistics: ***P < 0.001 in comparison to controls (SS group); ## P < 0.01 in comparison to SM rats

    Journal: Molecular Neurobiology

    Article Title: A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens

    doi: 10.1007/s12035-019-01830-3

    Figure Lengend Snippet: METH SA caused decreased DNA methylation in the NAc of SM rats. (a) DNA methylation at CpG-rich sites near the promoter of Kcna1 voltage-gated K + channels in the NAc of SM and MM rats. ( b ) DNA methylation at the Kcna3 promoter showed a decreasing trend ( p = 0.0548) in the NAc of SM rats in comparison to control rats; pre-exposure to METH normalized DNA methylation. ( c ) Decreased DNA methylation of calcium-activated K + channel, Kcnn1, in the NAc of SM rats and this was also reversed in the MM rats. Key to statistics: ***P < 0.001 in comparison to controls (SS group); ## P < 0.01 in comparison to SM rats

    Article Snippet: Subsequently, the membranes were incubated overnight at 4 °C with specific antibodies against KCNA1(Abcam, catalog # ab32433), KCNA3 (Santa Cruz, catalog # sc-398,855) and KCNN1 (Abcam, catalog # ab66624).

    Techniques: DNA Methylation Assay

    The CXCR4-Kv1.3 axis is implicated in gp120 LAV-induced NLRP3 inflammasome activation. a–f ELISA of IL-1β in supernatants of BV2 cells stimulated by gp120 LAV (0.5 μg/ml) in the presence of increasing doses of KCl (50–200 mM), the K+ efflux inhibitor glyburide (50–200 μM) (a); the ROS inhibitor ADPC (5–50 μM), NAC (5–25 μM) (b); MitoTEMPO (100–500 μM) (c); the actin polymerization inhibitor cytochalasin D (1–25 μM) (d); the lysosome inhibitor bafilomycin A (10–200 nM) (e); and the cathepsin B inhibitor CA-074Me (5–20 μM) (f). g Western blot (upper panel) and densitometric analysis (lower panel) of Kv1.3 in lysates of BV2 cells stimulated with increasing doses of gp120 LAV (0.01–0.5 μg/ml). h, i ELISA of IL-1β in supernatants of BV2 cells stimulated with gp120 LAV (0.5 μg/ml) in the presence of increasing doses of a Kv1.3-specific inhibitor (PAP-1, 0.1–2 μM) (h) or CXCR4-specific inhibitor (AMD3100, 0.1–10 μM) (i). j, k Immunoblot analysis of Casp-1-p20 and IL-1β-p17 (j) and ELISA of IL-1β (k) in supernatants (Sup) of BV2 cells transfected with control siRNA, CXCR4 or Kv1.3-specific siRNA and treated with or without gp120 LAV (0.5 μg/ml). CXCR4, Kv1.3, NLRP3, pro-casp-1, and pro-IL-1β in lysates (Lys) of these cells were also detected. l–n Western blots (l) and densitometric analysis of Kv1.3 (m) and p38-MAPK phosphorylation (P-p38, n) in lysates of BV2 cells transfected with siRNA control or CXCR4-specific siRNA and stimulated with or without gp120 LAV (0.5 μg/ml). The data are displayed as the mean ± SEM (n = 5) from three independent experiments (a–i, k, m, n). The Western blot results are representative of three (j) and five (g, l) independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

    Journal: Cellular and Molecular Immunology

    Article Title: NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology

    doi: 10.1038/s41423-019-0260-y

    Figure Lengend Snippet: The CXCR4-Kv1.3 axis is implicated in gp120 LAV-induced NLRP3 inflammasome activation. a–f ELISA of IL-1β in supernatants of BV2 cells stimulated by gp120 LAV (0.5 μg/ml) in the presence of increasing doses of KCl (50–200 mM), the K+ efflux inhibitor glyburide (50–200 μM) (a); the ROS inhibitor ADPC (5–50 μM), NAC (5–25 μM) (b); MitoTEMPO (100–500 μM) (c); the actin polymerization inhibitor cytochalasin D (1–25 μM) (d); the lysosome inhibitor bafilomycin A (10–200 nM) (e); and the cathepsin B inhibitor CA-074Me (5–20 μM) (f). g Western blot (upper panel) and densitometric analysis (lower panel) of Kv1.3 in lysates of BV2 cells stimulated with increasing doses of gp120 LAV (0.01–0.5 μg/ml). h, i ELISA of IL-1β in supernatants of BV2 cells stimulated with gp120 LAV (0.5 μg/ml) in the presence of increasing doses of a Kv1.3-specific inhibitor (PAP-1, 0.1–2 μM) (h) or CXCR4-specific inhibitor (AMD3100, 0.1–10 μM) (i). j, k Immunoblot analysis of Casp-1-p20 and IL-1β-p17 (j) and ELISA of IL-1β (k) in supernatants (Sup) of BV2 cells transfected with control siRNA, CXCR4 or Kv1.3-specific siRNA and treated with or without gp120 LAV (0.5 μg/ml). CXCR4, Kv1.3, NLRP3, pro-casp-1, and pro-IL-1β in lysates (Lys) of these cells were also detected. l–n Western blots (l) and densitometric analysis of Kv1.3 (m) and p38-MAPK phosphorylation (P-p38, n) in lysates of BV2 cells transfected with siRNA control or CXCR4-specific siRNA and stimulated with or without gp120 LAV (0.5 μg/ml). The data are displayed as the mean ± SEM (n = 5) from three independent experiments (a–i, k, m, n). The Western blot results are representative of three (j) and five (g, l) independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

    Article Snippet: The primary antibodies used are as follows: rabbit anti-IL-1β (1:2000), rabbit anti-arginase-1 (1:1000), rabbit anti-NF-κB p65 (1:50,000), rabbit anti-RELM alpha (1:3000), rabbit anti-CXCR4 (1:1000), rabbit anti-NLRP1 (1:1000), and rabbit anti-NLRP3 (1:1000) were all purchased from Abcam (Cambridge, USA); rabbit anti-caspase-1 (1:2000), rabbit anti-AIM2 (1:2000), rabbit anti-IκBα (1:2000), rabbit anti-GSDMD (1:2000), rabbit anti-Histone H3 (1:6000), and rabbit anti-Kv1.3 (1:2000) were all purchased from Proteintech Group (Chicago, USA); rabbit anti-β-actin (1:6000) (Bioss Antibodies, USA); mouse anti-ASC (1:200) (Santa Cruz Biotechnology, USA) were used; rabbit anti-NLRC4 (1:800) and rabbit anti-iNOS (1:800) were purchased from Boster Biotechnology (Wuhan, China); rabbit anti-cleaved-caspase-1 (1:1000), rabbit anti-cleaved-IL-1β (1:1000), rabbit anti-phospho-p38 MAPK (Thr180/Tyr182) (1:1000), and rabbit anti-p38 MAPK (1:1000) were all purchased from Cell Signaling Technology (Danvers, USA).

    Techniques: Activation Assay, Enzyme-linked Immunosorbent Assay, Western Blot, Transfection